BR122018074306B8 - Método para preparar um composto de fórmula 1a - Google Patents
Método para preparar um composto de fórmula 1aInfo
- Publication number
- BR122018074306B8 BR122018074306B8 BR122018074306A BR122018074306A BR122018074306B8 BR 122018074306 B8 BR122018074306 B8 BR 122018074306B8 BR 122018074306 A BR122018074306 A BR 122018074306A BR 122018074306 A BR122018074306 A BR 122018074306A BR 122018074306 B8 BR122018074306 B8 BR 122018074306B8
- Authority
- BR
- Brazil
- Prior art keywords
- formula
- preparing
- compound
- protecting group
- amine protecting
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
A presente invenção refere-se ao método para preparação de composto de fórmula 1A. O método utiliza um grupo que protege amina de carbamato de terc-butila e um intermediário de fórmula 7. O segundo método utiliza um grupo que protege amina de dibenzila.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38667310P | 2010-09-27 | 2010-09-27 | |
| US61/386,673 | 2010-09-27 | ||
| BR112013007040A BR112013007040B8 (pt) | 2010-09-27 | 2011-09-23 | Método para preparar um composto de fórmula 1 |
| PCT/US2011/052938 WO2012047543A1 (en) | 2010-09-27 | 2011-09-23 | Method for preparing 2-amino-n-(2,2,2-trifluoroethyl) acetamide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR122018074306B1 BR122018074306B1 (pt) | 2020-02-27 |
| BR122018074306B8 true BR122018074306B8 (pt) | 2022-12-06 |
Family
ID=44741725
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR122018074319A BR122018074319B8 (pt) | 2010-09-27 | 2011-09-23 | Método para preparar um composto de fórmula 14 |
| BR112013007040A BR112013007040B8 (pt) | 2010-09-27 | 2011-09-23 | Método para preparar um composto de fórmula 1 |
| BR122018074306A BR122018074306B8 (pt) | 2010-09-27 | 2011-09-23 | Método para preparar um composto de fórmula 1a |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR122018074319A BR122018074319B8 (pt) | 2010-09-27 | 2011-09-23 | Método para preparar um composto de fórmula 14 |
| BR112013007040A BR112013007040B8 (pt) | 2010-09-27 | 2011-09-23 | Método para preparar um composto de fórmula 1 |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US10202332B2 (pt) |
| EP (2) | EP3150575B1 (pt) |
| JP (2) | JP5859010B2 (pt) |
| KR (1) | KR101901466B1 (pt) |
| CN (1) | CN103124721B (pt) |
| AR (3) | AR083105A1 (pt) |
| AU (3) | AU2011312599B2 (pt) |
| BR (3) | BR122018074319B8 (pt) |
| CA (4) | CA2812718C (pt) |
| ES (2) | ES2962793T3 (pt) |
| IL (3) | IL225147A (pt) |
| LT (2) | LT2621894T (pt) |
| MX (2) | MX341417B (pt) |
| MY (1) | MY161570A (pt) |
| PT (2) | PT2621894T (pt) |
| RU (1) | RU2581841C2 (pt) |
| TW (3) | TWI591046B (pt) |
| UA (1) | UA113615C2 (pt) |
| WO (1) | WO2012047543A1 (pt) |
| ZA (1) | ZA201301830B (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014028758A (ja) | 2010-11-19 | 2014-02-13 | Nissan Chem Ind Ltd | 寄生虫及び衛生害虫防除剤 |
| WO2020222158A1 (en) * | 2019-04-30 | 2020-11-05 | Hikal Limited | Process for the preparation of 2-amino-n-(2,2,2-trifluoroethyl)-acetamide and salts thereof |
| CN114057594A (zh) * | 2020-07-31 | 2022-02-18 | 广东东阳光药业有限公司 | 2-氨基-n-(2,2,2-三氟乙基)乙酰胺或其盐的制备方法 |
| CN115710185B (zh) * | 2021-08-23 | 2024-05-03 | 中国石油化工股份有限公司 | 利用金属碳化物催化剂生产甲胺的方法 |
| CN114414678B (zh) * | 2021-12-27 | 2023-05-30 | 丽珠集团新北江制药股份有限公司 | 一种异噁唑啉类兽药中间体铵盐有关杂质的分析方法 |
| WO2023145372A1 (ja) * | 2022-01-28 | 2023-08-03 | 日本曹達株式会社 | アミド化合物の製造方法 |
| CN115536541A (zh) * | 2022-10-13 | 2022-12-30 | 湖北美天生物科技股份有限公司 | 氟雷拉纳和阿福拉纳共同中间体的合成方法 |
| CN116903488B (zh) * | 2022-11-25 | 2023-12-15 | 济南久隆医药科技有限公司 | 一种阿福拉纳的合成方法 |
| CN115772091B (zh) * | 2023-01-05 | 2023-06-23 | 济南久隆医药科技有限公司 | 一种2-氨基-n-(2,2,2-三氟乙基)乙酰胺的合成方法 |
| CN116143652B (zh) * | 2023-01-13 | 2024-06-28 | 四川青木制药有限公司 | 一种阿福拉纳中间体及其制备方法和应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4484001A (en) * | 1983-11-18 | 1984-11-20 | Ppg Industries, Inc. | Method for preparing N-benzyloxycarbonyl amino acids containing additional functionality |
| EP0221019B1 (en) * | 1985-10-14 | 1994-01-05 | Nippon Zoki Pharmaceutical Co. Ltd. | Peptides |
| US5952497A (en) * | 1996-07-10 | 1999-09-14 | University Of Georgia Research Foundation | N.sup.α -Bpoc amino acid pentafluorophenyl (Pfp) esters and 3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl (ODhbt) esters |
| JP2979139B2 (ja) * | 1998-03-11 | 1999-11-15 | 東北大学長 | Ｌ−パラボロノフェニルアラニンの製造方法 |
| US6472415B1 (en) * | 1998-12-18 | 2002-10-29 | Biophysica, Inc. | Androgen receptor suppressors in the therapy and diagnosis of prostate cancer, alopecia and other hyper-androgenic syndromes |
| US7297712B2 (en) * | 2002-03-27 | 2007-11-20 | Council Of Scientific And Industrial Research | Cationic amphiphiles for intracellular delivery of therapeutic molecules and its composition, process and method of treatment |
| US20040077618A1 (en) * | 2002-10-22 | 2004-04-22 | Bennani Youssef L. | Cycloalkylamides and their therapeutic applications |
| US8017151B2 (en) * | 2004-09-07 | 2011-09-13 | Board Of Regents Of The University Of Nebraska By And Behalf Of The University Of Nebraska Medical Center | Amphiphilic polymer-protein conjugates and methods of use thereof |
| TW200643015A (en) * | 2005-03-11 | 2006-12-16 | Akzo Nobel Nv | 2-(4-oxo-4H-quinazolin-3-yl)acetamide derivatives |
| WO2007016609A2 (en) * | 2005-08-02 | 2007-02-08 | Smithkline Beecham Corporation | Method for the synthesis of quinoliνe derivatives |
| EP1801086A1 (en) * | 2005-11-25 | 2007-06-27 | Synthacon GmbH | Synthesis of carbon acid amides |
| WO2008123207A1 (ja) * | 2007-03-26 | 2008-10-16 | Astellas Pharma Inc. | オルニチン誘導体 |
| TWI649303B (zh) | 2007-08-17 | 2019-02-01 | 杜邦股份有限公司 | 製備４-乙醯基-ｎ-〔２-側氧基-２-〔（２，２，２-三氟乙基）胺基〕乙基〕-１-萘甲醯胺之化合物及方法 |
| GB2453770A (en) * | 2007-10-19 | 2009-04-22 | Reckitt Benckiser Healthcare | Oral composition comprising a cooling agent |
| JP5403205B2 (ja) * | 2007-10-29 | 2014-01-29 | 日産化学工業株式会社 | ２−アミノ−ｎ−（２，２，２−トリフルオロエチル）アセトアミド化合物又はその塩の製造方法 |
| TWI518076B (zh) * | 2008-04-09 | 2016-01-21 | 杜邦股份有限公司 | 製備雜環化合物之方法 |
| EP2308857B1 (en) * | 2008-07-09 | 2016-04-27 | Nissan Chemical Industries, Ltd. | Process for production of isoxazoline-substituted benzoic acid amide compound |
| NZ593135A (en) * | 2008-12-19 | 2013-04-26 | Novartis Ag | Isoxazoline derivatives and their use as pesticide |
| EA201100980A1 (ru) * | 2008-12-23 | 2012-01-30 | Басф Се | Замещенные амидиновые соединения для подавления животных-вредителей |
| WO2011037947A1 (en) * | 2009-09-24 | 2011-03-31 | Sanofi-Aventis U.S. Llc | Synthesis of (4-fluoro-3-piperidin-4-yl-benzyl)-carbamic acid tert-butyl ester and intermediates thereof |
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2011
- 2011-09-23 CA CA2812718A patent/CA2812718C/en active Active
- 2011-09-23 MY MYPI2013000791A patent/MY161570A/en unknown
- 2011-09-23 PT PT117646505T patent/PT2621894T/pt unknown
- 2011-09-23 AU AU2011312599A patent/AU2011312599B2/en active Active
- 2011-09-23 LT LTEP11764650.5T patent/LT2621894T/lt unknown
- 2011-09-23 MX MX2013003462A patent/MX341417B/es active IP Right Grant
- 2011-09-23 BR BR122018074319A patent/BR122018074319B8/pt active IP Right Grant
- 2011-09-23 EP EP16197213.8A patent/EP3150575B1/en active Active
- 2011-09-23 RU RU2013119617/04A patent/RU2581841C2/ru active
- 2011-09-23 EP EP11764650.5A patent/EP2621894B1/en active Active
- 2011-09-23 US US13/824,309 patent/US10202332B2/en active Active
- 2011-09-23 CA CA3197676A patent/CA3197676A1/en active Pending
- 2011-09-23 CA CA3111132A patent/CA3111132C/en active Active
- 2011-09-23 LT LTEP16197213.8T patent/LT3150575T/lt unknown
- 2011-09-23 BR BR112013007040A patent/BR112013007040B8/pt active IP Right Grant
- 2011-09-23 BR BR122018074306A patent/BR122018074306B8/pt active IP Right Grant
- 2011-09-23 PT PT161972138T patent/PT3150575T/pt unknown
- 2011-09-23 ES ES16197213T patent/ES2962793T3/es active Active
- 2011-09-23 JP JP2013530349A patent/JP5859010B2/ja active Active
- 2011-09-23 UA UAA201303036A patent/UA113615C2/uk unknown
- 2011-09-23 KR KR1020137010835A patent/KR101901466B1/ko active IP Right Grant
- 2011-09-23 CA CA3021290A patent/CA3021290C/en active Active
- 2011-09-23 ES ES11764650.5T patent/ES2614812T3/es active Active
- 2011-09-23 MX MX2016009204A patent/MX346782B/es unknown
- 2011-09-23 WO PCT/US2011/052938 patent/WO2012047543A1/en active Application Filing
- 2011-09-23 CN CN201180046293.1A patent/CN103124721B/zh active Active
- 2011-09-26 TW TW105105614A patent/TWI591046B/zh active
- 2011-09-26 TW TW106104243A patent/TW201720792A/zh unknown
- 2011-09-26 TW TW100134656A patent/TWI535685B/zh active
- 2011-09-26 AR ARP110103504A patent/AR083105A1/es active IP Right Grant
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2013
- 2013-03-10 IL IL225147A patent/IL225147A/en active IP Right Grant
- 2013-03-11 ZA ZA2013/01830A patent/ZA201301830B/en unknown
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2015
- 2015-12-11 JP JP2015241840A patent/JP6175122B2/ja active Active
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2016
- 2016-04-26 AU AU2016202641A patent/AU2016202641B2/en active Active
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2017
- 2017-02-07 IL IL250489A patent/IL250489B/en active IP Right Grant
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2018
- 2018-02-27 AU AU2018201421A patent/AU2018201421B2/en active Active
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2019
- 2019-01-14 US US16/247,063 patent/US11613516B2/en active Active
- 2019-01-14 US US16/246,837 patent/US10745344B2/en active Active
- 2019-06-06 AR ARP190101555A patent/AR114920A2/es unknown
- 2019-06-06 AR ARP190101556A patent/AR114921A2/es active IP Right Grant
- 2019-11-17 IL IL270711A patent/IL270711B/en unknown
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2023
- 2023-03-24 US US18/126,225 patent/US20230303482A1/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 23/09/2011, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B25A | Requested transfer of rights approved |
Owner name: CORTEVA AGRISCIENCE LLC (US) |