NL185279C - Werkwijze ter bereiding van een farmaceutisch preparaat met analgetische werking en werkwijze ter bereiding van een gesubstitueerd n-(4-piperidinyl)-n-fenylamide of -carbamaat. - Google Patents

Werkwijze ter bereiding van een farmaceutisch preparaat met analgetische werking en werkwijze ter bereiding van een gesubstitueerd n-(4-piperidinyl)-n-fenylamide of -carbamaat.

Info

Publication number
NL185279C
NL185279C NLAANVRAGE7602612,A NL7602612A NL185279C NL 185279 C NL185279 C NL 185279C NL 7602612 A NL7602612 A NL 7602612A NL 185279 C NL185279 C NL 185279C
Authority
NL
Netherlands
Prior art keywords
preparing
piperidinyl
phenylamide
carbamate
substituted
Prior art date
Application number
NLAANVRAGE7602612,A
Other languages
English (en)
Dutch (nl)
Other versions
NL185279B (nl
NL7602612A (nl
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NL7602612A publication Critical patent/NL7602612A/xx
Publication of NL185279B publication Critical patent/NL185279B/xx
Application granted granted Critical
Publication of NL185279C publication Critical patent/NL185279C/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/333—Radicals substituted by oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/66—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having a hetero atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NLAANVRAGE7602612,A 1975-03-14 1976-03-12 Werkwijze ter bereiding van een farmaceutisch preparaat met analgetische werking en werkwijze ter bereiding van een gesubstitueerd n-(4-piperidinyl)-n-fenylamide of -carbamaat. NL185279C (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55851175A 1975-03-14 1975-03-14
US05/648,685 US3998834A (en) 1975-03-14 1976-01-13 N-(4-piperidinyl)-n-phenylamides and -carbamates

Publications (3)

Publication Number Publication Date
NL7602612A NL7602612A (nl) 1976-09-16
NL185279B NL185279B (nl) 1989-10-02
NL185279C true NL185279C (nl) 1990-03-01

Family

ID=27071767

Family Applications (1)

Application Number Title Priority Date Filing Date
NLAANVRAGE7602612,A NL185279C (nl) 1975-03-14 1976-03-12 Werkwijze ter bereiding van een farmaceutisch preparaat met analgetische werking en werkwijze ter bereiding van een gesubstitueerd n-(4-piperidinyl)-n-fenylamide of -carbamaat.

Country Status (28)

Country Link
US (1) US3998834A (ru)
JP (1) JPS5946217B2 (ru)
AT (1) AT359493B (ru)
AU (1) AU503632B2 (ru)
BG (1) BG28259A3 (ru)
CA (1) CA1080232A (ru)
CH (1) CH629486A5 (ru)
CZ (1) CZ278060B6 (ru)
DE (1) DE2610228A1 (ru)
DK (1) DK148960C (ru)
ES (1) ES446034A1 (ru)
FI (1) FI61481C (ru)
FR (1) FR2303546A1 (ru)
GB (1) GB1538938A (ru)
HU (1) HU172963B (ru)
IE (1) IE42512B1 (ru)
IL (1) IL49204A (ru)
IT (1) IT1057988B (ru)
LU (1) LU74511A1 (ru)
NL (1) NL185279C (ru)
NO (1) NO146162C (ru)
NZ (1) NZ180096A (ru)
PH (1) PH12746A (ru)
PL (1) PL102474B1 (ru)
PT (1) PT64898B (ru)
SE (1) SE426486B (ru)
SU (1) SU1227109A3 (ru)
YU (1) YU39960B (ru)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
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US4179569A (en) * 1975-03-14 1979-12-18 Janssen Pharmaceutica N.V. N-(4-piperidinyl)-N-phenylamides
US4208418A (en) * 1975-09-23 1980-06-17 Janssen Pharmaceutica N.V. N-Aryl-N-(1-alkyl-4-piperidinyl)arylacetamides
US4225606A (en) * 1975-09-23 1980-09-30 Janssen Pharmaceutica N.V. N-Aryl-N-(1-L-4-piperidinyl)arylacetamides
FR2389622B1 (ru) * 1977-05-05 1982-05-21 Janssen Pharmaceutica Nv
US4167574A (en) * 1978-03-13 1979-09-11 Janssen Pharmaceutica, N.V. N-phenyl-N-(4-piperidinyl)amides
US4584303A (en) * 1984-04-09 1986-04-22 The Boc Group, Inc. N-aryl-N-(4-piperidinyl)amides and pharmaceutical compositions and method employing such compounds
FR2608602A1 (fr) * 1986-12-23 1988-06-24 Cerm Cent Europ Rech Mauvernay Nouvelles 3-piperidineamines ou 3-azepineamines substituees, leur preparation et leurs applications en therapeutique
US4849521A (en) * 1987-11-02 1989-07-18 Boc, Inc. Stereoselective preparation of 3-substituted-4-piperidine compounds and derivatives
US4791121A (en) * 1987-11-02 1988-12-13 The Boc Group, Inc. 4-phenyl-4-(N-(phenyl)amido) piperidine derivatives and pharmaceutical compositions and method employing such compounds
US5013742A (en) * 1987-11-02 1991-05-07 Boc, Inc. 4-phenyl-4-N-(phenyl) amido piperidine derivatives and pharmaceutical compositions and method employing such compounds
US4957929A (en) * 1987-11-02 1990-09-18 Boc, Inc. 4-phenyl-4-[N-(phenyl)amido]piperidine compounds and pharmaceutical compositions employing such compounds
US4921864A (en) * 1987-11-02 1990-05-01 Boc, Inc. 4-Phenyl-4-(N-(phenyl)amido) piperidine derivatives and pharmaceutical compositions and method employing such compounds
USRE33495E (en) * 1987-11-02 1990-12-18 Boc, Inc. Stereoselective preparation of 3-substituted-4-anilino-piperidine compounds and derivatives
US4801615A (en) * 1987-12-31 1989-01-31 The Boc Group, Inc. 4-heterohexacyclic-4-(N-(phenyl)amido) piperidine derivatives and pharmaceutical compositions and method employing such compounds
US4791120A (en) * 1987-12-31 1988-12-13 The Boc Group, Inc. 4-heteropentacyclic-4-[N-(phenyl)amino] piperidine derivatives and pharmaceutical compositions and method employing such compounds
US5019583A (en) * 1989-02-15 1991-05-28 Glaxo Inc. N-phenyl-N-(4-piperidinyl)amides useful as analgesics
USRE34201E (en) * 1989-04-20 1993-03-23 Anaquest, Inc. N-aryl-N-[4-(1-heterocyclicalkyl)piperidinyl]amides and pharmaceutical compositions and methods employing such compounds
US5145967A (en) * 1989-04-20 1992-09-08 Anaquest, Inc. Method for preparing 4-alkoxyalkyl-4-phenylaminopiperdines and derivatives thereof
US5053411A (en) * 1989-04-20 1991-10-01 Anaquest, Inc. N-aryl-N-[4-(1-heterocyclicalkyl)piperidinyl]amides and pharmaceutical compositions and methods employing such compounds
US4994471A (en) * 1989-05-12 1991-02-19 Boc, Inc. N-aryl-N-(1-substituted-3-alkoxy-4-piperidinyl)amides and pharmaceutical compositions and methods employing such compounds
US4939161A (en) * 1989-05-12 1990-07-03 Boc, Inc. Analgesic N-aryl-N-[1-substituted-3,5-dimethyl-4-piperidinyl]amides
US5100903A (en) * 1989-05-12 1992-03-31 Anaquest, Inc. N-aryl-n-(1-substituted-3-alkoxy-4-piperidinyl)amides and pharmaceutical compositions and methods employing such compounds
US5039804A (en) * 1989-12-13 1991-08-13 Glaxo Inc. Preparation of substituted alkali metal piperidine-4-carboxylates
US5126455A (en) * 1989-12-13 1992-06-30 Glaxo Inc. Preparation of substituted alkali metal piperidine-4-carboxylates
US5130321A (en) * 1990-12-18 1992-07-14 Glaxo Inc. Analgesic n-phenyl-n-(3-or 1-3-me-4-piperidinyl)amides
US5214148A (en) * 1990-12-18 1993-05-25 Glaxo Inc. Analgesic N-phenyl-N-(3-OR1 -3-ME-4-piperidinyl)amides
FR2676054B1 (fr) * 1991-05-03 1993-09-03 Sanofi Elf Nouveaux composes n-alkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
GB9316863D0 (en) * 1993-08-13 1993-09-29 Glaxo Group Ltd Chemical process
US5489689A (en) * 1993-09-30 1996-02-06 Mallinckrodt Chemical, Inc. Preparation of piperidine derivatives
US6541021B1 (en) * 1999-03-18 2003-04-01 Durect Corporation Devices and methods for pain management
US6835194B2 (en) * 1999-03-18 2004-12-28 Durect Corporation Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners
WO2000061557A1 (fr) * 1999-04-09 2000-10-19 Mochida Pharmaceutical Co., Ltd. Derives de 4-hydroxypiperidine ayant un effet anti-arythmique
US6635661B2 (en) 2000-05-25 2003-10-21 Sepracor Inc. Heterocyclic analgesic compounds and methods of use thereof
US6677332B1 (en) 1999-05-25 2004-01-13 Sepracor, Inc. Heterocyclic analgesic compounds and methods of use thereof
US7361666B2 (en) * 1999-05-25 2008-04-22 Sepracor, Inc. Heterocyclic analgesic compounds and methods of use thereof
DE60030883T2 (de) * 1999-12-06 2007-09-06 Mallinckrodt, Inc. Verfahren zur herstellung von alfentanil, sufentanil und remifentanil
US7074803B2 (en) * 2001-03-02 2006-07-11 Durect Corporation Opioid formulations
US20040102476A1 (en) * 2002-11-25 2004-05-27 Chan Tai Wah High concentration formulations of opioids and opioid derivatives
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JP2008088057A (ja) * 2005-03-23 2008-04-17 Nippon Chemiphar Co Ltd Ｎ−置換−ｎ−（４−ピペリジニル）アミド誘導体
CN101312949A (zh) * 2005-11-17 2008-11-26 马林克罗特公司 合成瑞芬太尼的方法
CN101374812A (zh) * 2006-01-24 2009-02-25 马林克罗特公司 合成瑞芬太尼的方法
EP1867635A1 (en) * 2006-06-15 2007-12-19 Kern Pharma, S.L. Process for preparing remifentanil, intermediates thereof, use of said intermediates and processes for their preparation
US20080009782A1 (en) * 2006-06-28 2008-01-10 Alza Corporation Methods and Devices for Transdermal Electrotransport Delivery of Lofentanil and Carfentanil
WO2008005423A1 (en) * 2006-07-03 2008-01-10 Cambrex Charles City, Inc. Improved method of making sufentanil
CA2670704A1 (en) * 2006-11-29 2008-06-05 Mallinckrodt Inc. New process for remifentanil synthesis
WO2010027770A1 (en) * 2008-09-04 2010-03-11 Mallinckrodt Inc. Crystalline forms of sufentanil citrate
US8299258B2 (en) * 2008-11-04 2012-10-30 Cambrex Charles City Method of making piperidine derivatives
ES2664801T3 (es) 2010-09-17 2018-04-23 Mallinckrodt Llc Proceso mejorado para la preparación de un precursor de sufentanilo base
EP2455377B1 (de) 2010-11-11 2014-07-09 hameln rds gmbh Synthese von Fentanyl Analoga
CA2819635A1 (en) 2010-12-01 2012-06-07 Spinal Modulation, Inc. Directed delivery of agents to neural anatomy
AU2014244232B2 (en) * 2013-03-13 2019-05-02 President And Fellows Of Harvard College Stapled and stitched polypeptides and uses thereof
EP3233077A4 (en) 2014-12-19 2018-08-08 The Broad Institute Inc. Dopamine d2 receptor ligands
EP3233799B1 (en) 2014-12-19 2021-05-19 The Broad Institute, Inc. Dopamine d2 receptor ligands
ES2806631T3 (es) 2015-05-27 2021-02-18 SpecGx LLC Preparación de citrato de sufentanilo y base de sufentanilo
CN106854203B (zh) * 2015-12-08 2020-12-01 江苏恩华药业股份有限公司 枸橼酸舒芬太尼的新晶型及其制备方法
SI3199523T1 (sl) 2016-01-29 2018-12-31 Bioka S.R.O. Nov postopek za pridobivanje n-fenil-n-(4-piperinidil)amidnih derivatov kot sta remifentanil in karfentanil
CN108503579B (zh) * 2018-03-28 2021-03-26 南京医科大学 芬太尼类似物及其应用
CN113214140B (zh) * 2020-02-03 2022-09-09 江苏谛奇医药科技有限公司 哌啶酰胺类衍生物、其药物组合物及其应用
PE20230855A1 (es) 2020-08-14 2023-05-29 Novartis Ag Derivados de espiropiperidinilo sustituidos con heteroarilo y usos farmaceuticos de los mismos
CN114262320A (zh) * 2021-12-28 2022-04-01 宜昌人福药业有限责任公司 一种利用连续流微通道反应器制备苯胺基哌啶类药物的合成方法

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US3171838A (en) * 1961-10-10 1965-03-02 Res Lab Dr C Janssen N V Aroylalkyl and hydroxyaralkyl derivatives of 4-(n-arylalkanamido)-piperidines and related compounds
BE623427A (ru) * 1961-10-10

Also Published As

Publication number Publication date
NO146162B (no) 1982-05-03
YU65276A (en) 1982-08-31
PH12746A (en) 1979-08-09
LU74511A1 (ru) 1976-09-01
SE426486B (sv) 1983-01-24
DK148960B (da) 1985-12-02
IL49204A (en) 1979-11-30
YU39960B (en) 1985-06-30
AU503632B2 (en) 1979-09-13
CZ278060B6 (en) 1993-08-11
HU172963B (hu) 1979-01-28
FI61481C (fi) 1982-08-10
FI760646A (ru) 1976-09-15
FR2303546B1 (ru) 1980-11-28
NL185279B (nl) 1989-10-02
NZ180096A (en) 1978-06-02
AT359493B (de) 1980-11-10
ATA184676A (de) 1980-04-15
PT64898A (en) 1976-04-01
SU1227109A3 (ru) 1986-04-23
IE42512L (en) 1976-09-14
CZ163276A3 (en) 1993-03-17
DE2610228A1 (de) 1976-09-30
BG28259A3 (en) 1980-03-25
CA1080232A (en) 1980-06-24
IE42512B1 (en) 1980-08-27
PL102474B1 (pl) 1979-03-31
NO760591L (ru) 1976-09-15
GB1538938A (en) 1979-01-24
IT1057988B (it) 1982-03-30
DK148960C (da) 1986-06-23
NL7602612A (nl) 1976-09-16
IL49204A0 (en) 1976-05-31
CH629486A5 (de) 1982-04-30
AU1200676A (en) 1977-09-22
US3998834A (en) 1976-12-21
SE7602740L (sv) 1976-09-15
JPS51115478A (en) 1976-10-12
JPS5946217B2 (ja) 1984-11-10
DE2610228C2 (ru) 1990-04-05
FR2303546A1 (fr) 1976-10-08
FI61481B (fi) 1982-04-30
ES446034A1 (es) 1977-10-16
DK110376A (da) 1976-09-15
NO146162C (no) 1982-08-11
PT64898B (en) 1977-08-18

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BB A search report has been drawn up
BC A request for examination has been filed
A85 Still pending on 85-01-01
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