NL7605526A - Nieuwe tetracyclische derivaten. - Google Patents
Nieuwe tetracyclische derivaten.Info
- Publication number
- NL7605526A NL7605526A NL7605526A NL7605526A NL7605526A NL 7605526 A NL7605526 A NL 7605526A NL 7605526 A NL7605526 A NL 7605526A NL 7605526 A NL7605526 A NL 7605526A NL 7605526 A NL7605526 A NL 7605526A
- Authority
- NL
- Netherlands
- Prior art keywords
- tetracyclical
- derivatives
- new
- tetracyclical derivatives
- new tetracyclical
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Priority Applications (31)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL7605526A NL7605526A (nl) | 1976-05-24 | 1976-05-24 | Nieuwe tetracyclische derivaten. |
| ZA00772752A ZA772752B (en) | 1976-05-24 | 1977-05-09 | Novel tetracyclic derivatives |
| GB20275/77A GB1567862A (en) | 1976-05-24 | 1977-05-13 | Tetracyclic derivatives |
| IE1013/77A IE45419B1 (en) | 1976-05-24 | 1977-05-17 | Novel tetracylic derivatives |
| FR7715413A FR2352800A1 (fr) | 1976-05-24 | 1977-05-18 | Nouveaux composes tetracycliques utiles comme depresseurs |
| US05/798,222 US4145434A (en) | 1976-05-24 | 1977-05-18 | Tetracyclic derivatives and pharmaceutical compositions of matter |
| JP5929577A JPS532465A (en) | 1976-05-24 | 1977-05-20 | Novel tetracyclic derivative* its preparation and formulations containing same |
| CH626477A CH633536A5 (de) | 1976-05-24 | 1977-05-20 | Verfahren zur herstellung neuer tetracyclischer piperidin- oder pyrrolidinderivate. |
| AU25331/77A AU509073B2 (en) | 1976-05-24 | 1977-05-20 | Novel tetracyclic derivatives |
| SE7705957A SE436202B (sv) | 1976-05-24 | 1977-05-20 | Analogiforfarande for framstellning av tetracykliska derivat |
| ES459024A ES459024A1 (es) | 1976-05-24 | 1977-05-21 | Procedimiento para la preparacion de un compuesto tetraci- clico. |
| HU77AO447A HU173795B (hu) | 1976-05-24 | 1977-05-23 | Sposob poluchenija novykh tetraciklicheskikh soedinenij |
| DE2760372A DE2760372C2 (enExample) | 1976-05-24 | 1977-05-23 | |
| FI771635A FI65238C (fi) | 1976-05-24 | 1977-05-23 | Foerfarande foer framstaellning av terapeutiskt anvaendbara teracykliska foereningar |
| LU77387A LU77387A1 (enExample) | 1976-05-24 | 1977-05-23 | |
| BE177807A BE854915A (fr) | 1976-05-24 | 1977-05-23 | Nouveaux composes tetracycliques utiles comme depresseurs |
| DE19772723209 DE2723209A1 (de) | 1976-05-24 | 1977-05-23 | Tetracyclische pyridin- oder pyrrolderivate |
| DK227477A DK157868C (da) | 1976-05-24 | 1977-05-24 | Analogifremgangsmaade til fremstilling af tetracykliske forbindelser |
| CA279,010A CA1122976A (en) | 1976-05-24 | 1977-05-24 | Tetracyclic compounds |
| ES470407A ES470407A1 (es) | 1976-05-24 | 1978-06-01 | Procedimiento para la preparacion de un compuesto tetraci- clico |
| ES470408A ES470408A1 (es) | 1976-05-24 | 1978-06-01 | Procedimiento para la preparacion de un compuesto tetraci- clico |
| US05/918,217 US4154836A (en) | 1976-05-24 | 1978-06-23 | Tension reducing 1,2,3,4,4a,13b-hexahydro-dibenz[2,3;6,7]oxepino[4,5-c]pyridines |
| US05/918,219 US4158059A (en) | 1976-05-24 | 1978-06-23 | Tension reducing 2,3,4,4a,9,136-hexahydro-dibenz[1,2;5,6]cyclohepta[3,4-c]py |
| US05/923,606 US4271179A (en) | 1976-05-24 | 1978-06-26 | 1,2,3,3a,8,12b-Hexahydro-dibenzo[1,2;5,6]cyclohepta[3,4-C]pyrroles and pharmaceutical use thereof |
| US05/918,981 US4271177A (en) | 1976-05-24 | 1978-06-26 | 2,3,3a,12b-Tetrahydro-1H-dibenzo[2,3;6,7]thiepino[4,5-c]pyrroles and pharmaceutical use thereof |
| US05/919,196 US4271178A (en) | 1976-05-24 | 1978-06-26 | 1,2,3,3a,8,12b-Hexahydro-dibenzo[b,f]pyrrolo[3,4-d]azepines and pharmaceutical use thereof |
| US05/918,883 US4177275A (en) | 1976-05-24 | 1978-06-26 | Tension reducing 2,3,4,4a,9,13b-hexahydro-1H-dibenzo[b,f]pyrido[3,4-d]azepine derivatives |
| US05/919,110 US4158058A (en) | 1976-05-24 | 1978-06-26 | Tension reducing 1,2,3,4,4a,13b-hexahydro-dibenzo[2,3;6,7]thiepino[4,5-c]pyridines |
| CH351282A CH637382A5 (de) | 1976-05-24 | 1982-06-07 | Verfahren zur herstellung neuer tetracyclischer pyridin- oder pyrrolderivate. |
| FI832085A FI67701C (fi) | 1976-05-24 | 1983-06-09 | Foerfarande foer framstaellning av nya terapeutiskt anvaendbara tetracykliska foereningar |
| JP61007790A JPS61178965A (ja) | 1976-05-24 | 1986-01-17 | 新規な四環式誘導体 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL7605526A NL7605526A (nl) | 1976-05-24 | 1976-05-24 | Nieuwe tetracyclische derivaten. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL7605526A true NL7605526A (nl) | 1977-11-28 |
Family
ID=19826245
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL7605526A NL7605526A (nl) | 1976-05-24 | 1976-05-24 | Nieuwe tetracyclische derivaten. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4145434A (enExample) |
| JP (2) | JPS532465A (enExample) |
| AU (1) | AU509073B2 (enExample) |
| BE (1) | BE854915A (enExample) |
| CA (1) | CA1122976A (enExample) |
| CH (2) | CH633536A5 (enExample) |
| DE (2) | DE2760372C2 (enExample) |
| DK (1) | DK157868C (enExample) |
| ES (3) | ES459024A1 (enExample) |
| FI (1) | FI65238C (enExample) |
| FR (1) | FR2352800A1 (enExample) |
| GB (1) | GB1567862A (enExample) |
| HU (1) | HU173795B (enExample) |
| IE (1) | IE45419B1 (enExample) |
| LU (1) | LU77387A1 (enExample) |
| NL (1) | NL7605526A (enExample) |
| SE (1) | SE436202B (enExample) |
| ZA (1) | ZA772752B (enExample) |
Families Citing this family (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0007450A1 (de) * | 1978-07-07 | 1980-02-06 | Ciba-Geigy Ag | Azatetracyclische Carbonitrile, ihre Herstellung, pharmazeutische Präparate, die diese enthalten und deren Verwendung |
| DE3069086D1 (de) * | 1979-12-10 | 1984-10-04 | Ciba Geigy Ag | Azatetracyclic carbonitriles |
| FR2504140A1 (fr) * | 1981-04-16 | 1982-10-22 | Centre Nat Rech Scient | Nouveaux derives tetracycliques de la dibenzazepine, leur procede de preparation et les compositions pharmaceutiques en renfermant |
| IL68711A (en) * | 1982-05-18 | 1986-12-31 | Sparamedica Ag | Dihydro-8-halo-6-phenylpyrrolo-(3,4-d)(2)benzazepin derivatives,their preparation and pharmaceutical compositions containing them |
| JPS62101941U (enExample) * | 1985-12-16 | 1987-06-29 | ||
| IE62754B1 (en) * | 1988-08-26 | 1995-02-22 | Akzo Nv | Tetracyclic antidepressants |
| EP0569096A1 (en) * | 1992-05-08 | 1993-11-10 | Akzo Nobel N.V. | Depot preparation |
| DK0690863T3 (da) * | 1993-04-06 | 2003-06-30 | Abbott Lab | Tetracykliske forbindelser som dopamin-agonister |
| CN1079670C (zh) * | 1994-03-02 | 2002-02-27 | 阿克佐诺贝尔公司 | 舌下或颊给药的药物组合物 |
| JP3274579B2 (ja) * | 1995-01-12 | 2002-04-15 | 住友製薬株式会社 | 脳血管障害に伴う精神症候治療剤 |
| DE69720709T2 (de) * | 1996-04-12 | 2004-03-11 | Janssen Pharmaceutica N.V. | Substituierte tetracyclische tetrahydrofuranderivate |
| WO1998054186A1 (en) * | 1997-05-26 | 1998-12-03 | Akzo Nobel N.V. | Salts of aromatic sulphonic acids |
| HRP20020305A8 (en) * | 2002-04-10 | 2009-03-31 | GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. | 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof |
| HRP20020441A2 (en) * | 2002-05-21 | 2003-12-31 | Pliva D D | 1-oxa-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediate for preparation thereof |
| HRP20030160A2 (en) * | 2003-03-06 | 2005-04-30 | Pliva-Istra�iva�ki institut d.o.o. | 1-thiadibenzoazulene derivatives and biological action thereof |
| EP1633400A2 (en) * | 2003-05-16 | 2006-03-15 | Pfizer Products Inc. | Therapeutic combinations of atypical antipsychotics with gaba modulators, anticonvulsants or benzodiazapines |
| HRP20030885A2 (en) * | 2003-11-03 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 2-THIA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYYTEM DISEASES AND DISORDERS |
| HRP20030958A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 1,3-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
| HRP20030957A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 1-THIA-3-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
| HRP20030953A2 (en) * | 2003-11-21 | 2005-10-31 | Pliva-Istra�iva�ki institut d.o.o. | PREPARATION OF 1-AZA-2-OXA-DIBENZO[e,h]AZULENES AND THEIR USE FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
| HRP20030959A2 (enExample) * | 2003-11-21 | 2005-10-31 | Pliva-Istra�iva�ki institut d.o.o. | |
| HRP20030954A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva D.D. | USE OF 1-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
| HRP20030956A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 1,2-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANU |
| HRP20030955A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 1-OXADIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
| HRP20040104A2 (en) * | 2004-01-30 | 2005-10-31 | Pliva-Istra�iva�ki institut d.o.o. | Use of benzonaphthoazulenes for the manufacture of pharmaceutical formulations for the treatment and prevention of central nervous system diseases and disorders |
| AU2005215257A1 (en) * | 2004-02-13 | 2005-09-01 | Pfizer Products Inc. | Therapeutic combinations of atypical antipsychotics with corticotropin releasing factor antagonists |
| EP1753460A2 (en) * | 2004-05-11 | 2007-02-21 | Pfizer Products Inc. | Combination of atypical antipsychotics and 5-ht1b receptor antagonists |
| BRPI0516000A (pt) * | 2004-10-15 | 2008-05-06 | Pfizer | uso de um composto ou de um sal, solvato, hidrato ou isÈmero óptico farmaceuticamente aceitável do mesmo, método para tratar distúrbio bipolar em um mamìfero em necessidade do mesmo, e, kit para uso no tratamento de distúrbios bipolares |
| US7872147B2 (en) * | 2005-04-07 | 2011-01-18 | N. V. Organon | Intermediate compounds for the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole |
| CA2603181A1 (en) * | 2005-04-07 | 2006-10-12 | N.V. Organon | Intermediate compounds for the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1h-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole |
| PL1710245T3 (pl) * | 2005-04-07 | 2008-01-31 | Merck Sharp & Dohme | Postać krystaliczna maleinianu asenapiny |
| US7741358B2 (en) * | 2005-04-14 | 2010-06-22 | N.V. Organon | Crystal form of asenapine maleate |
| WO2007046554A1 (ja) * | 2005-10-21 | 2007-04-26 | Sumitomo Chemical Company, Limited | ジベンゾオキセピノピロール化合物の製造方法、その中間体及び該中間体の製造方法 |
| US7750167B2 (en) * | 2006-07-05 | 2010-07-06 | N.V. Organon | Process for the preparation of asenapine and intermediate products used in said process |
| TW200817414A (en) * | 2006-07-05 | 2008-04-16 | Organon Nv | Process for the preparation of asenapine and intermediate products used in said process |
| TW200831514A (en) * | 2006-10-06 | 2008-08-01 | Organon Nv | Amorphous asenapine and processes for preparing same |
| US7875729B2 (en) * | 2007-01-05 | 2011-01-25 | Synthon Bv | Process for making asenapine |
| WO2008148515A1 (en) * | 2007-06-05 | 2008-12-11 | Synthon B.V. | Intranasal administration of asenapine and pharmaceutical compositions therefor |
| JP5245428B2 (ja) * | 2007-07-06 | 2013-07-24 | 住友化学株式会社 | トランス−ジベンゾオキセノピロール化合物の製造方法およびその中間体 |
| JP2011508751A (ja) * | 2008-01-04 | 2011-03-17 | ナームローゼ・フエンノートチヤツプ・オルガノン | アセナピンの調製方法および前記方法において使用される中間生成物 |
| EP2254420A4 (en) | 2008-02-20 | 2012-02-15 | Targia Pharmaceuticals | CNS PHARMACEUTICALS AND METHOD FOR THEIR USE |
| EP2321011A1 (en) * | 2008-06-25 | 2011-05-18 | Pfizer Inc. | Diaryl compounds and uses thereof |
| MX2012000061A (es) * | 2009-06-24 | 2012-06-01 | Msd Oss Bv | Formulaciones inyectables que contienen asenapina, y metodo de tratamiento usando las mismas. |
| AR077429A1 (es) | 2009-07-29 | 2011-08-24 | Organon Nv | Compuestos hidroxiasenapina sus derivados y composiciones farmaceuticas que comprenden los mismos |
| WO2011159903A2 (en) | 2010-06-18 | 2011-12-22 | Dr. Reddy's Laboratories Ltd. | Asenapine maleate |
| WO2012013766A1 (en) | 2010-07-29 | 2012-02-02 | Laboratorios Lesvi, S.L. | Novel process for the preparation of asenapine |
| DK3034079T3 (en) | 2010-11-15 | 2018-02-05 | Agenebio Inc | PYRIDAZINE DERIVATIVES, COMPOSITIONS AND PROCEDURES FOR TREATING COGNITIVE WEAKNESS |
| WO2012066565A2 (en) | 2010-11-16 | 2012-05-24 | Cadila Healthcare Limited | Asenapine maleate amorphous and crystalline form and process for preparation thereof |
| EP2468750A1 (en) | 2010-12-13 | 2012-06-27 | Chemo Ibérica, S.A. | Polymorphic forms of asenapine maleate and processes for their preparation |
| EP2468751B1 (en) | 2010-12-24 | 2016-03-16 | Medichem, S.A. | Processes for the preparation of 5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole |
| WO2012123325A1 (en) | 2011-03-11 | 2012-09-20 | Medichem S.A. | NEW CRYSTAL FORMS OF THE SALT OF TRANS-5-CHLORO-2-METHYL-2,3,3A,12b-TETRAHYDRO-1H-DIBENZO[2,3:6,7]OXEPINO[4,5-c]PYRROLE WITH MALEIC ACID |
| ITMI20110734A1 (it) | 2011-05-02 | 2012-11-03 | Olon Spa | Sali cristallini di asenapina |
| EP2524919A1 (en) | 2011-05-17 | 2012-11-21 | Sandoz AG | Novel crystalline salts of Asenapine with organic Di-acids and Tri-acids |
| EP2524921A1 (en) * | 2011-05-17 | 2012-11-21 | Sandoz AG | Novel Crystalline Salts of Asenapine |
| EP2709615A1 (en) | 2011-05-18 | 2014-03-26 | Laboratorios Lesvi, S.L. | Monoclinic crystalline form of asenapine maleate with a specific particle size distribution |
| US9505771B2 (en) | 2011-05-18 | 2016-11-29 | Laboratories Lesvi S.L. | Stable micronised monoclin form of asenapine maleate and its synthesis |
| WO2013024492A2 (en) | 2011-07-01 | 2013-02-21 | Megafine Pharma (P) Ltd. | A process for the preparation of asenapine and novel salts thereof |
| WO2013011461A1 (en) | 2011-07-20 | 2013-01-24 | Ranbaxy Laboratories Limited | Process for the preparation of asenapine maleate |
| WO2013035109A1 (en) | 2011-09-08 | 2013-03-14 | Mylan Laboratories Ltd | Improved process for the preparation of asenapine maleate |
| EP2572703A1 (en) | 2011-09-21 | 2013-03-27 | Hexal AG | Compressed oral dosage form for asenapine maleate |
| WO2013041604A1 (en) | 2011-09-21 | 2013-03-28 | Sandoz Ag | Crystal form of asenapine maleate |
| US20140336391A1 (en) | 2011-11-28 | 2014-11-13 | Ranbaxy Laboratories Limited | Process for the preparation of asenapine intermediate |
| CN103254201B (zh) * | 2012-02-21 | 2016-04-13 | 四川科伦药物研究有限公司 | 一种阿塞那平的制备方法 |
| WO2013190481A1 (en) * | 2012-06-21 | 2013-12-27 | Alembic Pharmaceuticals Limited | Process for preparing asenapine and salts of intermediates thereof |
| ITMI20121810A1 (it) | 2012-10-24 | 2014-04-25 | Chemo Iberica Sa | Poliformi di maleato di asenapina e processo per la loro preparazione |
| WO2014078568A1 (en) | 2012-11-14 | 2014-05-22 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| WO2014127786A1 (en) | 2013-02-22 | 2014-08-28 | Zentiva, K.S. | Orally disintegrating pharmaceutical composition comprising asenapine |
| CN103113379A (zh) * | 2013-03-12 | 2013-05-22 | 盛世泰科生物医药技术(苏州)有限公司 | 阿塞那平马来酸盐的合成工艺 |
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| CN112409363B (zh) | 2013-12-20 | 2023-11-14 | 艾吉因生物股份有限公司 | 用于治疗认知损害的苯并二氮杂䓬衍生物、组合物和方法 |
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| CN103772400A (zh) * | 2014-01-07 | 2014-05-07 | 万特制药(海南)有限公司 | 反式-5-氯-2,3,3a,12b-四氢-1H-二苯并[2,3:6,7]氧杂卓并[4,5-c]吡咯的制备方法 |
| WO2016198113A1 (en) | 2015-06-11 | 2016-12-15 | Alrise Biosystems Gmbh | Process for the preparation of drug loaded microparticles |
| WO2016205739A1 (en) | 2015-06-19 | 2016-12-22 | Belew Mekonnen | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
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| US11505555B2 (en) | 2016-12-19 | 2022-11-22 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
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| ES3001152T3 (es) | 2016-12-20 | 2025-03-04 | Lts Lohmann Therapie Systeme Ag | Sistema terapéutico transdérmico que contiene asenapina y polisiloxano o poliisobutileno |
| WO2019002204A1 (en) | 2017-06-26 | 2019-01-03 | Lts Lohmann Therapie-Systeme Ag | TRANSDERMAL THERAPEUTIC SYSTEM CONTAINING ASENAPINE AND SILICONE-TYPE ACRYLIC HYBRID POLYMER |
| BR112020026062B1 (pt) | 2018-06-19 | 2023-04-04 | Agenebio, Inc | Compostos derivados de benzodiazepina ou um sal farmaceuticamente aceitavel, isômero ou combinação dos mesmos, composição farmacêutica compreendendo os mesmos e usos dos mesmos para o tratamento de comprometimento cognitivo, câncer cerebral e psicose da doença de parkinson |
| AU2019291060B2 (en) | 2018-06-20 | 2024-09-05 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine |
| EP3810099A1 (en) | 2018-06-20 | 2021-04-28 | LTS Lohmann Therapie-Systeme AG | Transdermal therapeutic system containing asenapine |
| CN110183457A (zh) * | 2019-06-27 | 2019-08-30 | 浙江天顺药业有限公司 | 一种阿塞那平及其制备方法 |
| CN112830931A (zh) | 2019-08-13 | 2021-05-25 | 浙江奥翔药业股份有限公司 | 制备阿塞那平的方法 |
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| WO2023006954A1 (en) | 2021-07-30 | 2023-02-02 | Fundació Institut D'investigació Biomèdica De Bellvitge (Idibell) | Asenapine for use in cancer |
| US20240132513A1 (en) | 2022-08-19 | 2024-04-25 | Agenebio, Inc. | Benzazepine derivatives, compositions, and methods for treating cognitive impairment |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH501007A (de) * | 1968-11-27 | 1970-12-31 | Ciba Geigy Ag | Verfahren zur Herstellung von neuen Thiepin- und Oxepinderivaten |
| NL178593C (nl) * | 1974-01-31 | 1986-04-16 | Akzo Nv | Werkwijze ter bereiding van een farmaceutisch preparaat op basis van een tetracyclische verbinding en werkwijze voor de bereiding van de daarbij te gebruiken tetracyclische verbindingen. |
| AU469026B2 (en) * | 1974-11-07 | 1976-01-29 | Ciba-Geigy Ag | New azepine derivatives and process forthe production thereof |
-
1976
- 1976-05-24 NL NL7605526A patent/NL7605526A/xx not_active Application Discontinuation
-
1977
- 1977-05-09 ZA ZA00772752A patent/ZA772752B/xx unknown
- 1977-05-13 GB GB20275/77A patent/GB1567862A/en not_active Expired
- 1977-05-17 IE IE1013/77A patent/IE45419B1/en not_active IP Right Cessation
- 1977-05-18 US US05/798,222 patent/US4145434A/en not_active Expired - Lifetime
- 1977-05-18 FR FR7715413A patent/FR2352800A1/fr active Granted
- 1977-05-20 SE SE7705957A patent/SE436202B/xx not_active IP Right Cessation
- 1977-05-20 AU AU25331/77A patent/AU509073B2/en not_active Expired
- 1977-05-20 JP JP5929577A patent/JPS532465A/ja active Granted
- 1977-05-20 CH CH626477A patent/CH633536A5/de not_active IP Right Cessation
- 1977-05-21 ES ES459024A patent/ES459024A1/es not_active Expired
- 1977-05-23 LU LU77387A patent/LU77387A1/xx unknown
- 1977-05-23 HU HU77AO447A patent/HU173795B/hu unknown
- 1977-05-23 DE DE2760372A patent/DE2760372C2/de not_active Expired - Lifetime
- 1977-05-23 FI FI771635A patent/FI65238C/fi not_active IP Right Cessation
- 1977-05-23 BE BE177807A patent/BE854915A/xx not_active IP Right Cessation
- 1977-05-23 DE DE19772723209 patent/DE2723209A1/de not_active Withdrawn
- 1977-05-24 CA CA279,010A patent/CA1122976A/en not_active Expired
- 1977-05-24 DK DK227477A patent/DK157868C/da not_active IP Right Cessation
-
1978
- 1978-06-01 ES ES470407A patent/ES470407A1/es not_active Expired
- 1978-06-01 ES ES470408A patent/ES470408A1/es not_active Expired
-
1982
- 1982-06-07 CH CH351282A patent/CH637382A5/de not_active IP Right Cessation
-
1986
- 1986-01-17 JP JP61007790A patent/JPS61178965A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| IE45419L (en) | 1977-11-24 |
| AU509073B2 (en) | 1980-04-17 |
| FI65238C (fi) | 1984-04-10 |
| CA1122976A (en) | 1982-05-04 |
| DK157868C (da) | 1990-07-30 |
| FI771635A7 (enExample) | 1977-11-25 |
| US4145434A (en) | 1979-03-20 |
| SE436202B (sv) | 1984-11-19 |
| ES459024A1 (es) | 1978-11-01 |
| DK227477A (da) | 1977-11-25 |
| GB1567862A (en) | 1980-05-21 |
| BE854915A (fr) | 1977-11-23 |
| IE45419B1 (en) | 1982-08-25 |
| FR2352800B1 (enExample) | 1980-02-01 |
| CH633536A5 (de) | 1982-12-15 |
| JPS6238348B2 (enExample) | 1987-08-17 |
| LU77387A1 (enExample) | 1977-08-29 |
| JPS61178965A (ja) | 1986-08-11 |
| JPS6134426B2 (enExample) | 1986-08-07 |
| HU173795B (hu) | 1979-08-28 |
| FI65238B (fi) | 1983-12-30 |
| DE2723209A1 (de) | 1977-12-15 |
| JPS532465A (en) | 1978-01-11 |
| DE2760372C2 (enExample) | 1991-05-29 |
| ES470408A1 (es) | 1979-01-01 |
| ES470407A1 (es) | 1979-01-01 |
| CH637382A5 (de) | 1983-07-29 |
| SE7705957L (sv) | 1977-11-25 |
| FR2352800A1 (fr) | 1977-12-23 |
| AU2533177A (en) | 1978-11-23 |
| DK157868B (da) | 1990-02-26 |
| ZA772752B (en) | 1978-04-26 |
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