RU2712562C2 - Модулирование клеточного роста и гликозилирования при производстве рекомбинантных гликопротеинов - Google Patents

Модулирование клеточного роста и гликозилирования при производстве рекомбинантных гликопротеинов Download PDF

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RU2712562C2
RU2712562C2 RU2016138176A RU2016138176A RU2712562C2 RU 2712562 C2 RU2712562 C2 RU 2712562C2 RU 2016138176 A RU2016138176 A RU 2016138176A RU 2016138176 A RU2016138176 A RU 2016138176A RU 2712562 C2 RU2712562 C2 RU 2712562C2
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zinc
manganese
copper
concentration
iron
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RU2016138176A
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RU2016138176A (ru
RU2016138176A3 (pt-PT
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Оливер ПОПП
Никола БОКАМП
Георг ДРАБНЕР
Штефани ЭССЛИНГЕР
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Ф.Хоффманн-Ля Рош Аг
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
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  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
RU2016138176A 2014-02-27 2015-02-24 Модулирование клеточного роста и гликозилирования при производстве рекомбинантных гликопротеинов RU2712562C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14157030 2014-02-27
EP14157030.9 2014-02-27
PCT/EP2015/053804 WO2015128314A1 (en) 2014-02-27 2015-02-24 Modulation of cell growth and glycosylation in recombinant glycoprotein production

Publications (3)

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RU2016138176A RU2016138176A (ru) 2018-03-29
RU2016138176A3 RU2016138176A3 (pt-PT) 2018-10-29
RU2712562C2 true RU2712562C2 (ru) 2020-01-29

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RU2016138176A RU2712562C2 (ru) 2014-02-27 2015-02-24 Модулирование клеточного роста и гликозилирования при производстве рекомбинантных гликопротеинов

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US (2) US20170058309A1 (pt-PT)
EP (1) EP3110961B1 (pt-PT)
JP (2) JP6831702B2 (pt-PT)
KR (1) KR102280638B1 (pt-PT)
CN (1) CN106133146B (pt-PT)
BR (1) BR112016017660B1 (pt-PT)
CA (1) CA2937611C (pt-PT)
DK (1) DK3110961T3 (pt-PT)
ES (1) ES2769003T3 (pt-PT)
HR (1) HRP20200100T1 (pt-PT)
HU (1) HUE047575T2 (pt-PT)
LT (1) LT3110961T (pt-PT)
MX (1) MX369395B (pt-PT)
PL (1) PL3110961T3 (pt-PT)
PT (1) PT3110961T (pt-PT)
RS (1) RS59881B1 (pt-PT)
RU (1) RU2712562C2 (pt-PT)
SG (1) SG11201606856SA (pt-PT)
SI (1) SI3110961T1 (pt-PT)
WO (1) WO2015128314A1 (pt-PT)

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US10010029B2 (en) 2011-11-21 2018-07-03 Innovation Hammer, Llc Methods and systems for growing plants using silicate-based substrates, cultivation of enhanced photosynthetic productivity and photosafening by utilization of exogenous glycopyranosides for endogenous glycopyranosyl-protein derivatives, and formulations, processes and systems for the same
SI3110961T1 (sl) * 2014-02-27 2020-03-31 F. Hoffmann-La Roche Ag Modulacija rasti celic in glikozilacije pri rekombinantni proizvodnji glikoproteina
EP3227454B1 (en) 2014-12-01 2020-01-29 Amgen Inc. Process for manipulating the level of glycan content of a glycoprotein
CN109414027A (zh) * 2016-04-29 2019-03-01 创新汉玛有限责任公司 用聚糖复合物制剂处理光合生物和增加品质和产量的制剂和方法
WO2019077628A1 (en) * 2017-10-16 2019-04-25 Council Of Scientific & Industrial Research ZINC SUPPLEMENTATION TO DECREASE GALACTOSYLATION OF RECOMBINANT GLYCOPROTEINS
MA52186A (fr) * 2018-03-26 2021-02-17 Amgen Inc Glycoformes afucosylées totales d'anticorps produits en culture cellulaire
JP2021524745A (ja) * 2018-05-24 2021-09-16 アレス トレーディング ソシエテ アノニム 糖タンパク質組成物の非フコシル化レベルを制御する方法
HUP1800376A2 (hu) 2018-11-07 2020-05-28 Richter Gedeon Nyrt Sejttenyészetben elõállított rekombináns glikoprotein glikozilációs-mintázatának megváltoztatására szolgáló módszer
US11634499B2 (en) * 2018-11-13 2023-04-25 Janssen Biotech, Inc. Control of trace metals during production of anti-CD38 antibodies
JP2020188737A (ja) * 2019-05-23 2020-11-26 東ソー株式会社 抗体依存性細胞傷害活性が向上した抗体の製造方法

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RU2463345C2 (ru) * 2006-07-13 2012-10-10 Вайет Получение гликопротеинов

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HRP20200100T1 (hr) 2020-04-03
BR112016017660A2 (pt-PT) 2017-08-08
JP6934507B2 (ja) 2021-09-15
WO2015128314A1 (en) 2015-09-03
EP3110961B1 (en) 2019-11-27
ES2769003T3 (es) 2020-06-24
CA2937611C (en) 2023-01-03
CN106133146A (zh) 2016-11-16
MX2016010236A (es) 2016-10-13
KR20160125514A (ko) 2016-10-31
KR102280638B1 (ko) 2021-07-22
JP2020054351A (ja) 2020-04-09
US20210222220A1 (en) 2021-07-22
RU2016138176A (ru) 2018-03-29
JP6831702B2 (ja) 2021-02-17
HUE047575T2 (hu) 2020-04-28
RU2016138176A3 (pt-PT) 2018-10-29
CN106133146B (zh) 2021-05-04
US20170058309A1 (en) 2017-03-02
SG11201606856SA (en) 2016-09-29
BR112016017660B1 (pt) 2022-04-19
MX369395B (es) 2019-11-07
SI3110961T1 (sl) 2020-03-31
EP3110961A1 (en) 2017-01-04
CA2937611A1 (en) 2015-09-03
RS59881B1 (sr) 2020-03-31
JP2017506515A (ja) 2017-03-09
DK3110961T3 (da) 2020-02-03
PL3110961T3 (pl) 2020-04-30
PT3110961T (pt) 2020-01-29
LT3110961T (lt) 2020-02-10

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