NL194067C - Farmaceutisch wateroplosbaar bruispreparaat dat N-acetylcysteine en aspartame bevat. - Google Patents
Farmaceutisch wateroplosbaar bruispreparaat dat N-acetylcysteine en aspartame bevat. Download PDFInfo
- Publication number
- NL194067C NL194067C NL8701743A NL8701743A NL194067C NL 194067 C NL194067 C NL 194067C NL 8701743 A NL8701743 A NL 8701743A NL 8701743 A NL8701743 A NL 8701743A NL 194067 C NL194067 C NL 194067C
- Authority
- NL
- Netherlands
- Prior art keywords
- aspartame
- citric acid
- nac
- acetylcysteine
- effervescent
- Prior art date
Links
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 title claims description 35
- 229960004308 acetylcysteine Drugs 0.000 title claims description 31
- 239000000203 mixture Substances 0.000 title claims description 25
- 108010011485 Aspartame Proteins 0.000 title claims description 22
- 239000000605 aspartame Substances 0.000 title claims description 22
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 title claims description 22
- 235000010357 aspartame Nutrition 0.000 title claims description 22
- 229960003438 aspartame Drugs 0.000 title claims description 22
- 238000009472 formulation Methods 0.000 title description 5
- 239000008238 pharmaceutical water Substances 0.000 title description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 66
- 238000002360 preparation method Methods 0.000 claims description 21
- 239000008187 granular material Substances 0.000 claims description 17
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 14
- 239000007938 effervescent tablet Substances 0.000 claims description 9
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 7
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 6
- 239000004698 Polyethylene Substances 0.000 claims description 5
- 229920000573 polyethylene Polymers 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 4
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 claims description 4
- 239000007968 orange flavor Substances 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 3
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229960004106 citric acid Drugs 0.000 description 17
- 239000000796 flavoring agent Substances 0.000 description 10
- 235000019634 flavors Nutrition 0.000 description 10
- 239000003826 tablet Substances 0.000 description 8
- 229930006000 Sucrose Natural products 0.000 description 5
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 239000005720 sucrose Substances 0.000 description 5
- 239000003765 sweetening agent Substances 0.000 description 4
- 239000003086 colorant Substances 0.000 description 3
- 244000248349 Citrus limon Species 0.000 description 2
- 235000005979 Citrus limon Nutrition 0.000 description 2
- -1 aluminum-polyethylene Chemical group 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 235000020971 citrus fruits Nutrition 0.000 description 2
- 208000002925 dental caries Diseases 0.000 description 2
- 235000003599 food sweetener Nutrition 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 2
- 235000021092 sugar substitutes Nutrition 0.000 description 2
- 239000004173 sunset yellow FCF Substances 0.000 description 2
- 241000207199 Citrus Species 0.000 description 1
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 235000011941 Tilia x europaea Nutrition 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 1
- 239000008122 artificial sweetener Substances 0.000 description 1
- 235000021311 artificial sweeteners Nutrition 0.000 description 1
- 235000013734 beta-carotene Nutrition 0.000 description 1
- 239000011648 beta-carotene Substances 0.000 description 1
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 1
- 229960002747 betacarotene Drugs 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 239000011363 dried mixture Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000008369 fruit flavor Substances 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- YECIFGHRMFEPJK-UHFFFAOYSA-N lidocaine hydrochloride monohydrate Chemical compound O.[Cl-].CC[NH+](CC)CC(=O)NC1=C(C)C=CC=C1C YECIFGHRMFEPJK-UHFFFAOYSA-N 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 230000000510 mucolytic effect Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000007967 peppermint flavor Substances 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000014860 sensory perception of taste Effects 0.000 description 1
- 235000021309 simple sugar Nutrition 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH2975/86A CH667590A5 (it) | 1986-07-24 | 1986-07-24 | Composizione farmaceutica effervescente idrosolubile contenente n-acetil-cisteina. . |
| CH297586 | 1986-07-24 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NL8701743A NL8701743A (nl) | 1988-02-16 |
| NL194067B NL194067B (nl) | 2001-02-01 |
| NL194067C true NL194067C (nl) | 2001-06-05 |
Family
ID=4245841
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8701743A NL194067C (nl) | 1986-07-24 | 1987-07-23 | Farmaceutisch wateroplosbaar bruispreparaat dat N-acetylcysteine en aspartame bevat. |
Country Status (8)
| Country | Link |
|---|---|
| BE (1) | BE1000355A3 (it) |
| CH (1) | CH667590A5 (it) |
| DE (1) | DE3723735A1 (it) |
| FR (1) | FR2601876B1 (it) |
| GB (1) | GB2192790B (it) |
| IT (1) | IT1222104B (it) |
| NL (1) | NL194067C (it) |
| SE (1) | SE500494C2 (it) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1217445B (it) * | 1988-04-29 | 1990-03-22 | Altergon Sa | Composizione farmaceutiche orosolubili contenti acetilcisteina |
| DE3822096A1 (de) * | 1988-06-30 | 1990-01-04 | Klinge Co Chem Pharm Fab | Stabilisierte arzneimittelzubereitung |
| SE462779B (sv) * | 1988-10-10 | 1990-09-03 | Lejus Medical Ab | Farmaceutisk komposition innehaallande n-acetylcystein i en kaerna belagd med hydroxipropylmetylcellulosaftalat |
| DE3909049A1 (de) * | 1989-03-18 | 1990-09-20 | Arthur Boskamp | Praeparat und dessen verwendung |
| IT1231012B (it) * | 1989-07-27 | 1991-11-08 | Zambon Spa | Composizione farmaceutica per uso orale contenente nac. |
| DE69209335T2 (de) * | 1991-01-26 | 1996-08-29 | Senju Pharma Co | Mittel zur Zersetzung von Gallensteinen |
| DE4103360A1 (de) * | 1991-02-05 | 1992-08-06 | Koehler Peter | Medikament zur linderung und heilung von asthma bronchiale und anderen lungenerkrankungen |
| US5296500A (en) * | 1991-08-30 | 1994-03-22 | The Procter & Gamble Company | Use of N-acetyl-cysteine and derivatives for regulating skin wrinkles and/or skin atrophy |
| IT1256616B (it) * | 1992-12-02 | 1995-12-12 | Zambon Spa | Sciroppo contenente n-acetil-cisteina |
| DE4406261C2 (de) * | 1993-08-31 | 1996-07-04 | Deutsches Krebsforsch | Verwendung von Thiolverbindungen zur Verminderung der Körperfettmenge |
| BE1007926A3 (fr) * | 1994-01-31 | 1995-11-21 | Zambon Int Pharma | Composition pharmaceutique contenant de la n-acetyl-cysteine. |
| US5451405A (en) * | 1994-04-25 | 1995-09-19 | Chesebrough-Pond's Usa Co. | Skin treatment composition |
| DE19509856C2 (de) * | 1995-03-17 | 1997-09-11 | Schwabe Willmar Gmbh & Co | Verwendung einer Brausezusammensetzung mit Ginkgo-Biloba Trockenextrakt zur Behandlung peripherer und cerebraler Durchblutungsstörungen |
| EP1115842A4 (en) | 1998-09-25 | 2002-08-21 | Glycox Corp Ltd | DETERMINATION OF FRUCTOSAMINE OXIDASE: METHODS AND SUBSTANCES |
| CN1324234A (zh) | 1998-09-25 | 2001-11-28 | 格利科克斯有限公司 | 果糖胺氧化酶,拮抗剂和抑制剂 |
| WO2003077901A1 (en) | 2002-03-08 | 2003-09-25 | Protemix Corporation Limited | Preventing and/or treating cardiovascular disease and/or associated heart failure |
| JP2006503014A (ja) | 2002-08-20 | 2006-01-26 | プロテミックス コーポレイション リミティド | 剤形及び関連する治療法 |
| ES2449066T3 (es) | 2004-07-19 | 2014-03-18 | Philera New Zealand Limited | Síntesis de trietilentetraminas |
| TR200900881A2 (tr) * | 2009-02-05 | 2010-08-23 | Bi̇lgi̇ç Mahmut | Tadı ve kokusu maskelenmiş stabil farmasötik bileşimler |
| TR200900882A2 (tr) * | 2009-02-05 | 2010-08-23 | Bi̇lgi̇ç Mahmut | Tadı ve kokusu maskelenmiş, bıyoyararlanımı yüksek farmasotık bileşimler. |
| IT1399492B1 (it) | 2010-04-13 | 2013-04-19 | Alpex Pharma Sa | Composizioni farmaceutiche effervescenti contenenti n-acetilcisteina. |
| CN102233139B (zh) * | 2010-04-21 | 2012-09-05 | 重庆健能医药开发有限公司 | 一种乙酰半胱氨酸泡腾片及其制备方法和应用 |
| EP2571499A1 (en) * | 2010-05-18 | 2013-03-27 | Mahmut Bilgic | Pharmaceutical composition comprising n- acetylcysteine and a xanthine |
| CN101947211A (zh) * | 2010-08-28 | 2011-01-19 | 浙江金华康恩贝生物制药有限公司 | 一种乙酰半胱氨酸泡腾片的制备方法 |
| TR201104738A2 (tr) * | 2011-05-16 | 2012-12-21 | Bi̇lgi̇ç Mahmut | N-Asetilsistein içeren farmasötik kombinasyon. |
| US8747894B2 (en) * | 2012-05-08 | 2014-06-10 | Alpex Pharma S.A. | Effervescent compositions containing N-acetylcysteine |
| EP2905020A1 (en) | 2014-02-05 | 2015-08-12 | Sanovel Ilac Sanayi ve Ticaret A.S. | Effervescent formulations comprising ibuprofen and N-acetylcystein |
| CN113559078A (zh) * | 2021-07-02 | 2021-10-29 | 安徽省先锋制药有限公司 | 一种乙酰半胱氨酸泡腾片的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2470M (fr) * | 1962-03-13 | 1964-04-20 | Mead Johnson & Co | Composition thérapeutique. |
| ZA723683B (en) * | 1971-07-12 | 1973-06-27 | Hoffmann La Roche | Improved effervescent preparations |
| DE3317558A1 (de) * | 1983-05-13 | 1984-11-15 | Dietrich Dr.med. Sta. Eulalia Ibiza Reichert | Orales antischnarchmittel |
| DE3317530A1 (de) * | 1983-05-13 | 1984-11-15 | Dietrich Dr.med. Sta. Eulalia Ibiza Reichert | Antischnarchmittel |
| IT1170268B (it) * | 1983-12-21 | 1987-06-03 | Zambon Spa | Uso dell'acetilcisteina per ridurre l'incremento della prolieferazione delle cellule basali dell'epitelio respiratoriotracheo-bronchiale indotto dal fumo di tabacco nei mammiferi |
| DE3514995A1 (de) * | 1985-04-25 | 1986-10-30 | Protopharma Ltd., 7831 Malterdingen | Verwendung von sulfydrylarzneimitteln zur bekaempfung von schaedigungen der magenschleimhaut |
-
1986
- 1986-07-24 CH CH2975/86A patent/CH667590A5/it not_active IP Right Cessation
-
1987
- 1987-07-17 DE DE19873723735 patent/DE3723735A1/de active Granted
- 1987-07-22 FR FR878710368A patent/FR2601876B1/fr not_active Expired
- 1987-07-23 NL NL8701743A patent/NL194067C/nl not_active IP Right Cessation
- 1987-07-23 BE BE8700816A patent/BE1000355A3/fr not_active IP Right Cessation
- 1987-07-23 IT IT21411/87A patent/IT1222104B/it active
- 1987-07-23 SE SE8702940A patent/SE500494C2/sv not_active IP Right Cessation
- 1987-07-27 GB GB8717582A patent/GB2192790B/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| SE8702940D0 (sv) | 1987-07-23 |
| NL194067B (nl) | 2001-02-01 |
| FR2601876A1 (fr) | 1988-01-29 |
| DE3723735A1 (de) | 1988-02-04 |
| SE8702940L (sv) | 1988-01-25 |
| BE1000355A3 (fr) | 1988-11-08 |
| CH667590A5 (it) | 1988-10-31 |
| IT8721411A0 (it) | 1987-07-23 |
| GB2192790A (en) | 1988-01-27 |
| IT1222104B (it) | 1990-08-31 |
| FR2601876B1 (fr) | 1989-10-13 |
| DE3723735C2 (it) | 1992-05-21 |
| GB8717582D0 (en) | 1987-09-03 |
| GB2192790B (en) | 1990-01-31 |
| SE500494C2 (sv) | 1994-07-04 |
| NL8701743A (nl) | 1988-02-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BA | A request for search or an international-type search has been filed | ||
| BB | A search report has been drawn up | ||
| BC | A request for examination has been filed | ||
| TNT | Modifications of names of proprietors of patents or applicants of examined patent applications |
Owner name: INPHARZAM S.A. |
|
| V4 | Discontinued because of reaching the maximum lifetime of a patent |
Effective date: 20070723 |