MXPA03008850A - Inhibidores de aldosa reductasa del grupo de las piridazinonas. - Google Patents

Inhibidores de aldosa reductasa del grupo de las piridazinonas.

Info

Publication number
MXPA03008850A
MXPA03008850A MXPA03008850A MXPA03008850A MXPA03008850A MX PA03008850 A MXPA03008850 A MX PA03008850A MX PA03008850 A MXPA03008850 A MX PA03008850A MX PA03008850 A MXPA03008850 A MX PA03008850A MX PA03008850 A MXPA03008850 A MX PA03008850A
Authority
MX
Mexico
Prior art keywords
reductase inhibitors
aldose reductase
pyridazinone aldose
pyridazinone
inhibitors
Prior art date
Application number
MXPA03008850A
Other languages
English (en)
Spanish (es)
Inventor
Banavara Lakshman Mylari
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of MXPA03008850A publication Critical patent/MXPA03008850A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12Antidiuretics, e.g. drugs for diabetes insipidus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
MXPA03008850A 2001-03-30 2002-01-31 Inhibidores de aldosa reductasa del grupo de las piridazinonas. MXPA03008850A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28005101P 2001-03-30 2001-03-30
PCT/IB2002/000320 WO2002079198A1 (en) 2001-03-30 2002-01-31 Pyridazinone aldose reductase inhibitors

Publications (1)

Publication Number Publication Date
MXPA03008850A true MXPA03008850A (es) 2003-12-04

Family

ID=23071435

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03008850A MXPA03008850A (es) 2001-03-30 2002-01-31 Inhibidores de aldosa reductasa del grupo de las piridazinonas.

Country Status (43)

Country Link
US (2) US6579879B2 (cg-RX-API-DMAC7.html)
EP (3) EP1373259B1 (cg-RX-API-DMAC7.html)
JP (1) JP2004528319A (cg-RX-API-DMAC7.html)
KR (1) KR100586138B1 (cg-RX-API-DMAC7.html)
CN (1) CN1215067C (cg-RX-API-DMAC7.html)
AP (1) AP2002002461A0 (cg-RX-API-DMAC7.html)
AR (1) AR035798A1 (cg-RX-API-DMAC7.html)
AT (3) ATE348100T1 (cg-RX-API-DMAC7.html)
AU (1) AU2002226634B2 (cg-RX-API-DMAC7.html)
BG (1) BG108179A (cg-RX-API-DMAC7.html)
BR (1) BR0208571A (cg-RX-API-DMAC7.html)
CA (1) CA2442476A1 (cg-RX-API-DMAC7.html)
CZ (1) CZ20032563A3 (cg-RX-API-DMAC7.html)
DE (3) DE60217930T2 (cg-RX-API-DMAC7.html)
DK (2) DK1491540T3 (cg-RX-API-DMAC7.html)
EA (1) EA006023B1 (cg-RX-API-DMAC7.html)
EC (1) ECSP034671A (cg-RX-API-DMAC7.html)
EE (1) EE200300470A (cg-RX-API-DMAC7.html)
ES (2) ES2274369T3 (cg-RX-API-DMAC7.html)
GE (1) GEP20053675B (cg-RX-API-DMAC7.html)
HR (1) HRP20030752A2 (cg-RX-API-DMAC7.html)
HU (1) HUP0303644A3 (cg-RX-API-DMAC7.html)
IL (1) IL156462A0 (cg-RX-API-DMAC7.html)
IS (3) IS2205B (cg-RX-API-DMAC7.html)
MA (1) MA27003A1 (cg-RX-API-DMAC7.html)
MX (1) MXPA03008850A (cg-RX-API-DMAC7.html)
MY (1) MY134304A (cg-RX-API-DMAC7.html)
NO (1) NO20034345D0 (cg-RX-API-DMAC7.html)
NZ (1) NZ528406A (cg-RX-API-DMAC7.html)
OA (1) OA12453A (cg-RX-API-DMAC7.html)
PA (1) PA8541801A1 (cg-RX-API-DMAC7.html)
PE (1) PE20030007A1 (cg-RX-API-DMAC7.html)
PL (1) PL365294A1 (cg-RX-API-DMAC7.html)
PT (2) PT1491540E (cg-RX-API-DMAC7.html)
SI (1) SI1373259T1 (cg-RX-API-DMAC7.html)
SK (1) SK11852003A3 (cg-RX-API-DMAC7.html)
TN (1) TNSN02037A1 (cg-RX-API-DMAC7.html)
TW (1) TWI245762B (cg-RX-API-DMAC7.html)
UA (1) UA73236C2 (cg-RX-API-DMAC7.html)
UY (1) UY27237A1 (cg-RX-API-DMAC7.html)
WO (1) WO2002079198A1 (cg-RX-API-DMAC7.html)
YU (1) YU71403A (cg-RX-API-DMAC7.html)
ZA (1) ZA200304671B (cg-RX-API-DMAC7.html)

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IL162594A0 (en) * 2002-01-09 2005-11-20 Pfizer Prod Inc Process and intermediates for pyridazinone antidiabetic agents
US20040092522A1 (en) * 2002-08-15 2004-05-13 Field Mark John Synergistic combinations
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US7262318B2 (en) * 2004-03-10 2007-08-28 Pfizer, Inc. Substituted heteroaryl- and phenylsulfamoyl compounds
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US8226977B2 (en) 2004-06-04 2012-07-24 Teva Pharmaceutical Industries Ltd. Pharmaceutical composition containing irbesartan
US20050288340A1 (en) * 2004-06-29 2005-12-29 Pfizer Inc Substituted heteroaryl- and phenylsulfamoyl compounds
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GB0514809D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
EP1973876A2 (en) * 2006-01-13 2008-10-01 Wyeth Sulfonyl substituted 1h-indoles as ligands for the 5-hydroxytryptamine receptors
RS52307B (sr) * 2006-06-27 2012-12-31 Takeda Pharmaceutical Company Limited Kondenzovana ciklična jedinjenja
ATE547394T1 (de) 2006-12-01 2012-03-15 Bristol Myers Squibb Co N-((3-benzyl)-2,2-(bis-phenyl)-propan-1- aminderivate als cetp-hemmer für die behandlung von atherosklerose und herz-kreislauf- erkrankungen
US8173645B2 (en) * 2007-03-21 2012-05-08 Takeda San Diego, Inc. Glucokinase activators
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CA2783699C (en) 2009-12-08 2019-01-15 Case Western Reserve University Primary amine compounds for treating ocular disorders
US8916563B2 (en) 2010-07-16 2014-12-23 The Trustees Of Columbia University In The City Of New York Aldose reductase inhibitors and uses thereof
EP2763673B1 (en) * 2011-09-15 2018-08-01 Taipei Medical University Use of indolyl hydroxamates for treating heart failure or neuronal injury
US9339542B2 (en) * 2013-04-16 2016-05-17 John L Couvaras Hypertension reducing composition
AU2014255381A1 (en) 2013-04-17 2015-10-08 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
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AU2016248080A1 (en) * 2015-04-14 2017-11-02 Board Of Regents Of The University Of Texas System Compositions and methods of modulating short-chain dehydrogenase activity
WO2017168174A1 (en) 2016-04-02 2017-10-05 N4 Pharma Uk Limited New pharmaceutical forms of sildenafil
EP3352754B1 (en) 2016-06-21 2020-09-02 The Trustees of Columbia University in the City of New York Aldose reductase inhibitors and methods of use thereof
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WO2018058109A1 (en) * 2016-09-26 2018-03-29 Nusirt Sciences, Inc. Compositions and methods for treating metabolic disorders
JP7595413B2 (ja) 2016-11-30 2024-12-06 ケース ウエスタン リザーブ ユニバーシティ 15-pgdh阻害剤とコルチコステロイドおよび/またはtnf阻害剤との組み合わせならびにその使用
EP3576737A4 (en) 2017-02-06 2021-04-21 Case Western Reserve University COMPOSITIONS AND METHODS OF MODULATING THE ACTIVITY OF SHORT CHAIN DEHYDROGENASE
IL272246B1 (en) 2017-07-28 2025-09-01 Applied Therapeutics Inc Derivatives of 2-(4-oxo/thioketone/azo-3-((substituted)benzo[d]thiazol-2-yl)methyl)- 3,4-dihydrothieno[3,4-d]pyridazin-1-yl)acetic acid for use as aldose reductase inhibitors in treating galactosemia or preventing complications associated with galactosemia
EP3883577A4 (en) 2018-11-21 2022-06-15 Case Western Reserve University COMPOSITIONS AND METHODS FOR MODULATION OF SHORT CHAIN DEHYDROGENASE ACTIVITY
DK3911648T3 (da) 2019-01-18 2025-01-13 Astrazeneca Ab 6'-[[(1s,3s)-3-[[5-(difluormethoxy)-2-pyrimidinyl]amino]cyclopentyl]amino][1(2h),3'-bipyridin]-2-on som pcsk9-hæmmer og fremgangsmåder til anvendelse deraf
BR112021021939A2 (pt) 2019-05-07 2022-02-22 Ucl Business Ltd Tratamento e detecção de neuropatias herdadas e distúrbios associados
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TW438587B (en) 1995-06-20 2001-06-07 Takeda Chemical Industries Ltd A pharmaceutical composition for prophylaxis and treatment of diabetes
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FR2822827B1 (fr) * 2001-03-28 2003-05-16 Sanofi Synthelabo Nouveaux derives de n-(arylsulfonyl) beta-aminoacides comportant un groupe aminomethyle substitue, leur procede de preparation et les compositions pharmaceutiques en contenant
EE200300470A (et) * 2001-03-30 2004-02-16 Pfizer Products Inc. Aldoosreduktaasi püridasinooninhibiitorid
AU2002236131B2 (en) * 2001-04-30 2005-04-14 Pfizer Products Inc. Combinations of aldose reductase inhibitors and cyclooxygenase-2 inhibitors
IL162594A0 (en) * 2002-01-09 2005-11-20 Pfizer Prod Inc Process and intermediates for pyridazinone antidiabetic agents

Also Published As

Publication number Publication date
IS8251A (is) 2006-01-23
CN1215067C (zh) 2005-08-17
EA200300673A1 (ru) 2003-12-25
DE60217930T2 (de) 2007-10-18
ATE348100T1 (de) 2007-01-15
IS2205B (is) 2007-02-15
ATE352551T1 (de) 2007-02-15
HRP20030752A2 (en) 2005-06-30
HUP0303644A2 (hu) 2004-03-01
DE60217930D1 (de) 2007-03-15
UA73236C2 (en) 2005-06-15
DK1491540T3 (da) 2007-03-26
DE60202452D1 (de) 2005-02-03
TWI245762B (en) 2005-12-21
DK1373259T3 (da) 2005-03-29
EE200300470A (et) 2004-02-16
DE60202452C5 (de) 2006-11-23
DE60202452T2 (de) 2006-02-09
HUP0303644A3 (en) 2008-06-30
JP2004528319A (ja) 2004-09-16
AP2002002461A0 (en) 2002-06-30
NO20034345L (no) 2003-09-29
US6579879B2 (en) 2003-06-17
US20020143017A1 (en) 2002-10-03
IS8250A (is) 2006-01-23
YU71403A (sh) 2006-05-25
KR100586138B1 (ko) 2006-06-07
AR035798A1 (es) 2004-07-14
US6849629B2 (en) 2005-02-01
US20030162784A1 (en) 2003-08-28
PT1491540E (pt) 2007-01-31
MA27003A1 (fr) 2004-12-20
DE60216823T2 (de) 2007-10-04
EP1373259A1 (en) 2004-01-02
PE20030007A1 (es) 2003-01-28
MY134304A (en) 2007-12-31
IL156462A0 (en) 2004-01-04
OA12453A (en) 2006-05-24
GEP20053675B (en) 2005-11-25
CA2442476A1 (en) 2002-10-10
EP1491541A1 (en) 2004-12-29
HK1061678A1 (en) 2004-09-30
AU2002226634B2 (en) 2007-01-25
PT1373259E (pt) 2005-03-31
SI1373259T1 (en) 2005-04-30
PA8541801A1 (es) 2002-10-28
WO2002079198A1 (en) 2002-10-10
EA006023B1 (ru) 2005-08-25
BR0208571A (pt) 2004-03-23
DE60216823D1 (de) 2007-01-25
CN1500087A (zh) 2004-05-26
NO20034345D0 (no) 2003-09-29
NZ528406A (en) 2004-03-26
IS6845A (is) 2003-06-16
EP1373259B1 (en) 2004-12-29
ATE286049T1 (de) 2005-01-15
KR20030088484A (ko) 2003-11-19
CZ20032563A3 (cs) 2004-05-12
EP1491540A1 (en) 2004-12-29
BG108179A (en) 2004-09-30
ZA200304671B (en) 2004-06-25
ES2274369T3 (es) 2007-05-16
EP1491540B1 (en) 2006-12-13
UY27237A1 (es) 2002-12-31
TNSN02037A1 (fr) 2005-12-23
ES2231681T3 (es) 2005-05-16
EP1491541B1 (en) 2007-01-24
PL365294A1 (en) 2004-12-27
SK11852003A3 (sk) 2004-07-07
ECSP034671A (es) 2003-08-29

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