MXPA03007853A - Metodo para la sintesis de 2',3'-didesoxi-2',3'-dideshidronucleosidos. - Google Patents
Metodo para la sintesis de 2',3'-didesoxi-2',3'-dideshidronucleosidos.Info
- Publication number
- MXPA03007853A MXPA03007853A MXPA03007853A MXPA03007853A MXPA03007853A MX PA03007853 A MXPA03007853 A MX PA03007853A MX PA03007853 A MXPA03007853 A MX PA03007853A MX PA03007853 A MXPA03007853 A MX PA03007853A MX PA03007853 A MXPA03007853 A MX PA03007853A
- Authority
- MX
- Mexico
- Prior art keywords
- dideoxy
- halonucleoside
- haloacylation
- bgr
- didehydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invencion es una ruta de sintesis eficiente para 2',3'-didesoxi-2',3'- dideshidro-nucleosidos a partir de precursores disponibles con la opcion de introducir grupos funcionales segun se necesite, tales como los analogos 2',3'-didesoxi y 2'- o 3'- desoxirribonucleosido asi como los derivados adicionales obtenidos por manipulaciones subsiguientes de grupo funcional. En breve, la presente invencion describe un metodo para preparar '-D- y '-L-2',3'-didesoxi-2',3'-dideshideshidro-nucleosidos partiendo de los ribonucleosidos sustituidos apropiadamente en dos, opcionalmente en tres pasos: Paso (1) una halogenoacilacion, tal como halogenoacetilacion, y en particular, bromoacetilacion; Paso (2) una eliminacion reductiva; y opcionalmente, Paso (3) una desproteccion. La halogenoacilacion del paso (1) puede formar el 2'-acil-3'-halogenonucleosido, el 3'-acil-2'-halogenonucleosido, o una mezcla de los mismos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27244101P | 2001-03-01 | 2001-03-01 | |
US27243401P | 2001-03-01 | 2001-03-01 | |
PCT/US2002/006460 WO2002070533A2 (en) | 2001-03-01 | 2002-03-01 | Method for the synthesis of 2',3'-dideoxy-2',3'-didehydronucleosides |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA03007853A true MXPA03007853A (es) | 2004-05-24 |
Family
ID=26955519
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA03007853A MXPA03007853A (es) | 2001-03-01 | 2002-03-01 | Metodo para la sintesis de 2',3'-didesoxi-2',3'-dideshidronucleosidos. |
Country Status (13)
Country | Link |
---|---|
US (2) | US6927291B2 (es) |
EP (1) | EP1363927A2 (es) |
JP (1) | JP2004527504A (es) |
KR (1) | KR20030092006A (es) |
CN (1) | CN1505635A (es) |
AU (1) | AU2002255654B2 (es) |
BR (1) | BR0207746A (es) |
CA (1) | CA2439836A1 (es) |
IL (1) | IL157478A0 (es) |
MX (1) | MXPA03007853A (es) |
NZ (1) | NZ540956A (es) |
RU (1) | RU2003129164A (es) |
WO (1) | WO2002070533A2 (es) |
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MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
NZ547204A (en) | 2000-05-26 | 2008-01-31 | Idenix Cayman Ltd | Methods and compositions for treating flaviviruses and pestiviruses |
US7608600B2 (en) | 2002-06-28 | 2009-10-27 | Idenix Pharmaceuticals, Inc. | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
EP1536804A4 (en) * | 2002-06-28 | 2007-10-31 | Idenix Cayman Ltd | 2'-C-METHYL-3'-O-L-VALINESTER-RIBOFURANOSYLCYTIDINE FOR THE TREATMENT OF FLAVIVIRIDAE INFECTIONS |
BR0313164A (pt) | 2002-08-01 | 2007-07-17 | Pharmasset Inc | compostos com o sistema biciclo[4.2.1] nonano para o tratamento de infecções por flaviviridae |
HUE033832T2 (en) | 2002-11-15 | 2018-01-29 | Idenix Pharmaceuticals Llc | 2'-methyl nucleosides in combination with interferon and Flaviviridae mutation |
ES2586668T3 (es) | 2003-05-30 | 2016-10-18 | Gilead Pharmasset Llc | Análogos de nucleósidos fluorados modificados |
WO2007075876A2 (en) | 2005-12-23 | 2007-07-05 | Idenix Pharmaceuticals, Inc. | Process for preparing a synthetic intermediate for preparation of branched nucleosides |
CA2636007A1 (en) * | 2006-01-13 | 2007-07-26 | Wyeth | Sulfonyl substituted 1h-indoles as ligands for the 5-hydroxytryptamine receptors |
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US20140249105A1 (en) * | 2011-07-25 | 2014-09-04 | Diverchim | Novel ceramide analogues, processes for preparing same and uses thereof |
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-
2002
- 2002-03-01 US US10/087,112 patent/US6927291B2/en not_active Expired - Lifetime
- 2002-03-01 MX MXPA03007853A patent/MXPA03007853A/es not_active Application Discontinuation
- 2002-03-01 EP EP02725067A patent/EP1363927A2/en not_active Withdrawn
- 2002-03-01 CA CA002439836A patent/CA2439836A1/en not_active Abandoned
- 2002-03-01 NZ NZ540956A patent/NZ540956A/en unknown
- 2002-03-01 JP JP2002569852A patent/JP2004527504A/ja active Pending
- 2002-03-01 CN CNA028089146A patent/CN1505635A/zh active Pending
- 2002-03-01 KR KR10-2003-7011287A patent/KR20030092006A/ko not_active Application Discontinuation
- 2002-03-01 IL IL15747802A patent/IL157478A0/xx unknown
- 2002-03-01 WO PCT/US2002/006460 patent/WO2002070533A2/en active Application Filing
- 2002-03-01 RU RU2003129164/04A patent/RU2003129164A/ru not_active Application Discontinuation
- 2002-03-01 BR BR0207746-9A patent/BR0207746A/pt not_active IP Right Cessation
- 2002-03-01 AU AU2002255654A patent/AU2002255654B2/en not_active Ceased
-
2005
- 2005-07-18 US US11/182,862 patent/US20050250946A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20020198224A1 (en) | 2002-12-26 |
US6927291B2 (en) | 2005-08-09 |
RU2003129164A (ru) | 2005-03-20 |
IL157478A0 (en) | 2004-03-28 |
US20050250946A1 (en) | 2005-11-10 |
WO2002070533A3 (en) | 2002-12-19 |
AU2002255654B2 (en) | 2008-05-15 |
WO2002070533A2 (en) | 2002-09-12 |
CN1505635A (zh) | 2004-06-16 |
NZ540956A (en) | 2007-01-26 |
EP1363927A2 (en) | 2003-11-26 |
BR0207746A (pt) | 2004-06-29 |
KR20030092006A (ko) | 2003-12-03 |
JP2004527504A (ja) | 2004-09-09 |
CA2439836A1 (en) | 2002-09-12 |
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