JPS6440484A - Benzopyranopyridineacetic acid ester compound - Google Patents
Benzopyranopyridineacetic acid ester compoundInfo
- Publication number
- JPS6440484A JPS6440484A JP19679887A JP19679887A JPS6440484A JP S6440484 A JPS6440484 A JP S6440484A JP 19679887 A JP19679887 A JP 19679887A JP 19679887 A JP19679887 A JP 19679887A JP S6440484 A JPS6440484 A JP S6440484A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- substituted
- group
- benzopyranopyridineacetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:The compound of formula I {R<1> and R<2> are H or lower alkyl; R<3> is (substituted)phenyl, haloalkyl or group of formula -A-R<4> [A is alkylene; R<4> is (substituted)phenyl, hetero-aryl, OH, alkoxy, alkylthio, phenylthio, acyloxy, carboxy, (substituted)benzoyl, group of formula II, etc.]}. EXAMPLE:2-Hydroxyethyl.alpha,2-dimethyl-5H-[ 1 ]benzopyrano[2,3-b]pyridine-7-ace tic acid 2-hydroxyethyl ester. USE:An anti-inflammatory agent, an analgesic and an antipyretic. The side effect of gastric disorder is remarkably mitigated. PREPARATION:The compound of formula III is made to react with the compound of formula R<3>-X [X is reactive atom. or group (e.g. halogen or methanesulfonyloxy)] preferably in the presence of a base (e.g. potassium carbonate) in an inert solvent (e.g. DMF) at 0-100 deg.C for 1-24hr.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP19679887A JPS6440484A (en) | 1987-08-06 | 1987-08-06 | Benzopyranopyridineacetic acid ester compound |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP19679887A JPS6440484A (en) | 1987-08-06 | 1987-08-06 | Benzopyranopyridineacetic acid ester compound |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS6440484A true JPS6440484A (en) | 1989-02-10 |
Family
ID=16363825
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP19679887A Pending JPS6440484A (en) | 1987-08-06 | 1987-08-06 | Benzopyranopyridineacetic acid ester compound |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6440484A (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5607966A (en) * | 1994-12-23 | 1997-03-04 | Alcon Laboratories, Inc. | Esters and amides of non-steroidal anti-inflammatory carboxylic acids which may be used as anti-oxidants, 5-lipoxygenase inhibitors and non-steroidal anti-inflammatory prodrugs |
US5643943A (en) * | 1994-12-23 | 1997-07-01 | Alcon Laboratories, Inc. | Systemic administration of esters and amides of antioxidants which may be used as antioxidant prodrug therapy for oxidative and inflammatory pathogenesis |
US5750564A (en) * | 1995-09-12 | 1998-05-12 | Hellberg; Mark | Anti-oxidant esters of non-steroidal anti-inflammatory agents |
US5811453A (en) * | 1994-12-23 | 1998-09-22 | Alcon Laboratories, Inc. | Viscoelastic compositions and methods of use |
US5925673A (en) * | 1994-12-23 | 1999-07-20 | Alcon Laboratories, Inc. | Benzofurans and benzopyrans as cytoprotective agents |
WO2023046078A1 (en) * | 2021-09-24 | 2023-03-30 | 石家庄迪斯凯威医药科技有限公司 | Novel pranoprofen derivative, and pharmaceutical composition and use thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4993397A (en) * | 1973-01-13 | 1974-09-05 | ||
JPS49125365A (en) * | 1973-04-03 | 1974-11-30 |
-
1987
- 1987-08-06 JP JP19679887A patent/JPS6440484A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4993397A (en) * | 1973-01-13 | 1974-09-05 | ||
JPS49125365A (en) * | 1973-04-03 | 1974-11-30 |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5607966A (en) * | 1994-12-23 | 1997-03-04 | Alcon Laboratories, Inc. | Esters and amides of non-steroidal anti-inflammatory carboxylic acids which may be used as anti-oxidants, 5-lipoxygenase inhibitors and non-steroidal anti-inflammatory prodrugs |
US5643943A (en) * | 1994-12-23 | 1997-07-01 | Alcon Laboratories, Inc. | Systemic administration of esters and amides of antioxidants which may be used as antioxidant prodrug therapy for oxidative and inflammatory pathogenesis |
US5811453A (en) * | 1994-12-23 | 1998-09-22 | Alcon Laboratories, Inc. | Viscoelastic compositions and methods of use |
US5811438A (en) * | 1994-12-23 | 1998-09-22 | Alcon Laboratories, Inc. | Esters and amides of non-steroidal anti-inflammatory carboxylic acids which may be used as anti-oxidants, 5-lipoxygenase inhibitors and non-steroidal anti-inflammatory products |
US5925673A (en) * | 1994-12-23 | 1999-07-20 | Alcon Laboratories, Inc. | Benzofurans and benzopyrans as cytoprotective agents |
US6242480B1 (en) | 1994-12-23 | 2001-06-05 | Alcon Laboratories, Inc. | Ophthalmic viscoelastic compositions |
US5750564A (en) * | 1995-09-12 | 1998-05-12 | Hellberg; Mark | Anti-oxidant esters of non-steroidal anti-inflammatory agents |
US5908849A (en) * | 1995-09-12 | 1999-06-01 | Alcon Laboratories, Inc. | Anti-oxidant esters of non-steroidal anti-inflammatory agents |
US5998465A (en) * | 1995-09-12 | 1999-12-07 | Alcon Laboratories, Inc. | Esters of non-steroidal anti-flammatory carboxylic acids |
WO2023046078A1 (en) * | 2021-09-24 | 2023-03-30 | 石家庄迪斯凯威医药科技有限公司 | Novel pranoprofen derivative, and pharmaceutical composition and use thereof |
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