MX357496B - Moduladores del receptor de estrógenos fluorados y sus usos. - Google Patents
Moduladores del receptor de estrógenos fluorados y sus usos.Info
- Publication number
- MX357496B MX357496B MX2014007048A MX2014007048A MX357496B MX 357496 B MX357496 B MX 357496B MX 2014007048 A MX2014007048 A MX 2014007048A MX 2014007048 A MX2014007048 A MX 2014007048A MX 357496 B MX357496 B MX 357496B
- Authority
- MX
- Mexico
- Prior art keywords
- receptor modulators
- estrogen receptor
- fluorinated
- compounds
- estrogen
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Virology (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Addiction (AREA)
- Biotechnology (AREA)
- Gynecology & Obstetrics (AREA)
- Molecular Biology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161570756P | 2011-12-14 | 2011-12-14 | |
| PCT/US2012/069933 WO2013090836A1 (en) | 2011-12-14 | 2012-12-14 | Fluorinated estrogen receptor modulators and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014007048A MX2014007048A (es) | 2015-01-16 |
| MX357496B true MX357496B (es) | 2018-07-11 |
Family
ID=48613247
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014007048A MX357496B (es) | 2011-12-14 | 2012-12-14 | Moduladores del receptor de estrógenos fluorados y sus usos. |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US9187460B2 (enExample) |
| EP (2) | EP2791132A4 (enExample) |
| JP (2) | JP2015500346A (enExample) |
| KR (1) | KR20140101399A (enExample) |
| CN (1) | CN104114551B (enExample) |
| AU (1) | AU2012351942B2 (enExample) |
| BR (1) | BR112014014124A2 (enExample) |
| CA (1) | CA2857057A1 (enExample) |
| EA (1) | EA029559B1 (enExample) |
| HK (1) | HK1198165A1 (enExample) |
| IL (1) | IL232793A (enExample) |
| MX (1) | MX357496B (enExample) |
| PH (1) | PH12014501351B1 (enExample) |
| SG (1) | SG11201403002RA (enExample) |
| WO (2) | WO2013090829A1 (enExample) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3205648A1 (en) | 2010-06-10 | 2017-08-16 | Seragon Pharmaceuticals, Inc. | Estrogen receptor modulators and uses thereof |
| EP2791132A4 (en) | 2011-12-14 | 2015-08-05 | Seragon Pharmaceuticals Inc | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF |
| BR112014014767A2 (pt) | 2011-12-16 | 2017-06-13 | Olema Pharmaceuticals Inc | novos compostos de benzopirano, composições e usos dos mesmos |
| BR112015030595A2 (pt) | 2013-06-19 | 2017-07-25 | Seragon Pharmaceuticals Inc | moduladores de receptor de estrogênio de azetidina e usos dos mesmos |
| EA031077B1 (ru) * | 2013-06-19 | 2018-11-30 | Серагон Фармасьютикалз, Инк. | Модулятор рецептора эстрогена и его применения |
| MA39740A (fr) * | 2014-03-13 | 2017-01-18 | Hoffmann La Roche | Méthodes et compositions pour moduler des mutants du récepteur des oestrogènes |
| SG11201607334YA (en) | 2014-03-13 | 2016-10-28 | Hoffmann La Roche | Therapeutic combinations with estrogen receptor modulators |
| EP3215149A4 (en) | 2014-11-06 | 2018-06-27 | Northwestern University | Inhibition of cancer cell motility |
| TWI784255B (zh) * | 2014-12-18 | 2022-11-21 | 瑞士商赫孚孟拉羅股份公司 | 四氫-吡啶并[3,4-b]吲哚雌激素受體調節劑及其用途 |
| WO2016097071A1 (en) * | 2014-12-18 | 2016-06-23 | F. Hoffmann-La Roche Ag | Estrogen receptor modulators and uses thereof |
| CN107406433A (zh) * | 2014-12-18 | 2017-11-28 | 豪夫迈·罗氏有限公司 | 用于治疗癌症的2,3‑二苯基色烯的衍生物 |
| EA038835B1 (ru) * | 2015-04-02 | 2021-10-27 | Ф. Хоффманн-Ля Рош Аг | ТЕТРАГИДРОПИРИДО[3,4-b]ИНДОЛОВЫЕ МОДУЛЯТОРЫ ЭСТРОГЕНОВЫХ РЕЦЕПТОРОВ И ИХ ПРИМЕНЕНИЕ |
| JP6768711B2 (ja) * | 2015-05-26 | 2020-10-14 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 複素環式エストロゲン受容体モジュレーター及びその使用 |
| WO2017000125A1 (en) * | 2015-06-29 | 2017-01-05 | Merck Sharp & Dohme Corp. | Purine inhibitors of human phosphatidylinositol 3-kinase delta |
| CA2994969A1 (en) | 2015-08-06 | 2017-02-09 | Dana-Farber Cancer Institute, Inc. | Targeted protein degradation to attenuate adoptive t-cell therapy associated adverse inflammatory responses |
| WO2017059139A1 (en) | 2015-10-01 | 2017-04-06 | Olema Pharmaceuticals, Inc. | TETRAHYDRO-1H-PYRIDO[3,4-b]INDOLE ANTI-ESTROGENIC DRUGS |
| US10865199B2 (en) | 2015-10-27 | 2020-12-15 | Sun Pharma Advanced Research Company Limited | Heterocyclic antiestrogens |
| DK3386500T3 (da) | 2015-12-09 | 2022-12-12 | Univ Illinois | Benzothiophen-baserede selektive østrogenreceptor ned-regulatorer |
| CN109362222B (zh) | 2016-02-05 | 2021-03-19 | 益方生物科技(上海)股份有限公司 | 选择性雌激素受体降解物及其用途 |
| KR20220071293A (ko) | 2016-04-01 | 2022-05-31 | 리커리엄 아이피 홀딩스, 엘엘씨 | 에스트로겐 수용체 조절제 |
| TW201803870A (zh) | 2016-04-20 | 2018-02-01 | 阿斯特捷利康公司 | 化學化合物 |
| WO2017197046A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | C3-carbon linked glutarimide degronimers for target protein degradation |
| CN109562107A (zh) | 2016-05-10 | 2019-04-02 | C4医药公司 | 用于靶蛋白降解的杂环降解决定子体 |
| CN109562113A (zh) | 2016-05-10 | 2019-04-02 | C4医药公司 | 用于靶蛋白降解的螺环降解决定子体 |
| CN121974842A (zh) | 2016-05-10 | 2026-05-05 | C4医药公司 | 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体 |
| CN109311876B (zh) | 2016-06-16 | 2022-05-03 | 豪夫迈·罗氏有限公司 | 杂芳基雌激素受体调节剂及其用途 |
| US20180002344A1 (en) | 2016-06-16 | 2018-01-04 | Genentech, Inc. | Heteroaryl estrogen receptor modulators and uses thereof |
| CN109843882A (zh) * | 2016-06-16 | 2019-06-04 | 豪夫迈·罗氏有限公司 | 四氢-吡啶并[3,4-b]吲哚雌激素受体调节剂及其用途 |
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2012
- 2012-12-14 EP EP12857161.9A patent/EP2791132A4/en not_active Withdrawn
- 2012-12-14 HK HK14111641.4A patent/HK1198165A1/xx unknown
- 2012-12-14 KR KR1020147018020A patent/KR20140101399A/ko not_active Ceased
- 2012-12-14 MX MX2014007048A patent/MX357496B/es active IP Right Grant
- 2012-12-14 US US14/364,993 patent/US9187460B2/en active Active
- 2012-12-14 SG SG11201403002RA patent/SG11201403002RA/en unknown
- 2012-12-14 AU AU2012351942A patent/AU2012351942B2/en not_active Ceased
- 2012-12-14 WO PCT/US2012/069926 patent/WO2013090829A1/en not_active Ceased
- 2012-12-14 BR BR112014014124A patent/BR112014014124A2/pt not_active Application Discontinuation
- 2012-12-14 WO PCT/US2012/069933 patent/WO2013090836A1/en not_active Ceased
- 2012-12-14 CA CA2857057A patent/CA2857057A1/en not_active Abandoned
- 2012-12-14 JP JP2014547524A patent/JP2015500346A/ja active Pending
- 2012-12-14 EP EP12857534.7A patent/EP2791133B1/en active Active
- 2012-12-14 JP JP2014547528A patent/JP6112625B2/ja active Active
- 2012-12-14 US US14/364,974 patent/US9193714B2/en active Active
- 2012-12-14 EA EA201491161A patent/EA029559B1/ru not_active IP Right Cessation
- 2012-12-14 CN CN201280069778.7A patent/CN104114551B/zh active Active
-
2014
- 2014-05-26 IL IL232793A patent/IL232793A/en active IP Right Grant
- 2014-06-13 PH PH12014501351A patent/PH12014501351B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2791133A4 (en) | 2015-04-15 |
| SG11201403002RA (en) | 2014-07-30 |
| EP2791133A1 (en) | 2014-10-22 |
| US20150005286A1 (en) | 2015-01-01 |
| CN104114551B (zh) | 2017-01-18 |
| US9193714B2 (en) | 2015-11-24 |
| EP2791133B1 (en) | 2019-04-17 |
| IL232793A0 (en) | 2014-08-03 |
| JP2015500346A (ja) | 2015-01-05 |
| EA201491161A1 (ru) | 2014-11-28 |
| WO2013090836A1 (en) | 2013-06-20 |
| EP2791132A4 (en) | 2015-08-05 |
| US20140364427A1 (en) | 2014-12-11 |
| PH12014501351A1 (en) | 2014-09-22 |
| EP2791132A1 (en) | 2014-10-22 |
| CN104114551A (zh) | 2014-10-22 |
| AU2012351942A1 (en) | 2014-06-12 |
| PH12014501351B1 (en) | 2014-09-22 |
| EA029559B1 (ru) | 2018-04-30 |
| MX2014007048A (es) | 2015-01-16 |
| IL232793A (en) | 2016-09-29 |
| HK1198165A1 (en) | 2015-03-13 |
| JP6112625B2 (ja) | 2017-04-12 |
| WO2013090829A1 (en) | 2013-06-20 |
| BR112014014124A2 (pt) | 2017-08-22 |
| KR20140101399A (ko) | 2014-08-19 |
| AU2012351942B2 (en) | 2017-07-06 |
| JP2015501847A (ja) | 2015-01-19 |
| CA2857057A1 (en) | 2013-06-20 |
| US9187460B2 (en) | 2015-11-17 |
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