MX349711B - Método óptico para la detección de la enfermedad de alzheimer. - Google Patents

Método óptico para la detección de la enfermedad de alzheimer.

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Publication number
MX349711B
MX349711B MX2011002930A MX2011002930A MX349711B MX 349711 B MX349711 B MX 349711B MX 2011002930 A MX2011002930 A MX 2011002930A MX 2011002930 A MX2011002930 A MX 2011002930A MX 349711 B MX349711 B MX 349711B
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MX
Mexico
Prior art keywords
alzheimer
disease
subject matter
present subject
detection
Prior art date
Application number
MX2011002930A
Other languages
English (en)
Other versions
MX2011002930A (es
Inventor
Yosef Koronyo
Maya Koronyo
Keith L Black
Michal Schwartz
Daniel L Farkas
Original Assignee
Cedars Sinai Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cedars Sinai Medical Center filed Critical Cedars Sinai Medical Center
Publication of MX2011002930A publication Critical patent/MX2011002930A/es
Publication of MX349711B publication Critical patent/MX349711B/es

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    • A—HUMAN NECESSITIES
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    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
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    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
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Abstract

El presente tema se relaciona con un método de formación de imágenes óptico no invasivo para monitorizar episodios temprano patológicos específicos para la enfermedad de Alzheimer (AD), como el desarrollo, cantidad y ubicación de placas amiloides. La capacidad de monitorizar los episodios proporciona una base, entre otras cosas, para terapias potenciales de diagnóstico, pronóstico y evaluación de AD. Además, el presente tema introduce novedosos métodos para tratar la AD y dolencias retinales asociadas con AD. La detección de placas Aß en cerebros vivos es sumamente limitada, sobre todo a una alta resolución; por lo tanto, la presente invención se basa en estudios que se concentran en los ojos como una alternativa al tejido derivado del cerebro que puede ser procesado gráficamente, directamente, reiterativamente y no invasivamente.
MX2011002930A 2008-09-18 2009-09-18 Método óptico para la detección de la enfermedad de alzheimer. MX349711B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9820608P 2008-09-18 2008-09-18
PCT/US2009/057569 WO2010033861A1 (en) 2008-09-18 2009-09-18 Optical method for the detection of alzheimer's disease

Publications (2)

Publication Number Publication Date
MX2011002930A MX2011002930A (es) 2011-10-11
MX349711B true MX349711B (es) 2017-08-09

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MX2011002930A MX349711B (es) 2008-09-18 2009-09-18 Método óptico para la detección de la enfermedad de alzheimer.

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US (2) US9839699B2 (es)
EP (1) EP2323696B1 (es)
JP (4) JP5771525B2 (es)
KR (2) KR101679438B1 (es)
CN (1) CN102186504B (es)
CA (1) CA2735869C (es)
DK (1) DK2323696T3 (es)
ES (1) ES2694278T3 (es)
IL (1) IL211540A (es)
MX (1) MX349711B (es)
PT (1) PT2323696T (es)
TR (1) TR201816335T4 (es)
WO (1) WO2010033861A1 (es)

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UA81216C2 (en) * 1999-06-01 2007-12-25 Prevention and treatment of amyloid disease
MY139983A (en) 2002-03-12 2009-11-30 Janssen Alzheimer Immunotherap Humanized antibodies that recognize beta amyloid peptide
JP2008523815A (ja) 2004-12-15 2008-07-10 エラン ファーマ インターナショナル リミテッド 認知の改善における使用のためのヒト化アミロイドβ抗体
US8784810B2 (en) 2006-04-18 2014-07-22 Janssen Alzheimer Immunotherapy Treatment of amyloidogenic diseases
DK2182983T3 (da) 2007-07-27 2014-07-14 Janssen Alzheimer Immunotherap Behandling af amyloidogene sygdomme med humaniserede anti-abeta antistoffer
JO3076B1 (ar) 2007-10-17 2017-03-15 Janssen Alzheimer Immunotherap نظم العلاج المناعي المعتمد على حالة apoe
KR101679438B1 (ko) * 2008-09-18 2016-11-24 세다르스-신나이 메디칼 센터 알츠하이머병의 검출을 위한 광학적 방법
US9067981B1 (en) 2008-10-30 2015-06-30 Janssen Sciences Ireland Uc Hybrid amyloid-beta antibodies
ES2351454A1 (es) * 2009-07-23 2011-02-04 Universidad Complutense De Madrid Kit y metodo de detección pre mortem de la enfermedad de alzheimer in vitro.
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