MX341417B - Metodo para preparar 2-amino-n-(2,2,2-trifluoroetil) acetamida. - Google Patents

Metodo para preparar 2-amino-n-(2,2,2-trifluoroetil) acetamida.

Info

Publication number
MX341417B
MX341417B MX2013003462A MX2013003462A MX341417B MX 341417 B MX341417 B MX 341417B MX 2013003462 A MX2013003462 A MX 2013003462A MX 2013003462 A MX2013003462 A MX 2013003462A MX 341417 B MX341417 B MX 341417B
Authority
MX
Mexico
Prior art keywords
formula
compound
preparing
trifluoroethyl
amino
Prior art date
Application number
MX2013003462A
Other languages
English (en)
Other versions
MX2013003462A (es
Inventor
Bruening Joerg
Original Assignee
E I Du Pont De Nemours And Company *
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by E I Du Pont De Nemours And Company * filed Critical E I Du Pont De Nemours And Company *
Publication of MX2013003462A publication Critical patent/MX2013003462A/es
Publication of MX341417B publication Critical patent/MX341417B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Se describen métodos para preparar compuestos de Fórmulas 1 y 1A. El primer método usa un grupo protector de carbamato de bencilo de amina y un intermedio de Fórmula 4. El segundo método usa un grupo protector de terc-butilo carbamato de amina y un intermedio de Fórmula 7. El tercer método usa un grupo protector de dibencilo de amina. Además, se describe un compuesto, carbamato de fenilmetil N-[2-oxo-2-[(2,2,2 - trifluoroetilo)amino]etil] (un compuesto de Fórmula 4) . Además, se describe un método para preparar un compuesto de Fórmula 14 a partir de un compuesto de Fórmula 15 y un compuesto de Fórmulas 1 o 1A.
MX2013003462A 2010-09-27 2011-09-23 Metodo para preparar 2-amino-n-(2,2,2-trifluoroetil) acetamida. MX341417B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38667310P 2010-09-27 2010-09-27
PCT/US2011/052938 WO2012047543A1 (en) 2010-09-27 2011-09-23 Method for preparing 2-amino-n-(2,2,2-trifluoroethyl) acetamide

Publications (2)

Publication Number Publication Date
MX2013003462A MX2013003462A (es) 2013-05-28
MX341417B true MX341417B (es) 2016-08-19

Family

ID=44741725

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2013003462A MX341417B (es) 2010-09-27 2011-09-23 Metodo para preparar 2-amino-n-(2,2,2-trifluoroetil) acetamida.
MX2016009204A MX346782B (es) 2010-09-27 2011-09-23 Método para preparar 2-amino-n- (2,2,2-trifluoroetil) acetamida.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2016009204A MX346782B (es) 2010-09-27 2011-09-23 Método para preparar 2-amino-n- (2,2,2-trifluoroetil) acetamida.

Country Status (20)

Country Link
US (4) US10202332B2 (es)
EP (2) EP3150575B1 (es)
JP (2) JP5859010B2 (es)
KR (1) KR101901466B1 (es)
CN (1) CN103124721B (es)
AR (3) AR083105A1 (es)
AU (3) AU2011312599B2 (es)
BR (3) BR122018074319B8 (es)
CA (4) CA2812718C (es)
ES (2) ES2962793T3 (es)
IL (3) IL225147A (es)
LT (2) LT2621894T (es)
MX (2) MX341417B (es)
MY (1) MY161570A (es)
PT (2) PT2621894T (es)
RU (1) RU2581841C2 (es)
TW (3) TWI591046B (es)
UA (1) UA113615C2 (es)
WO (1) WO2012047543A1 (es)
ZA (1) ZA201301830B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014028758A (ja) 2010-11-19 2014-02-13 Nissan Chem Ind Ltd 寄生虫及び衛生害虫防除剤
WO2020222158A1 (en) * 2019-04-30 2020-11-05 Hikal Limited Process for the preparation of 2-amino-n-(2,2,2-trifluoroethyl)-acetamide and salts thereof
CN114057594A (zh) * 2020-07-31 2022-02-18 广东东阳光药业有限公司 2-氨基-n-(2,2,2-三氟乙基)乙酰胺或其盐的制备方法
CN115710185B (zh) * 2021-08-23 2024-05-03 中国石油化工股份有限公司 利用金属碳化物催化剂生产甲胺的方法
CN114414678B (zh) * 2021-12-27 2023-05-30 丽珠集团新北江制药股份有限公司 一种异噁唑啉类兽药中间体铵盐有关杂质的分析方法
WO2023145372A1 (ja) * 2022-01-28 2023-08-03 日本曹達株式会社 アミド化合物の製造方法
CN115536541A (zh) * 2022-10-13 2022-12-30 湖北美天生物科技股份有限公司 氟雷拉纳和阿福拉纳共同中间体的合成方法
CN116903488B (zh) * 2022-11-25 2023-12-15 济南久隆医药科技有限公司 一种阿福拉纳的合成方法
CN115772091B (zh) * 2023-01-05 2023-06-23 济南久隆医药科技有限公司 一种2-氨基-n-(2,2,2-三氟乙基)乙酰胺的合成方法
CN116143652B (zh) * 2023-01-13 2024-06-28 四川青木制药有限公司 一种阿福拉纳中间体及其制备方法和应用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4484001A (en) * 1983-11-18 1984-11-20 Ppg Industries, Inc. Method for preparing N-benzyloxycarbonyl amino acids containing additional functionality
EP0221019B1 (en) * 1985-10-14 1994-01-05 Nippon Zoki Pharmaceutical Co. Ltd. Peptides
US5952497A (en) * 1996-07-10 1999-09-14 University Of Georgia Research Foundation N.sup.α -Bpoc amino acid pentafluorophenyl (Pfp) esters and 3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl (ODhbt) esters
JP2979139B2 (ja) * 1998-03-11 1999-11-15 東北大学長 Ｌ−パラボロノフェニルアラニンの製造方法
US6472415B1 (en) * 1998-12-18 2002-10-29 Biophysica, Inc. Androgen receptor suppressors in the therapy and diagnosis of prostate cancer, alopecia and other hyper-androgenic syndromes
US7297712B2 (en) * 2002-03-27 2007-11-20 Council Of Scientific And Industrial Research Cationic amphiphiles for intracellular delivery of therapeutic molecules and its composition, process and method of treatment
US20040077618A1 (en) * 2002-10-22 2004-04-22 Bennani Youssef L. Cycloalkylamides and their therapeutic applications
US8017151B2 (en) * 2004-09-07 2011-09-13 Board Of Regents Of The University Of Nebraska By And Behalf Of The University Of Nebraska Medical Center Amphiphilic polymer-protein conjugates and methods of use thereof
TW200643015A (en) * 2005-03-11 2006-12-16 Akzo Nobel Nv 2-(4-oxo-4H-quinazolin-3-yl)acetamide derivatives
WO2007016609A2 (en) * 2005-08-02 2007-02-08 Smithkline Beecham Corporation Method for the synthesis of quinoliνe derivatives
EP1801086A1 (en) * 2005-11-25 2007-06-27 Synthacon GmbH Synthesis of carbon acid amides
WO2008123207A1 (ja) * 2007-03-26 2008-10-16 Astellas Pharma Inc. オルニチン誘導体
TWI649303B (zh) 2007-08-17 2019-02-01 杜邦股份有限公司 製備４-乙醯基-ｎ-〔２-側氧基-２-〔（２，２，２-三氟乙基）胺基〕乙基〕-１-萘甲醯胺之化合物及方法
GB2453770A (en) * 2007-10-19 2009-04-22 Reckitt Benckiser Healthcare Oral composition comprising a cooling agent
JP5403205B2 (ja) * 2007-10-29 2014-01-29 日産化学工業株式会社 ２−アミノ−ｎ−（２，２，２−トリフルオロエチル）アセトアミド化合物又はその塩の製造方法
TWI518076B (zh) * 2008-04-09 2016-01-21 杜邦股份有限公司 製備雜環化合物之方法
EP2308857B1 (en) * 2008-07-09 2016-04-27 Nissan Chemical Industries, Ltd. Process for production of isoxazoline-substituted benzoic acid amide compound
NZ593135A (en) * 2008-12-19 2013-04-26 Novartis Ag Isoxazoline derivatives and their use as pesticide
EA201100980A1 (ru) * 2008-12-23 2012-01-30 Басф Се Замещенные амидиновые соединения для подавления животных-вредителей
WO2011037947A1 (en) * 2009-09-24 2011-03-31 Sanofi-Aventis U.S. Llc Synthesis of (4-fluoro-3-piperidin-4-yl-benzyl)-carbamic acid tert-butyl ester and intermediates thereof

Also Published As

Publication number Publication date
RU2581841C2 (ru) 2016-04-20
CA2812718A1 (en) 2012-04-12
TW201623220A (zh) 2016-07-01
AU2018201421A1 (en) 2018-03-22
KR20130099121A (ko) 2013-09-05
RU2013119617A (ru) 2014-11-10
BR112013007040B8 (pt) 2022-11-08
LT3150575T (lt) 2023-12-27
IL250489B (en) 2019-12-31
KR101901466B1 (ko) 2018-09-21
BR122018074319B1 (pt) 2020-02-27
US10745344B2 (en) 2020-08-18
US20130267729A1 (en) 2013-10-10
TWI535685B (zh) 2016-06-01
PT3150575T (pt) 2023-11-13
EP3150575A1 (en) 2017-04-05
CA3021290A1 (en) 2012-04-12
IL225147A (en) 2017-04-30
IL250489A0 (en) 2017-03-30
BR112013007040A2 (pt) 2016-06-14
US20190144374A1 (en) 2019-05-16
WO2012047543A1 (en) 2012-04-12
TWI591046B (zh) 2017-07-11
AU2016202641A1 (en) 2016-05-19
CA3197676A1 (en) 2012-04-12
EP2621894B1 (en) 2016-11-16
JP2016117720A (ja) 2016-06-30
MX2013003462A (es) 2013-05-28
PT2621894T (pt) 2017-01-04
CN103124721B (zh) 2015-06-03
ZA201301830B (en) 2014-04-28
CA3021290C (en) 2021-05-25
TW201720792A (zh) 2017-06-16
ES2962793T3 (es) 2024-03-21
BR112013007040B1 (pt) 2019-04-02
AU2016202641B2 (en) 2017-11-30
EP3150575B1 (en) 2023-08-09
AU2018201421B2 (en) 2019-05-02
CA3111132A1 (en) 2012-04-12
TW201213281A (en) 2012-04-01
IL270711A (en) 2020-01-30
JP2013537914A (ja) 2013-10-07
AR114921A2 (es) 2020-10-28
AU2011312599B2 (en) 2016-02-25
JP5859010B2 (ja) 2016-02-10
AR083105A1 (es) 2013-01-30
BR122018074319B8 (pt) 2022-12-06
AR114920A2 (es) 2020-10-28
BR122018074306B1 (pt) 2020-02-27
ES2614812T3 (es) 2017-06-02
AU2011312599A1 (en) 2013-03-28
US20190144373A1 (en) 2019-05-16
LT2621894T (lt) 2017-01-25
US20230303482A1 (en) 2023-09-28
CN103124721A (zh) 2013-05-29
CA3111132C (en) 2023-06-20
EP2621894A1 (en) 2013-08-07
JP6175122B2 (ja) 2017-08-02
IL270711B (en) 2021-09-30
CA2812718C (en) 2018-11-27
US11613516B2 (en) 2023-03-28
US10202332B2 (en) 2019-02-12
UA113615C2 (xx) 2017-02-27
MX346782B (es) 2017-03-31
BR122018074306B8 (pt) 2022-12-06
MY161570A (en) 2017-04-28

Similar Documents

Publication Publication Date Title
MY161570A (en) Method for preparing 2-amino-n-(2,2,2-trifluoroethyl)acetamide
IL185108A0 (en) Processes for preparing cinacalcet hydrochloride crystal form i
TN2010000148A1 (en) Amide compound
TW200609215A (en) Organic compounds
ATE405603T1 (de) Hochfunktionelle, hochverzweigte polyharnstoffe
DK1888604T3 (da) Fremgangsmåde til fremstilling af (alfa-s, beta-r)-6-brom-alfa-[2-(dimethylamino)ethyl]-2-mehtoxy-alfa-1-naphthalenyl-beta-phenyl-3-quinolinethsnol
ATE412688T1 (de) Hochfunktionelle, hochverzweigte polyharnstoffe
TW200635913A (en) Process for preparing pharmaceutically acceptable salts of duloxetine and intermediates thereof
MY151986A (en) Adamantyl diamide derivatives and uses of same
UA108378C2 (uk) Спосіб одержання плеуромутилінів
NZ610378A (en) Lipoyl compounds and their use for treating ischemic injury
WO2010128516A3 (en) Process for the preparation of flibanserin involving novel intermediates
JO2413B1 (en) Benzoxazine derivatives and their use
BR112013001721A2 (pt) processo de síntese de compostos de ureia substituída
WO2015049645A3 (en) An improved process for the preparation of dasatinib
IN2015DN02424A (es)
WO2012176218A8 (en) Process for preparing rosuvastatin calcium through novel amine salt
TW200719889A (en) Amino acid derivatives
NZ707115A (en) Processes for the synthesis of 2-amino-4,6-dimethoxybenzamide and other benzamide compounds
NO20074259L (no) Fremgangsmate for fremstilling av substituerte benzoksazolforbindelser
MY198008A (en) Crystal of benzofuran derivative free base and preparation method
ZA200800138B (en) Process for the preparation of crystalline perindopril
MX2013004881A (es) Proceso para la preparacion de n-(bencil)ciclopropanaminas sustituidas mediante hidrogenacion de iminas.
WO2006122072A3 (en) Processes for preparing biaryl ureas and analogs thereof
WO2010114909A8 (en) Sulfonyl-piperidin-4-yl methylamine amide analogs as glyt1 inhibitors, methods for making same, and use of same in treating psychiatric disorders

Legal Events

Date Code Title Description
FG Grant or registration