NL188219C - Camptothecinederivaten, werkwijze voor het bereiden daarvan, farmaceutische preparaten met anti-tumorwerking, werkwijze voor het bereiden daarvan. - Google Patents
Camptothecinederivaten, werkwijze voor het bereiden daarvan, farmaceutische preparaten met anti-tumorwerking, werkwijze voor het bereiden daarvan.Info
- Publication number
- NL188219C NL188219C NLAANVRAGE8003988,A NL8003988A NL188219C NL 188219 C NL188219 C NL 188219C NL 8003988 A NL8003988 A NL 8003988A NL 188219 C NL188219 C NL 188219C
- Authority
- NL
- Netherlands
- Prior art keywords
- preparing
- camphothecin
- derivatives
- same
- pharmaceutical preparations
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8641279A JPS5612393A (en) | 1979-07-10 | 1979-07-10 | Novel camptothecin derivative |
JP8641379 | 1979-07-10 | ||
JP8641079 | 1979-07-10 | ||
JP8641179A JPS5612392A (en) | 1979-07-10 | 1979-07-10 | Novel camptothecin derivative and its preparation |
JP8641179 | 1979-07-10 | ||
JP8641079A JPS5612391A (en) | 1979-07-10 | 1979-07-10 | Novel camptothecin derivative and its preparaion |
JP8641379A JPS5612394A (en) | 1979-07-10 | 1979-07-10 | Novel camptothecin derivative |
JP8641279 | 1979-07-10 | ||
JP6073680 | 1980-05-09 | ||
JP6073680A JPS56158786A (en) | 1980-05-09 | 1980-05-09 | Novel camptothecin derivative and its preparation |
Publications (3)
Publication Number | Publication Date |
---|---|
NL8003988A NL8003988A (nl) | 1981-01-13 |
NL188219B NL188219B (nl) | 1991-12-02 |
NL188219C true NL188219C (nl) | 1992-05-06 |
Family
ID=27523606
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NLAANVRAGE8003988,A NL188219C (nl) | 1979-07-10 | 1980-07-10 | Camptothecinederivaten, werkwijze voor het bereiden daarvan, farmaceutische preparaten met anti-tumorwerking, werkwijze voor het bereiden daarvan. |
Country Status (9)
Country | Link |
---|---|
US (2) | US4399282A (nl) |
AR (1) | AR228575A1 (nl) |
AU (1) | AU536181B2 (nl) |
CH (1) | CH648316A5 (nl) |
DE (1) | DE3026172A1 (nl) |
FR (1) | FR2462437A1 (nl) |
GB (1) | GB2056973B (nl) |
IT (1) | IT1199976B (nl) |
NL (1) | NL188219C (nl) |
Families Citing this family (71)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4399276A (en) * | 1981-01-09 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | 7-Substituted camptothecin derivatives |
US4473692A (en) * | 1981-09-04 | 1984-09-25 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives and process for preparing same |
JPS5839685A (ja) * | 1981-09-04 | 1983-03-08 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体及びその製造法 |
JPS58154582A (ja) * | 1982-03-10 | 1983-09-14 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体およびその製造法 |
JPS6019790A (ja) * | 1983-07-14 | 1985-01-31 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体 |
CA1268178A (en) * | 1984-05-03 | 1990-04-24 | Gordon H. Phillipps | Isoquinoline derivatives |
NO872963L (no) * | 1986-07-29 | 1988-02-01 | Glaxo Group Ltd | Isokinolinderivater. |
DK616087A (da) * | 1986-11-27 | 1988-05-28 | Glaxo Group Ltd | Isoquinolinderivater og farmaceutiske praeparater indeholdende dem |
US4939255A (en) * | 1987-06-24 | 1990-07-03 | Daiichi Pharmaceutical Co., Ltd. | Hexa-cyclic camptothecin derivatives |
CA1332413C (en) * | 1987-06-25 | 1994-10-11 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives and process for preparing same |
US4943579A (en) * | 1987-10-06 | 1990-07-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Water soluble prodrugs of camptothecin |
US5004758A (en) * | 1987-12-01 | 1991-04-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells |
GB8800312D0 (en) * | 1988-01-07 | 1988-02-10 | Glaxo Group Ltd | Process |
US5225404A (en) * | 1989-11-06 | 1993-07-06 | New York University | Methods of treating colon tumors with tumor-inhibiting camptothecin compounds |
US5552154A (en) | 1989-11-06 | 1996-09-03 | The Stehlin Foundation For Cancer Research | Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof |
US6080751A (en) * | 1992-01-14 | 2000-06-27 | The Stehlin Foundation For Cancer Research | Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof |
CN1036197C (zh) * | 1992-01-28 | 1997-10-22 | 格拉克索有限公司 | 水溶性喜树碱衍生物 |
US5446047A (en) * | 1992-07-23 | 1995-08-29 | Sloan-Kettering Institute For Cancer Research | Camptothecin analogues |
US5391745A (en) * | 1992-07-23 | 1995-02-21 | Sloan-Kettering Institute For Cancer Research | Methods of preparation of camptothecin analogs |
AP9300587A0 (en) * | 1992-11-12 | 1995-05-05 | Glaxo Inc | Water soluble camptothecin derivatives. |
US5527913A (en) * | 1993-02-25 | 1996-06-18 | The Stehlin Foundation For Cancer Research | Methods for purifying camptothecin compounds |
US5447936A (en) * | 1993-12-22 | 1995-09-05 | Bionumerik Pharmaceuticals, Inc. | Lactone stable formulation of 10-hydroxy 7-ethyl camptothecin and methods for uses thereof |
US5468754A (en) * | 1994-04-19 | 1995-11-21 | Bionumerik Pharmaceuticals, Inc. | 11,7 substituted camptothecin derivatives and formulations of 11,7 substituted camptothecin derivatives and methods for uses thereof |
US5597829A (en) * | 1994-05-09 | 1997-01-28 | Bionumerik Pharmaceuticals, Inc. | Lactone stable formulation of camptothecin and methods for uses thereof |
US5604233A (en) * | 1994-04-28 | 1997-02-18 | Bionumerik Pharmaceuticals, Inc. | Lactone stable formulation of 7-ethyl camptothecin and methods for uses thereof |
US5491237A (en) * | 1994-05-03 | 1996-02-13 | Glaxo Wellcome Inc. | Intermediates in pharmaceutical camptothecin preparation |
US5677286A (en) * | 1995-04-27 | 1997-10-14 | The University Of Michigan | Glycosylated analogs of camptothecin |
US5972955A (en) * | 1995-06-06 | 1999-10-26 | Dr. Reddy's Research Foundation | Water soluble C-ring analogues of 20(S)-camptothecin |
US6214836B1 (en) | 1995-06-06 | 2001-04-10 | Dr. Reddy's Research Foundation | Water soluble analogues of 20(S)-camptothecin |
US6177439B1 (en) | 1995-06-06 | 2001-01-23 | Reddy's Research Foundation | Water soluble analogues of 20(S)-camptothecin |
WO1996040886A1 (en) * | 1995-06-07 | 1996-12-19 | Thomas Jefferson University | Anti-fungal agents and methods of identifying and using the same |
US5731316A (en) * | 1996-01-30 | 1998-03-24 | The Stehlin Foundation For Cancer Research | Derivatives of camptothecin and methods of treating cancer using these derivatives |
US6096336A (en) * | 1996-01-30 | 2000-08-01 | The Stehlin Foundation For Cancer Research | Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs |
US6407118B1 (en) | 1996-01-30 | 2002-06-18 | The Stehlin Foundation For Cancer Research | Derivatives of camptothecin and methods of treating cancer using these derivatives |
IT1282673B1 (it) * | 1996-02-23 | 1998-03-31 | Ist Naz Stud Cura Dei Tumori | Derivati della camptotecina e loro uso come agenti antitumorali |
HU225989B1 (en) * | 1996-06-05 | 2008-02-28 | Reddys Lab Ltd Dr | 20-(s)-camptothecin derivatives substituted at position 5, process for their preparation, their use and pharmaceutical compositions containing the same compounds |
WO1998007727A1 (en) * | 1996-08-19 | 1998-02-26 | Bionumerik Pharmaceuticals, Inc. | Highly lipophilic camptothecin derivatives |
SG116433A1 (en) * | 1996-10-30 | 2005-11-28 | Tanabe Seiyaku Co | S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof. |
US6559309B2 (en) | 1996-11-01 | 2003-05-06 | Osi Pharmaceuticals, Inc. | Preparation of a camptothecin derivative by intramolecular cyclisation |
DE69715138T2 (de) * | 1996-12-19 | 2003-04-24 | Reddys Lab Ltd Dr | Wasserlösliche c-ring analoge des 20(s)-camphothecins |
US6169080B1 (en) * | 1997-02-13 | 2001-01-02 | Bionumerik Pharmaceuticals, Inc. | Highly lipophilic camptothecin derivatives |
US6214330B1 (en) * | 1998-07-13 | 2001-04-10 | Enzon, Inc. | Coumarin and related aromatic-based polymeric prodrugs |
US6291676B1 (en) | 1999-03-03 | 2001-09-18 | University Of Kentucky Research Foundation | Water-soluble derivatives of camptothecin/homocamptothecin |
US6228855B1 (en) | 1999-08-03 | 2001-05-08 | The Stehlin Foundation For Cancer Research | Aromatic esters of camptothecins and methods to treat cancers |
US6352996B1 (en) | 1999-08-03 | 2002-03-05 | The Stehlin Foundation For Cancer Research | Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs |
EP2266607A3 (en) | 1999-10-01 | 2011-04-20 | Immunogen, Inc. | Immunoconjugates for treating cancer |
WO2001068098A2 (en) * | 2000-03-15 | 2001-09-20 | Chemgenex Therapeutics, Inc. | Cephalotaxine alkaloid combination compositions and uses thereof |
US6825206B1 (en) * | 2000-11-16 | 2004-11-30 | Research Triangle Institute | Camptothecin compounds with a thioether group |
US6350756B1 (en) * | 2001-01-18 | 2002-02-26 | California Pacific Medical Center | Camptothecin derivatives |
US6855720B2 (en) | 2001-03-01 | 2005-02-15 | California Pacific Medical Center | Nitrogen-based camptothecin derivatives |
US6653319B1 (en) | 2001-08-10 | 2003-11-25 | University Of Kentucky Research Foundation | Pharmaceutical formulation for poorly water soluble camptothecin analogues |
US6699875B2 (en) | 2002-05-06 | 2004-03-02 | The Stehlin Foundation For Cancer Research | Cascade esters of camptothecins and methods of treating cancer using these compounds |
US6703399B2 (en) * | 2002-05-06 | 2004-03-09 | The Stehlin Foundation For Cancer Research | Halo-alkyl esters of camptothecins and methods of treating cancer using these compounds |
US20040034050A1 (en) * | 2002-06-03 | 2004-02-19 | Yang Li-Xi | Homo-camptothecin derivatives |
AU2003243380A1 (en) * | 2002-06-03 | 2003-12-19 | California Pacific Medical Center | Nitrogen-based homo-camptothecin derivatives |
CN100443486C (zh) * | 2002-09-11 | 2008-12-17 | 中国医学科学院药物研究所 | 7-酯化和7,20-双酯化的喜树碱衍生物及其制法和其药物组合物与用途 |
US8129330B2 (en) | 2002-09-30 | 2012-03-06 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
US20040062748A1 (en) | 2002-09-30 | 2004-04-01 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
WO2004055020A1 (en) * | 2002-12-16 | 2004-07-01 | Council Of Scientific And Industrial Research | Process for the direct preparation of 5-alkoxy and 5-acyloxy analogues of campthothecins or mappicene ketones |
CN100344633C (zh) | 2003-05-12 | 2007-10-24 | 台湾神隆股份有限公司 | 用于制备7-烷基-10-羟基-20(s)-喜树碱的方法 |
US7067666B2 (en) * | 2003-06-27 | 2006-06-27 | Research Triangle Institute | 7-substituted camptothecin and camptothecin analogs and methods for producing the same |
CZ299329B6 (cs) * | 2003-08-26 | 2008-06-18 | Pliva-Lachema A.S. | Zpusob výroby 7-ethyl-10-[ 4-(1-piperidino)-1-piperidino]karbonyloxykamptothecinu |
CZ299593B6 (cs) * | 2003-12-16 | 2008-09-10 | Pliva-Lachema A. S. | Zpusob výroby 7-ethyl-10-hydroxykamptothecinu |
US20050267141A1 (en) * | 2004-05-28 | 2005-12-01 | Phytogen Life Sciences Inc. | Process to prepare camptothecin derivatives |
US20050272757A1 (en) * | 2004-06-04 | 2005-12-08 | Phytogen Life Sciences Inc. | Process to prepare camptothecin derivatives and novel intermediate and compounds thereof |
US7875602B2 (en) * | 2005-10-21 | 2011-01-25 | Sutter West Bay Hospitals | Camptothecin derivatives as chemoradiosensitizing agents |
TW200731990A (en) | 2005-12-16 | 2007-09-01 | Sonus Pharma Inc | Lipophilic anticancer drug compounds, compositions, and related methods |
WO2007075825A2 (en) * | 2005-12-20 | 2007-07-05 | Sonus Pharmaceuticals, Inc. | Lipophilic anticancer drug compounds |
TWI396690B (zh) | 2006-04-27 | 2013-05-21 | Yakult Honsha Kk | 喜樹鹼衍生物的製造方法 |
CN103333172B (zh) * | 2013-06-28 | 2015-09-30 | 兰州大学 | 喜树碱缩氨基硫脲类化合物及其制备方法和用途 |
CN113121438B (zh) * | 2020-01-10 | 2023-05-23 | 江苏希迪制药有限公司 | 一种异喹啉酮类化合物的制备方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3894029A (en) * | 1971-08-26 | 1975-07-08 | Basf Ag | Production of camptothecin and camptothecin-like compounds |
JPS5198300A (en) * | 1975-02-20 | 1976-08-30 | Kanputoteshin oyobi sonoruijitaino seizoho |
-
1980
- 1980-07-08 US US06/166,953 patent/US4399282A/en not_active Ceased
- 1980-07-09 AU AU60273/80A patent/AU536181B2/en not_active Expired
- 1980-07-09 GB GB8022438A patent/GB2056973B/en not_active Expired
- 1980-07-09 IT IT23348/80A patent/IT1199976B/it active
- 1980-07-09 CH CH5265/80A patent/CH648316A5/de not_active IP Right Cessation
- 1980-07-10 AR AR281720A patent/AR228575A1/es active
- 1980-07-10 DE DE19803026172 patent/DE3026172A1/de active Granted
- 1980-07-10 NL NLAANVRAGE8003988,A patent/NL188219C/nl not_active IP Right Cessation
- 1980-07-10 FR FR8015418A patent/FR2462437A1/fr active Granted
-
1984
- 1984-11-29 US US06/676,248 patent/USRE32518E/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
NL188219B (nl) | 1991-12-02 |
GB2056973A (en) | 1981-03-25 |
GB2056973B (en) | 1984-02-08 |
IT1199976B (it) | 1989-01-05 |
AU6027380A (en) | 1981-01-15 |
US4399282A (en) | 1983-08-16 |
DE3026172A1 (de) | 1981-02-05 |
AU536181B2 (en) | 1984-04-19 |
DE3026172C2 (nl) | 1991-05-08 |
CH648316A5 (de) | 1985-03-15 |
FR2462437B1 (nl) | 1983-08-19 |
USRE32518E (en) | 1987-10-13 |
FR2462437A1 (fr) | 1981-02-13 |
IT8023348A0 (it) | 1980-07-09 |
IT8023348A1 (it) | 1982-01-09 |
AR228575A1 (es) | 1983-03-30 |
NL8003988A (nl) | 1981-01-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
BA | A request for search or an international-type search has been filed | ||
BB | A search report has been drawn up | ||
BC | A request for examination has been filed | ||
A85 | Still pending on 85-01-01 | ||
V4 | Discontinued because of reaching the maximum lifetime of a patent |
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