CN104592091B - 一种含吲哚乙酸核心结构的化合物及其应用 - Google Patents
一种含吲哚乙酸核心结构的化合物及其应用 Download PDFInfo
- Publication number
- CN104592091B CN104592091B CN201510040470.5A CN201510040470A CN104592091B CN 104592091 B CN104592091 B CN 104592091B CN 201510040470 A CN201510040470 A CN 201510040470A CN 104592091 B CN104592091 B CN 104592091B
- Authority
- CN
- China
- Prior art keywords
- compound
- formula
- pharmaceutically acceptable
- acceptable salt
- medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 CC(CC(C(OC=N)=C1O*)=O)=C(C)C1=O Chemical compound CC(CC(C(OC=N)=C1O*)=O)=C(C)C1=O 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Molecular Biology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
Abstract
Description
化合物 | 剂量(μM/kg) | 溃疡指数 |
溶剂(DMSO)对照 | 90 | 0 |
中间体I | 90 | 72.8±6.82 |
化合物a | 90 | |
化合物b | 90 | 0 |
Claims (13)
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510040470.5A CN104592091B (zh) | 2015-01-27 | 2015-01-27 | 一种含吲哚乙酸核心结构的化合物及其应用 |
EP16742705.3A EP3252039B1 (en) | 2015-01-27 | 2016-01-25 | Compound containing indoleacetic acid core structure and use thereof |
KR1020177021530A KR101975299B1 (ko) | 2015-01-27 | 2016-01-25 | 인돌아세트산의 코어구조를 함유하는 화합물 및 그의 용도 |
JP2017540779A JP6442615B2 (ja) | 2015-01-27 | 2016-01-25 | インドール酢酸コア構造を含む化合物とその応用 |
EP21203847.5A EP3978473A1 (en) | 2015-01-27 | 2016-01-25 | Compound containing an indoleacetic acid core structure and use thereof |
AU2016212552A AU2016212552B2 (en) | 2015-01-27 | 2016-01-25 | Compound containing indoleacetic acid core structure and use thereof |
PCT/CN2016/071934 WO2016119643A1 (zh) | 2015-01-27 | 2016-01-25 | 一种含吲哚乙酸核心结构的化合物及其应用 |
US15/547,013 US10494341B2 (en) | 2015-01-27 | 2016-01-25 | Compound containing indoleacetic acid core structure and use thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510040470.5A CN104592091B (zh) | 2015-01-27 | 2015-01-27 | 一种含吲哚乙酸核心结构的化合物及其应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104592091A CN104592091A (zh) | 2015-05-06 |
CN104592091B true CN104592091B (zh) | 2017-07-04 |
Family
ID=53118197
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510040470.5A Active CN104592091B (zh) | 2015-01-27 | 2015-01-27 | 一种含吲哚乙酸核心结构的化合物及其应用 |
Country Status (7)
Country | Link |
---|---|
US (1) | US10494341B2 (zh) |
EP (2) | EP3978473A1 (zh) |
JP (1) | JP6442615B2 (zh) |
KR (1) | KR101975299B1 (zh) |
CN (1) | CN104592091B (zh) |
AU (1) | AU2016212552B2 (zh) |
WO (1) | WO2016119643A1 (zh) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104592091B (zh) | 2015-01-27 | 2017-07-04 | 冉瑞琼 | 一种含吲哚乙酸核心结构的化合物及其应用 |
CN109180521B (zh) * | 2018-09-05 | 2021-08-31 | 中国人民解放军陆军军医大学 | 一种抗肿瘤化合物及其制备方法、用途 |
US20210113597A1 (en) * | 2019-06-27 | 2021-04-22 | Linheng Li | Methods for overcoming wnt/beta-catenin anti-cancer resistance in leukemia stem cells |
AU2022367624A1 (en) * | 2021-10-15 | 2024-05-09 | Beijing Anjianxi Bio-Medical Technology Co., Ltd. | 2,3-dimethoxy-5-methyl-1,4-benzoquinone alkyl alcohol derivative and use thereof |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3654349A (en) * | 1970-05-01 | 1972-04-04 | Merck & Co Inc | Substituted indenyl acetic acids |
CN1237162A (zh) * | 1996-11-12 | 1999-12-01 | 美国家用产品公司 | Cox-2的茚抑制剂 |
WO2006099416A1 (en) * | 2005-03-11 | 2006-09-21 | Nitromed, Inc. | 2-methyl indole cyclooxygenase-2 selective inhibitors, compositions and methods of use |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5643943A (en) * | 1994-12-23 | 1997-07-01 | Alcon Laboratories, Inc. | Systemic administration of esters and amides of antioxidants which may be used as antioxidant prodrug therapy for oxidative and inflammatory pathogenesis |
WO2014138922A1 (en) * | 2013-03-15 | 2014-09-18 | Indanio Bioscience Inc. | Uses for idebenone and related benzoouinones in ppar-related diseases and conditions |
CN104592091B (zh) * | 2015-01-27 | 2017-07-04 | 冉瑞琼 | 一种含吲哚乙酸核心结构的化合物及其应用 |
-
2015
- 2015-01-27 CN CN201510040470.5A patent/CN104592091B/zh active Active
-
2016
- 2016-01-25 AU AU2016212552A patent/AU2016212552B2/en active Active
- 2016-01-25 US US15/547,013 patent/US10494341B2/en active Active
- 2016-01-25 EP EP21203847.5A patent/EP3978473A1/en active Pending
- 2016-01-25 KR KR1020177021530A patent/KR101975299B1/ko active IP Right Grant
- 2016-01-25 JP JP2017540779A patent/JP6442615B2/ja active Active
- 2016-01-25 WO PCT/CN2016/071934 patent/WO2016119643A1/zh active Application Filing
- 2016-01-25 EP EP16742705.3A patent/EP3252039B1/en active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3654349A (en) * | 1970-05-01 | 1972-04-04 | Merck & Co Inc | Substituted indenyl acetic acids |
CN1237162A (zh) * | 1996-11-12 | 1999-12-01 | 美国家用产品公司 | Cox-2的茚抑制剂 |
WO2006099416A1 (en) * | 2005-03-11 | 2006-09-21 | Nitromed, Inc. | 2-methyl indole cyclooxygenase-2 selective inhibitors, compositions and methods of use |
Also Published As
Publication number | Publication date |
---|---|
EP3252039A1 (en) | 2017-12-06 |
AU2016212552B2 (en) | 2018-10-25 |
JP2018505184A (ja) | 2018-02-22 |
EP3252039B1 (en) | 2021-11-03 |
US10494341B2 (en) | 2019-12-03 |
JP6442615B2 (ja) | 2018-12-19 |
EP3252039A4 (en) | 2018-07-25 |
KR101975299B1 (ko) | 2019-05-07 |
AU2016212552A1 (en) | 2017-08-17 |
WO2016119643A1 (zh) | 2016-08-04 |
EP3978473A1 (en) | 2022-04-06 |
KR20170129688A (ko) | 2017-11-27 |
US20180022700A1 (en) | 2018-01-25 |
CN104592091A (zh) | 2015-05-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN104592091B (zh) | 一种含吲哚乙酸核心结构的化合物及其应用 | |
Zhang et al. | Anticancer effect evaluation in vitro and in vivo of iridium (III) polypyridyl complexes targeting DNA and mitochondria | |
CN110256313A (zh) | 一种光敏剂前药化合物及其制备方法和应用 | |
CN109081852B (zh) | 一种双重靶向酞菁类抗癌光敏剂及其制备方法 | |
CN106749478A (zh) | pH敏感的1,4‑二取代酞菁锌配合物及其制备方法和在医药上的应用 | |
CN101940569B (zh) | 含有索拉非尼和青蒿素及青蒿素类衍生物的药物组合物及其在制备治疗癌症的药物中的应用 | |
CN102627685A (zh) | 一氧化氮供体型谷胱甘肽类化合物、其制备方法及医药用途 | |
CN107793410B (zh) | 苯并硒二唑的衍生物及其应用 | |
CN101402667A (zh) | 糖基化修饰的一氧化氮供体型齐墩果酸类化合物、其制备方法及用途 | |
CN106518933A (zh) | 二茂铁衍生物及其制备方法和用途 | |
JP6404220B2 (ja) | テアニン誘導体とカルボン酸クマリン誘導体との縮合生成物、その中間体、調製方法、及びその使用 | |
CN109336940A (zh) | 一类含半乳糖的吖啶酮衍生物及其制备方法和应用 | |
CN111349092B (zh) | 一种线粒体靶向化合物及其制备方法和应用 | |
CN104725372B (zh) | 四环吲哚生物碱衍生物及其制备和应用 | |
Mishra et al. | Anti-HIV and cytotoxic ruthenium (II) complexes containing flavones: Biochemical evaluation in mice | |
RO129522A0 (ro) | Agenţi antitumorali derivaţi ai n-()-1-metil-1h-pirazol-4-carboxamidei | |
CN102702297B (zh) | 胆酸-萘酰亚胺类化合物的制备方法 | |
CN113461563A (zh) | Nqo1激活型6-重氮基-5-氧代-l-正亮氨酸前药及其制备方法和应用 | |
CN106795169B (zh) | 光己醚化合物及其药物组合物和用途 | |
CN103351383A (zh) | 5-氟尿嘧啶氮氧自由基抗肿瘤药物 | |
CN115057798B (zh) | 荧光探针、其制备方法和应用 | |
CN102690313B (zh) | 胆酸-萘酰亚胺类化合物及其应用 | |
CN102504013B (zh) | 一种靶向抗癌转移化学药物padm及制备方法和用途 | |
CN112358492B (zh) | 碳硼烷基塞来昔布及其制备和在头颈癌硼中子俘获治疗药物中的应用 | |
CN113149930B (zh) | 一种细胞糖转运通道抑制剂 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20161024 Address after: 430075 No. 666, hi tech Avenue, East Lake Development Zone, Hubei, Wuhan Applicant after: Ran Ruiqiong Applicant after: Xu Yao Address before: 430075 No. 666, hi tech Avenue, East Lake Development Zone, Hubei, Wuhan Applicant before: Ran Ruiqiong |
|
GR01 | Patent grant | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right |
Effective date of registration: 20171108 Address after: 100036 Beijing city Haidian District Cuiwei Road No. 2 on Printing No. 5 X301 Patentee after: Beijing An Jianxi medical science and Technology Co., Ltd. Address before: 430075 No. 666, hi tech Avenue, East Lake Development Zone, Hubei, Wuhan Co-patentee before: Xu Yao Patentee before: Ran Ruiqiong |
|
TR01 | Transfer of patent right |