MX9704671A - Esteres y amidas de acidos carboxilicos antiinflamatorios no esteroidales que pueden usarse como antioxidantes, inhibidores de 5-lipoxigenasa y productos antiiflamatorios no esteroidales. - Google Patents

Esteres y amidas de acidos carboxilicos antiinflamatorios no esteroidales que pueden usarse como antioxidantes, inhibidores de 5-lipoxigenasa y productos antiiflamatorios no esteroidales.

Info

Publication number
MX9704671A
MX9704671A MX9704671A MX9704671A MX9704671A MX 9704671 A MX9704671 A MX 9704671A MX 9704671 A MX9704671 A MX 9704671A MX 9704671 A MX9704671 A MX 9704671A MX 9704671 A MX9704671 A MX 9704671A
Authority
MX
Mexico
Prior art keywords
inflammatory
compounds
present
flammatory
amides
Prior art date
Application number
MX9704671A
Other languages
English (en)
Spanish (es)
Inventor
Mark Hellberg
Gustav Graff
Daniel A Gamache
Jon C Nixon
William H Garner
Original Assignee
Alcon Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27001775&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX9704671(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/362,718 external-priority patent/US5607966A/en
Application filed by Alcon Lab Inc filed Critical Alcon Lab Inc
Publication of MX9704671A publication Critical patent/MX9704671A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
MX9704671A 1994-12-23 1995-12-21 Esteres y amidas de acidos carboxilicos antiinflamatorios no esteroidales que pueden usarse como antioxidantes, inhibidores de 5-lipoxigenasa y productos antiiflamatorios no esteroidales. MX9704671A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/362,718 US5607966A (en) 1994-12-23 1994-12-23 Esters and amides of non-steroidal anti-inflammatory carboxylic acids which may be used as anti-oxidants, 5-lipoxygenase inhibitors and non-steroidal anti-inflammatory prodrugs
US08/472,445 US5643943A (en) 1994-12-23 1995-06-07 Systemic administration of esters and amides of antioxidants which may be used as antioxidant prodrug therapy for oxidative and inflammatory pathogenesis
PCT/US1995/016779 WO1996020187A2 (en) 1994-12-23 1995-12-21 Esters and amides of non-steroidal anti-inflammatory carboxylic acids which may be used as anti-oxidants, 5-lipoxygenase inhibitors and non-steroidal anti-inflammatory products

Publications (1)

Publication Number Publication Date
MX9704671A true MX9704671A (es) 1997-09-30

Family

ID=27001775

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9704671A MX9704671A (es) 1994-12-23 1995-12-21 Esteres y amidas de acidos carboxilicos antiinflamatorios no esteroidales que pueden usarse como antioxidantes, inhibidores de 5-lipoxigenasa y productos antiiflamatorios no esteroidales.

Country Status (16)

Country Link
US (2) US5643943A (cg-RX-API-DMAC7.html)
EP (1) EP0799219B1 (cg-RX-API-DMAC7.html)
JP (1) JP4021935B2 (cg-RX-API-DMAC7.html)
KR (1) KR19980700975A (cg-RX-API-DMAC7.html)
CN (2) CN1169805C (cg-RX-API-DMAC7.html)
AT (1) ATE239717T1 (cg-RX-API-DMAC7.html)
AU (1) AU689024B2 (cg-RX-API-DMAC7.html)
CA (1) CA2207574C (cg-RX-API-DMAC7.html)
CL (1) CL2010000383A1 (cg-RX-API-DMAC7.html)
DE (1) DE69530702T2 (cg-RX-API-DMAC7.html)
ES (1) ES2199262T3 (cg-RX-API-DMAC7.html)
FI (1) FI119474B (cg-RX-API-DMAC7.html)
HK (1) HK1039617B (cg-RX-API-DMAC7.html)
MX (1) MX9704671A (cg-RX-API-DMAC7.html)
NO (1) NO972879L (cg-RX-API-DMAC7.html)
WO (1) WO1996020187A2 (cg-RX-API-DMAC7.html)

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Also Published As

Publication number Publication date
WO1996020187A2 (en) 1996-07-04
AU4687796A (en) 1996-07-19
NO972879L (no) 1997-08-25
NO972879D0 (no) 1997-06-20
ES2199262T3 (es) 2004-02-16
FI119474B (fi) 2008-11-28
CA2207574A1 (en) 1996-07-04
US5811438A (en) 1998-09-22
DE69530702T2 (de) 2004-04-08
ATE239717T1 (de) 2003-05-15
HK1039617A1 (en) 2002-05-03
CN1171107A (zh) 1998-01-21
US5643943A (en) 1997-07-01
CL2010000383A1 (es) 2010-09-10
AU689024B2 (en) 1998-03-19
CN1318544A (zh) 2001-10-24
EP0799219A2 (en) 1997-10-08
HK1039617B (zh) 2005-09-02
CA2207574C (en) 2002-03-05
CN1193996C (zh) 2005-03-23
JPH10511663A (ja) 1998-11-10
WO1996020187A3 (en) 1996-12-12
JP4021935B2 (ja) 2007-12-12
CN1169805C (zh) 2004-10-06
FI972621A7 (fi) 1997-06-18
KR19980700975A (cg-RX-API-DMAC7.html) 1998-04-30
EP0799219B1 (en) 2003-05-07
FI972621A0 (fi) 1997-06-18
DE69530702D1 (de) 2003-06-12

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