MX375424B - Derivados de 1,1,1-trifluoro-3-hidroxipropan-2-il carbamato y derivados de 1,1,1-trifluoro-4- hidroxibutan-2-il carbamato como inhibidores de magl - Google Patents

Derivados de 1,1,1-trifluoro-3-hidroxipropan-2-il carbamato y derivados de 1,1,1-trifluoro-4- hidroxibutan-2-il carbamato como inhibidores de magl

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Publication number
MX375424B
MX375424B MX2018000929A MX2018000929A MX375424B MX 375424 B MX375424 B MX 375424B MX 2018000929 A MX2018000929 A MX 2018000929A MX 2018000929 A MX2018000929 A MX 2018000929A MX 375424 B MX375424 B MX 375424B
Authority
MX
Mexico
Prior art keywords
trifluoro
carbamate derivatives
hydroxybutan
hydroxypropan
magl inhibitors
Prior art date
Application number
MX2018000929A
Other languages
English (en)
Other versions
MX2018000929A (es
Inventor
Adam Matthew Gilbert
Bruce Nelsen Rogers
Christopher John Helal
Christopher Ryan Butler
Damien Webb
Douglas Scott Johnson
Elizabeth Mary Beck
Justin Ian Montgomery
Laura Ann Mcallister
Michael Aaron Brodney
Patrick Robert Verhoest
Steven Victor O'neil
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MX2018000929A publication Critical patent/MX2018000929A/es
Publication of MX375424B publication Critical patent/MX375424B/es

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Abstract

La presente invención proporciona, en parte, compuestos de la fórmula I: (ver fórmula I) y sus sales farmacéuticamente aceptables; procesos para su preparación; intermediarios usados en su preparación; y composiciones que contienen tales compuestos o sales y sus usos para tratar enfermedades y trastornos mediados por MAGL que incluye, por ejemplo, dolor, un trastorno inflamatorio, depresión, ansiedad, enfermedad de Alzheimer, un trastorno metabólico, ACV o cáncer.
MX2018000929A 2015-07-31 2016-07-18 Derivados de 1,1,1-trifluoro-3-hidroxipropan-2-il carbamato y derivados de 1,1,1-trifluoro-4- hidroxibutan-2-il carbamato como inhibidores de magl MX375424B (es)

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US201562199330P 2015-07-31 2015-07-31
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PCT/IB2016/054266 WO2017021805A1 (en) 2015-07-31 2016-07-18 1,1,1-trifluoro-3-hydroxypropan-2-yl carbamate derivatives and 1,1,1-trifluoro-4-hydroxybutan-2-yl carbamate derivatives as magl inhibitors

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KR20180021860A (ko) 2018-03-05
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KR102096349B1 (ko) 2020-04-02
EP3328849B1 (en) 2020-09-09
DK3328849T5 (da) 2021-02-15
EP3328849B9 (en) 2021-01-06
PH12018500087A1 (en) 2018-07-09
UA121775C2 (uk) 2020-07-27
US20180065943A1 (en) 2018-03-08
DOP2018000031A (es) 2018-07-15
EA201800064A1 (ru) 2018-09-28
IL257203A (en) 2018-03-29
SV2017005591A (es) 2018-04-11
US10723711B2 (en) 2020-07-28
MX2018000929A (es) 2018-05-22
HK1249101A1 (zh) 2018-10-26
GEAP201914688A (en) 2019-11-25
TWI616436B (zh) 2018-03-01
ZA201708144B (en) 2019-05-29
IL257203B (en) 2020-08-31
CA2937210A1 (en) 2017-01-31
BR112018000041A2 (pt) 2018-09-04
AU2016304408B2 (en) 2019-02-21
JP6832914B2 (ja) 2021-02-24
PE20180694A1 (es) 2018-04-23
TN2017000544A1 (en) 2019-04-12
AU2016304408A1 (en) 2018-01-04
ECSP18006893A (es) 2018-04-30
US10428034B2 (en) 2019-10-01
TW201718493A (zh) 2017-06-01
WO2017021805A1 (en) 2017-02-09
CL2018000024A1 (es) 2018-07-13
US20190382359A1 (en) 2019-12-19
US9845301B2 (en) 2017-12-19
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US20170029390A1 (en) 2017-02-02
DK3328849T3 (da) 2020-09-21
EA035823B1 (ru) 2020-08-17
CN107849017B (zh) 2021-03-30
ES2823049T3 (es) 2021-05-05
CU20170166A7 (es) 2018-03-13
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