JPS5612391A - Novel camptothecin derivative and its preparaion - Google Patents

Novel camptothecin derivative and its preparaion

Info

Publication number
JPS5612391A
JPS5612391A JP8641079A JP8641079A JPS5612391A JP S5612391 A JPS5612391 A JP S5612391A JP 8641079 A JP8641079 A JP 8641079A JP 8641079 A JP8641079 A JP 8641079A JP S5612391 A JPS5612391 A JP S5612391A
Authority
JP
Japan
Prior art keywords
preparaion
camptothecin derivative
peroxide
formula
novel camptothecin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP8641079A
Other languages
Japanese (ja)
Other versions
JPS6242911B2 (en
Inventor
Sada Miyasaka
Masahiko Mutai
Seigo Sawada
Kenichiro Nogata
Hisao Hagiwara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yakult Honsha Co Ltd
Original Assignee
Yakult Honsha Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yakult Honsha Co Ltd filed Critical Yakult Honsha Co Ltd
Priority to JP8641079A priority Critical patent/JPS5612391A/en
Priority to US06/166,953 priority patent/US4399282A/en
Priority to GB8022438A priority patent/GB2056973B/en
Priority to AU60273/80A priority patent/AU536181B2/en
Priority to IT23348/80A priority patent/IT1199976B/en
Priority to CH5265/80A priority patent/CH648316A5/en
Priority to DE19803026172 priority patent/DE3026172A1/en
Priority to NLAANVRAGE8003988,A priority patent/NL188219C/en
Priority to ES493287A priority patent/ES493287A0/en
Priority to FR8015418A priority patent/FR2462437A1/en
Priority to AR281720A priority patent/AR228575A1/en
Publication of JPS5612391A publication Critical patent/JPS5612391A/en
Priority to ES499986A priority patent/ES499986A0/en
Priority to ES499987A priority patent/ES499987A0/en
Priority to US06/676,248 priority patent/USRE32518E/en
Publication of JPS6242911B2 publication Critical patent/JPS6242911B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:7-Hydroxymethylcamptothecin of the formula.
USE: A medicine having a carcinostatic activity and an intermediate therefor.
PROCESS: Camptothecin is dissolved in an aqueous solution of methanol and sulfuric acid, and a peroxide is added to the solution as a radical initiator to give the compound of the formula. A persulfate, e.g. potassium persulfate, may be cited as the peroxide. Preferably, metallic ions, e.g. silver ions, are present for initiating the free radical reaction rapidly and efficiently.
COPYRIGHT: (C)1981,JPO&Japio
JP8641079A 1979-07-10 1979-07-10 Novel camptothecin derivative and its preparaion Granted JPS5612391A (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
JP8641079A JPS5612391A (en) 1979-07-10 1979-07-10 Novel camptothecin derivative and its preparaion
US06/166,953 US4399282A (en) 1979-07-10 1980-07-08 Camptothecin derivatives
GB8022438A GB2056973B (en) 1979-07-10 1980-07-09 Camptothecin derivatives useful as antitumour agents
AU60273/80A AU536181B2 (en) 1979-07-10 1980-07-09 Derivatives of camptothecin
IT23348/80A IT1199976B (en) 1979-07-10 1980-07-09 CAMPTOTECIMA DERIVATIVES AND PROCESSES FOR THEIR PREPARATION
CH5265/80A CH648316A5 (en) 1979-07-10 1980-07-09 CAMPTOTHECINE DERIVATIVES AND METHOD FOR THEIR PRODUCTION.
NLAANVRAGE8003988,A NL188219C (en) 1979-07-10 1980-07-10 CAMPHOTHECIN DERIVATIVES, METHOD FOR PREPARING THE SAME, PHARMACEUTICAL PREPARATIONS WITH ANTI-TUMOR EFFECTS, METHOD FOR PREPARING THEREOF
DE19803026172 DE3026172A1 (en) 1979-07-10 1980-07-10 CAMPTOTHECINE DERIVATIVES AND THEIR PRODUCTION
ES493287A ES493287A0 (en) 1979-07-10 1980-07-10 A PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF CAMPTO TECINA.
FR8015418A FR2462437A1 (en) 1979-07-10 1980-07-10 NEW CAMPTOTHECINE DERIVATIVES WITH ANTI-TUMOR ACTIVITY AND PROCESS FOR THEIR PREPARATION
AR281720A AR228575A1 (en) 1979-07-10 1980-07-10 PROCEDURE FOR OBTAINING DERIVATIVES OF 7-HYDROXIMETIL OR 7-CARBOXICAMPTOTECINA AND ITS SALTS
ES499986A ES499986A0 (en) 1979-07-10 1981-03-02 A PROCEDURE FOR THE PREPARATION OF CAMPTO-TECINA DERIVATIVES
ES499987A ES499987A0 (en) 1979-07-10 1981-03-02 A PROCEDURE FOR THE PREPARATION OF CAMPTO-TECINA DERIVATIVES
US06/676,248 USRE32518E (en) 1979-07-10 1984-11-29 Camptothecin derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8641079A JPS5612391A (en) 1979-07-10 1979-07-10 Novel camptothecin derivative and its preparaion

Publications (2)

Publication Number Publication Date
JPS5612391A true JPS5612391A (en) 1981-02-06
JPS6242911B2 JPS6242911B2 (en) 1987-09-10

Family

ID=13886088

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8641079A Granted JPS5612391A (en) 1979-07-10 1979-07-10 Novel camptothecin derivative and its preparaion

Country Status (1)

Country Link
JP (1) JPS5612391A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59227884A (en) * 1983-06-09 1984-12-21 Yakult Honsha Co Ltd Novel 7-hydroxyalkylcamptothecin derivative

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59227884A (en) * 1983-06-09 1984-12-21 Yakult Honsha Co Ltd Novel 7-hydroxyalkylcamptothecin derivative
JPH0314316B2 (en) * 1983-06-09 1991-02-26 Yakult Honsha Kk

Also Published As

Publication number Publication date
JPS6242911B2 (en) 1987-09-10

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