FR2303546A1 - N-(4-piperidinyl)-n-phenylamides et -carbamates et procede pour leur preparation - Google Patents

N-(4-piperidinyl)-n-phenylamides et -carbamates et procede pour leur preparation

Info

Publication number
FR2303546A1
FR2303546A1 FR7606870A FR7606870A FR2303546A1 FR 2303546 A1 FR2303546 A1 FR 2303546A1 FR 7606870 A FR7606870 A FR 7606870A FR 7606870 A FR7606870 A FR 7606870A FR 2303546 A1 FR2303546 A1 FR 2303546A1
Authority
FR
France
Prior art keywords
phenylamides
carbamates
piperidinyl
preparation
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7606870A
Other languages
English (en)
Other versions
FR2303546B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of FR2303546A1 publication Critical patent/FR2303546A1/fr
Application granted granted Critical
Publication of FR2303546B1 publication Critical patent/FR2303546B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/333—Radicals substituted by oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/66—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having a hetero atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
FR7606870A 1975-03-14 1976-03-10 N-(4-piperidinyl)-n-phenylamides et -carbamates et procede pour leur preparation Granted FR2303546A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55851175A 1975-03-14 1975-03-14
US05/648,685 US3998834A (en) 1975-03-14 1976-01-13 N-(4-piperidinyl)-n-phenylamides and -carbamates

Publications (2)

Publication Number Publication Date
FR2303546A1 true FR2303546A1 (fr) 1976-10-08
FR2303546B1 FR2303546B1 (fr) 1980-11-28

Family

ID=27071767

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7606870A Granted FR2303546A1 (fr) 1975-03-14 1976-03-10 N-(4-piperidinyl)-n-phenylamides et -carbamates et procede pour leur preparation

Country Status (28)

Country Link
US (1) US3998834A (fr)
JP (1) JPS5946217B2 (fr)
AT (1) AT359493B (fr)
AU (1) AU503632B2 (fr)
BG (1) BG28259A3 (fr)
CA (1) CA1080232A (fr)
CH (1) CH629486A5 (fr)
CZ (1) CZ278060B6 (fr)
DE (1) DE2610228A1 (fr)
DK (1) DK148960C (fr)
ES (1) ES446034A1 (fr)
FI (1) FI61481C (fr)
FR (1) FR2303546A1 (fr)
GB (1) GB1538938A (fr)
HU (1) HU172963B (fr)
IE (1) IE42512B1 (fr)
IL (1) IL49204A (fr)
IT (1) IT1057988B (fr)
LU (1) LU74511A1 (fr)
NL (1) NL185279C (fr)
NO (1) NO146162C (fr)
NZ (1) NZ180096A (fr)
PH (1) PH12746A (fr)
PL (1) PL102474B1 (fr)
PT (1) PT64898B (fr)
SE (1) SE426486B (fr)
SU (1) SU1227109A3 (fr)
YU (1) YU39960B (fr)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179569A (en) * 1975-03-14 1979-12-18 Janssen Pharmaceutica N.V. N-(4-piperidinyl)-N-phenylamides
US4208418A (en) * 1975-09-23 1980-06-17 Janssen Pharmaceutica N.V. N-Aryl-N-(1-alkyl-4-piperidinyl)arylacetamides
US4225606A (en) * 1975-09-23 1980-09-30 Janssen Pharmaceutica N.V. N-Aryl-N-(1-L-4-piperidinyl)arylacetamides
FR2389622B1 (fr) * 1977-05-05 1982-05-21 Janssen Pharmaceutica Nv
US4167574A (en) * 1978-03-13 1979-09-11 Janssen Pharmaceutica, N.V. N-phenyl-N-(4-piperidinyl)amides
US4584303A (en) * 1984-04-09 1986-04-22 The Boc Group, Inc. N-aryl-N-(4-piperidinyl)amides and pharmaceutical compositions and method employing such compounds
FR2608602A1 (fr) * 1986-12-23 1988-06-24 Cerm Cent Europ Rech Mauvernay Nouvelles 3-piperidineamines ou 3-azepineamines substituees, leur preparation et leurs applications en therapeutique
US4849521A (en) * 1987-11-02 1989-07-18 Boc, Inc. Stereoselective preparation of 3-substituted-4-piperidine compounds and derivatives
US4957929A (en) * 1987-11-02 1990-09-18 Boc, Inc. 4-phenyl-4-[N-(phenyl)amido]piperidine compounds and pharmaceutical compositions employing such compounds
US4791121A (en) * 1987-11-02 1988-12-13 The Boc Group, Inc. 4-phenyl-4-(N-(phenyl)amido) piperidine derivatives and pharmaceutical compositions and method employing such compounds
USRE33495E (en) * 1987-11-02 1990-12-18 Boc, Inc. Stereoselective preparation of 3-substituted-4-anilino-piperidine compounds and derivatives
US4921864A (en) * 1987-11-02 1990-05-01 Boc, Inc. 4-Phenyl-4-(N-(phenyl)amido) piperidine derivatives and pharmaceutical compositions and method employing such compounds
US5013742A (en) * 1987-11-02 1991-05-07 Boc, Inc. 4-phenyl-4-N-(phenyl) amido piperidine derivatives and pharmaceutical compositions and method employing such compounds
US4801615A (en) * 1987-12-31 1989-01-31 The Boc Group, Inc. 4-heterohexacyclic-4-(N-(phenyl)amido) piperidine derivatives and pharmaceutical compositions and method employing such compounds
US4791120A (en) * 1987-12-31 1988-12-13 The Boc Group, Inc. 4-heteropentacyclic-4-[N-(phenyl)amino] piperidine derivatives and pharmaceutical compositions and method employing such compounds
US5019583A (en) * 1989-02-15 1991-05-28 Glaxo Inc. N-phenyl-N-(4-piperidinyl)amides useful as analgesics
US5053411A (en) * 1989-04-20 1991-10-01 Anaquest, Inc. N-aryl-N-[4-(1-heterocyclicalkyl)piperidinyl]amides and pharmaceutical compositions and methods employing such compounds
US5145967A (en) * 1989-04-20 1992-09-08 Anaquest, Inc. Method for preparing 4-alkoxyalkyl-4-phenylaminopiperdines and derivatives thereof
USRE34201E (en) * 1989-04-20 1993-03-23 Anaquest, Inc. N-aryl-N-[4-(1-heterocyclicalkyl)piperidinyl]amides and pharmaceutical compositions and methods employing such compounds
US4994471A (en) * 1989-05-12 1991-02-19 Boc, Inc. N-aryl-N-(1-substituted-3-alkoxy-4-piperidinyl)amides and pharmaceutical compositions and methods employing such compounds
US4939161A (en) * 1989-05-12 1990-07-03 Boc, Inc. Analgesic N-aryl-N-[1-substituted-3,5-dimethyl-4-piperidinyl]amides
US5100903A (en) * 1989-05-12 1992-03-31 Anaquest, Inc. N-aryl-n-(1-substituted-3-alkoxy-4-piperidinyl)amides and pharmaceutical compositions and methods employing such compounds
US5039804A (en) * 1989-12-13 1991-08-13 Glaxo Inc. Preparation of substituted alkali metal piperidine-4-carboxylates
US5126455A (en) * 1989-12-13 1992-06-30 Glaxo Inc. Preparation of substituted alkali metal piperidine-4-carboxylates
US5130321A (en) * 1990-12-18 1992-07-14 Glaxo Inc. Analgesic n-phenyl-n-(3-or 1-3-me-4-piperidinyl)amides
US5214148A (en) * 1990-12-18 1993-05-25 Glaxo Inc. Analgesic N-phenyl-N-(3-OR1 -3-ME-4-piperidinyl)amides
FR2676054B1 (fr) * 1991-05-03 1993-09-03 Sanofi Elf Nouveaux composes n-alkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
GB9316863D0 (en) * 1993-08-13 1993-09-29 Glaxo Group Ltd Chemical process
US5489689A (en) * 1993-09-30 1996-02-06 Mallinckrodt Chemical, Inc. Preparation of piperidine derivatives
US6835194B2 (en) * 1999-03-18 2004-12-28 Durect Corporation Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners
US6541021B1 (en) * 1999-03-18 2003-04-01 Durect Corporation Devices and methods for pain management
WO2000061557A1 (fr) * 1999-04-09 2000-10-19 Mochida Pharmaceutical Co., Ltd. Derives de 4-hydroxypiperidine ayant un effet anti-arythmique
US7361666B2 (en) * 1999-05-25 2008-04-22 Sepracor, Inc. Heterocyclic analgesic compounds and methods of use thereof
US6677332B1 (en) 1999-05-25 2004-01-13 Sepracor, Inc. Heterocyclic analgesic compounds and methods of use thereof
US6635661B2 (en) 2000-05-25 2003-10-21 Sepracor Inc. Heterocyclic analgesic compounds and methods of use thereof
US7074935B2 (en) * 1999-12-06 2006-07-11 Mallinckrodt Inc. Methods for the syntheses of alfentanil, sufentanil and remifentanil
US7074803B2 (en) * 2001-03-02 2006-07-11 Durect Corporation Opioid formulations
US20040102476A1 (en) * 2002-11-25 2004-05-27 Chan Tai Wah High concentration formulations of opioids and opioid derivatives
JPWO2006030931A1 (ja) * 2004-09-14 2008-05-15 日本ケミファ株式会社 Ｎ−置換−ｎ−（４−ピペリジニル）アミド誘導体
JP2008088057A (ja) * 2005-03-23 2008-04-17 Nippon Chemiphar Co Ltd Ｎ−置換−ｎ−（４−ピペリジニル）アミド誘導体
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JP2009524659A (ja) * 2006-01-24 2009-07-02 マリンクロッド・インコーポレイテッド レミフェンタニルの合成方法
EP1867635A1 (fr) * 2006-06-15 2007-12-19 Kern Pharma, S.L. Procédé de préparation de remifentanil, ses produits intermédiaires, leur application et procédé pour leur préparation
US20080009782A1 (en) * 2006-06-28 2008-01-10 Alza Corporation Methods and Devices for Transdermal Electrotransport Delivery of Lofentanil and Carfentanil
WO2008005423A1 (fr) * 2006-07-03 2008-01-10 Cambrex Charles City, Inc. Méthode améliorée de fabrication de sufentanil
CA2670704A1 (fr) * 2006-11-29 2008-06-05 Mallinckrodt Inc. Nouveau procede de synthese du remifentanil
WO2010027770A1 (fr) * 2008-09-04 2010-03-11 Mallinckrodt Inc. Formes cristallines de sufentanil citrate
US8299258B2 (en) * 2008-11-04 2012-10-30 Cambrex Charles City Method of making piperidine derivatives
EP2616464B1 (fr) 2010-09-17 2018-01-03 Mallinckrodt LLC Procédé amélioré de préparation d'un précurseur de sufentanil base
EP2455377B1 (fr) 2010-11-11 2014-07-09 hameln rds gmbh Synthèse d'analogues de fentanyl
JP2014504184A (ja) 2010-12-01 2014-02-20 スパイナル・モデュレーション・インコーポレイテッド 神経構造への薬剤の直接送達
US10081654B2 (en) * 2013-03-13 2018-09-25 President And Fellows Of Harvard College Stapled and stitched polypeptides and uses thereof
EP3233799B1 (fr) 2014-12-19 2021-05-19 The Broad Institute, Inc. Ligands du récepteur d2 de la dopamine
WO2016100940A1 (fr) 2014-12-19 2016-06-23 The Broad Institute, Inc. Ligands des récepteurs dopaminergiques d2
EP3302473B1 (fr) * 2015-05-27 2020-07-08 SpecGx LLC Préparation de citrate de sufentanile et base de sufentanile
CN106854203B (zh) * 2015-12-08 2020-12-01 江苏恩华药业股份有限公司 枸橼酸舒芬太尼的新晶型及其制备方法
DK3199523T3 (en) 2016-01-29 2018-11-26 Bioka S R O NEW PROCEDURE FOR THE PREPARATION OF N-PHENYL-N- (4-PIPERIDINYL) AMIDE DERIVATIVES, SUCH AS REMIFENTANIL AND CARFENTANIL
CN108503579B (zh) * 2018-03-28 2021-03-26 南京医科大学 芬太尼类似物及其应用
CN113214140B (zh) * 2020-02-03 2022-09-09 江苏谛奇医药科技有限公司 哌啶酰胺类衍生物、其药物组合物及其应用
US11708366B2 (en) 2020-08-14 2023-07-25 Novartis Ag Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof
CN114262320A (zh) * 2021-12-28 2022-04-01 宜昌人福药业有限责任公司 一种利用连续流微通道反应器制备苯胺基哌啶类药物的合成方法

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BE623427A (fr) * 1961-10-10
US3171838A (en) * 1961-10-10 1965-03-02 Res Lab Dr C Janssen N V Aroylalkyl and hydroxyaralkyl derivatives of 4-(n-arylalkanamido)-piperidines and related compounds

Also Published As

Publication number Publication date
AU503632B2 (en) 1979-09-13
YU65276A (en) 1982-08-31
DK110376A (da) 1976-09-15
PL102474B1 (pl) 1979-03-31
DK148960C (da) 1986-06-23
JPS5946217B2 (ja) 1984-11-10
SE7602740L (sv) 1976-09-15
DE2610228C2 (fr) 1990-04-05
NL185279B (nl) 1989-10-02
PT64898A (en) 1976-04-01
FI760646A (fr) 1976-09-15
NZ180096A (en) 1978-06-02
PH12746A (en) 1979-08-09
NL7602612A (nl) 1976-09-16
ES446034A1 (es) 1977-10-16
FR2303546B1 (fr) 1980-11-28
CA1080232A (fr) 1980-06-24
IL49204A (en) 1979-11-30
LU74511A1 (fr) 1976-09-01
IL49204A0 (en) 1976-05-31
CH629486A5 (de) 1982-04-30
ATA184676A (de) 1980-04-15
GB1538938A (en) 1979-01-24
SU1227109A3 (ru) 1986-04-23
IE42512L (en) 1976-09-14
BG28259A3 (en) 1980-03-25
CZ163276A3 (en) 1993-03-17
US3998834A (en) 1976-12-21
AU1200676A (en) 1977-09-22
PT64898B (en) 1977-08-18
NO146162C (no) 1982-08-11
YU39960B (en) 1985-06-30
AT359493B (de) 1980-11-10
IE42512B1 (en) 1980-08-27
NO146162B (no) 1982-05-03
SE426486B (sv) 1983-01-24
JPS51115478A (en) 1976-10-12
DK148960B (da) 1985-12-02
HU172963B (hu) 1979-01-28
FI61481B (fi) 1982-04-30
NL185279C (nl) 1990-03-01
FI61481C (fi) 1982-08-10
CZ278060B6 (en) 1993-08-11
NO760591L (fr) 1976-09-15
DE2610228A1 (de) 1976-09-30
IT1057988B (it) 1982-03-30

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Legal Events

Date Code Title Description
CC Supplementary protection certificate (spc) laid open to the public (law of 25 june 1990)

Free format text: 92C0446, 920618

CB Supplementary protection certificate (spc) granted (law of 25 june 1990)

Free format text: 92C0446, 760310

CL Concession to grant licences