MX369395B - Modulacion del crecimiento celular y glucosilacion en la produccion de glucoproteina recombinante. - Google Patents

Modulacion del crecimiento celular y glucosilacion en la produccion de glucoproteina recombinante.

Info

Publication number
MX369395B
MX369395B MX2016010236A MX2016010236A MX369395B MX 369395 B MX369395 B MX 369395B MX 2016010236 A MX2016010236 A MX 2016010236A MX 2016010236 A MX2016010236 A MX 2016010236A MX 369395 B MX369395 B MX 369395B
Authority
MX
Mexico
Prior art keywords
glycosylation
cell growth
medium
modulation
conditions
Prior art date
Application number
MX2016010236A
Other languages
English (en)
Spanish (es)
Other versions
MX2016010236A (es
Inventor
Popp Oliver
Beaucamp Nicola
DRABNER Georg
Esslinger Stephanie
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50184787&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX369395(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2016010236A publication Critical patent/MX2016010236A/es
Publication of MX369395B publication Critical patent/MX369395B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
MX2016010236A 2014-02-27 2015-02-24 Modulacion del crecimiento celular y glucosilacion en la produccion de glucoproteina recombinante. MX369395B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14157030 2014-02-27
PCT/EP2015/053804 WO2015128314A1 (en) 2014-02-27 2015-02-24 Modulation of cell growth and glycosylation in recombinant glycoprotein production

Publications (2)

Publication Number Publication Date
MX2016010236A MX2016010236A (es) 2016-10-13
MX369395B true MX369395B (es) 2019-11-07

Family

ID=50184787

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016010236A MX369395B (es) 2014-02-27 2015-02-24 Modulacion del crecimiento celular y glucosilacion en la produccion de glucoproteina recombinante.

Country Status (20)

Country Link
US (2) US20170058309A1 (pt-PT)
EP (1) EP3110961B1 (pt-PT)
JP (2) JP6831702B2 (pt-PT)
KR (1) KR102280638B1 (pt-PT)
CN (1) CN106133146B (pt-PT)
BR (1) BR112016017660B1 (pt-PT)
CA (1) CA2937611C (pt-PT)
DK (1) DK3110961T3 (pt-PT)
ES (1) ES2769003T3 (pt-PT)
HR (1) HRP20200100T1 (pt-PT)
HU (1) HUE047575T2 (pt-PT)
LT (1) LT3110961T (pt-PT)
MX (1) MX369395B (pt-PT)
PL (1) PL3110961T3 (pt-PT)
PT (1) PT3110961T (pt-PT)
RS (1) RS59881B1 (pt-PT)
RU (1) RU2712562C2 (pt-PT)
SG (1) SG11201606856SA (pt-PT)
SI (1) SI3110961T1 (pt-PT)
WO (1) WO2015128314A1 (pt-PT)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10010029B2 (en) 2011-11-21 2018-07-03 Innovation Hammer, Llc Methods and systems for growing plants using silicate-based substrates, cultivation of enhanced photosynthetic productivity and photosafening by utilization of exogenous glycopyranosides for endogenous glycopyranosyl-protein derivatives, and formulations, processes and systems for the same
SI3110961T1 (sl) * 2014-02-27 2020-03-31 F. Hoffmann-La Roche Ag Modulacija rasti celic in glikozilacije pri rekombinantni proizvodnji glikoproteina
EP3227454B1 (en) 2014-12-01 2020-01-29 Amgen Inc. Process for manipulating the level of glycan content of a glycoprotein
CN109414027A (zh) * 2016-04-29 2019-03-01 创新汉玛有限责任公司 用聚糖复合物制剂处理光合生物和增加品质和产量的制剂和方法
WO2019077628A1 (en) * 2017-10-16 2019-04-25 Council Of Scientific & Industrial Research ZINC SUPPLEMENTATION TO DECREASE GALACTOSYLATION OF RECOMBINANT GLYCOPROTEINS
MA52186A (fr) * 2018-03-26 2021-02-17 Amgen Inc Glycoformes afucosylées totales d'anticorps produits en culture cellulaire
JP2021524745A (ja) * 2018-05-24 2021-09-16 アレス トレーディング ソシエテ アノニム 糖タンパク質組成物の非フコシル化レベルを制御する方法
HUP1800376A2 (hu) 2018-11-07 2020-05-28 Richter Gedeon Nyrt Sejttenyészetben elõállított rekombináns glikoprotein glikozilációs-mintázatának megváltoztatására szolgáló módszer
US11634499B2 (en) * 2018-11-13 2023-04-25 Janssen Biotech, Inc. Control of trace metals during production of anti-CD38 antibodies
JP2020188737A (ja) * 2019-05-23 2020-11-26 東ソー株式会社 抗体依存性細胞傷害活性が向上した抗体の製造方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4767704A (en) 1983-10-07 1988-08-30 Columbia University In The City Of New York Protein-free culture medium
IL87737A (en) 1987-09-11 1993-08-18 Genentech Inc Method for culturing polypeptide factor dependent vertebrate recombinant cells
US5705364A (en) * 1995-06-06 1998-01-06 Genentech, Inc. Mammalian cell culture process
US6030945A (en) 1996-01-09 2000-02-29 Genentech, Inc. Apo-2 ligand
EP1482031B1 (en) 1996-08-30 2015-10-28 Life Technologies Corporation Serum-free mammalian cell culture medium, and uses thereof
WO1999061650A1 (en) * 1998-05-29 1999-12-02 Genentech, Inc. Cell culture process for producing glycoproteins
JP2001120262A (ja) * 1999-10-26 2001-05-08 Welfide Corp 生理活性物質の産生増強方法
WO2002066603A2 (en) 2001-02-15 2002-08-29 Centocor, Inc. Chemically defined medium for cultured mammalian cells
US20050287666A1 (en) * 2004-06-29 2005-12-29 Invitrogen Corporation Cell culture medium comprising transition metals or trace elements
TWI384069B (zh) 2004-08-27 2013-02-01 Pfizer Ireland Pharmaceuticals 多胜肽之製法
JP4833991B2 (ja) 2004-11-02 2011-12-07 アレス トレーディング ソシエテ アノニム 哺乳動物細胞のための無血清細胞培養培地
US20070231895A1 (en) 2005-11-02 2007-10-04 Lee Gene W Methods for adapting mammalian cells
US7972810B2 (en) 2005-12-08 2011-07-05 Amgen Inc. Production of glycoproteins using manganese
AU2007272957B2 (en) * 2006-07-13 2014-05-01 Wyeth Llc Production of glycoproteins
EP2064315B1 (en) 2006-11-03 2015-05-13 Wyeth LLC Glycolysis-inhibiting substances in cell culture
EP2924113B1 (en) 2007-03-02 2019-04-10 Wyeth LLC Use of copper and glutamate in cell culture for production of polypeptides
WO2011019622A1 (en) * 2009-08-14 2011-02-17 Genentech, Inc. Cell culture methods to make antibodies with enhanced adcc function
US20120309056A1 (en) * 2010-02-04 2012-12-06 Leon Arnaud Fed-batch process using concentrated cell culture medium for the efficient production of biologics in eb66 cells
EP3330370B1 (en) 2010-04-26 2021-02-24 Novartis AG Process for cultivation of cho cells
EP2702077A2 (en) 2011-04-27 2014-03-05 AbbVie Inc. Methods for controlling the galactosylation profile of recombinantly-expressed proteins
RU2592680C2 (ru) 2011-04-29 2016-07-27 Биокон Рисерч Лимитед Способ снижения накопления лактата при культивировании и способ получения антитела
EP2809773B1 (en) * 2012-01-30 2020-09-02 Dr. Reddy's Laboratories Limited Process of modulating man5 and/or afucosylation content of glycoprotein composition
EP3052640A2 (en) 2013-10-04 2016-08-10 AbbVie Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
SI3110961T1 (sl) * 2014-02-27 2020-03-31 F. Hoffmann-La Roche Ag Modulacija rasti celic in glikozilacije pri rekombinantni proizvodnji glikoproteina

Also Published As

Publication number Publication date
HRP20200100T1 (hr) 2020-04-03
BR112016017660A2 (pt-PT) 2017-08-08
JP6934507B2 (ja) 2021-09-15
WO2015128314A1 (en) 2015-09-03
EP3110961B1 (en) 2019-11-27
ES2769003T3 (es) 2020-06-24
CA2937611C (en) 2023-01-03
CN106133146A (zh) 2016-11-16
MX2016010236A (es) 2016-10-13
KR20160125514A (ko) 2016-10-31
KR102280638B1 (ko) 2021-07-22
JP2020054351A (ja) 2020-04-09
US20210222220A1 (en) 2021-07-22
RU2712562C2 (ru) 2020-01-29
RU2016138176A (ru) 2018-03-29
JP6831702B2 (ja) 2021-02-17
HUE047575T2 (hu) 2020-04-28
RU2016138176A3 (pt-PT) 2018-10-29
CN106133146B (zh) 2021-05-04
US20170058309A1 (en) 2017-03-02
SG11201606856SA (en) 2016-09-29
BR112016017660B1 (pt) 2022-04-19
SI3110961T1 (sl) 2020-03-31
EP3110961A1 (en) 2017-01-04
CA2937611A1 (en) 2015-09-03
RS59881B1 (sr) 2020-03-31
JP2017506515A (ja) 2017-03-09
DK3110961T3 (da) 2020-02-03
PL3110961T3 (pl) 2020-04-30
PT3110961T (pt) 2020-01-29
LT3110961T (lt) 2020-02-10

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