MY162232A - Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway - Google Patents

Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway

Info

Publication number
MY162232A
MY162232A MYPI2012002026A MYPI2012002026A MY162232A MY 162232 A MY162232 A MY 162232A MY PI2012002026 A MYPI2012002026 A MY PI2012002026A MY PI2012002026 A MYPI2012002026 A MY PI2012002026A MY 162232 A MY162232 A MY 162232A
Authority
MY
Malaysia
Prior art keywords
production
chemical
pharmaceutical products
isoprenoid pathway
microbial engineering
Prior art date
Application number
MYPI2012002026A
Other languages
English (en)
Inventor
Parayil K Ajikumar
Gregory Stephanopoulos
Phon Too Heng
Original Assignee
Massachusetts Inst Technology
Nat Univ Singapore
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology, Nat Univ Singapore filed Critical Massachusetts Inst Technology
Publication of MY162232A publication Critical patent/MY162232A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P15/00—Preparation of compounds containing at least three condensed carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
MYPI2012002026A 2009-11-10 2010-11-10 Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway MY162232A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28087709P 2009-11-10 2009-11-10
US38854310P 2010-09-30 2010-09-30

Publications (1)

Publication Number Publication Date
MY162232A true MY162232A (en) 2017-05-31

Family

ID=43304815

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI2012002026A MY162232A (en) 2009-11-10 2010-11-10 Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway

Country Status (11)

Country Link
US (4) US8512988B2 (pt)
EP (2) EP2499257A1 (pt)
JP (1) JP5844738B2 (pt)
KR (1) KR101834020B1 (pt)
CN (1) CN102812129B (pt)
BR (1) BR112012011073B8 (pt)
CA (1) CA2780415C (pt)
ES (1) ES2575790T3 (pt)
MY (1) MY162232A (pt)
SG (1) SG181422A1 (pt)
WO (1) WO2011060057A1 (pt)

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US8927241B2 (en) * 2009-11-10 2015-01-06 Massachusetts Institute Of Technology Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway
BR112012011073B8 (pt) 2009-11-10 2023-01-10 Massachusetts Inst Technology Método para aumentar a produção de terpenoide em uma célula que produz um ou mais terpenoides
CA2819253A1 (en) 2010-11-30 2012-06-07 Massachusetts Institute Of Technology Microbial production of natural sweeteners, diterpenoid steviol glycosides
EP3339426B1 (en) * 2011-10-07 2022-08-24 Danisco US Inc. Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene
US8889381B2 (en) 2011-11-21 2014-11-18 University Of British Columbia Diterpene synthases and method for producing diterpenoids
WO2013110191A1 (en) 2012-01-23 2013-08-01 The University Of British Columbia Abc trepenoid transporters and methods of using the same
TW201402599A (zh) 2012-05-30 2014-01-16 Suntory Holdings Ltd 甜菊糖苷糖苷轉化酵素及編碼該酵素之基因
EP2880159A1 (en) 2012-07-30 2015-06-10 Allylix, Inc. Sclareol and labdenediol diphosphate synthase polypeptides encoding nucleic acid molecules and uses thereof
CN103773729B (zh) * 2012-10-22 2017-07-11 中国科学院上海生命科学研究院 高效合成萜类化合物的重组大肠杆菌底盘细胞及其制法和应用
AU2013337574B2 (en) 2012-11-01 2018-07-05 The University Of British Columbia Cytochrome P450 and cytochrome P450 reductase polypeptides, encoding nucleic acid molecules and uses thereof
SG10201703671SA (en) * 2012-11-15 2017-08-30 Nat Univ Singapore Univariant extrinsic initiator control system for microbes and an in vitro assembly of large recombinant dna molecules from multiple components
CN105051195B (zh) 2013-02-06 2019-09-06 埃沃尔瓦公司 用于提高莱鲍迪苷d和莱鲍迪苷m之产生的方法
CA2900882A1 (en) 2013-02-11 2014-08-14 Evolva Sa Efficient production of steviol glycosides in recombinants hosts
CN103146729A (zh) * 2013-02-28 2013-06-12 天津大学 生产紫杉二烯的酵母菌及构建方法
US10000749B2 (en) 2013-03-14 2018-06-19 Evolva, Inc. Valencene synthase polypeptides, encoding nucleic acid molecules and uses thereof
CN103404518B (zh) * 2013-05-02 2014-10-29 中国农业大学 一种防除杂草—紫茎泽兰的靶标及其应用
ES2834978T3 (es) 2013-07-04 2021-06-21 Isobionics B V Proceso de fermentación de dos fases para la producción de un isoprenoide
CN103571835B (zh) * 2013-11-22 2016-01-20 武汉大学 一种生产紫杉二烯的系统和微生物及其应用
ES2747844T3 (es) * 2014-01-08 2020-03-11 Fraunhofer Ges Forschung Agrupación de genes para biosíntesis de meleólidos y su aplicación
EP3126492A2 (en) 2014-03-31 2017-02-08 Evolva, Inc. Modified santalene synthase polypeptides, encoding nucleic acid molecules and uses thereof
MX2017001859A (es) 2014-08-11 2017-04-11 Evolva Sa Produccion de glicosidos de esteviol en hospederos recombinantes.
WO2016029187A2 (en) 2014-08-21 2016-02-25 Givaudan Sa Methods for production of oxygenated terpenes
WO2016073740A1 (en) 2014-11-05 2016-05-12 Manus Biosynthesis, Inc. Microbial production of steviol glycosides
CN104694557B (zh) * 2015-02-10 2018-03-09 江苏省海洋水产研究所 一种牻牛儿基牻牛儿基二磷酸合酶基因及其编码蛋白和应用
CA2979931A1 (en) 2015-03-16 2016-09-22 Dsm Ip Assets B.V. Udp-glycosyltransferases
JP2018521636A (ja) 2015-05-29 2018-08-09 カーギル・インコーポレイテッド 多段階供給を用いる、ステビオール配糖体を生成するための発酵方法
JP2018516600A (ja) 2015-05-29 2018-06-28 カーギル・インコーポレイテッド 高いｐＨを使用してステビオールグリコシドを産生するための発酵方法及びそこから得られる組成物
CN107613786A (zh) 2015-05-29 2018-01-19 嘉吉公司 产生糖苷的热处理
BR112018002371A2 (pt) 2015-08-06 2019-09-17 Cargill Inc método para a produção de glicosídeo(s) de esteviol
AU2016307066A1 (en) 2015-08-07 2018-02-08 Evolva Sa Production of steviol glycosides in recombinant hosts
EP3337893B1 (en) 2015-08-21 2023-07-19 Manus Bio Inc. Increasing productivity of e. coli host cells that functionally express p450 enzymes
CN106884041B (zh) * 2015-12-16 2021-03-09 上海交通大学医学院附属第九人民医院 适用于中国人群的17α羟化酶缺乏症常见基因突变的检测方法
CN105400842B (zh) * 2015-12-31 2018-10-12 浙江省林业科学研究院 一种提高内生真菌发酵产物中紫杉醇产量的方法
AU2017251462B2 (en) 2016-04-13 2022-02-03 Evolva Sa Production of steviol glycosides in recombinant hosts
EP3458599A1 (en) 2016-05-16 2019-03-27 Evolva SA Production of steviol glycosides in recombinant hosts
CN107674881A (zh) * 2016-08-02 2018-02-09 武汉臻智生物科技有限公司 紫杉二烯过表达载体及其应用
AU2017350309A1 (en) * 2016-10-27 2019-05-02 Dsm Ip Assets B.V. Geranylgeranyl pyrophosphate synthases
WO2018083338A1 (en) 2016-11-07 2018-05-11 Evolva Sa Production of steviol glycosides in recombinant hosts
CN110869500B (zh) 2017-01-26 2023-10-27 马努斯生物合成股份有限公司 用于萜类化合物产物的微生物生产的代谢工程化
US10662442B2 (en) * 2017-02-03 2020-05-26 Manus Bio Inc. Metabolic engineering for microbial production of terpenoid products
US11365417B2 (en) 2017-09-12 2022-06-21 Bio Capital Holdings, LLC Biological devices and methods of use thereof to produce steviol glycosides
KR20200095534A (ko) 2017-12-07 2020-08-10 지머젠 인코포레이티드 발효에 의한 (6e)-8-히드록시제라니올의 제조를 위해 조작된 생합성 경로
JP2021506316A (ja) 2017-12-21 2021-02-22 ザイマージェン インコーポレイテッド ネペタラクトールオキシドレダクターゼ、ネペタラクトールシンターゼ、及びネペタラクトンを産生する能力がある微生物
US11034980B2 (en) 2018-05-29 2021-06-15 Massachusetts Institute Of Technology Microbial engineering for the production of isoprenoids
US10801049B2 (en) 2018-06-14 2020-10-13 Syntiva Therapeutics, Inc. Genetically engineered microorganisms and processes for the production of cannabinoids from a carbon source precursor
WO2020051488A1 (en) 2018-09-06 2020-03-12 Manus Bio, Inc. Microbial production of rotundone
CN110734927B (zh) * 2019-11-07 2021-08-24 江南大学 一种重组大肠杆菌及其在筛选赤藓糖醇生产菌株中的应用
CN110904148A (zh) * 2019-11-19 2020-03-24 湖北大学 一种合成紫杉二烯的植物表达载体、菌株dzggppsts和盾叶薯蓣及其制备方法
CN111534497B (zh) * 2020-05-26 2022-10-28 中国烟草总公司郑州烟草研究院 Ggpps定向单点突变蛋白ggpps-161
CN111593032B (zh) * 2020-05-26 2022-10-28 中国烟草总公司郑州烟草研究院 酶口袋和酶分子表面的定向五位点突变蛋白ggpps
CN111549010B (zh) * 2020-05-26 2022-10-28 中国烟草总公司郑州烟草研究院 Ggpps定向双位点突变蛋白209-233
CN111748547B (zh) * 2020-07-07 2021-12-03 中国农业科学院深圳农业基因组研究所 紫杉二烯合酶TcTS2、编码核苷酸序列及其应用
KR102600520B1 (ko) * 2021-06-09 2023-11-09 씨제이제일제당 주식회사 제라닐제라닐 피로포스페이트 신타아제 변이체 및 이를 이용한 테트라테르펜, 이의 전구체, 및 테트라테르펜을 전구체로 하는 물질의 생산방법
US11694876B2 (en) 2021-12-08 2023-07-04 Applied Materials, Inc. Apparatus and method for delivering a plurality of waveform signals during plasma processing

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BR112012011073B8 (pt) 2009-11-10 2023-01-10 Massachusetts Inst Technology Método para aumentar a produção de terpenoide em uma célula que produz um ou mais terpenoides
CN105671108A (zh) 2010-06-02 2016-06-15 沃维公司 甜菊糖苷的重组生产
CA2819253A1 (en) * 2010-11-30 2012-06-07 Massachusetts Institute Of Technology Microbial production of natural sweeteners, diterpenoid steviol glycosides

Also Published As

Publication number Publication date
ES2575790T3 (es) 2016-07-01
WO2011060057A1 (en) 2011-05-19
EP2594648B1 (en) 2016-03-16
US9796980B2 (en) 2017-10-24
CA2780415A1 (en) 2011-05-19
US20180080035A1 (en) 2018-03-22
CN102812129A (zh) 2012-12-05
BR112012011073B8 (pt) 2023-01-10
US8512988B2 (en) 2013-08-20
EP2594648A1 (en) 2013-05-22
US20110189717A1 (en) 2011-08-04
US20170002366A1 (en) 2017-01-05
JP2013510573A (ja) 2013-03-28
KR20120101445A (ko) 2012-09-13
US9359624B2 (en) 2016-06-07
BR112012011073B1 (pt) 2022-02-08
KR101834020B1 (ko) 2018-03-02
SG181422A1 (en) 2012-07-30
BR112012011073A2 (pt) 2020-10-06
CN102812129B (zh) 2015-08-26
EP2499257A1 (en) 2012-09-19
US10227597B2 (en) 2019-03-12
JP5844738B2 (ja) 2016-01-20
US20140024089A1 (en) 2014-01-23
CA2780415C (en) 2018-05-01

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