MX9707430A - Complejos radiofarmaceuticos ternarios. - Google Patents

Complejos radiofarmaceuticos ternarios.

Info

Publication number
MX9707430A
MX9707430A MX9707430A MX9707430A MX9707430A MX 9707430 A MX9707430 A MX 9707430A MX 9707430 A MX9707430 A MX 9707430A MX 9707430 A MX9707430 A MX 9707430A MX 9707430 A MX9707430 A MX 9707430A
Authority
MX
Mexico
Prior art keywords
radiopharmaceuticals
ternary
radiopharmaceutical complexes
loci
phosphine
Prior art date
Application number
MX9707430A
Other languages
English (en)
Inventor
David Scott Edwards
Shuang Liu
Original Assignee
Du Pont Pharm Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Pharm Co filed Critical Du Pont Pharm Co
Publication of MX9707430A publication Critical patent/MX9707430A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0476—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from monodendate ligands, e.g. sestamibi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/004—Acyclic, carbocyclic or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/008—Peptides; Proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invencion proporciona complejos radiofarmacéuticos nuevos, los cuales son utiles como agentes para formacion de imágenes, para el diagnostico de transtornos cardiovasculares, enfermedades infecciosas y cáncer. Los complejos radiofarmacéuticos comprenden moléculas biologicamente activas modificadas con hidrazino o diazino, marcadas con tecnecio-99m y ligadas a fosfina y arsina, que se localizan selectivamente en sitios de enfermedad, así permiten que se obtenga una imagen del sitio escintigrafía gamma. Esta invencion también proporciona métodos para usar los complejos radiofarmacéuticos, y estuches que comprenden los precursores de los complejos radiofarmacéuticos. Los complejos radiofarmaceuticos de esta invencion tienen la estructura: [(Q)d'Ln-Ch']x-Mt(Al1) y (Al2)z; en donde las variables son como se definen en la presente.
MX9707430A 1995-04-03 1996-04-03 Complejos radiofarmaceuticos ternarios. MX9707430A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/415,908 US5744120A (en) 1993-03-30 1995-04-03 Ternary radiopharmaceutical complexes
PCT/US1996/004567 WO1996031243A1 (en) 1995-04-03 1996-04-03 Ternary radiopharmaceutical complexes

Publications (1)

Publication Number Publication Date
MX9707430A true MX9707430A (es) 1997-12-31

Family

ID=23647726

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9707430A MX9707430A (es) 1995-04-03 1996-04-03 Complejos radiofarmaceuticos ternarios.

Country Status (32)

Country Link
US (2) US5744120A (es)
EP (2) EP1195168A3 (es)
JP (1) JPH11503166A (es)
KR (1) KR100417558B1 (es)
CN (1) CN1080127C (es)
AR (1) AR006077A1 (es)
AT (1) ATE220335T1 (es)
AU (1) AU719529B2 (es)
BR (1) BR9608065A (es)
CA (1) CA2216423C (es)
CZ (1) CZ291658B6 (es)
DE (1) DE69622267T2 (es)
DK (1) DK0820312T3 (es)
EA (1) EA000636B1 (es)
EE (1) EE9700250A (es)
ES (1) ES2179196T3 (es)
HR (1) HRP960148A2 (es)
HU (1) HU225674B1 (es)
IL (1) IL117642A (es)
LT (1) LT4391B (es)
LV (1) LV12039B (es)
MX (1) MX9707430A (es)
NO (1) NO317177B1 (es)
NZ (2) NZ308284A (es)
PL (1) PL185325B1 (es)
PT (1) PT820312E (es)
SI (1) SI9620044B (es)
SK (1) SK283276B6 (es)
TW (1) TW503110B (es)
UA (1) UA56127C2 (es)
WO (1) WO1996031243A1 (es)
ZA (1) ZA962672B (es)

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US5855867A (en) * 1995-03-29 1999-01-05 The Curators Of The University Of Missouri Hydroxymethyl phosphine compounds for use as diagnostic and therapeutic pharmaceuticals and method of making same
US5739313A (en) 1995-11-13 1998-04-14 Regents Of The University Of Minnesota Radionuclide labeling of vitamin B12 and coenzymes thereof
JP2000507233A (ja) * 1996-03-13 2000-06-13 デュポン ファーマシューティカルズ カンパニー 新規の三元複合体放射性薬剤
US6416733B1 (en) * 1996-10-07 2002-07-09 Bristol-Myers Squibb Pharma Company Radiopharmaceuticals for imaging infection and inflammation
US20030124053A1 (en) * 1996-10-07 2003-07-03 Barrett John Andrew Radiopharmaceuticals for imaging infection and inflammation
US6403054B1 (en) * 1997-05-28 2002-06-11 Bristol-Myers Squibb Pharma Company Ternary ligand complexes useful as radiopharmaceuticals
WO1999012579A1 (en) * 1997-09-08 1999-03-18 The General Hospital Corporation Imaging agents for early detection and monitoring of cardiovascular plaque
US7060251B1 (en) * 1997-09-08 2006-06-13 The General Hospital Corporation Imaging agents for early detection and monitoring of cardiovascular plaque
US6548663B1 (en) 1998-03-31 2003-04-15 Bristol-Myers Squibb Pharma Company Benzodiazepine vitronectin receptor antagonist pharmaceuticals
US6524553B2 (en) 1998-03-31 2003-02-25 Bristol-Myers Squibb Pharma Company Quinolone vitronectin receptor antagonist pharmaceuticals
US6537520B1 (en) 1998-03-31 2003-03-25 Bristol-Myers Squibb Pharma Company Pharmaceuticals for the imaging of angiogenic disorders
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CA2326978A1 (en) * 1998-04-03 1999-10-14 Milind Rajopadhye Radiopharmaceuticals for imaging infection and inflammation and for imaging and treatment of cancer
AU2371400A (en) * 1998-12-18 2000-07-03 Du Pont Pharmaceuticals Company Vitronectin receptor antagonist pharmaceuticals
US6569402B1 (en) 1998-12-18 2003-05-27 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
CA2727746A1 (en) 1998-12-18 2000-06-22 Bristol-Myers Squibb Pharma Company Quinolone vitronectin receptor antagonist pharmaceuticals
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US6844425B1 (en) * 1999-02-24 2005-01-18 Mallinckrodt Inc. Combination of intercalating organometallic complexes and tumor seeking biomolecules for DNA cleavage and radiotherapy
US6808698B1 (en) 1999-03-26 2004-10-26 Bristol-Myers Squibb Pharma Company Method for localization of blood clots
WO2000057787A2 (en) * 1999-03-26 2000-10-05 Du Pont Pharmaceuticals Company Method for localization of blood clots
US6806363B1 (en) 1999-04-16 2004-10-19 Mayo Foundation For Medical Education & Research Cobalamin conjugates useful as antitumor agents
EP1239887A1 (en) 1999-10-15 2002-09-18 Mayo Foundation For Medical Education And Research Cobalamin conjugates useful as imaging and therapeutic agents
US7591995B2 (en) 1999-10-15 2009-09-22 Mayo Foundation For Medical Education And Research Cobalamin conjugates useful as imaging and therapeutic agents
US6534038B2 (en) 2000-04-07 2003-03-18 Bristol-Myers Squibb Pharma Company Ternary ligand complexes useful as radiopharmaceuticals
WO2001087354A2 (en) * 2000-05-17 2001-11-22 Bristol-Myers Squibb Pharma Company Use of small molecule radioligands for diagnostic imaging
BR0106717A (pt) 2000-06-01 2002-04-16 Bristol Myers Squibb Pharma Co Compostos, composição farmacêutica e usos dos compostos de lactama inovadora
JP2004512382A (ja) * 2000-11-03 2004-04-22 ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー 心臓灌流および心臓炎症の２核種同時イメージング
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US20020094316A1 (en) * 2001-01-09 2002-07-18 Shuang Liu Polypodal chelants for metallopharmaceuticals
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Also Published As

Publication number Publication date
HUP9801949A3 (en) 2000-09-28
CZ291658B6 (cs) 2003-04-16
NO974549L (no) 1997-12-02
PL322583A1 (en) 1998-02-02
US5744120A (en) 1998-04-28
EA199700291A1 (ru) 1998-04-30
EE9700250A (et) 1998-04-15
AR006077A1 (es) 1999-08-11
HU225674B1 (en) 2007-06-28
SI9620044A (sl) 1998-06-30
EP0820312A1 (en) 1998-01-28
PT820312E (pt) 2002-10-31
DE69622267T2 (de) 2003-02-20
LV12039B (en) 1998-10-20
WO1996031243A1 (en) 1996-10-10
TW503110B (en) 2002-09-21
SI9620044B (sl) 1999-02-28
CA2216423C (en) 2004-03-09
AU719529B2 (en) 2000-05-11
LT97157A (en) 1998-05-25
HRP960148A2 (en) 1997-10-31
UA56127C2 (uk) 2003-05-15
IL117642A (en) 2003-04-10
EP0820312B1 (en) 2002-07-10
CA2216423A1 (en) 1996-10-10
CZ302797A3 (cs) 1998-11-11
DE69622267D1 (de) 2002-08-14
JPH11503166A (ja) 1999-03-23
IL117642A0 (en) 1996-07-23
ZA962672B (en) 1997-10-03
CN1080127C (zh) 2002-03-06
AU5787496A (en) 1996-10-23
KR100417558B1 (ko) 2004-03-19
SK132997A3 (en) 1999-01-11
DK0820312T3 (da) 2002-09-02
LT4391B (lt) 1998-10-26
EP1195168A2 (en) 2002-04-10
NO317177B1 (no) 2004-09-06
ATE220335T1 (de) 2002-07-15
ES2179196T3 (es) 2003-01-16
SK283276B6 (sk) 2003-05-02
LV12039A (lv) 1998-05-20
NO974549D0 (no) 1997-10-02
HUP9801949A2 (hu) 1999-02-01
KR19980703560A (ko) 1998-11-05
EP1195168A3 (en) 2007-05-30
BR9608065A (pt) 1999-06-29
CN1185116A (zh) 1998-06-17
US6010679A (en) 2000-01-04
NZ333276A (en) 2000-07-28
PL185325B1 (pl) 2003-04-30
NZ308284A (en) 1999-05-28
EA000636B1 (ru) 1999-12-29
EP0820312A4 (en) 1998-03-18

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