MX367768B - Composiciones que representan un virus de la enfermedad de newcastle atenuado y métodos de uso en el tratamiento de neoplasias. - Google Patents

Composiciones que representan un virus de la enfermedad de newcastle atenuado y métodos de uso en el tratamiento de neoplasias.

Info

Publication number
MX367768B
MX367768B MX2016002771A MX2016002771A MX367768B MX 367768 B MX367768 B MX 367768B MX 2016002771 A MX2016002771 A MX 2016002771A MX 2016002771 A MX2016002771 A MX 2016002771A MX 367768 B MX367768 B MX 367768B
Authority
MX
Mexico
Prior art keywords
methods
disease virus
newcastle disease
treating neoplasia
modified
Prior art date
Application number
MX2016002771A
Other languages
English (en)
Spanish (es)
Other versions
MX2016002771A (es
Inventor
Jin Hong
Cheng Xing
GALINSKI Mark
MCCOURT Matthew
Carroll Danielle
Original Assignee
Medimmune Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medimmune Ltd filed Critical Medimmune Ltd
Publication of MX2016002771A publication Critical patent/MX2016002771A/es
Publication of MX367768B publication Critical patent/MX367768B/es

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    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/76Viruses; Subviral particles; Bacteriophages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/76Viruses; Subviral particles; Bacteriophages
    • A61K35/768Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/155Paramyxoviridae, e.g. parainfluenza virus
    • A61K39/17Newcastle disease virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N2710/16011Herpesviridae
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    • C12N2710/16011Herpesviridae
    • C12N2710/16111Cytomegalovirus, e.g. human herpesvirus 5
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    • C12N2760/18011Paramyxoviridae
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    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/18011Paramyxoviridae
    • C12N2760/18111Avulavirus, e.g. Newcastle disease virus
    • C12N2760/18132Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
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    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/18011Paramyxoviridae
    • C12N2760/18111Avulavirus, e.g. Newcastle disease virus
    • C12N2760/18133Use of viral protein as therapeutic agent other than vaccine, e.g. apoptosis inducing or anti-inflammatory
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    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/18011Paramyxoviridae
    • C12N2760/18111Avulavirus, e.g. Newcastle disease virus
    • C12N2760/18141Use of virus, viral particle or viral elements as a vector
    • C12N2760/18143Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
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  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
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  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
MX2016002771A 2013-09-03 2014-09-02 Composiciones que representan un virus de la enfermedad de newcastle atenuado y métodos de uso en el tratamiento de neoplasias. MX367768B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361873039P 2013-09-03 2013-09-03
PCT/EP2014/068619 WO2015032755A1 (en) 2013-09-03 2014-09-02 Compositions featuring an attenuated newcastle disease virus and methods of use for treating neoplasia

Publications (2)

Publication Number Publication Date
MX2016002771A MX2016002771A (es) 2016-09-06
MX367768B true MX367768B (es) 2019-09-05

Family

ID=51492938

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016002771A MX367768B (es) 2013-09-03 2014-09-02 Composiciones que representan un virus de la enfermedad de newcastle atenuado y métodos de uso en el tratamiento de neoplasias.
MX2019010364A MX2019010364A (es) 2013-09-03 2016-03-02 Composiciones que presentan un virus de la enfermedad de newcastle atenuado y metodos de uso en el tratamiento de neoplasias.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2019010364A MX2019010364A (es) 2013-09-03 2016-03-02 Composiciones que presentan un virus de la enfermedad de newcastle atenuado y metodos de uso en el tratamiento de neoplasias.

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US (2) US10519426B2 (cg-RX-API-DMAC7.html)
EP (3) EP4101457A1 (cg-RX-API-DMAC7.html)
JP (2) JP6557234B2 (cg-RX-API-DMAC7.html)
KR (2) KR102310692B1 (cg-RX-API-DMAC7.html)
CN (2) CN111944767A (cg-RX-API-DMAC7.html)
AU (2) AU2014317215C1 (cg-RX-API-DMAC7.html)
CA (1) CA2922071C (cg-RX-API-DMAC7.html)
CY (2) CY1121993T1 (cg-RX-API-DMAC7.html)
DK (2) DK3041490T3 (cg-RX-API-DMAC7.html)
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ES (2) ES2708755T3 (cg-RX-API-DMAC7.html)
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HR (2) HRP20220653T1 (cg-RX-API-DMAC7.html)
HU (1) HUE042382T2 (cg-RX-API-DMAC7.html)
LT (2) LT3508209T (cg-RX-API-DMAC7.html)
ME (1) ME03345B (cg-RX-API-DMAC7.html)
MX (2) MX367768B (cg-RX-API-DMAC7.html)
PL (2) PL3508209T3 (cg-RX-API-DMAC7.html)
PT (2) PT3041490T (cg-RX-API-DMAC7.html)
RS (2) RS63291B1 (cg-RX-API-DMAC7.html)
SI (2) SI3041490T1 (cg-RX-API-DMAC7.html)
SM (2) SMT201900094T1 (cg-RX-API-DMAC7.html)
TR (1) TR201902073T4 (cg-RX-API-DMAC7.html)
TW (1) TWI653334B (cg-RX-API-DMAC7.html)
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Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA016217B1 (ru) 2005-12-02 2012-03-30 Маунт Синай Скул Оф Медсин Химерные вирусы, представляющие неприродные поверхностные белки, и их применение
EP2987856B1 (en) 2009-02-05 2018-07-25 Icahn School of Medicine at Mount Sinai Chimeric newcastle disease viruses and uses thereof
CA2905272A1 (en) 2013-03-14 2014-10-02 Icahn School Of Medicine At Mount Sinai Newcastle disease viruses and uses thereof
WO2015032755A1 (en) * 2013-09-03 2015-03-12 Medimmune Limited Compositions featuring an attenuated newcastle disease virus and methods of use for treating neoplasia
EP3110443A4 (en) 2014-02-27 2017-11-15 Viralytics Limited Combination method for treatment of cancer
CN107847610B (zh) * 2015-04-28 2022-02-01 塞维卡有限责任公司 基于piv5的扩增病毒样颗粒
CN109415703B (zh) 2016-01-08 2024-08-30 雷普利穆内有限公司 经修饰的溶瘤病毒
EP3246410A1 (en) * 2016-05-19 2017-11-22 Klinikum rechts der Isar der Technischen Universität München Vsv/ndv hybrid viruses for oncolytic therapy of cancer
GB201700350D0 (en) 2017-01-09 2017-02-22 Replimune Ltd Altered virus
KR101964610B1 (ko) * 2017-03-13 2019-04-03 대한민국 신규한 종양용해성 바이러스 및 이의 용도
JOP20190256A1 (ar) 2017-05-12 2019-10-28 Icahn School Med Mount Sinai فيروسات داء نيوكاسل واستخداماتها
CN107254450A (zh) * 2017-07-20 2017-10-17 扬州大学 克服鸡新城疫母源抗体影响的嵌合新城疫病毒疫苗载体候选株及构建方法
CN108486279A (zh) * 2017-09-21 2018-09-04 山东省农业科学院家禽研究所 一种基于荧光定量pcr技术检测鸽新城疫病毒的方法
EP3552608A1 (en) * 2018-04-09 2019-10-16 Rapo Yerape B.H. Ltd Increased activity of oncoloytic newcastle disease virus
CN112739359A (zh) * 2018-07-13 2021-04-30 西奈山伊坎医学院 Apmv及其用于治疗癌症的用途
WO2020037215A1 (en) 2018-08-17 2020-02-20 Icahn School Of Medicine At Mount Sinai Recombinant newcastle disease viruses and uses thereof for the prevention of rsv disease or human metapneumovirus disease
CN110859968A (zh) * 2019-11-21 2020-03-06 四川安可康生物医药有限公司 激活对肿瘤的系统免疫反应的基因生物药物
US20240245805A1 (en) * 2020-03-20 2024-07-25 Orna Therapeutics, Inc. Circular rna compositions and methods
CN115197949A (zh) * 2021-04-13 2022-10-18 江苏康缘瑞翱生物医药科技有限公司 一种重组新城疫病毒rNDV-OX40L、其基因组、制备方法及其用途
CA3161532A1 (en) * 2021-06-03 2022-12-03 University Of Guelph Engineered newcastle disease virus vector and uses thereof
US20240287544A1 (en) * 2023-02-06 2024-08-29 Cyanvac Llc Modified piv5 vaccine vectors: methods of making and uses
WO2025116613A1 (ko) * 2023-11-29 2025-06-05 주식회사 카브 재조합 뉴캣슬병 바이러스 벡터를 포함하는 암 치료용 약제학적 조성물

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7724558B1 (en) * 1999-03-19 2010-05-25 Nec Corporation Magnetic signal transmission line
DE60043547D1 (de) * 1999-09-24 2010-01-28 Mayo Foundation Therapeutische verfahren und zusammensetzungen unter verwendung von viren der rekombinanten familie der paramyxoviridae
KR100801180B1 (ko) * 2006-09-26 2008-02-05 주식회사 고려비엔피 약독화된 재조합 뉴캐슬병 바이러스 및 이를 함유하는뉴캐슬병 백신
EP2085092A1 (en) * 2008-01-29 2009-08-05 Bayer Schering Pharma Aktiengesellschaft Attenuated oncolytic paramyxoviruses encoding avian cytokines
US20090208495A1 (en) 2008-02-14 2009-08-20 Bayer Schering Pharma Ag Anti-tumor effective paramyxovirus
EP2987856B1 (en) * 2009-02-05 2018-07-25 Icahn School of Medicine at Mount Sinai Chimeric newcastle disease viruses and uses thereof
CA2905272A1 (en) * 2013-03-14 2014-10-02 Icahn School Of Medicine At Mount Sinai Newcastle disease viruses and uses thereof
WO2015032755A1 (en) * 2013-09-03 2015-03-12 Medimmune Limited Compositions featuring an attenuated newcastle disease virus and methods of use for treating neoplasia
CN109099045A (zh) * 2018-10-30 2018-12-28 浙江斯泰新材料科技股份有限公司 防松锁固型螺钉

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EA039404B1 (ru) 2022-01-24
US20160208222A1 (en) 2016-07-21
JP2016533749A (ja) 2016-11-04
TR201902073T4 (tr) 2019-03-21
EP3508209B1 (en) 2022-03-09
EA201690425A1 (ru) 2016-08-31
PL3508209T3 (pl) 2022-06-13
EA202191926A2 (ru) 2021-10-29
HK1231393A1 (zh) 2017-12-22
US11471499B2 (en) 2022-10-18
RS63291B1 (sr) 2022-06-30
JP6557234B2 (ja) 2019-08-07
ES2914577T3 (es) 2022-06-14
KR20210048605A (ko) 2021-05-03
HUE042382T2 (hu) 2019-06-28
HRP20190250T1 (hr) 2019-05-31
ES2708755T3 (es) 2019-04-11
CA2922071A1 (en) 2015-03-12
PL3041490T3 (pl) 2019-05-31
CN106163532B (zh) 2019-12-31
JP2019193662A (ja) 2019-11-07
CA2922071C (en) 2022-05-03
SMT202200214T1 (it) 2022-07-21
EA202191926A3 (ru) 2022-01-31
CY1126790T1 (el) 2024-12-13
MX2016002771A (es) 2016-09-06
AU2019204419A1 (en) 2019-07-11
DK3508209T3 (da) 2022-05-30
JP6862500B2 (ja) 2021-04-21
AU2014317215C1 (en) 2019-09-12
LT3508209T (lt) 2022-06-10
HK1225643B (en) 2017-09-15
EP3041490B1 (en) 2018-11-14
CY1121993T1 (el) 2020-10-14
AU2014317215B2 (en) 2019-03-28
PT3041490T (pt) 2019-02-06
SI3041490T1 (sl) 2019-03-29
LT3041490T (lt) 2019-02-25
SI3508209T1 (sl) 2023-01-31
EP4101457A1 (en) 2022-12-14
AU2014317215A1 (en) 2016-04-14
CN111944767A (zh) 2020-11-17
PT3508209T (pt) 2022-05-27
EP3041490A1 (en) 2016-07-13
AU2019204419B2 (en) 2021-09-02
ME03345B (me) 2019-10-20
EP3508209A1 (en) 2019-07-10
KR102285894B1 (ko) 2021-08-04
RS58332B1 (sr) 2019-03-29
US10519426B2 (en) 2019-12-31
TWI653334B (zh) 2019-03-11
CN106163532A (zh) 2016-11-23
KR102310692B1 (ko) 2021-10-12
KR20160047570A (ko) 2016-05-02
WO2015032755A1 (en) 2015-03-12
TW201606079A (zh) 2016-02-16
AU2014317215A8 (en) 2016-04-21
MX2019010364A (es) 2019-10-07
US20200181581A1 (en) 2020-06-11
DK3041490T3 (en) 2019-03-04
SMT201900094T1 (it) 2019-02-28
HRP20220653T1 (hr) 2022-06-24

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