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Priority claimed from US09/629,632external-prioritypatent/US6608174B1/en
Application filed by Dabur Res FoundationfiledCriticalDabur Res Foundation
Publication of MY129008ApublicationCriticalpatent/MY129008A/en
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents
(AREA)
Peptides Or Proteins
(AREA)
Abstract
THE PRESENT INVENTION ENCOMPASES RADIOLABELED PEPTIDE ANALOGS OF VASOACTIVE INTESTINAL PEPTIDE (VIP) LABELED WITH A RADIONUCLIDE USEFUL FOR IMAGING TARGET SITES WITHIN MAMMALIAN LIVING SYSTEMS. THE INVENTION PARTICULARLY PROVIDES RADIOLABELED VIP DERIVATIVES THAT BIND SELECTIVELY TO THE VIP RECEPTOR ON TARGET CELLS.SPECIFICALLY, THE INVENTION RELATES TO THE RADIOLABELING OF VIP-RECEPTOR SPECIFIC AGENTS AND THEIR SUBSEQUENTS USE FOR RADIODIAGNOSTIC AND RADIOTHERAPEUTIC PURPOSES. THE INVENTION ENCOMPASSES METHODS FOR RADIOLABELING THESE PEPTIDES WITH RADIO-NUCLIDES AND THE USE OF THESE PEPTIDES AS SCINTIGRAPHIC IMAGING AGENTS. THE RADIOLABELED VIP DERIVATIVES OF THE PRESENT INVENTION EXHIBIT PHARMACOLOGICAL ACTIVITY AND THEREFORE ARE USEFUL AS EITHER IMAGING AGENT FOR VISUALIZATION OF VIP-RECEPTOR POSITIVE TUMORS AND MATESTASES, AS A RADIODIAGNOSTIC AGENT OR AS A RADIO- THERAPEUTIC AGENT FOR THE TREATMENT OF SUCH TUMORS IN VIVO BY SPECIFICALLY TARGETING THE CYTOTOXIC RADIONUCLIDE SELECTIVELY TO THE TUMOR SITE IN MAMMALIAN LIVING SYSTEMS.(FIG.1)
MYPI200124702000-07-312001-05-24Radiolabeled vasoactive intestinal peptide analogs for diagnosis and radiotheraphy
MY129008A
(en)
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