MX2023007853A - Compuesto heterociclico puenteado que contiene nitrogeno, metodo de preparacion y uso medico del mismo. - Google Patents
Compuesto heterociclico puenteado que contiene nitrogeno, metodo de preparacion y uso medico del mismo.Info
- Publication number
- MX2023007853A MX2023007853A MX2023007853A MX2023007853A MX2023007853A MX 2023007853 A MX2023007853 A MX 2023007853A MX 2023007853 A MX2023007853 A MX 2023007853A MX 2023007853 A MX2023007853 A MX 2023007853A MX 2023007853 A MX2023007853 A MX 2023007853A
- Authority
- MX
- Mexico
- Prior art keywords
- nitrogen
- preparation
- method therefor
- heterocyclic compound
- bridged heterocyclic
- Prior art date
Links
- 150000002391 heterocyclic compounds Chemical class 0.000 title abstract 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 3
- 102000003712 Complement factor B Human genes 0.000 abstract 2
- 108090000056 Complement factor B Proteins 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 230000000295 complement effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente invención se refiere a un compuesto heterocíclico puenteado que contiene nitrógeno, un método de preparación del mismo y una aplicación médica del mismo. Específicamente, se describen un compuesto heterocíclico puenteado que contiene nitrógeno representado por la fórmula general (I), un método de preparación para el mismo, una composición farmacéutica que contiene el compuesto y su uso como agente terapéutico, en particular, su uso como inhibidor del factor del sistema del complemento (Factor B) y el uso en la preparación de un fármaco para el tratamiento y/o prevención de enfermedades o trastornos mediados por el factor B. (ver Fórmula).
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202011609415 | 2020-12-30 | ||
CN202110022338 | 2021-01-08 | ||
CN202110679456 | 2021-06-18 | ||
CN202110982108 | 2021-08-25 | ||
PCT/CN2021/142760 WO2022143845A1 (zh) | 2020-12-30 | 2021-12-30 | 含氮桥杂环化合物、其制备方法及其在医药上的应用 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2023007853A true MX2023007853A (es) | 2023-07-07 |
Family
ID=82259056
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2023007853A MX2023007853A (es) | 2020-12-30 | 2021-12-30 | Compuesto heterociclico puenteado que contiene nitrogeno, metodo de preparacion y uso medico del mismo. |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP4273136A1 (es) |
JP (1) | JP2024504870A (es) |
KR (1) | KR20230128039A (es) |
CN (1) | CN116438170A (es) |
AU (1) | AU2021414185A1 (es) |
CA (1) | CA3203320A1 (es) |
MX (1) | MX2023007853A (es) |
TW (1) | TW202229271A (es) |
WO (1) | WO2022143845A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023072197A1 (en) * | 2021-10-27 | 2023-05-04 | Hansoh Bio Llc | Piperidinyl indole derivatives, preparation methods and medicinal uses thereof |
WO2023237041A1 (zh) * | 2022-06-10 | 2023-12-14 | 正大天晴药业集团股份有限公司 | 双环取代的芳香羧酸酯类化合物 |
WO2024002353A1 (zh) * | 2022-06-30 | 2024-01-04 | 江苏恒瑞医药股份有限公司 | 一种含氮桥杂环衍生物的可药用盐、晶型及其制备方法 |
WO2024017299A1 (zh) * | 2022-07-20 | 2024-01-25 | 正大天晴药业集团股份有限公司 | 一种桥杂环取代的苯酸衍生物或其盐的结晶及其制备方法 |
WO2024046277A1 (zh) * | 2022-08-29 | 2024-03-07 | 南京明德新药研发有限公司 | 一系列含氮桥杂环化合物及其制备方法 |
CN115536511B (zh) * | 2022-10-20 | 2023-08-22 | 徐州医科大学 | 1,4-二醛酮化合物、其合成方法及应用 |
WO2024114677A1 (zh) * | 2022-11-29 | 2024-06-06 | 上海济煜医药科技有限公司 | 苯并螺环吲哚化合物的制备、应用及用途 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JO3425B1 (ar) * | 2013-07-15 | 2019-10-20 | Novartis Ag | مشتقات البابيريدينيل-اندول واستخدامها كعامل متمم لمثبطات b |
CN117398384A (zh) * | 2017-08-31 | 2024-01-16 | 诺华股份有限公司 | 哌啶基-吲哚衍生物的用途 |
CN112513025A (zh) | 2018-07-16 | 2021-03-16 | 诺华股份有限公司 | 用于制备苯基哌啶基吲哚衍生物的化学方法 |
AU2021323300A1 (en) * | 2020-08-07 | 2023-04-06 | Shanghai Meiyue Biotech Development Co., Ltd. | Complement factor B inhibitor, and pharmaceutical composition thereof, preparation method therefor and use thereof |
-
2021
- 2021-12-30 EP EP21912340.3A patent/EP4273136A1/en active Pending
- 2021-12-30 MX MX2023007853A patent/MX2023007853A/es unknown
- 2021-12-30 WO PCT/CN2021/142760 patent/WO2022143845A1/zh active Application Filing
- 2021-12-30 KR KR1020237025025A patent/KR20230128039A/ko unknown
- 2021-12-30 JP JP2023564260A patent/JP2024504870A/ja active Pending
- 2021-12-30 CN CN202180072698.6A patent/CN116438170A/zh active Pending
- 2021-12-30 CA CA3203320A patent/CA3203320A1/en active Pending
- 2021-12-30 TW TW110149713A patent/TW202229271A/zh unknown
- 2021-12-30 AU AU2021414185A patent/AU2021414185A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2022143845A1 (zh) | 2022-07-07 |
EP4273136A1 (en) | 2023-11-08 |
CN116438170A (zh) | 2023-07-14 |
TW202229271A (zh) | 2022-08-01 |
CA3203320A1 (en) | 2022-07-07 |
AU2021414185A1 (en) | 2023-08-10 |
KR20230128039A (ko) | 2023-09-01 |
JP2024504870A (ja) | 2024-02-01 |
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