MX347982B - Morfolina-piperidina espirociclica-amidas como moduladores de canales ionicos. - Google Patents
Morfolina-piperidina espirociclica-amidas como moduladores de canales ionicos.Info
- Publication number
- MX347982B MX347982B MX2013010476A MX2013010476A MX347982B MX 347982 B MX347982 B MX 347982B MX 2013010476 A MX2013010476 A MX 2013010476A MX 2013010476 A MX2013010476 A MX 2013010476A MX 347982 B MX347982 B MX 347982B
- Authority
- MX
- Mexico
- Prior art keywords
- morpholine
- ion channels
- modulators
- spirocyclic piperidine
- piperidine amides
- Prior art date
Links
- 102000004310 Ion Channels Human genes 0.000 title abstract 2
- -1 piperidine amides Chemical class 0.000 title 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 1
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- JSPCTNUQYWIIOT-UHFFFAOYSA-N piperidine-1-carboxamide Chemical class NC(=O)N1CCCCC1 JSPCTNUQYWIIOT-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
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Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Psychology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161452538P | 2011-03-14 | 2011-03-14 | |
| US201161567809P | 2011-12-07 | 2011-12-07 | |
| PCT/US2012/028882 WO2012125613A1 (en) | 2011-03-14 | 2012-03-13 | Morpholine-spirocyclic piperidine amides as modulators of ion channels |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2013010476A MX2013010476A (es) | 2013-10-30 |
| MX347982B true MX347982B (es) | 2017-05-22 |
Family
ID=45888492
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013010476A MX347982B (es) | 2011-03-14 | 2012-03-13 | Morfolina-piperidina espirociclica-amidas como moduladores de canales ionicos. |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US8828996B2 (OSRAM) |
| EP (1) | EP2686325B1 (OSRAM) |
| JP (1) | JP6088443B2 (OSRAM) |
| CN (1) | CN103517910B (OSRAM) |
| AU (1) | AU2012229187B2 (OSRAM) |
| CA (1) | CA2829803A1 (OSRAM) |
| ES (1) | ES2618929T3 (OSRAM) |
| MX (1) | MX347982B (OSRAM) |
| WO (1) | WO2012125613A1 (OSRAM) |
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|---|---|---|---|---|
| HUE028983T2 (en) | 2010-05-06 | 2017-01-30 | Vertex Pharma | Heterocyclic chromene-spirocyclic piperidine amides as ion channel modulators |
| JP6021824B2 (ja) | 2011-02-02 | 2016-11-09 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | イオンチャネルのモジュレーターとしてのピロロピラジン−スピロ環式ピペリジンアミド |
| WO2012112743A1 (en) | 2011-02-18 | 2012-08-23 | Vertex Pharmaceuticals Incorporated | Chroman - spirocyclic piperidine amides as modulators of ion channels |
| EP2804868B1 (en) * | 2012-01-16 | 2017-04-12 | Vertex Pharmaceuticals Incorporated | Pyran-spirocyclic piperidine amides as modulators of ion channels |
| CN108164457B (zh) | 2013-01-31 | 2021-07-09 | 沃泰克斯药物股份有限公司 | 作为钠通道调节剂的吡啶酮酰胺 |
| AU2014212426B8 (en) | 2013-01-31 | 2018-05-10 | Vertex Pharmaceuticals Incorporated | Quinoline and Quinoxaline Amides as Modulators of Sodium Channels |
| CA2918365C (en) | 2013-07-19 | 2021-09-07 | Vertex Pharmaceuticals Incorporated | Sulfonamides as modulators of sodium channels |
| EP3626717A1 (en) | 2013-10-14 | 2020-03-25 | Eisai R&D Management Co., Ltd. | Selectively substituted quinoline compounds |
| US9663486B2 (en) | 2013-10-14 | 2017-05-30 | Eisai R&D Management Co., Ltd. | Selectively substituted quinoline compounds |
| ES2986650T3 (es) | 2013-12-13 | 2024-11-12 | Vertex Pharma | Proceso y productos intermedios para preparar profármacos de amidas de piridona útiles como moduladores de los canales de sodio |
| TWI685497B (zh) * | 2014-06-02 | 2020-02-21 | 西班牙商伊史帝夫製藥公司 | 具有多重模式抗疼痛活性的１-氧雜-４,９-二氮雜螺十一烷化合物之烷基衍生物 |
| TW201615642A (zh) | 2014-06-02 | 2016-05-01 | 伊史帝夫博士實驗室股份有限公司 | 具有多重模式抗疼痛活性的１－氧雜－４，９－二氮雜螺十一烷化合物之醯胺衍生物 |
| TW201615643A (zh) | 2014-06-02 | 2016-05-01 | 伊史帝夫博士實驗室股份有限公司 | 具有多重模式抗疼痛活性之１－氧雜－４，９－二氮雜螺十一烷化合物之烷基與芳基衍生物 |
| MX375424B (es) | 2015-07-31 | 2025-03-06 | Pfizer | Derivados de 1,1,1-trifluoro-3-hidroxipropan-2-il carbamato y derivados de 1,1,1-trifluoro-4- hidroxibutan-2-il carbamato como inhibidores de magl |
| CN108349998B (zh) * | 2015-10-23 | 2021-10-29 | 埃斯蒂文制药股份有限公司 | 具有抗疼痛活性的氧杂-二氮杂螺环化合物 |
| WO2017067663A1 (en) * | 2015-10-23 | 2017-04-27 | Laboratorios Del Dr. Esteve, S.A. | Oxa-azaspiro compounds having activity against pain |
| AR106445A1 (es) * | 2015-10-23 | 2018-01-17 | Esteve Labor Dr | Derivados de morfolina sustituida que tienen actividad contra el dolor |
| US10927128B2 (en) | 2015-11-16 | 2021-02-23 | Esteve Pharmaceuticals. S.A. | Oxadiazaspiro compounds for the treatment of drug abuse and addiction |
| WO2017160933A1 (en) * | 2016-03-17 | 2017-09-21 | Fmc Corporation | Process for converting s-enantiomer to its racemic form |
| MX2019008626A (es) | 2017-01-20 | 2019-09-19 | Pfizer | Derivados de 1,1,1-trifluoro-3-hidroxipropan-2-ilcarbamato como inhibidores de monoacilglicerol lipasa (magl). |
| SG11201906427QA (en) | 2017-01-23 | 2019-08-27 | Pfizer | Heterocyclic spiro compounds as magl inhibitors |
| ES2927712T3 (es) | 2017-05-16 | 2022-11-10 | Vertex Pharma | Amidas deuteradas de piridona y profármacos de las mismas como moduladores de canales de sodio |
| ES3008911T3 (en) | 2017-07-11 | 2025-03-25 | Vertex Pharma | Carboxamides as modulators of sodium channels |
| US11236110B2 (en) | 2017-10-17 | 2022-02-01 | Esteve Pharmaceuticals, S.A. | Salts of (R)-9-(2,5-difluorophenethyl)-4-ethyl-2-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one |
| TW202002971A (zh) | 2018-02-12 | 2020-01-16 | 美商維泰克斯製藥公司 | 治療疼痛的方法 |
| US12234221B2 (en) | 2018-07-09 | 2025-02-25 | Lieber Institute, Inc. | Pyridine carboxamide compounds for inhibiting NAV1.8 |
| CA3105748A1 (en) | 2018-07-09 | 2020-01-16 | Lieber Institute, Inc. | Pyridazine compounds for inhibiting nav1.8 |
| WO2020146612A1 (en) | 2019-01-10 | 2020-07-16 | Vertex Pharmaceuticals Incorporated | Esters and carbamates as modulators of sodium channels |
| US12441703B2 (en) | 2019-01-10 | 2025-10-14 | Vertex Pharmaceuticals Incorporated | Carboxamides as modulators of sodium channels |
| WO2020176763A1 (en) | 2019-02-27 | 2020-09-03 | Vertex Pharmaceuticals Incorporated | Dosage form comprising prodrug of na 1.8 sodium channel inhibitor |
| WO2020219867A1 (en) | 2019-04-25 | 2020-10-29 | Vertex Pharmaceuticals Incorporated | Pyridone amide co-crystal compositions for the treatment of pain |
| CN110452183B (zh) * | 2019-09-04 | 2023-03-14 | 中国科学院上海有机化学研究所 | 一种手性杂环化合物的制备方法 |
| PT4069691T (pt) | 2019-12-06 | 2024-12-18 | Vertex Pharma | Tetrahidrofuranos substituídos como moduladores dos canais de sódio |
| US20230089247A1 (en) * | 2019-12-24 | 2023-03-23 | Zydus Lifesciences Limited | Novel compounds suitable for the treatment of dyslipidemia |
| CN113278021B (zh) * | 2021-05-29 | 2022-09-23 | 天津全和诚科技有限责任公司 | 1,7-二氮杂螺[3.5]壬烷-7-甲酸叔丁酯及其草酸盐的制备方法 |
| WO2022256702A1 (en) | 2021-06-04 | 2022-12-08 | Vertex Pharmaceuticals Incorporated | Substituted tetrahydrofuran-2-carboxamides as modulators of sodium channels |
| AU2022286438A1 (en) | 2021-06-04 | 2023-11-30 | Vertex Pharmaceuticals Incorporated | N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamide analogs as modulators of sodium channels |
| CA3221938A1 (en) | 2021-06-04 | 2022-12-08 | Vertex Pharmaceuticals Incorporated | Substituted tetrahydrofuran analogs as modulators of sodium channels |
| CN117858875A (zh) | 2021-06-04 | 2024-04-09 | 沃泰克斯药物股份有限公司 | 羟基和(卤代)烷氧基取代的四氢呋喃作为钠通道调节剂 |
| GEAP202416430A (en) | 2021-06-04 | 2024-03-25 | Vertex Pharma | N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels |
| EP4346818B1 (en) | 2021-06-04 | 2025-12-03 | Vertex Pharmaceuticals Incorporated | Solid dosage forms and dosing regimens comprising (2r,3s,4s,5r)-4-[[3-(3,4-difluoro-2-methoxy-phenyl)-4,5-dimethyl-5-(trifluoromethyl) tetrahydrofuran-2-carbonyl]amino]pyridine-2-carboxamide |
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| JP2025513454A (ja) | 2022-04-22 | 2025-04-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | 疼痛の治療のためのヘテロアリール化合物 |
| WO2023205778A1 (en) | 2022-04-22 | 2023-10-26 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| CN119677737A (zh) | 2022-04-22 | 2025-03-21 | 沃泰克斯药物股份有限公司 | 用于治疗疼痛的杂芳基化合物 |
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| TW202523313A (zh) | 2023-10-23 | 2025-06-16 | 美商維泰克斯製藥公司 | 用於治療疼痛之雜芳基化合物 |
| WO2025090511A1 (en) | 2023-10-23 | 2025-05-01 | Vertex Pharmaceuticals Incorporated | Methods of preparing modulators of sodium channels and solid forms of the same for treating pain |
| WO2025090516A1 (en) | 2023-10-23 | 2025-05-01 | Vertex Pharmaceuticals Incorporated | Methods of preparing compounds for treating pain and solid forms thereof |
| US20250186419A1 (en) | 2023-12-07 | 2025-06-12 | Vertex Pharmaceuticals Incorporated | Dosing regimens for treating pain |
Family Cites Families (65)
| Publication number | Priority date | Publication date | Assignee | Title |
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2012
- 2012-03-13 MX MX2013010476A patent/MX347982B/es active IP Right Grant
- 2012-03-13 AU AU2012229187A patent/AU2012229187B2/en not_active Ceased
- 2012-03-13 JP JP2013558104A patent/JP6088443B2/ja not_active Expired - Fee Related
- 2012-03-13 US US13/418,737 patent/US8828996B2/en active Active
- 2012-03-13 EP EP12710841.3A patent/EP2686325B1/en active Active
- 2012-03-13 CN CN201280018832.5A patent/CN103517910B/zh not_active Expired - Fee Related
- 2012-03-13 CA CA2829803A patent/CA2829803A1/en not_active Abandoned
- 2012-03-13 WO PCT/US2012/028882 patent/WO2012125613A1/en not_active Ceased
- 2012-03-13 ES ES12710841.3T patent/ES2618929T3/es active Active
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2014
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Also Published As
| Publication number | Publication date |
|---|---|
| EP2686325B1 (en) | 2016-12-14 |
| WO2012125613A1 (en) | 2012-09-20 |
| US9181273B2 (en) | 2015-11-10 |
| US8828996B2 (en) | 2014-09-09 |
| CA2829803A1 (en) | 2012-09-20 |
| AU2012229187B2 (en) | 2016-11-10 |
| JP6088443B2 (ja) | 2017-03-01 |
| US20150025073A1 (en) | 2015-01-22 |
| ES2618929T3 (es) | 2017-06-22 |
| US20120264749A1 (en) | 2012-10-18 |
| CN103517910B (zh) | 2016-12-14 |
| CN103517910A (zh) | 2014-01-15 |
| AU2012229187A1 (en) | 2013-09-19 |
| EP2686325A1 (en) | 2014-01-22 |
| NZ615014A (en) | 2016-08-26 |
| MX2013010476A (es) | 2013-10-30 |
| JP2014508169A (ja) | 2014-04-03 |
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