MX2022005985A - Derivado de pirazolo-heteroarilo, metodo de preparacion y uso medico del mismo. - Google Patents

Derivado de pirazolo-heteroarilo, metodo de preparacion y uso medico del mismo.

Info

Publication number
MX2022005985A
MX2022005985A MX2022005985A MX2022005985A MX2022005985A MX 2022005985 A MX2022005985 A MX 2022005985A MX 2022005985 A MX2022005985 A MX 2022005985A MX 2022005985 A MX2022005985 A MX 2022005985A MX 2022005985 A MX2022005985 A MX 2022005985A
Authority
MX
Mexico
Prior art keywords
preparation
pyrazolo
method therefor
medical use
heteroaryl derivative
Prior art date
Application number
MX2022005985A
Other languages
English (en)
Inventor
Feng He
Weikang Tao
Xin Li
Huaide Dong
Dongdong Bai
Original Assignee
Jiangsu Hengrui Medicine Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Hengrui Medicine Co filed Critical Jiangsu Hengrui Medicine Co
Publication of MX2022005985A publication Critical patent/MX2022005985A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Se describe un derivado de pirazolo-heteroarilo, un método de preparación del mismo y uso médico del mismo. En particular, la presente invención se refiere a un derivado de pirazolo-heteroarilo como se muestra en la fórmula general (I), un método de preparación del mismo, una composición farmacéutica que contiene el derivado y su uso como agente terapéutico, particularmente como inhibidor de la quinasa ATR y en la preparación de fármacos para el tratamiento y/o prevención de enfermedades hiperproliferativas. La definición de cada grupo en la fórmula general (I) es idéntica a la de la memoria descriptiva. (ver Fórmula).
MX2022005985A 2019-11-21 2020-11-20 Derivado de pirazolo-heteroarilo, metodo de preparacion y uso medico del mismo. MX2022005985A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201911147956 2019-11-21
CN202010837381 2020-08-19
PCT/CN2020/130326 WO2021098811A1 (zh) 2019-11-21 2020-11-20 吡唑并杂芳基类衍生物、其制备方法及其在医药上的应用

Publications (1)

Publication Number Publication Date
MX2022005985A true MX2022005985A (es) 2022-06-17

Family

ID=75981069

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022005985A MX2022005985A (es) 2019-11-21 2020-11-20 Derivado de pirazolo-heteroarilo, metodo de preparacion y uso medico del mismo.

Country Status (11)

Country Link
US (1) US20230018728A1 (es)
EP (1) EP4063363A4 (es)
JP (1) JP2023502458A (es)
KR (1) KR20220103987A (es)
CN (1) CN114423760A (es)
AU (1) AU2020386587A1 (es)
BR (1) BR112022008000A2 (es)
CA (1) CA3159376A1 (es)
MX (1) MX2022005985A (es)
TW (1) TW202128690A (es)
WO (1) WO2021098811A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL300261A (en) * 2020-08-07 2023-03-01 Antengene Discovery Ltd ATR inhibitors and their uses
WO2022135560A1 (en) * 2020-12-25 2022-06-30 Impact Therapeutics (Shanghai) , Inc Substituted imidazo[1,5-b]pyridazine compounds as kinase inhibitors and use thereof
EP4342897A1 (en) 2021-05-21 2024-03-27 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Pharmaceutically acceptable salt of pyrazoloheteroaryl derivative and crystal form thereof
WO2023109883A1 (zh) * 2021-12-15 2023-06-22 上海翊石医药科技有限公司 一类芳杂环取代的化合物及其制备方法和用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY32351A (es) * 2008-12-22 2010-07-30 Astrazeneca Ab Compuestos de pirimidinil indol para uso como inhibidores de atr
SA111320519B1 (ar) * 2010-06-11 2014-07-02 Astrazeneca Ab مركبات بيريميدينيل للاستخدام كمثبطات atr
EP2649065A1 (en) * 2010-12-09 2013-10-16 Amgen Inc. Bicyclic compounds as pim inhibitors
HUE041544T2 (hu) * 2013-03-12 2019-05-28 Vertex Pharma DNS-PK inhibitorok
TWI656121B (zh) * 2014-08-04 2019-04-11 德商拜耳製藥公司 ２－（嗎啉－４－基）－１，７－萘啶
CA3011189C (en) * 2016-01-14 2024-02-20 Bayer Pharma Aktiengesellschaft 5-substituted 2-(morpholin-4-yl)-1,7-naphthyridines
WO2018153970A1 (en) * 2017-02-24 2018-08-30 Bayer Pharma Aktiengesellschaft Solid forms of 2-[(3r)-3-methylmorpholin-4-yl]-4-(1-methyl-1h-pyrazol-5-yl)-8-(1h-pyrazol-5-yl)-1,7-naphthyridine
ES2954572T3 (es) * 2018-09-07 2023-11-23 Merck Patent Gmbh Derivados de 5-morfolin-4-il-pirazolo[4,3-b]piridina
MA53726A (fr) * 2018-09-25 2022-05-11 Incyte Corp Composés pyrazolo[4,3-d]pyrimidine en tant que modulateurs des alk2 et/ou fgfr

Also Published As

Publication number Publication date
TW202128690A (zh) 2021-08-01
JP2023502458A (ja) 2023-01-24
CA3159376A1 (en) 2021-05-27
EP4063363A1 (en) 2022-09-28
EP4063363A4 (en) 2023-11-29
CN114423760A (zh) 2022-04-29
WO2021098811A1 (zh) 2021-05-27
US20230018728A1 (en) 2023-01-19
AU2020386587A1 (en) 2022-06-02
BR112022008000A2 (pt) 2022-07-12
KR20220103987A (ko) 2022-07-25

Similar Documents

Publication Publication Date Title
MX2022005985A (es) Derivado de pirazolo-heteroarilo, metodo de preparacion y uso medico del mismo.
MX2021007970A (es) Derivado de 6-oxo-1,6-dihidropiridazina, metodo de preparacion del mismo y uso medico del mismo.
MX2016013529A (es) Derivados de amidas y sales farmaceuticamente aceptables de los mismos, método de preparación de los mismos y aplicación médica de los mismos.
MX2019001481A (es) Derivado de oxopicolinamida, metodo de preparacion y uso farmaceutico del mismo.
MX2019003143A (es) Compuesto heterociclico sustituido con alquinilo, su metodo de preparacion y su uso medico.
MX2012012438A (es) Formulaciones farmaceuticas que comprenden pioglitazona y linagliptina.
EA200970611A1 (ru) Замещенные пиразолохиназолиновые производные, способ их получения и их применение в качестве ингибиторов киназы
BR112019006047A2 (pt) compostos, um ou dois ou mais compostos, sal farmaceuticamente aceitável, sal metanossulfonato, inibidor de quinase ret, medicamento, usos do composto e de um composto, métodos para tratar ou prevenir câncer e para tratar ou prevenir câncer em um indivíduo, e, composição farmacêutica
UA104988C2 (uk) Похідні піроніндолу та спосіб їх отримання
MX2021006884A (es) Compuestos y su uso para el tratamiento de la deficiencia de alfa1-antitripsina.
MY163235A (en) Pharmaceutical preparation containing pyridylaminoacetic acid compound
MX2023007853A (es) Compuesto heterociclico puenteado que contiene nitrogeno, metodo de preparacion y uso medico del mismo.
PL2081910T3 (pl) Nowe związki
MX2022015531A (es) Derivado de piridina-pirimidina, metodo de preparacion y uso farmaceutico del mismo.
MX2021009539A (es) Derivado del profarmaco 6-oxo-1,6-dihidropiridazina, metodo de preparacion del mismo y aplicacion del mismo en medicina.
MX2021006724A (es) Compuestos de halo-alilamina y uso de los mismos.
PH12021551057A1 (en) Macrocyclic tyrosine kinase inhibitor and uses thereof
SA519410865B1 (ar) مركب حلقي شبيه بكُومارين بوصفه مثبط mek واستخدامه
CR20220538A (es) Compuestos y composiciones para inhibir la actividad de hif2-alfa y sus métodos de uso
MX2019007213A (es) Derivado de azaciclobutil triazol del grupo anular condensado, metodo de preparacion del mismo y uso del mismo en medicina.
EA202191955A1 (ru) Таблетированные составы с модифицированным высвобождением, содержащие ингибиторы фосфодиэстеразы
MY197442A (en) Novel compounds and their use in the treatment of schistosomiasis
PH12020500436A1 (en) Aromatic derivative, preparation method for same, and medical applications thereof
MX2019007360A (es) Derivado de triazol azabiciclo-sustituido, preparacion, metodo del mismo, y aplicacion de la misma en medicina.
MX2019004822A (es) Derivado del pirazol 3,4-bipiridilo y metodo de preparacion del mismo y aplicacion medica del mismo.