MX9405132A - Tetrahidro pirazolopiridinas biciclicas. - Google Patents

Tetrahidro pirazolopiridinas biciclicas.

Info

Publication number
MX9405132A
MX9405132A MX9405132A MX9405132A MX9405132A MX 9405132 A MX9405132 A MX 9405132A MX 9405132 A MX9405132 A MX 9405132A MX 9405132 A MX9405132 A MX 9405132A MX 9405132 A MX9405132 A MX 9405132A
Authority
MX
Mexico
Prior art keywords
pirazolopiridinas
biciclicas
tetrahidro
tnf
formula
Prior art date
Application number
MX9405132A
Other languages
English (en)
Spanish (es)
Inventor
Allen Jacob Duplantier
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MX9405132A publication Critical patent/MX9405132A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
MX9405132A 1993-07-06 1994-07-05 Tetrahidro pirazolopiridinas biciclicas. MX9405132A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8829293A 1993-07-06 1993-07-06

Publications (1)

Publication Number Publication Date
MX9405132A true MX9405132A (es) 1995-01-31

Family

ID=22210524

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9405132A MX9405132A (es) 1993-07-06 1994-07-05 Tetrahidro pirazolopiridinas biciclicas.

Country Status (20)

Country Link
EP (1) EP0707585A1 (en:Method)
JP (1) JP2944048B2 (en:Method)
KR (1) KR100228949B1 (en:Method)
CN (1) CN1048015C (en:Method)
AU (1) AU695301B2 (en:Method)
BR (1) BR9406946A (en:Method)
CA (1) CA2166721C (en:Method)
CZ (1) CZ3696A3 (en:Method)
EG (1) EG20513A (en:Method)
FI (1) FI943208L (en:Method)
HU (1) HUT74170A (en:Method)
IL (1) IL110175A (en:Method)
MX (1) MX9405132A (en:Method)
NO (1) NO305029B1 (en:Method)
NZ (1) NZ266525A (en:Method)
PL (1) PL312426A1 (en:Method)
RU (1) RU2131876C1 (en:Method)
TW (1) TW316904B (en:Method)
WO (1) WO1995001980A1 (en:Method)
ZA (1) ZA944844B (en:Method)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996012720A1 (en) * 1994-10-20 1996-05-02 Pfizer Inc. Bicyclic tetrahydro pyrazolopyridines and their use as medicaments
ES2172583T3 (es) * 1995-06-06 2002-10-01 Pfizer 5,6-dihidro-9h-pirazol(3,4-c)-1,2,4-triazol(4,3-alfa)piridinas triciclicas.
AP932A (en) * 1996-08-26 2001-02-02 Pfizer Tricyclic 5,6-dihydro-9H-pyrazolo (3,4c)-1,2,4,-triazolo (4,3-a) pyridines.
CA2264798A1 (en) * 1996-09-04 1998-03-12 Pfizer Inc. Indazole derivatives and their use as inhibitors of phosphodiesterase (pde) type iv and the production of tumor necrosis factor (tnf)
US6093728A (en) * 1997-09-26 2000-07-25 Asta Medica Aktiengesellschaft Methods of modulating serine/threonine protein kinase function with azabenzimidazole-based compounds
ATE280171T1 (de) 1998-12-23 2004-11-15 Bristol Myers Squibb Pharma Co Stickstoffhaltige heterobicyclen als faktor-xa- hemmer
US6858616B2 (en) 1998-12-23 2005-02-22 Bristol-Myers Squibb Pharma Company Nitrogen containing heterobicycles as factor Xa inhibitors
US6326495B2 (en) 1999-04-30 2001-12-04 Pfizer Inc. Process for preparing 8-cyclopentyl-6-ethyl-3-[substituted]-5,8-dihydro-4H-1,2,3a,7,8-pentaaza-as-indacenes and intermediates useful therein
EP1671651B1 (en) 1999-08-21 2009-11-11 Nycomed GmbH Synergistic combination of pumafentrine and salmeterol
TWI243055B (en) * 2000-04-13 2005-11-11 Nippon Zoki Pharmaceutical Co Pharmaceutical composition for use in treatment of dermatitis
AU2001287654B2 (en) * 2000-08-10 2006-12-14 Pfizer Italia S.R.I. Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
CA2419552C (en) * 2000-08-14 2010-10-12 Ortho-Mcneil Pharmaceutical, Inc. Substituted pyrazoles
US6960595B2 (en) * 2001-03-23 2005-11-01 Bristol-Myers Squibb Pharma Company 5-6 to 5-7 Heterobicycles as factor Xa inhibitors
EP1379244A4 (en) 2001-04-18 2006-03-15 Bristol Myers Squibb Co 1,4,5,6-TETRAHYDROPYRAZOLO-3,4-C] -PYRIDINE-7-ONE AS FACTOR XA HEMMER
CA2444571A1 (en) 2001-04-18 2002-10-31 Bristol-Myers Squibb Company 1, 4, 5, 6-tetrahydropyrazolo-¬3, 4-c|-pyridin-7-ones as factor xa inhi bitors
EP1396493A4 (en) * 2001-04-26 2005-08-03 Ajinomoto Kk HETEROCYCLIC COMPOUNDS
IL160693A0 (en) * 2001-09-21 2004-08-31 Bristol Myers Squibb Co Lactam-containing compounds and derivatives thereof as factor xa inhibitors
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
CL2004000398A1 (es) 2003-02-27 2005-03-18 Uriach Y Compania S A J Compuestos derivados de pirazolopiridinas, sus sales; procedimiento de preparacion; composicion farmaceutica; y su uso para tratar enfermedades mediadas por quinasas p38, en especial por citocinas, tnf-alfa, il-1, il-6 y/o il-8, tales como enfermedad
US7135469B2 (en) * 2003-03-18 2006-11-14 Bristol Myers Squibb, Co. Linear chain substituted monocyclic and bicyclic derivatives as factor Xa inhibitors
JP2006522151A (ja) 2003-04-01 2006-09-28 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ 不妊症におけるホスホジエステラーゼ阻害剤
US7145012B2 (en) 2003-04-23 2006-12-05 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
AR050188A1 (es) * 2004-08-03 2006-10-04 Uriach Y Compania S A J Compuestos heterociclicos condensados utiles en terapia como inhibidores de quinasas p38 y composiciones farmaceuticas que los contienen
DE102005031580A1 (de) * 2005-07-06 2007-01-11 Aicuris Gmbh & Co. Kg Substituierte Sulfolanylpyrazole und ihre Verwendung
AR065804A1 (es) * 2007-03-23 2009-07-01 Smithkline Beecham Corp Compuesto de indol carboxamida, composicion farmaceutica que lo comprende y uso de dicho compuesto para preparar un medicamento
AU2008261102B2 (en) 2007-06-04 2013-11-28 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CA2930674A1 (en) 2008-06-04 2009-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP3241839B1 (en) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
EA201391254A1 (ru) 2011-03-01 2014-02-28 Синерджи Фармасьютикалз Инк. Способ получения агонистов гуанилатциклазы c
US9545446B2 (en) 2013-02-25 2017-01-17 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
HK1220611A1 (zh) 2013-03-15 2017-05-12 Bausch Health Ireland Limited 用於治疗胃肠道病症的组成物
SI3004138T1 (sl) 2013-06-05 2024-07-31 Bausch Health Ireland Limited Ultra čisti agonisti gvanilat ciklaze C, postopek za njihovo pripravo in uporabo
US20160184387A1 (en) 2013-08-09 2016-06-30 Dominique Charmot Compounds and methods for inhibiting phosphate transport
CN110357888A (zh) * 2018-04-09 2019-10-22 南京药捷安康生物科技有限公司 杂环磷酸二酯酶抑制剂及其用途
WO2020237096A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Combination for lowering serum phosphate in a patient

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1463883A (fr) * 1964-09-08 1966-07-22 Ciba Geigy Procédé de préparation de triaza-composés bicycliques
US3365459A (en) * 1964-09-08 1968-01-23 Ciba Geigy Corp Certain tetrahydro pyrazolo-pyridine and pyrazolo-piperidine derivatives
US3340269A (en) * 1964-09-08 1967-09-05 Ciba Geigy Corp 1-substituted 4-acyl-2, 3-dioxo-piperidine
HU183325B (en) * 1981-02-11 1984-04-28 Richter Gedeon Vegyeszet Process for preparing new apovincaminol-3',4',5'-trimethoxy-benzoates substituted with a nitro group
EP0068378B1 (en) * 1981-06-26 1986-03-05 Schering Corporation Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them
FR2525602A1 (fr) * 1982-04-21 1983-10-28 Synthelabo Imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique
US4668686A (en) * 1985-04-25 1987-05-26 Bristol-Myers Company Imidazoquinoline antithrombrogenic cardiotonic agents
US5356897A (en) * 1991-09-09 1994-10-18 Fujisawa Pharmaceutical Co., Ltd. 3-(heteroaryl)-pyrazololi[1,5-a]pyrimidines

Also Published As

Publication number Publication date
EP0707585A1 (en) 1996-04-24
BR9406946A (pt) 1996-08-06
HU9503934D0 (en) 1996-03-28
CA2166721C (en) 1999-07-27
NO960056D0 (no) 1996-01-05
FI943208A7 (fi) 1995-01-07
NZ266525A (en) 1997-10-24
FI943208L (fi) 1995-01-07
CZ3696A3 (en) 1997-06-11
CN1129940A (zh) 1996-08-28
HUT74170A (en) 1996-11-28
NO305029B1 (no) 1999-03-22
JP2944048B2 (ja) 1999-08-30
EG20513A (en) 1999-06-30
IL110175A (en) 2000-01-31
PL312426A1 (en) 1996-04-29
IL110175A0 (en) 1994-10-07
KR100228949B1 (ko) 1999-11-01
NO960056L (no) 1996-01-05
AU695301B2 (en) 1998-08-13
TW316904B (en:Method) 1997-10-01
JPH08507084A (ja) 1996-07-30
CN1048015C (zh) 2000-01-05
WO1995001980A1 (en) 1995-01-19
RU2131876C1 (ru) 1999-06-20
FI943208A0 (fi) 1994-07-05
ZA944844B (en) 1996-01-05
AU6805794A (en) 1995-02-06
KR960703852A (ko) 1996-08-31
CA2166721A1 (en) 1995-01-19

Similar Documents

Publication Publication Date Title
MX9405132A (es) Tetrahidro pirazolopiridinas biciclicas.
MX9504422A (es) Tetrahidropirazolopiridinas biciclicas.
ES2192192T3 (es) Dieteres de catecol como inhibidores selectivos de pde iv.
FI945555A0 (fi) Substituoituja oksindoleja
CO4180606A1 (es) Compuestos de isoxazolina como agentes antiinflamatorios
ATE370138T1 (de) Neue imidazopyridine und ihre verwendung
ES2139754T3 (es) 3-fenil-2-isoxazolinas como agentes antiinflamatorios.
GT199700102A (es) Derivados de indazol.
ES2115985T3 (es) Dihidropirazolopirroles.
GT199700075A (es) Analogos de indazol sustituido
EA199700209A1 (ru) ПРОИЗВОДНЫЕ ИМИДАЗО[1,2-a]ПИРИДИНА
DK1678166T3 (da) Proteinkinaseinhibitorer
PE99698A1 (es) Derivados del acido arilsulfonilamino hidroxamico
ATE284860T1 (de) Neue verwendung von phenylheteroalkylamin- derivaten
RU96103653A (ru) Бициклические тетрагидропиразолопиридины
MX9709897A (es) 5-6-dihidro-9h-pirazol[3,4-c]-1,2,4-triazol[4,3-a]piridinas triciclicas y el uso de las mismas.
DE60305514D1 (de) Neue verwendung von benzothiazolderivaten
ES2193196T3 (es) Derivados de dieteres de catecol como agentes farmaceuticos.
ATE482211T1 (de) Imidazoä1,2-aüpyridin-anxiolytika
ES2138366T3 (es) Indol carbamatos como antagonistas de leucotrienos.
ATE265428T1 (de) Neue verwendung von phenylheteroalkylamin- derivaten
KR850007602A (ko) 트리아졸로피리미딘 유도체의 제조방법
ECSP961759A (es) 5,6 dihidro -9h- pirazol (3,4-c)-1,2,4- triazol (4- 3 -a) piridinas triciclicas
GT199600030A (es) 5-6-dihidro-9h-pirazol [3,4-c]-1,2,4-triazol [4,3-a] piridinas triciclicas.
TH35996A (th) การใช้ 1-ไฮดรอกซี-2-ไพริโดนสำหรับรักษาโรคผิวหนังอักเสบเนื่องจากไขมันมากผิดปกติ