MX352074B - Derivados de 5-bencilaminometil-6-aminopirazolo [3,4-b] piridina como inhibidores de proteina de transferencia de ester de colesterilo (cetp) utiles para el tratamiento de aterosclerosis. - Google Patents
Derivados de 5-bencilaminometil-6-aminopirazolo [3,4-b] piridina como inhibidores de proteina de transferencia de ester de colesterilo (cetp) utiles para el tratamiento de aterosclerosis.Info
- Publication number
- MX352074B MX352074B MX2014003660A MX2014003660A MX352074B MX 352074 B MX352074 B MX 352074B MX 2014003660 A MX2014003660 A MX 2014003660A MX 2014003660 A MX2014003660 A MX 2014003660A MX 352074 B MX352074 B MX 352074B
- Authority
- MX
- Mexico
- Prior art keywords
- cetp
- benzylaminomethyl
- aminopyrazolo
- atherosclerosis
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN3337CH2011 | 2011-09-27 | ||
| US201161558262P | 2011-11-10 | 2011-11-10 | |
| PCT/IB2012/002435 WO2013046045A1 (en) | 2011-09-27 | 2012-09-27 | 5 - benzylaminomethyl - 6 - aminopyrazolo [3, 4 -b] pyridine derivatives as cholesteryl ester -transfer protein (cetp) inhibitors useful for the treatment of atherosclerosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014003660A MX2014003660A (es) | 2014-10-17 |
| MX352074B true MX352074B (es) | 2017-11-08 |
Family
ID=47994351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014003660A MX352074B (es) | 2011-09-27 | 2012-09-27 | Derivados de 5-bencilaminometil-6-aminopirazolo [3,4-b] piridina como inhibidores de proteina de transferencia de ester de colesterilo (cetp) utiles para el tratamiento de aterosclerosis. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9000007B2 (enExample) |
| EP (1) | EP2760864B1 (enExample) |
| JP (1) | JP6140168B2 (enExample) |
| KR (1) | KR101803866B1 (enExample) |
| CN (1) | CN103958511A (enExample) |
| AU (1) | AU2012313971B2 (enExample) |
| CA (1) | CA2850022C (enExample) |
| HK (1) | HK1197238A1 (enExample) |
| IN (1) | IN2014CN02290A (enExample) |
| MX (1) | MX352074B (enExample) |
| WO (1) | WO2013046045A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3081864B2 (ja) | 1996-01-08 | 2000-08-28 | 三井化学株式会社 | 金属製接続部材付き合成樹脂製管継手及びその製造方法 |
| WO2014017569A1 (ja) * | 2012-07-26 | 2014-01-30 | 興和株式会社 | 血中ｌｄｌを低下させるための医薬 |
| JP2015054838A (ja) * | 2013-09-12 | 2015-03-23 | 興和株式会社 | 血中ｌｄｌコレステロールを低下させる医薬 |
| RS57088B1 (sr) * | 2013-12-13 | 2018-06-29 | Daiichi Sankyo Co Ltd | 5-hidroksi-4-(trifluorometil)pirazolopiridin derivat |
| CN109956940A (zh) * | 2019-05-14 | 2019-07-02 | 上海贤鼎生物科技有限公司 | 一种帕博昔布中间体氰基化反应制备杂芳基氰化物的方法 |
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| UA90269C2 (ru) | 2004-04-02 | 2010-04-26 | Мицубиси Танабе Фарма Корпорейшн | Тетрагидрохинолиновые производные и способ их получения |
| JP4922924B2 (ja) | 2004-04-13 | 2012-04-25 | メルク・シャープ・エンド・ドーム・コーポレイション | Ｃｅｔｐ阻害薬 |
| US20090239865A1 (en) | 2004-11-23 | 2009-09-24 | George Chang | Dibenzyl amine compounds and derivatives |
| US8604055B2 (en) * | 2004-12-31 | 2013-12-10 | Dr. Reddy's Laboratories Ltd. | Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors |
| MX2007007919A (es) * | 2004-12-31 | 2008-01-22 | Reddy Us Therapeutics Inc | Nuevos derivados de bencilaminas como inhibidores de la proteina de transferencia de colesteril-ester(cetp). |
| EP1893178A1 (en) | 2005-05-31 | 2008-03-05 | Pfizer Products Incorporated | PHARMACEUTICAL COMPOSITIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS AND HMG-CoA REDUCTASE INHIBITORS |
| EP1981342B1 (en) * | 2005-12-28 | 2016-11-30 | Dr. Reddy's Laboratories Ltd. | Selective benzylamine derivatives and their utility as cholesterol ester-transfer protein inhibitors |
| PE20071025A1 (es) * | 2006-01-31 | 2007-10-17 | Mitsubishi Tanabe Pharma Corp | Compuesto amina trisustituido |
| KR101418267B1 (ko) | 2006-02-09 | 2014-07-11 | 머크 샤프 앤드 돔 코포레이션 | Ｃｅｔｐ 억제제의 중합체 제형 |
| EP2024356A1 (en) | 2006-05-10 | 2009-02-18 | Novartis AG | Bicyclic derivatives as cetp inhibitors |
| US7790737B2 (en) * | 2007-03-13 | 2010-09-07 | Kowa Company, Ltd. | Substituted pyrimidine compounds and their utility as CETP inhibitors |
| JP4834699B2 (ja) * | 2007-07-30 | 2011-12-14 | 田辺三菱製薬株式会社 | 医薬組成物 |
| CN101418397A (zh) * | 2008-12-02 | 2009-04-29 | 西北有色金属研究院 | 一种TiB2强化的MgAlB14超硬材料的制备方法 |
-
2012
- 2012-09-27 KR KR1020147009133A patent/KR101803866B1/ko not_active Expired - Fee Related
- 2012-09-27 AU AU2012313971A patent/AU2012313971B2/en not_active Ceased
- 2012-09-27 IN IN2290CHN2014 patent/IN2014CN02290A/en unknown
- 2012-09-27 JP JP2014532500A patent/JP6140168B2/ja not_active Expired - Fee Related
- 2012-09-27 WO PCT/IB2012/002435 patent/WO2013046045A1/en not_active Ceased
- 2012-09-27 EP EP12816102.3A patent/EP2760864B1/en not_active Not-in-force
- 2012-09-27 CA CA2850022A patent/CA2850022C/en not_active Expired - Fee Related
- 2012-09-27 CN CN201280057987.XA patent/CN103958511A/zh active Pending
- 2012-09-27 US US14/347,519 patent/US9000007B2/en not_active Expired - Fee Related
- 2012-09-27 HK HK14110754.9A patent/HK1197238A1/xx unknown
- 2012-09-27 MX MX2014003660A patent/MX352074B/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| JP6140168B2 (ja) | 2017-05-31 |
| US9000007B2 (en) | 2015-04-07 |
| WO2013046045A1 (en) | 2013-04-04 |
| HK1197238A1 (en) | 2015-01-09 |
| JP2014527997A (ja) | 2014-10-23 |
| EP2760864A1 (en) | 2014-08-06 |
| KR101803866B1 (ko) | 2017-12-04 |
| MX2014003660A (es) | 2014-10-17 |
| AU2012313971B2 (en) | 2016-09-29 |
| AU2012313971A1 (en) | 2014-05-01 |
| AU2012313971A8 (en) | 2014-06-19 |
| NZ622698A (en) | 2016-09-30 |
| US20140288072A1 (en) | 2014-09-25 |
| CA2850022C (en) | 2018-05-01 |
| KR20140082689A (ko) | 2014-07-02 |
| EP2760864B1 (en) | 2018-01-24 |
| IN2014CN02290A (enExample) | 2015-06-19 |
| CA2850022A1 (en) | 2013-04-04 |
| CN103958511A (zh) | 2014-07-30 |
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