MY155318A - Arylsulfonyl pyrazoline carboxamidine derivatives as 5-ht6 antagonists - Google Patents

Arylsulfonyl pyrazoline carboxamidine derivatives as 5-ht6 antagonists

Info

Publication number
MY155318A
MY155318A MYPI2010004094A MYPI20104094A MY155318A MY 155318 A MY155318 A MY 155318A MY PI2010004094 A MYPI2010004094 A MY PI2010004094A MY PI20104094 A MYPI20104094 A MY PI20104094A MY 155318 A MY155318 A MY 155318A
Authority
MY
Malaysia
Prior art keywords
disorders
compounds
disorder
antagonists
disease
Prior art date
Application number
MYPI2010004094A
Other languages
English (en)
Inventor
Loevezijn Van Arnold
Bakker Wouter I Iwema
Stoit Axel
Agatha A M Rensink
Venhorst Jennifer
Neut Martina A W Van Der
De Haan Martin
Cornelis G Kruse
Original Assignee
Abbvie Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Bv filed Critical Abbvie Bv
Publication of MY155318A publication Critical patent/MY155318A/en

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Nutrition Science (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
MYPI2010004094A 2008-03-18 2009-03-17 Arylsulfonyl pyrazoline carboxamidine derivatives as 5-ht6 antagonists MY155318A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3746308P 2008-03-18 2008-03-18
EP08152873 2008-03-18

Publications (1)

Publication Number Publication Date
MY155318A true MY155318A (en) 2015-09-30

Family

ID=39639064

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI2010004094A MY155318A (en) 2008-03-18 2009-03-17 Arylsulfonyl pyrazoline carboxamidine derivatives as 5-ht6 antagonists

Country Status (29)

Country Link
US (3) US8563723B2 (enExample)
EP (2) EP2265589B1 (enExample)
JP (1) JP5504252B2 (enExample)
KR (1) KR101623357B1 (enExample)
CN (2) CN104003937A (enExample)
AR (1) AR070898A1 (enExample)
AU (1) AU2009226956C1 (enExample)
BR (1) BRPI0908738A8 (enExample)
CA (1) CA2717922A1 (enExample)
CO (1) CO6290679A2 (enExample)
CR (1) CR11742A (enExample)
DK (2) DK2265589T3 (enExample)
DO (2) DOP2010000276A (enExample)
EA (1) EA023176B1 (enExample)
EC (1) ECSP10010476A (enExample)
ES (2) ES2565184T3 (enExample)
HK (1) HK1201823A1 (enExample)
IL (1) IL207846A0 (enExample)
MX (1) MX2010010299A (enExample)
MY (1) MY155318A (enExample)
NZ (1) NZ587743A (enExample)
PH (1) PH12013502376A1 (enExample)
PL (2) PL2265589T3 (enExample)
PT (1) PT2610247T (enExample)
SG (1) SG183688A1 (enExample)
TW (1) TWI557110B (enExample)
UA (1) UA105629C2 (enExample)
WO (1) WO2009115515A1 (enExample)
ZA (1) ZA201006272B (enExample)

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AR079935A1 (es) * 2010-01-29 2012-02-29 Abbott Healthcare Products Bv Sintesis de derivados de pirazolin carboxamidina sustituida
BR112014003382B1 (pt) * 2011-08-15 2022-03-15 University Of Utah Research Foundation Análogos de (e)-n-(1-feniletilideno) benzo-hidrazida substituída como inibidores de histona desmetilase e composições farmacêuticas compreendendo-os
SG11201503556PA (en) * 2012-11-16 2015-06-29 Bristol Myers Squibb Co Dihydropyrazole gpr40 modulators
EP2925726B1 (en) * 2012-11-16 2016-10-26 Bristol-Myers Squibb Company Dihydropyrazole gpr40 modulators
EA026913B1 (ru) * 2012-11-16 2017-05-31 Бристол-Майерс Сквибб Компани Дигидропиразольные модуляторы gpr40
AU2015255765A1 (en) * 2014-05-09 2016-11-24 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Pyrazole derivatives and their use as cannabinoid receptor mediators
EP3180312B1 (en) 2014-08-12 2019-10-16 Loyola University Of Chicago Indoline sulfonamide inhibitors of dape and ndm-1 and use of the same
EP3109237A1 (en) * 2015-06-22 2016-12-28 AnaMar AB Novel 5-ht2 antagonists
CN107460160A (zh) * 2017-08-23 2017-12-12 世贸天阶制药（江苏）有限责任公司 一种cho细胞无血清培养基
US10879709B2 (en) 2018-05-31 2020-12-29 National Taipei University Of Technology Power management system and operating method thereof
TW202128664A (zh) 2019-10-09 2021-08-01 德商拜耳廠股份有限公司 作為除害劑之新穎雜芳基三唑化合物
CA3185968A1 (en) 2020-07-13 2022-01-20 Tony Lahoutte Antibody fragment against folr1
WO2023203135A1 (en) 2022-04-22 2023-10-26 Precirix N.V. Improved radiolabelled antibody
CN119584994A (zh) 2022-05-02 2025-03-07 普雷西里克斯公司 预靶向

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HUP0402113A3 (en) * 2001-09-21 2012-05-29 Solvay Pharm Bv 4,5-dihydro-1h-pyrazole derivatives having cb1-antagonistic activity, preparation and use thereof
GB0422263D0 (en) * 2004-10-07 2004-11-10 Glaxo Group Ltd Novel compounds
SA07280510B1 (ar) * 2006-09-22 2012-02-07 سولفاي فارماسوتيكالز بي . في سلفونيل بيرازول ومشتقات سلفونيل كربوكساميدين كمضادات ht6-5

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PH12013502376B1 (en) 2015-01-12
DK2610247T3 (en) 2016-06-13
DOP2010000277A (es) 2011-01-31
BRPI0908738A8 (pt) 2017-10-10
US20140011775A1 (en) 2014-01-09
EP2610247B1 (en) 2016-05-25
CN102036967A (zh) 2011-04-27
HK1152708A1 (en) 2012-03-09
PH12013502376A1 (en) 2015-01-12
ECSP10010476A (es) 2010-10-30
US8901108B2 (en) 2014-12-02
DOP2010000276A (es) 2010-11-15
CR11742A (es) 2011-03-03
TWI557110B (zh) 2016-11-11
CO6290679A2 (es) 2011-06-20
BRPI0908738A2 (pt) 2017-06-13
US20110046171A1 (en) 2011-02-24
AU2009226956C1 (en) 2014-03-06
WO2009115515A1 (en) 2009-09-24
AU2009226956B2 (en) 2013-05-23
CA2717922A1 (en) 2009-09-24
JP2011517443A (ja) 2011-06-09
EA201071083A1 (ru) 2011-04-29
AU2009226956A1 (en) 2009-09-24
NZ587743A (en) 2012-06-29
US20150051239A1 (en) 2015-02-19
UA105629C2 (uk) 2014-06-10
EA023176B1 (ru) 2016-05-31
KR101623357B1 (ko) 2016-05-23
CN104003937A (zh) 2014-08-27
HK1201823A1 (en) 2015-09-11
PT2610247T (pt) 2016-07-07
PL2265589T3 (pl) 2016-06-30
TW200942519A (en) 2009-10-16
AU2009226956A8 (en) 2010-09-23
CN102036967B (zh) 2014-10-15
AR070898A1 (es) 2010-05-12
ZA201006272B (en) 2011-05-25
US8563723B2 (en) 2013-10-22
ES2577867T3 (es) 2016-07-19
SG183688A1 (en) 2012-09-27
EP2265589B1 (en) 2016-01-27
ES2565184T3 (es) 2016-04-01
US9126942B2 (en) 2015-09-08
MX2010010299A (es) 2010-12-15
KR20100136504A (ko) 2010-12-28
EP2610247A1 (en) 2013-07-03
PL2610247T3 (pl) 2017-02-28
EP2265589A1 (en) 2010-12-29
IL207846A0 (en) 2010-12-30
JP5504252B2 (ja) 2014-05-28
DK2265589T3 (en) 2016-03-21

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