MX338024B - Derivado de dibencilamina opticamente activa y metodo para prepararla. - Google Patents

Derivado de dibencilamina opticamente activa y metodo para prepararla.

Info

Publication number
MX338024B
MX338024B MX2012014149A MX2012014149A MX338024B MX 338024 B MX338024 B MX 338024B MX 2012014149 A MX2012014149 A MX 2012014149A MX 2012014149 A MX2012014149 A MX 2012014149A MX 338024 B MX338024 B MX 338024B
Authority
MX
Mexico
Prior art keywords
manufacturing
same
optically active
derivative
dibenzylamine derivative
Prior art date
Application number
MX2012014149A
Other languages
English (en)
Other versions
MX2012014149A (es
Inventor
Tadaaki Ohgiya
Koichi Yamazaki
Katsutoshi Miyosawa
Takeshi Murakami
Kimiyuki Shibuya
Taichi Kusakabe
Original Assignee
Kowa Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Co filed Critical Kowa Co
Publication of MX2012014149A publication Critical patent/MX2012014149A/es
Publication of MX338024B publication Critical patent/MX338024B/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

El ácido (S)-trans-{4-[({2-[({1-[3,5-bis (trifluorometil) fenil] etil}{5-[2-(metilsulfonil)etoxi]pirimidin-2-il}amino)metil]-4-(tr ifluorometil)fenil} (etil)amino)metil]ciclohexil}acético sustancialmente ópticamente puro, o una sal de él o un solvato de él, que tiene acciones de reducción de la cantidad de proteína PCSK9 y aumento de la cantidad del receptor de LDL.
MX2012014149A 2010-06-04 2011-06-03 Derivado de dibencilamina opticamente activa y metodo para prepararla. MX338024B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2010128585 2010-06-04
JP2010218299 2010-09-29
PCT/JP2011/062751 WO2011152508A1 (ja) 2010-06-04 2011-06-03 光学活性ジベンジルアミン誘導体及びその製造方法

Publications (2)

Publication Number Publication Date
MX2012014149A MX2012014149A (es) 2013-02-27
MX338024B true MX338024B (es) 2016-03-31

Family

ID=45066863

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012014149A MX338024B (es) 2010-06-04 2011-06-03 Derivado de dibencilamina opticamente activa y metodo para prepararla.

Country Status (17)

Country Link
US (1) US8906895B2 (es)
EP (1) EP2578574B1 (es)
JP (1) JP5555320B2 (es)
KR (2) KR20130111512A (es)
CN (2) CN102933559B (es)
AU (1) AU2011259929B2 (es)
BR (1) BR112012030787A2 (es)
CA (1) CA2801417C (es)
EA (1) EA024241B1 (es)
ES (1) ES2581557T3 (es)
IL (1) IL223377A (es)
IN (1) IN2012CN10925A (es)
MX (1) MX338024B (es)
PT (1) PT2578574E (es)
TW (1) TWI492749B (es)
WO (1) WO2011152508A1 (es)
ZA (1) ZA201209372B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5793143B2 (ja) * 2010-07-22 2015-10-14 興和株式会社 光学活性１−ブロモ−１−［３，５−ビス（トリフルオロメチル）フェニル］エタンの製造方法
EP2626351A4 (en) * 2010-10-04 2014-03-12 Kowa Co MEANS FOR INHIBITING THE EXPRESSION OF MRNA INVOLVED IN THE FAT REPLACEMENT
US20140303198A1 (en) * 2011-11-29 2014-10-09 Kowa Company, Ltd. Agent for inhibiting expression of npc1l1 and/or lipg mrna and agent for preventing and/or treating obesity
TW201335109A (zh) * 2011-12-02 2013-09-01 Kowa Co 光學活性化合物之製造方法
WO2013137371A1 (ja) * 2012-03-15 2013-09-19 興和株式会社 新規ピリミジン化合物及びそれらを含有する医薬
US9255154B2 (en) 2012-05-08 2016-02-09 Alderbio Holdings, Llc Anti-PCSK9 antibodies and use thereof
JP2016516804A (ja) 2013-04-17 2016-06-09 ファイザー・インク 心血管疾患を治療するためのｎ−ピペリジン−３−イルベンズアミド誘導体
KR20160014620A (ko) 2013-05-31 2016-02-11 코와 가부시키가이샤 디벤질아민 구조를 갖는 피리미딘 화합물의 신규 형태
US10034892B2 (en) * 2014-08-21 2018-07-31 Srx Cardio, Llc Composition and methods of use of small molecules as binding ligands for the modulation of proprotein convertase subtilisin/kexin type 9(PCSK9) protein activity
TWI691331B (zh) * 2014-09-26 2020-04-21 日商興和股份有限公司 脂質異常症治療劑
WO2016084950A1 (ja) * 2014-11-28 2016-06-02 興和株式会社 医薬組成物
JPWO2016084949A1 (ja) * 2014-11-28 2017-09-07 興和株式会社 医薬
JP2019131472A (ja) * 2016-05-31 2019-08-08 興和株式会社 医薬組成物
HRP20241674T1 (hr) 2019-01-18 2025-02-14 Astrazeneca Ab 6'-[[(1s,3s)-3-[[5-(difluormetoksi)-2-pirimidinil]amino]ciklopentil]amino][1(2h),3'-bipiridin]-2-on kao inhibitor pcsk9 i postupci njegove upotrebe
MX2021008661A (es) 2019-01-18 2021-08-19 Astrazeneca Ab Inhibidores de la pcsk9 y metodos de uso de los mismos.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5189208A (en) 1991-07-01 1993-02-23 Ethyl Corporation Ibuprofen resolution
EA017321B1 (ru) 2007-04-13 2012-11-30 Кова Компани, Лтд. Производные n,n-дибензил-2-аминопиримидина и лекарственные средства, их содержащие
US8673850B2 (en) * 2008-05-30 2014-03-18 Institut De Recherches Cliniques De Montreal PCSK9 inhibitors and methods of use thereof
EP2626351A4 (en) 2010-10-04 2014-03-12 Kowa Co MEANS FOR INHIBITING THE EXPRESSION OF MRNA INVOLVED IN THE FAT REPLACEMENT

Also Published As

Publication number Publication date
IL223377A (en) 2016-12-29
BR112012030787A2 (pt) 2020-09-01
WO2011152508A1 (ja) 2011-12-08
KR20170078865A (ko) 2017-07-07
US20130225814A1 (en) 2013-08-29
TWI492749B (zh) 2015-07-21
EP2578574A1 (en) 2013-04-10
CN104529910A (zh) 2015-04-22
PT2578574E (pt) 2016-06-17
ES2581557T3 (es) 2016-09-06
IN2012CN10925A (es) 2015-04-24
HK1179959A1 (en) 2013-10-11
CN102933559B (zh) 2016-01-27
IL223377A0 (en) 2013-03-05
ZA201209372B (en) 2014-02-26
KR20130111512A (ko) 2013-10-10
TW201208688A (en) 2012-03-01
JP5555320B2 (ja) 2014-07-23
US8906895B2 (en) 2014-12-09
CN104529910B (zh) 2017-05-10
EA201291447A1 (ru) 2013-05-30
JPWO2011152508A1 (ja) 2013-08-01
EP2578574B1 (en) 2016-04-27
CA2801417A1 (en) 2011-12-08
EA024241B1 (ru) 2016-08-31
CN102933559A (zh) 2013-02-13
AU2011259929A1 (en) 2013-01-17
MX2012014149A (es) 2013-02-27
EP2578574A4 (en) 2013-12-04
AU2011259929B2 (en) 2014-07-31
CA2801417C (en) 2017-07-11

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