HU172963B - Sposob poluchenija n-skobka-4-piperidinil-skobka zakryta-n-fenil-amidov i -karbonatov i farmacevticheskikh kompozicijj soderzhahhikh ikh aktinymi agentami - Google Patents

Sposob poluchenija n-skobka-4-piperidinil-skobka zakryta-n-fenil-amidov i -karbonatov i farmacevticheskikh kompozicijj soderzhahhikh ikh aktinymi agentami

Info

Publication number
HU172963B
HU172963B HU76JA00000751A HUJA000751A HU172963B HU 172963 B HU172963 B HU 172963B HU 76JA00000751 A HU76JA00000751 A HU 76JA00000751A HU JA000751 A HUJA000751 A HU JA000751A HU 172963 B HU172963 B HU 172963B
Authority
HU
Hungary
Prior art keywords
bracket
piperidinyl
carbonates
amides
phenyl
Prior art date
Application number
HU76JA00000751A
Other languages
English (en)
Inventor
Paul A J Janssen
Daele Georges H P Van
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of HU172963B publication Critical patent/HU172963B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/333—Radicals substituted by oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/66—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having a hetero atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HU76JA00000751A 1975-03-14 1976-03-11 Sposob poluchenija n-skobka-4-piperidinil-skobka zakryta-n-fenil-amidov i -karbonatov i farmacevticheskikh kompozicijj soderzhahhikh ikh aktinymi agentami HU172963B (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55851175A 1975-03-14 1975-03-14
US05/648,685 US3998834A (en) 1975-03-14 1976-01-13 N-(4-piperidinyl)-n-phenylamides and -carbamates

Publications (1)

Publication Number Publication Date
HU172963B true HU172963B (hu) 1979-01-28

Family

ID=27071767

Family Applications (1)

Application Number Title Priority Date Filing Date
HU76JA00000751A HU172963B (hu) 1975-03-14 1976-03-11 Sposob poluchenija n-skobka-4-piperidinil-skobka zakryta-n-fenil-amidov i -karbonatov i farmacevticheskikh kompozicijj soderzhahhikh ikh aktinymi agentami

Country Status (28)

Country Link
US (1) US3998834A (hu)
JP (1) JPS5946217B2 (hu)
AT (1) AT359493B (hu)
AU (1) AU503632B2 (hu)
BG (1) BG28259A3 (hu)
CA (1) CA1080232A (hu)
CH (1) CH629486A5 (hu)
CZ (1) CZ278060B6 (hu)
DE (1) DE2610228A1 (hu)
DK (1) DK148960C (hu)
ES (1) ES446034A1 (hu)
FI (1) FI61481C (hu)
FR (1) FR2303546A1 (hu)
GB (1) GB1538938A (hu)
HU (1) HU172963B (hu)
IE (1) IE42512B1 (hu)
IL (1) IL49204A (hu)
IT (1) IT1057988B (hu)
LU (1) LU74511A1 (hu)
NL (1) NL185279C (hu)
NO (1) NO146162C (hu)
NZ (1) NZ180096A (hu)
PH (1) PH12746A (hu)
PL (1) PL102474B1 (hu)
PT (1) PT64898B (hu)
SE (1) SE426486B (hu)
SU (1) SU1227109A3 (hu)
YU (1) YU39960B (hu)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179569A (en) * 1975-03-14 1979-12-18 Janssen Pharmaceutica N.V. N-(4-piperidinyl)-N-phenylamides
US4208418A (en) * 1975-09-23 1980-06-17 Janssen Pharmaceutica N.V. N-Aryl-N-(1-alkyl-4-piperidinyl)arylacetamides
US4225606A (en) * 1975-09-23 1980-09-30 Janssen Pharmaceutica N.V. N-Aryl-N-(1-L-4-piperidinyl)arylacetamides
FR2389622B1 (hu) * 1977-05-05 1982-05-21 Janssen Pharmaceutica Nv
US4167574A (en) * 1978-03-13 1979-09-11 Janssen Pharmaceutica, N.V. N-phenyl-N-(4-piperidinyl)amides
US4584303A (en) * 1984-04-09 1986-04-22 The Boc Group, Inc. N-aryl-N-(4-piperidinyl)amides and pharmaceutical compositions and method employing such compounds
FR2608602A1 (fr) * 1986-12-23 1988-06-24 Cerm Cent Europ Rech Mauvernay Nouvelles 3-piperidineamines ou 3-azepineamines substituees, leur preparation et leurs applications en therapeutique
US4849521A (en) * 1987-11-02 1989-07-18 Boc, Inc. Stereoselective preparation of 3-substituted-4-piperidine compounds and derivatives
US4957929A (en) * 1987-11-02 1990-09-18 Boc, Inc. 4-phenyl-4-[N-(phenyl)amido]piperidine compounds and pharmaceutical compositions employing such compounds
US4791121A (en) * 1987-11-02 1988-12-13 The Boc Group, Inc. 4-phenyl-4-(N-(phenyl)amido) piperidine derivatives and pharmaceutical compositions and method employing such compounds
USRE33495E (en) * 1987-11-02 1990-12-18 Boc, Inc. Stereoselective preparation of 3-substituted-4-anilino-piperidine compounds and derivatives
US4921864A (en) * 1987-11-02 1990-05-01 Boc, Inc. 4-Phenyl-4-(N-(phenyl)amido) piperidine derivatives and pharmaceutical compositions and method employing such compounds
US5013742A (en) * 1987-11-02 1991-05-07 Boc, Inc. 4-phenyl-4-N-(phenyl) amido piperidine derivatives and pharmaceutical compositions and method employing such compounds
US4801615A (en) * 1987-12-31 1989-01-31 The Boc Group, Inc. 4-heterohexacyclic-4-(N-(phenyl)amido) piperidine derivatives and pharmaceutical compositions and method employing such compounds
US4791120A (en) * 1987-12-31 1988-12-13 The Boc Group, Inc. 4-heteropentacyclic-4-[N-(phenyl)amino] piperidine derivatives and pharmaceutical compositions and method employing such compounds
US5019583A (en) * 1989-02-15 1991-05-28 Glaxo Inc. N-phenyl-N-(4-piperidinyl)amides useful as analgesics
US5053411A (en) * 1989-04-20 1991-10-01 Anaquest, Inc. N-aryl-N-[4-(1-heterocyclicalkyl)piperidinyl]amides and pharmaceutical compositions and methods employing such compounds
US5145967A (en) * 1989-04-20 1992-09-08 Anaquest, Inc. Method for preparing 4-alkoxyalkyl-4-phenylaminopiperdines and derivatives thereof
USRE34201E (en) * 1989-04-20 1993-03-23 Anaquest, Inc. N-aryl-N-[4-(1-heterocyclicalkyl)piperidinyl]amides and pharmaceutical compositions and methods employing such compounds
US4994471A (en) * 1989-05-12 1991-02-19 Boc, Inc. N-aryl-N-(1-substituted-3-alkoxy-4-piperidinyl)amides and pharmaceutical compositions and methods employing such compounds
US4939161A (en) * 1989-05-12 1990-07-03 Boc, Inc. Analgesic N-aryl-N-[1-substituted-3,5-dimethyl-4-piperidinyl]amides
US5100903A (en) * 1989-05-12 1992-03-31 Anaquest, Inc. N-aryl-n-(1-substituted-3-alkoxy-4-piperidinyl)amides and pharmaceutical compositions and methods employing such compounds
US5039804A (en) * 1989-12-13 1991-08-13 Glaxo Inc. Preparation of substituted alkali metal piperidine-4-carboxylates
US5126455A (en) * 1989-12-13 1992-06-30 Glaxo Inc. Preparation of substituted alkali metal piperidine-4-carboxylates
US5130321A (en) * 1990-12-18 1992-07-14 Glaxo Inc. Analgesic n-phenyl-n-(3-or 1-3-me-4-piperidinyl)amides
US5214148A (en) * 1990-12-18 1993-05-25 Glaxo Inc. Analgesic N-phenyl-N-(3-OR1 -3-ME-4-piperidinyl)amides
FR2676054B1 (fr) * 1991-05-03 1993-09-03 Sanofi Elf Nouveaux composes n-alkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
GB9316863D0 (en) * 1993-08-13 1993-09-29 Glaxo Group Ltd Chemical process
US5489689A (en) * 1993-09-30 1996-02-06 Mallinckrodt Chemical, Inc. Preparation of piperidine derivatives
US6835194B2 (en) * 1999-03-18 2004-12-28 Durect Corporation Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners
US6541021B1 (en) * 1999-03-18 2003-04-01 Durect Corporation Devices and methods for pain management
WO2000061557A1 (fr) * 1999-04-09 2000-10-19 Mochida Pharmaceutical Co., Ltd. Derives de 4-hydroxypiperidine ayant un effet anti-arythmique
US7361666B2 (en) * 1999-05-25 2008-04-22 Sepracor, Inc. Heterocyclic analgesic compounds and methods of use thereof
US6677332B1 (en) 1999-05-25 2004-01-13 Sepracor, Inc. Heterocyclic analgesic compounds and methods of use thereof
US6635661B2 (en) 2000-05-25 2003-10-21 Sepracor Inc. Heterocyclic analgesic compounds and methods of use thereof
US7074935B2 (en) * 1999-12-06 2006-07-11 Mallinckrodt Inc. Methods for the syntheses of alfentanil, sufentanil and remifentanil
US7074803B2 (en) * 2001-03-02 2006-07-11 Durect Corporation Opioid formulations
US20040102476A1 (en) * 2002-11-25 2004-05-27 Chan Tai Wah High concentration formulations of opioids and opioid derivatives
JPWO2006030931A1 (ja) * 2004-09-14 2008-05-15 日本ケミファ株式会社 Ｎ−置換−ｎ−（４−ピペリジニル）アミド誘導体
JP2008088057A (ja) * 2005-03-23 2008-04-17 Nippon Chemiphar Co Ltd Ｎ−置換−ｎ−（４−ピペリジニル）アミド誘導体
AU2006317591A1 (en) * 2005-11-17 2007-05-31 Mallinckrodt Inc. Process for synthesizing remifentanil
JP2009524659A (ja) * 2006-01-24 2009-07-02 マリンクロッド・インコーポレイテッド レミフェンタニルの合成方法
EP1867635A1 (en) * 2006-06-15 2007-12-19 Kern Pharma, S.L. Process for preparing remifentanil, intermediates thereof, use of said intermediates and processes for their preparation
US20080009782A1 (en) * 2006-06-28 2008-01-10 Alza Corporation Methods and Devices for Transdermal Electrotransport Delivery of Lofentanil and Carfentanil
WO2008005423A1 (en) * 2006-07-03 2008-01-10 Cambrex Charles City, Inc. Improved method of making sufentanil
CA2670704A1 (en) * 2006-11-29 2008-06-05 Mallinckrodt Inc. New process for remifentanil synthesis
WO2010027770A1 (en) * 2008-09-04 2010-03-11 Mallinckrodt Inc. Crystalline forms of sufentanil citrate
US8299258B2 (en) * 2008-11-04 2012-10-30 Cambrex Charles City Method of making piperidine derivatives
EP2616464B1 (en) 2010-09-17 2018-01-03 Mallinckrodt LLC Improved process for the preparation of a precursor of sufentanil base
EP2455377B1 (de) 2010-11-11 2014-07-09 hameln rds gmbh Synthese von Fentanyl Analoga
JP2014504184A (ja) 2010-12-01 2014-02-20 スパイナル・モデュレーション・インコーポレイテッド 神経構造への薬剤の直接送達
US10081654B2 (en) * 2013-03-13 2018-09-25 President And Fellows Of Harvard College Stapled and stitched polypeptides and uses thereof
EP3233799B1 (en) 2014-12-19 2021-05-19 The Broad Institute, Inc. Dopamine d2 receptor ligands
WO2016100940A1 (en) 2014-12-19 2016-06-23 The Broad Institute, Inc. Dopamine d2 receptor ligands
EP3302473B1 (en) * 2015-05-27 2020-07-08 SpecGx LLC Preparation of sufentanil citrate and sufentanil base
CN106854203B (zh) * 2015-12-08 2020-12-01 江苏恩华药业股份有限公司 枸橼酸舒芬太尼的新晶型及其制备方法
DK3199523T3 (en) 2016-01-29 2018-11-26 Bioka S R O NEW PROCEDURE FOR THE PREPARATION OF N-PHENYL-N- (4-PIPERIDINYL) AMIDE DERIVATIVES, SUCH AS REMIFENTANIL AND CARFENTANIL
CN108503579B (zh) * 2018-03-28 2021-03-26 南京医科大学 芬太尼类似物及其应用
CN113214140B (zh) * 2020-02-03 2022-09-09 江苏谛奇医药科技有限公司 哌啶酰胺类衍生物、其药物组合物及其应用
US11708366B2 (en) 2020-08-14 2023-07-25 Novartis Ag Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof
CN114262320A (zh) * 2021-12-28 2022-04-01 宜昌人福药业有限责任公司 一种利用连续流微通道反应器制备苯胺基哌啶类药物的合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE623427A (hu) * 1961-10-10
US3171838A (en) * 1961-10-10 1965-03-02 Res Lab Dr C Janssen N V Aroylalkyl and hydroxyaralkyl derivatives of 4-(n-arylalkanamido)-piperidines and related compounds

Also Published As

Publication number Publication date
AU503632B2 (en) 1979-09-13
YU65276A (en) 1982-08-31
DK110376A (da) 1976-09-15
PL102474B1 (pl) 1979-03-31
DK148960C (da) 1986-06-23
JPS5946217B2 (ja) 1984-11-10
SE7602740L (sv) 1976-09-15
DE2610228C2 (hu) 1990-04-05
NL185279B (nl) 1989-10-02
PT64898A (en) 1976-04-01
FI760646A (hu) 1976-09-15
NZ180096A (en) 1978-06-02
PH12746A (en) 1979-08-09
NL7602612A (nl) 1976-09-16
ES446034A1 (es) 1977-10-16
FR2303546B1 (hu) 1980-11-28
CA1080232A (en) 1980-06-24
IL49204A (en) 1979-11-30
LU74511A1 (hu) 1976-09-01
IL49204A0 (en) 1976-05-31
CH629486A5 (de) 1982-04-30
ATA184676A (de) 1980-04-15
GB1538938A (en) 1979-01-24
SU1227109A3 (ru) 1986-04-23
IE42512L (en) 1976-09-14
BG28259A3 (en) 1980-03-25
CZ163276A3 (en) 1993-03-17
US3998834A (en) 1976-12-21
FR2303546A1 (fr) 1976-10-08
AU1200676A (en) 1977-09-22
PT64898B (en) 1977-08-18
NO146162C (no) 1982-08-11
YU39960B (en) 1985-06-30
AT359493B (de) 1980-11-10
IE42512B1 (en) 1980-08-27
NO146162B (no) 1982-05-03
SE426486B (sv) 1983-01-24
JPS51115478A (en) 1976-10-12
DK148960B (da) 1985-12-02
FI61481B (fi) 1982-04-30
NL185279C (nl) 1990-03-01
FI61481C (fi) 1982-08-10
CZ278060B6 (en) 1993-08-11
NO760591L (hu) 1976-09-15
DE2610228A1 (de) 1976-09-30
IT1057988B (it) 1982-03-30

Similar Documents

Publication Publication Date Title
HU172963B (hu) Sposob poluchenija n-skobka-4-piperidinil-skobka zakryta-n-fenil-amidov i -karbonatov i farmacevticheskikh kompozicijj soderzhahhikh ikh aktinymi agentami
PT78751B (en) Preparation process of 2-pyrimidinyl-1-piperazine derivatives and medicines containing them
ES8106891A1 (es) Procedimiento para la obtencion de 2-hidroxialquil-3,4,5- trihidroxi-piperidinas
HU174927B (hu) Sposob poluchenija proizvodnykh 1-benzazolilalkil-4-zamehhennykh-piperidinov i farmacevticheskikh kompozicijj soderzhahhikh ikh aktivnymi agentami
HU173950B (hu) Sposob poluchenija al'fa-al'fa-dvoezamehhennykh proizvodnykh uksusnojj kisloty i farmacevticheskikh kompozicijj soderzhahhikh ikh aktivnymi agentami
ES434431A1 (es) Procedimiento para preparar derivados del xanteno.
ES466239A1 (es) Un procedimiento de preparacion de azacicloalcanos, azaci- cloalquenos y sus derivados
HU174097B (hu) Sposob poluchenija proizvodnykh fenolefirov dvoe-zamehhennykh 3-amino-2-gidroksipropanom i farmacevticheskikh kompozicijj soderzhahhikh ikh aktivnymi agentami
ES452174A1 (es) Procedimiento de preparacion de 2,9-dioxatriciclo (4,3,1, 03,7) decanos.
HU174882B (hu) Sposob poluchenija proizvodnykh 1,12-metanooksimetano-indolo-kvadratnaja skobka-2,3-a-kvadratnaja skobka zakryta-kinolizina i farmacevticheskikh kompozicijj soderzhahhikh ikh aktivnymi agentami
HU172133B (hu) Sposob poluchenija kondensirovannykh proizvodnykh kinoksalina kak aktivnye immunregulirujuhhie agenty
YU273475A (en) Process for obtaining 10,11-dihydro-3-carboxy-cyproheptadine
HU175697B (hu) Sposob poluchenija proizvodnykh beta-laktama i farmacevticheskikh komozicijj soderzhahhikh ikh aktivnymi agentami
HU175391B (hu) Sposob poluchenija proizvodnykh 4-amino-trans-dekagidrokinolina i farmacevticheskikh kompozicijj soderzhahhikh ikh aktivnymi agentami
HU173382B (hu) Sposob poluchenija zamehhennykh proizvodnykh krotonanilida i gerbicidnye kompozicii soderzhahhie ikh aktivnymi agentami
HU173383B (hu) Sposob poluchenija proizvodnykh karboksamido-tiazola i farmacevticheskikh kompozicijj soderzhahhikh ikh aktivnymi agentami
HU179266B (en) Process for producing phenoxyalkylcarboxylic acid derivatives and pharmaceutical compositions containing them as active agents

Legal Events

Date Code Title Description
HU90 Patent valid on 900628