MX9800622A - Agentes terapeuticos mejorados. - Google Patents

Agentes terapeuticos mejorados.

Info

Publication number
MX9800622A
MX9800622A MX9800622A MX9800622A MX9800622A MX 9800622 A MX9800622 A MX 9800622A MX 9800622 A MX9800622 A MX 9800622A MX 9800622 A MX9800622 A MX 9800622A MX 9800622 A MX9800622 A MX 9800622A
Authority
MX
Mexico
Prior art keywords
hydrogen
oleoyl
stearoyl
therapeutic agents
improved therapeutic
Prior art date
Application number
MX9800622A
Other languages
English (en)
Inventor
Finn Myhren
Bernt Borretzen
Are Dalen
Kjell Torgeir Sotkke
Original Assignee
Norsk Hydro As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Norsk Hydro As filed Critical Norsk Hydro As
Publication of MX9800622A publication Critical patent/MX9800622A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/056—Triazole or tetrazole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Abstract

Esta invencion se relaciona con derivados de nucleosidos nuevos de formula (I): en donde R1 y R2 se seleccionan independientemente de hidrogeno, elaidoilo, oleoilo, estearoilo, eicosenoilo (cis o trans) y eicosanoilo, con las condiciones de que R1 y R2 no pueden ser, ambos, hidrogeno, oleoilo o estearoilo, R1 no puede ser hidrogeno cuando R2 es oleoilo o esteraroilo, y R2 no puede ser hidrogeno cuando R1 es elaidoilo, oleoilo o estearoilo. Además, la invencion se relaciona con el uso de los derivados de nucleosidos de formula (I) en los que R1 y R2 se seleccionan independientemente de hidrogeno, y grupos asilo saturados y monoinsaturados de C18 y C20, con las condiciones de que R1 y R2 no pueden ser ambos hidrogeno, en la fabricacion de una preparacion farmacéutica para el tratamiento de tumores.
MX9800622A 1995-07-25 1998-01-21 Agentes terapeuticos mejorados. MX9800622A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9515279.9A GB9515279D0 (en) 1995-07-25 1995-07-25 Improved therapeutic agents

Publications (1)

Publication Number Publication Date
MX9800622A true MX9800622A (es) 1998-11-30

Family

ID=10778247

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9800622A MX9800622A (es) 1995-07-25 1998-01-21 Agentes terapeuticos mejorados.

Country Status (25)

Country Link
US (2) US6316425B1 (es)
EP (1) EP0842185B1 (es)
JP (2) JP4372227B2 (es)
KR (1) KR100401909B1 (es)
AT (1) ATE207076T1 (es)
AU (1) AU714814B2 (es)
CA (1) CA2227533C (es)
CZ (1) CZ291612B6 (es)
DE (1) DE69616074T2 (es)
DK (1) DK0842185T3 (es)
ES (1) ES2166900T3 (es)
GB (1) GB9515279D0 (es)
HU (1) HU224839B1 (es)
IL (2) IL122942A0 (es)
MX (1) MX9800622A (es)
NO (1) NO313985B1 (es)
NZ (1) NZ313790A (es)
PL (1) PL183601B1 (es)
PT (1) PT842185E (es)
RU (1) RU2165260C2 (es)
SK (1) SK283003B6 (es)
TW (1) TW434251B (es)
UA (1) UA55389C2 (es)
WO (1) WO1997005154A1 (es)
ZA (1) ZA966047B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458772B1 (en) 1909-10-07 2002-10-01 Medivir Ab Prodrugs
CA2271135A1 (en) * 1996-11-12 1998-05-22 Medivir Ab Nucleosides
JP4352115B2 (ja) * 1997-01-24 2009-10-28 クラヴィス・ファルマ・アーエスアー ゲムシタビン誘導体
US7393862B2 (en) 2002-05-17 2008-07-01 Celgene Corporation Method using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias
KR20060092242A (ko) * 2003-11-03 2006-08-22 코그니스 아이피 매니지먼트 게엠베하 아실 리보뉴클레오시드 및 아실 데옥시리보뉴클레오시드
NO324263B1 (no) * 2005-12-08 2007-09-17 Clavis Pharma Asa Kjemiske forbindelser, anvendelse derav ved behandling av kreft, samt farmasoytiske preparater som omfatter slike forbindelser
US8497292B2 (en) * 2005-12-28 2013-07-30 Translational Therapeutics, Inc. Translational dysfunction based therapeutics
KR20100072230A (ko) * 2007-09-26 2010-06-30 마운트 시나이 스쿨 오브 메디신 오브 뉴욕 유니버시티 아자시티딘 유사체 및 이의 용도
GB0808357D0 (en) * 2008-05-08 2008-06-18 Cyclacel Ltd Process
AU2010322516A1 (en) * 2009-11-20 2012-05-17 Clavis Pharma Asa Parenteral formulations of gemcitabine derivatives
CN103108625A (zh) 2010-07-13 2013-05-15 克拉维斯制药股份有限公司 艾西拉滨衍生物的肠胃外制剂
TWI637963B (zh) * 2012-03-28 2018-10-11 富士軟片股份有限公司 １－（２－脫氧－２－氟－４－硫－β－Ｄ－阿拉伯呋喃糖基）胞嘧啶之鹽
EP3740287A4 (en) 2018-01-15 2021-11-03 Yinuoke Medicine Science And Technology Company Ltd. TREATMENTS FOR CACHEXIA

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3894000A (en) * 1971-01-27 1975-07-08 Upjohn Co Ara-cytidine derivatives and process of preparation
CA2079413C (en) 1991-09-30 2003-09-09 Masakatsu Kaneko Pyrimidine nucleoside derivatives having anti-tumor activity, their preparation and use
GB9307043D0 (en) * 1993-04-05 1993-05-26 Norsk Hydro As Chemical compounds
US5641758A (en) 1993-11-10 1997-06-24 Kluge; Michael Cytarabine derivatives, the preparation and use thereof

Also Published As

Publication number Publication date
US6316425B1 (en) 2001-11-13
CZ291612B6 (cs) 2003-04-16
PL183601B1 (pl) 2002-06-28
PL324690A1 (en) 1998-06-08
RU2165260C2 (ru) 2001-04-20
IL122942A (en) 2006-12-10
NO980296D0 (no) 1998-01-23
GB9515279D0 (en) 1995-09-20
ES2166900T3 (es) 2002-05-01
WO1997005154A1 (en) 1997-02-13
PT842185E (pt) 2002-04-29
AU714814B2 (en) 2000-01-13
EP0842185B1 (en) 2001-10-17
JP2002504068A (ja) 2002-02-05
US6335322B1 (en) 2002-01-01
KR19990035804A (ko) 1999-05-25
AU6633596A (en) 1997-02-26
SK283003B6 (sk) 2003-01-09
JP5087052B2 (ja) 2012-11-28
DE69616074T2 (de) 2002-06-06
DK0842185T3 (da) 2002-02-04
ZA966047B (en) 1997-02-04
CA2227533C (en) 2007-01-09
EP0842185A1 (en) 1998-05-20
DE69616074D1 (de) 2001-11-22
NZ313790A (en) 1999-07-29
JP4372227B2 (ja) 2009-11-25
NO980296L (no) 1998-01-23
TW434251B (en) 2001-05-16
UA55389C2 (uk) 2003-04-15
JP2009215326A (ja) 2009-09-24
NO313985B1 (no) 2003-01-13
HUP9900924A3 (en) 2001-06-28
HU224839B1 (en) 2006-03-28
IL122942A0 (en) 1999-05-09
CZ16398A3 (cs) 1998-06-17
ATE207076T1 (de) 2001-11-15
CA2227533A1 (en) 1997-02-13
KR100401909B1 (ko) 2004-02-14
HUP9900924A2 (hu) 2001-05-28
SK8098A3 (en) 1998-07-08

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Legal Events

Date Code Title Description
FG Grant or registration
PD Change of proprietorship

Owner name: CONPHARMA AS

MM Annulment or lapse due to non-payment of fees