MXPA02012398A - Proceso para la preparacion de derivados de quinolina. - Google Patents

Proceso para la preparacion de derivados de quinolina.

Info

Publication number
MXPA02012398A
MXPA02012398A MXPA02012398A MXPA02012398A MXPA02012398A MX PA02012398 A MXPA02012398 A MX PA02012398A MX PA02012398 A MXPA02012398 A MX PA02012398A MX PA02012398 A MXPA02012398 A MX PA02012398A MX PA02012398 A MXPA02012398 A MX PA02012398A
Authority
MX
Mexico
Prior art keywords
formula
compound
amount
reacted
hydrogen
Prior art date
Application number
MXPA02012398A
Other languages
English (en)
Inventor
Karl Scheuzger
Original Assignee
Syngenta Participations Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syngenta Participations Ag filed Critical Syngenta Participations Ag
Publication of MXPA02012398A publication Critical patent/MXPA02012398A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C07D215/28—Alcohols; Ethers thereof with halogen atoms or nitro radicals in positions 5, 6 or 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Los compuestos de la formula I (Ver formula I) en donde R1 es hidrogeno o cloro y R2 es hidrogeno, alquilo de 1 a 8 atomos de carbono, o alquilo de 1 a 8 atomos de carbono sustituido con alcoxi de 1 a 6 atomos de carbono o con alqueniloxi de 3 a 6 atomos de carbono, pueden ser preparados mediante: a) la introduccion de la porcion mayor de la cantidad que va a hacerse reaccionar de un compuesto de la formula II (Ver formula II) en una mezcla de solventes que comprende al menos un solvente organico capaz de formar un azeotropo con agua, y al menos un solvente aprotico-dipolar; b) la dosificacion en una base fuerte acuosa, en una cantidad equivalente a aquella porcion mayor de la cantidad total del compuesto de la formula II; c) la adicion de la porcion remanente de la cantidad que se va a hacer reaccionar, del compuesto de la formula II; d) la adicion de una base debil en una cantidad que es al menos equivalente a aquella porcion remanente; e) el retiro del agua de la mezcla de reaccion mediante destilacion azeotropica; f) la adicion de un compuesto de la formula III (Ver formula) en donde R2 es como se define para la formula I; y g) el aislamiento del compuesto resultante de la formula I a partir de la mezcla de reaccion.
MXPA02012398A 2000-06-28 2001-06-26 Proceso para la preparacion de derivados de quinolina. MXPA02012398A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH12742000 2000-06-28
PCT/EP2001/007258 WO2002000625A2 (en) 2000-06-28 2001-06-26 Process for the preparation of quinoline derivatives

Publications (1)

Publication Number Publication Date
MXPA02012398A true MXPA02012398A (es) 2003-04-25

Family

ID=4565202

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02012398A MXPA02012398A (es) 2000-06-28 2001-06-26 Proceso para la preparacion de derivados de quinolina.

Country Status (23)

Country Link
US (1) US6660865B2 (es)
EP (1) EP1294694B1 (es)
JP (1) JP3955814B2 (es)
KR (1) KR100572818B1 (es)
CN (1) CN1256327C (es)
AR (1) AR029283A1 (es)
AT (1) ATE280760T1 (es)
AU (1) AU780534B2 (es)
BR (2) BR0112064B1 (es)
CA (1) CA2412543C (es)
DE (1) DE60106760T2 (es)
DK (1) DK1294694T3 (es)
ES (1) ES2228923T3 (es)
HU (1) HU230214B1 (es)
IL (2) IL153424A0 (es)
MX (1) MXPA02012398A (es)
PL (1) PL200447B1 (es)
PT (1) PT1294694E (es)
RU (1) RU2263110C2 (es)
TW (1) TWI230154B (es)
UA (1) UA73587C2 (es)
WO (1) WO2002000625A2 (es)
ZA (1) ZA200300328B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2350012B1 (en) * 2008-10-06 2017-06-28 The Johns Hopkins University Quinoline compounds as inhibitors of angiogenesis, human methionine aminopeptidase, and sirt1, and methods of treating disorders
CN101805288A (zh) * 2010-04-21 2010-08-18 新沂市永诚化工有限公司 一种合成解毒喹的新方法
GB201119690D0 (en) * 2011-11-14 2011-12-28 Syngenta Participations Ag Process for the preparation of compounds
CN102718706B (zh) * 2012-05-31 2014-05-07 绍兴文理学院 一种2-(5-氯-8-喹啉氧基)乙酸的制备方法
CN103524411B (zh) * 2013-10-21 2015-03-04 哈尔滨理工大学 一种5-氯-8-喹啉氧基乙酸的合成方法
CN105001158B (zh) * 2015-07-09 2018-02-02 北京颖泰嘉和生物科技股份有限公司 一种合成解草酯的方法
CN113135851A (zh) * 2021-04-26 2021-07-20 甘肃联凯生物科技有限公司 一种解毒喹的合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0094349B1 (de) * 1982-05-07 1994-04-06 Ciba-Geigy Ag Verwendung von Chinolinderivaten zum Schützen von Kulturpflanzen
EP0492366B1 (de) * 1990-12-21 1997-03-26 Hoechst Schering AgrEvo GmbH Neue 5-Chlorchinolin-8-oxyalkancarbonsäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Antidots von Herbiziden

Also Published As

Publication number Publication date
IL153424A0 (en) 2003-07-06
CN1568314A (zh) 2005-01-19
US6660865B2 (en) 2003-12-09
DE60106760T2 (de) 2005-11-03
WO2002000625A3 (en) 2002-07-18
PL363224A1 (en) 2004-11-15
AU780534B2 (en) 2005-03-24
PL200447B1 (pl) 2009-01-30
ATE280760T1 (de) 2004-11-15
EP1294694A2 (en) 2003-03-26
US20030181724A1 (en) 2003-09-25
WO2002000625A2 (en) 2002-01-03
KR100572818B1 (ko) 2006-04-25
HUP0300703A3 (en) 2005-01-28
EP1294694B1 (en) 2004-10-27
BRPI0112064B8 (pt) 2018-08-14
HU230214B1 (hu) 2015-10-28
HUP0300703A2 (hu) 2003-07-28
ZA200300328B (en) 2004-03-31
BR0112064A (pt) 2003-05-13
IL153424A (en) 2007-08-19
JP3955814B2 (ja) 2007-08-08
AR029283A1 (es) 2003-06-18
TWI230154B (en) 2005-04-01
PT1294694E (pt) 2005-02-28
CA2412543C (en) 2010-05-25
CN1256327C (zh) 2006-05-17
RU2263110C2 (ru) 2005-10-27
DE60106760D1 (de) 2004-12-02
ES2228923T3 (es) 2005-04-16
JP2004501898A (ja) 2004-01-22
DK1294694T3 (da) 2004-12-27
UA73587C2 (en) 2005-08-15
BR0112064B1 (pt) 2012-12-25
AU7968901A (en) 2002-01-08
KR20030036245A (ko) 2003-05-09
CA2412543A1 (en) 2002-01-03

Similar Documents

Publication Publication Date Title
WO2004103977A3 (en) Process for the preparation of pyrimidine derivatives
BRPI0408160A (pt) processo para o preparo de ésteres do ácido nicotìnico substituìdo
BRPI0406500A (pt) processo farmacêutico e compostos preparados pelo mesmo
MXPA02012398A (es) Proceso para la preparacion de derivados de quinolina.
HUP0102657A2 (hu) Eljárás orto-alkilezett benzoesav-származékok, mint intermedierek és hatóanyagok előállítására
TW200619201A (en) Process for the preparation of pyrazoles
EP1036793A3 (en) A process for preparing 2-alkyl-3-aminothiophene derivative and 3-aminothiophene derivative
JO2433B1 (en) Preparation of heterocyclic lindane landscapes
GEP20033119B (en) Novel Octahydro-6, 10-Dioxo-6H-Pyridazino {1,2-a}{1 Carboxylic Acid Derivatives, Method for Preparation and Use Thereof
HU902079D0 (en) Process for producing glutaric acid derivatives and pharmaceutical preparatives containing such compounds
JPS5659727A (en) Preparation of substituted phenol
EP1359145A4 (en) PROCESS FOR THE PREPARATION OF BENZYLPIPERIDINE COMPOUNDS
DE60239793D1 (de) Verfahren zur herstellung von 7-chinolinyl-3,5-dihydroxyhept-6-enoat
WO2005023793A3 (en) Direct synthesis of di-heteroatom containing cyclic organic compounds
JPS6479138A (en) 1-biphenylylethanol derivative and production thereof
DE50105269D1 (de) Verfahren zur herstellung von formylphenylboronsäuren
JPS56158776A (en) 3-cyano-8-hydroxycoumarin and its preparation
JPS5668668A (en) Preparation of 2-indolinones
JPS55127366A (en) Preparation of 4-(3-isopropylamino-2-hydroxypropoxy)-indole
JPS54125678A (en) Preparation of 4-hydroxy-6-methylnicotinic acid
JPS5640685A (en) Preparation of theobromine derivative
MXPA03000917A (es) Procedimiento para la preparacion de 9,10-dihidropirrolo (2,1-b)(1,3)benzotiazepinas sustituidas con 9-amino.
JPS5762270A (en) Preparation of 2-hydroxyquinoxaline derivative
JPS55102581A (en) Preparation of 4-piperidone spiroketal compound

Legal Events

Date Code Title Description
FG Grant or registration