MX369019B - Compuestos inhibidores de quinasa map p38 como agentes antiadherencias, conjugados con una unidad estructural de polímeros básicos solubles en agua y su uso para el tratamiento o prevención de adherencias en tejidos u órganos. - Google Patents

Compuestos inhibidores de quinasa map p38 como agentes antiadherencias, conjugados con una unidad estructural de polímeros básicos solubles en agua y su uso para el tratamiento o prevención de adherencias en tejidos u órganos.

Info

Publication number
MX369019B
MX369019B MX2013013409A MX2013013409A MX369019B MX 369019 B MX369019 B MX 369019B MX 2013013409 A MX2013013409 A MX 2013013409A MX 2013013409 A MX2013013409 A MX 2013013409A MX 369019 B MX369019 B MX 369019B
Authority
MX
Mexico
Prior art keywords
prophylaxis
treatment
compounds
pharmaceutical compositions
vii
Prior art date
Application number
MX2013013409A
Other languages
English (en)
Other versions
MX2013013409A (es
Inventor
Gennadievich Shurygin Mikhail
Aleksandrovna Shurygina Irina
Original Assignee
Pharmasyntez
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from RU2011119848/15A external-priority patent/RU2011119848A/ru
Application filed by Pharmasyntez filed Critical Pharmasyntez
Publication of MX2013013409A publication Critical patent/MX2013013409A/es
Publication of MX369019B publication Critical patent/MX369019B/es

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    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/06Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02Polyamines
    • C08G73/0206Polyalkylene(poly)amines
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/06Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
    • C08G73/0605Polycondensates containing five-membered rings, not condensed with other rings, with nitrogen atoms as the only ring hetero atoms
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L79/00Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing nitrogen with or without oxygen or carbon only, not provided for in groups C08L61/00 - C08L77/00
    • C08L79/04Polycondensates having nitrogen-containing heterocyclic rings in the main chain; Polyhydrazides; Polyamide acids or similar polyimide precursors
    • C08L79/06Polyhydrazides; Polytriazoles; Polyamino-triazoles; Polyoxadiazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

La invención se refiere al campo de la farmacéutica, la medicina clínica y experimental y la medicina veterinaria, y en particular, a nuevos compuestos inhibidores de una quinasa MAP p38 con una estructura de tipo (I) - (VII) que puede ser utilizada para el tratamiento y la prevención de adherencias. La invención describe composiciones farmacéuticas que contienen una cantidad efectiva de la sustancia SB203580 o uno de los compuestos de tipo (I) - (VII) o una combinación de los mismos y un portador, diluyente o excipiente farmacéuticamente aceptable. También, se describe el uso de la sustancia SB203580 como un agente que tiene actividad anti-adherencia. Además se describe: un método para la prevención y/o tratamiento de una enfermedad o condición en el que existe la posibilidad de formación y/o crecimiento de adherencias lo que hace posible prescindir de la administración adicional de una preparación en el período postoperatorio.
MX2013013409A 2011-05-17 2012-05-17 Compuestos inhibidores de quinasa map p38 como agentes antiadherencias, conjugados con una unidad estructural de polímeros básicos solubles en agua y su uso para el tratamiento o prevención de adherencias en tejidos u órganos. MX369019B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
RU2011119848/15A RU2011119848A (ru) 2011-05-17 2011-05-17 Способ профилактики спайкообразования
RU2011153043 2011-12-26
PCT/IB2012/052483 WO2012156938A1 (ru) 2011-05-17 2012-05-17 Соединения, фармацевтические композиции и способ профилактики и лечения спаечного процесса

Publications (2)

Publication Number Publication Date
MX2013013409A MX2013013409A (es) 2014-07-11
MX369019B true MX369019B (es) 2019-10-24

Family

ID=47176372

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2013013409A MX369019B (es) 2011-05-17 2012-05-17 Compuestos inhibidores de quinasa map p38 como agentes antiadherencias, conjugados con una unidad estructural de polímeros básicos solubles en agua y su uso para el tratamiento o prevención de adherencias en tejidos u órganos.
MX2019011386A MX2019011386A (es) 2011-05-17 2013-11-15 Compuestos, composiciones farmaceuticas y un metodo para la profilaxis y tratamiento del proceso de adhesion.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2019011386A MX2019011386A (es) 2011-05-17 2013-11-15 Compuestos, composiciones farmaceuticas y un metodo para la profilaxis y tratamiento del proceso de adhesion.

Country Status (31)

Country Link
US (2) US10172952B2 (es)
EP (2) EP2716684B1 (es)
JP (2) JP5936683B2 (es)
KR (2) KR20140074259A (es)
CN (1) CN103534293B (es)
AP (1) AP3694A (es)
AU (3) AU2012257347A1 (es)
BR (1) BR112013029616B1 (es)
CA (1) CA2836268C (es)
CL (1) CL2013003305A1 (es)
CO (1) CO6801779A2 (es)
CR (1) CR20130600A (es)
CY (1) CY1122190T1 (es)
DK (1) DK2716684T3 (es)
DO (1) DOP2013000266A (es)
EA (1) EA025493B1 (es)
GE (1) GEP201706614B (es)
HK (1) HK1189012A1 (es)
IL (1) IL229423B (es)
LT (1) LT2716684T (es)
MA (1) MA35189B1 (es)
MX (2) MX369019B (es)
NI (1) NI201300124A (es)
PE (1) PE20141161A1 (es)
PL (1) PL2716684T3 (es)
RS (1) RS59382B1 (es)
RU (1) RU2582975C2 (es)
SI (1) SI2716684T1 (es)
SV (1) SV2013004582A (es)
WO (1) WO2012156938A1 (es)
ZA (1) ZA201308542B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112013029616B1 (pt) * 2011-05-17 2022-09-20 Joint Stock Company "Pharmasyntez" Composto inibidor de p38 map quinase e composição farmacêutica
RU2745965C1 (ru) * 2020-11-23 2021-04-05 Галина Анатольевна Пучкина Способ профилактики послеоперационного спаечного процесса органов малого таза
RU2749435C1 (ru) * 2020-11-27 2021-06-10 Федеральное государственное бюджетное научное учреждение "Иркутский научный центр хирургии и травматологии" Способ лечения энтеральной недостаточности при воспалительных и травматических повреждениях брюшины

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AU7629594A (en) * 1993-07-21 1995-02-20 Smithkline Beecham Corporation Imidazoles for treating cytokine mediated disease
US20020028798A1 (en) * 1995-12-12 2002-03-07 Omeros Medical Systems Irrigation solution and method for inhibition of pain and inflammation
US5837719A (en) * 1995-08-10 1998-11-17 Merck & Co., Inc. 2,5-substituted aryl pyrroles, compositions containing such compounds and methods of use
EP0871444A4 (en) * 1995-08-10 1999-01-13 Merck & Co Inc 2.5 SUBSTITUTED ARYL PYRROL, THE COMPOSITIONS THAT CONTAIN AND THE USE THEREOF
US5894971A (en) 1998-02-02 1999-04-20 Huang; Te Chien Tool holder for attaching tools to user's hand
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CN1443173A (zh) * 2000-08-17 2003-09-17 辉瑞大药厂 作为TAFIa抑制剂的取代的咪唑
AU2003249977A1 (en) * 2002-07-05 2004-01-23 Axxima Pharmaceuticals Ag Imidazole compounds for the treatment of hepatitis c virus infections
CA2511486A1 (en) * 2002-12-30 2004-07-22 Angiotech International Ag Tissue reactive compounds and compositions and uses thereof
JP2009508938A (ja) * 2005-09-22 2009-03-05 ハダシット メディカル リサーチ サーヴィスィズ アンド ディベロップメント リミテッド 治療上活性な化合物の結合体
JP5530635B2 (ja) * 2007-02-14 2014-06-25 独立行政法人科学技術振興機構 腸管癒着抑制剤
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US8205286B1 (en) 2008-10-21 2012-06-26 Milagros Diaz Pillow for female breasts
BR112013029616B1 (pt) * 2011-05-17 2022-09-20 Joint Stock Company "Pharmasyntez" Composto inibidor de p38 map quinase e composição farmacêutica
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Also Published As

Publication number Publication date
MX2019011386A (es) 2019-10-30
AP3694A (en) 2016-04-30
EP2716684B1 (en) 2019-06-26
EP3569636A1 (en) 2019-11-20
MA35189B1 (fr) 2014-06-02
CR20130600A (es) 2014-04-29
BR112013029616A2 (pt) 2020-08-25
US10172952B2 (en) 2019-01-08
PL2716684T3 (pl) 2020-01-31
AU2012257347A1 (en) 2014-01-09
CO6801779A2 (es) 2013-11-29
KR20170034950A (ko) 2017-03-29
EP2716684A4 (en) 2015-07-15
KR20140074259A (ko) 2014-06-17
CY1122190T1 (el) 2020-11-25
IL229423B (en) 2018-04-30
CN103534293B (zh) 2015-10-21
US20140079663A1 (en) 2014-03-20
CN103534293A (zh) 2014-01-22
EA201301275A1 (ru) 2014-03-31
CA2836268A1 (en) 2012-11-22
CA2836268C (en) 2018-07-03
RU2582975C2 (ru) 2016-04-27
AP2013007258A0 (en) 2013-11-30
ZA201308542B (en) 2014-07-30
PE20141161A1 (es) 2014-10-01
BR112013029616B1 (pt) 2022-09-20
NI201300124A (es) 2014-02-25
JP2014515057A (ja) 2014-06-26
DK2716684T3 (da) 2019-09-30
SI2716684T1 (sl) 2019-11-29
EA025493B1 (ru) 2016-12-30
LT2716684T (lt) 2019-09-25
RS59382B1 (sr) 2019-11-29
US10493164B2 (en) 2019-12-03
WO2012156938A1 (ru) 2012-11-22
DOP2013000266A (es) 2014-06-01
IL229423A0 (en) 2014-01-30
US20190125886A1 (en) 2019-05-02
AU2017221883B2 (en) 2019-06-20
GEP201706614B (en) 2017-02-10
EP2716684A1 (en) 2014-04-09
CL2013003305A1 (es) 2014-07-18
JP2016175931A (ja) 2016-10-06
RU2013155582A (ru) 2015-06-27
NZ618882A (en) 2016-03-31
AU2015213303A1 (en) 2015-09-03
MX2013013409A (es) 2014-07-11
JP5936683B2 (ja) 2016-06-22
HK1189012A1 (en) 2014-05-23
SV2013004582A (es) 2018-11-12
AU2017221883A1 (en) 2017-09-28

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