AU2012351942B2 - Fluorinated estrogen receptor modulators and uses thereof - Google Patents
Fluorinated estrogen receptor modulators and uses thereof Download PDFInfo
- Publication number
- AU2012351942B2 AU2012351942B2 AU2012351942A AU2012351942A AU2012351942B2 AU 2012351942 B2 AU2012351942 B2 AU 2012351942B2 AU 2012351942 A AU2012351942 A AU 2012351942A AU 2012351942 A AU2012351942 A AU 2012351942A AU 2012351942 B2 AU2012351942 B2 AU 2012351942B2
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- substituted
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- compound
- pharmaceutically acceptable
- cancer
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- C07—ORGANIC CHEMISTRY
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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-
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- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161570756P | 2011-12-14 | 2011-12-14 | |
| US61/570,756 | 2011-12-14 | ||
| PCT/US2012/069933 WO2013090836A1 (en) | 2011-12-14 | 2012-12-14 | Fluorinated estrogen receptor modulators and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2012351942A1 AU2012351942A1 (en) | 2014-06-12 |
| AU2012351942B2 true AU2012351942B2 (en) | 2017-07-06 |
Family
ID=48613247
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2012351942A Ceased AU2012351942B2 (en) | 2011-12-14 | 2012-12-14 | Fluorinated estrogen receptor modulators and uses thereof |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US9193714B2 (enExample) |
| EP (2) | EP2791133B1 (enExample) |
| JP (2) | JP6112625B2 (enExample) |
| KR (1) | KR20140101399A (enExample) |
| CN (1) | CN104114551B (enExample) |
| AU (1) | AU2012351942B2 (enExample) |
| BR (1) | BR112014014124A2 (enExample) |
| CA (1) | CA2857057A1 (enExample) |
| EA (1) | EA029559B1 (enExample) |
| HK (1) | HK1198165A1 (enExample) |
| IL (1) | IL232793A (enExample) |
| MX (1) | MX357496B (enExample) |
| PH (1) | PH12014501351A1 (enExample) |
| SG (1) | SG11201403002RA (enExample) |
| WO (2) | WO2013090829A1 (enExample) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE033581T2 (hu) | 2010-06-10 | 2017-12-28 | Seragon Pharmaceuticals Inc | Ösztrogén receptor modulátorok és alkalmazásaik |
| SG11201403002RA (en) | 2011-12-14 | 2014-07-30 | Seragon Pharmaceuticals Inc | Fluorinated estrogen receptor modulators and uses thereof |
| EP2791128A4 (en) | 2011-12-16 | 2015-04-22 | Olema Pharmaceuticals Inc | NOVEL BENZOPYRAN COMPOUNDS, COMPOSITIONS AND USES THEREOF |
| WO2014205138A1 (en) * | 2013-06-19 | 2014-12-24 | Seragon Pharmaceuticals, Inc. | Estrogen receptor modulator and uses thereof |
| MX2015016171A (es) * | 2013-06-19 | 2016-08-08 | Seragon Pharmaceuticals Inc | Moduladores del receptor de estrogeno de azetidina y usos de los mismos. |
| US9855270B2 (en) * | 2014-03-13 | 2018-01-02 | Genentech, Inc. | Methods and compositions for modulating estrogen receptor mutants |
| AU2015228859A1 (en) | 2014-03-13 | 2016-07-07 | F. Hoffmann-La Roche Ag | Therapeutic combinations with estrogen receptor modulators |
| US9839625B2 (en) | 2014-11-06 | 2017-12-12 | Northwestern University | Inhibition of cancer cell motility |
| JP2017538727A (ja) * | 2014-12-18 | 2017-12-28 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 癌の治療に有用な2,3−ジフェニルクロメンの誘導体 |
| CN117865872A (zh) * | 2014-12-18 | 2024-04-12 | 豪夫迈·罗氏有限公司 | 四氢-吡啶并[3,4-b]吲哚雌激素受体调节剂及其用途 |
| CN107406424B (zh) * | 2014-12-18 | 2020-08-25 | 豪夫迈·罗氏有限公司 | 雌激素受体调节剂及其用途 |
| EA038835B1 (ru) * | 2015-04-02 | 2021-10-27 | Ф. Хоффманн-Ля Рош Аг | ТЕТРАГИДРОПИРИДО[3,4-b]ИНДОЛОВЫЕ МОДУЛЯТОРЫ ЭСТРОГЕНОВЫХ РЕЦЕПТОРОВ И ИХ ПРИМЕНЕНИЕ |
| EP3303326B1 (en) * | 2015-05-26 | 2020-12-16 | H. Hoffnabb-La Roche Ag | Heterocyclic estrogen receptor modulators and uses thereof |
| WO2017000125A1 (en) | 2015-06-29 | 2017-01-05 | Merck Sharp & Dohme Corp. | Purine inhibitors of human phosphatidylinositol 3-kinase delta |
| AU2016301196B2 (en) | 2015-08-06 | 2022-09-08 | Dana-Farber Cancer Institute, Inc. | Tunable endogenous protein degradation |
| DK3355884T3 (da) | 2015-10-01 | 2021-08-02 | Olema Pharmaceuticals Inc | Tetrahydro-1h-pyrido[3,4-b]indol-antiøstrogenlægemidler |
| HRP20220640T1 (hr) | 2015-10-27 | 2022-07-08 | Sun Pharma Advanced Research Company Limited | Novi heterociklični antiestrogeni |
| ES2935125T3 (es) | 2015-12-09 | 2023-03-01 | Univ Illinois | Reguladores a la baja selectivos de los receptores de estrógenos con base en benzotiofeno |
| KR102479822B1 (ko) | 2016-02-05 | 2022-12-21 | 인벤티스바이오 엘엘씨 | 선택적 에스트로겐 수용체 분해제 및 이들의 용도 |
| US20190142811A1 (en) | 2016-04-01 | 2019-05-16 | Zeno Royalties & Milestones, LLC | Estrogen receptor modulators |
| US10125135B2 (en) | 2016-04-20 | 2018-11-13 | Astrazeneca Ab | Chemical compounds |
| EP3455219A4 (en) | 2016-05-10 | 2019-12-18 | C4 Therapeutics, Inc. | AMINE-RELATED C3-GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN REDUCTION |
| CN109641874A (zh) | 2016-05-10 | 2019-04-16 | C4医药公司 | 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体 |
| EP4483875A3 (en) | 2016-05-10 | 2025-04-02 | C4 Therapeutics, Inc. | Spirocyclic degronimers for target protein degradation |
| CN109562107A (zh) | 2016-05-10 | 2019-04-02 | C4医药公司 | 用于靶蛋白降解的杂环降解决定子体 |
| WO2017216279A1 (en) * | 2016-06-16 | 2017-12-21 | F. Hoffmann-La Roche Ag | Heteroaryl estrogen receptor modulators and uses thereof |
| US20180002344A1 (en) | 2016-06-16 | 2018-01-04 | Genentech, Inc. | Heteroaryl estrogen receptor modulators and uses thereof |
| US20170362228A1 (en) * | 2016-06-16 | 2017-12-21 | Genentech, Inc. | TETRAHYDRO-PYRIDO[3,4-b]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF |
| BR112018077136A2 (pt) | 2016-07-01 | 2019-04-30 | G1 Therapeutics, Inc. | composto, e, métodos para tratar um distúrbio associado com proliferação celular anormal e para reduzir o efeito de quimioterapia em células saudáveis. |
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- 2012-12-14 HK HK14111641.4A patent/HK1198165A1/xx unknown
- 2012-12-14 US US14/364,974 patent/US9193714B2/en active Active
- 2012-12-14 AU AU2012351942A patent/AU2012351942B2/en not_active Ceased
- 2012-12-14 US US14/364,993 patent/US9187460B2/en active Active
- 2012-12-14 KR KR1020147018020A patent/KR20140101399A/ko not_active Ceased
- 2012-12-14 EP EP12857161.9A patent/EP2791132A4/en not_active Withdrawn
- 2012-12-14 JP JP2014547524A patent/JP2015500346A/ja active Pending
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2014
- 2014-05-26 IL IL232793A patent/IL232793A/en active IP Right Grant
- 2014-06-13 PH PH12014501351A patent/PH12014501351A1/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001068634A1 (de) * | 2000-03-15 | 2001-09-20 | Schering Aktiengesellschaft | 4-fluoralkyl-2h-benzopyrane mit antiestrogener wirksamkeit |
Also Published As
| Publication number | Publication date |
|---|---|
| EA029559B1 (ru) | 2018-04-30 |
| MX2014007048A (es) | 2015-01-16 |
| PH12014501351B1 (en) | 2014-09-22 |
| IL232793A0 (en) | 2014-08-03 |
| MX357496B (es) | 2018-07-11 |
| EP2791132A4 (en) | 2015-08-05 |
| CN104114551B (zh) | 2017-01-18 |
| PH12014501351A1 (en) | 2014-09-22 |
| AU2012351942A1 (en) | 2014-06-12 |
| JP2015501847A (ja) | 2015-01-19 |
| WO2013090836A1 (en) | 2013-06-20 |
| EP2791133A4 (en) | 2015-04-15 |
| BR112014014124A2 (pt) | 2017-08-22 |
| US20140364427A1 (en) | 2014-12-11 |
| US20150005286A1 (en) | 2015-01-01 |
| SG11201403002RA (en) | 2014-07-30 |
| EP2791133B1 (en) | 2019-04-17 |
| US9187460B2 (en) | 2015-11-17 |
| EA201491161A1 (ru) | 2014-11-28 |
| CN104114551A (zh) | 2014-10-22 |
| HK1198165A1 (en) | 2015-03-13 |
| EP2791133A1 (en) | 2014-10-22 |
| JP6112625B2 (ja) | 2017-04-12 |
| IL232793A (en) | 2016-09-29 |
| US9193714B2 (en) | 2015-11-24 |
| JP2015500346A (ja) | 2015-01-05 |
| WO2013090829A1 (en) | 2013-06-20 |
| CA2857057A1 (en) | 2013-06-20 |
| KR20140101399A (ko) | 2014-08-19 |
| EP2791132A1 (en) | 2014-10-22 |
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| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |