EA201291447A1 - Оптически активное производное дибензиламина и способ его получения - Google Patents

Оптически активное производное дибензиламина и способ его получения

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Publication number
EA201291447A1
EA201291447A1 EA201291447A EA201291447A EA201291447A1 EA 201291447 A1 EA201291447 A1 EA 201291447A1 EA 201291447 A EA201291447 A EA 201291447A EA 201291447 A EA201291447 A EA 201291447A EA 201291447 A1 EA201291447 A1 EA 201291447A1
Authority
EA
Eurasian Patent Office
Prior art keywords
dibenzylamine
obtaining
optically active
active derivative
trifluoromethyl
Prior art date
Application number
EA201291447A
Other languages
English (en)
Other versions
EA024241B1 (ru
Inventor
Тадааки Охгия
Такеси Мураками
Кацутоси Мисава
Кимиюки Сибуя
Коити Ямадзаки
Таити Кусакабе
Original Assignee
Кова Компани, Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Кова Компани, Лтд. filed Critical Кова Компани, Лтд.
Publication of EA201291447A1 publication Critical patent/EA201291447A1/ru
Publication of EA024241B1 publication Critical patent/EA024241B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
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    • A61P3/06—Antihyperlipidemics
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    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

По существу, оптически чистая (S)-транс-{4-[({2-[({1-[3,5-бис(трифторметил)фенил]этил}{5-[2-(метилсульфонил)этокси]пиримидин-2-ил}амино)метил]-4-(трифторметил)фенил}(этил)амино)метил]циклогексил}уксусная кислота, или ее соль, или ее сольват, которая обладает воздействиями в отношении снижения количества РСSK9-белка и повышения количества LDL-рецептора.
EA201291447A 2010-06-04 2011-06-03 Оптически активное производное дибензиламина и способ его получения EA024241B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2010128585 2010-06-04
JP2010218299 2010-09-29
PCT/JP2011/062751 WO2011152508A1 (ja) 2010-06-04 2011-06-03 光学活性ジベンジルアミン誘導体及びその製造方法

Publications (2)

Publication Number Publication Date
EA201291447A1 true EA201291447A1 (ru) 2013-05-30
EA024241B1 EA024241B1 (ru) 2016-08-31

Family

ID=45066863

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201291447A EA024241B1 (ru) 2010-06-04 2011-06-03 Оптически активное производное дибензиламина и способ его получения

Country Status (18)

Country Link
US (1) US8906895B2 (ru)
EP (1) EP2578574B1 (ru)
JP (1) JP5555320B2 (ru)
KR (2) KR20130111512A (ru)
CN (2) CN104529910B (ru)
AU (1) AU2011259929B2 (ru)
BR (1) BR112012030787A2 (ru)
CA (1) CA2801417C (ru)
EA (1) EA024241B1 (ru)
ES (1) ES2581557T3 (ru)
HK (1) HK1179959A1 (ru)
IL (1) IL223377A (ru)
IN (1) IN2012CN10925A (ru)
MX (1) MX338024B (ru)
PT (1) PT2578574E (ru)
TW (1) TWI492749B (ru)
WO (1) WO2011152508A1 (ru)
ZA (1) ZA201209372B (ru)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9272966B2 (en) 2010-07-22 2016-03-01 Kowa Company, Ltd. Method for preparing optically active 1-bromo-1[3,5-bis(trifluoromethyl)phenyl]ethane
EP2626351A4 (en) * 2010-10-04 2014-03-12 Kowa Co AGENT CAPABLE OF INHIBITING THE EXPRESSION OF LIPID METABOLISM-RELATED MRNA
WO2013080999A1 (ja) * 2011-11-29 2013-06-06 興和株式会社 ＮＰＣ１Ｌ１及び／又はＬＩＰＧ ｍＲＮＡの発現抑制剤並びに肥満症の予防及び／又は治療剤
JPWO2013081087A1 (ja) * 2011-12-02 2015-04-27 興和株式会社 光学活性化合物の製造方法
JPWO2013137371A1 (ja) * 2012-03-15 2015-08-03 興和株式会社 新規ピリミジン化合物及びそれらを含有する医薬
US9255154B2 (en) 2012-05-08 2016-02-09 Alderbio Holdings, Llc Anti-PCSK9 antibodies and use thereof
BR112015026513A2 (pt) 2013-04-17 2017-07-25 Pfizer derivados de n-piperidin-3-ilbenzamida para tratar as doenças cardiovasculares
TW201512175A (zh) 2013-05-31 2015-04-01 Kowa Co 具有二苄基胺構造之嘧啶化合物的新穎形態
EP3182971A4 (en) * 2014-08-21 2018-04-25 SRX Cardio, LLC Composition and methods of use of small molecules as binding ligands for the modulation of proprotein convertase subtilisin/kexin type 9(pcsk9) protein activity
TWI691331B (zh) * 2014-09-26 2020-04-21 日商興和股份有限公司 脂質異常症治療劑
KR20170087880A (ko) * 2014-11-28 2017-07-31 코와 가부시키가이샤 의약
JPWO2016084950A1 (ja) * 2014-11-28 2017-09-07 興和株式会社 医薬組成物
JP2019131472A (ja) * 2016-05-31 2019-08-08 興和株式会社 医薬組成物
MX2021008533A (es) 2019-01-18 2021-08-19 Astrazeneca Ab Inhibidores de la pcsk9 y metodos de uso de los mismos.
EA202191890A1 (ru) 2019-01-18 2022-02-03 Астразенека Аб Ингибиторы pcsk9 и способы их применения

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5189208A (en) 1991-07-01 1993-02-23 Ethyl Corporation Ibuprofen resolution
CN101679309B (zh) 2007-04-13 2012-02-29 兴和株式会社 具有二苄胺结构的新型嘧啶化合物和含有该化合物的药物
US8673850B2 (en) 2008-05-30 2014-03-18 Institut De Recherches Cliniques De Montreal PCSK9 inhibitors and methods of use thereof
EP2626351A4 (en) 2010-10-04 2014-03-12 Kowa Co AGENT CAPABLE OF INHIBITING THE EXPRESSION OF LIPID METABOLISM-RELATED MRNA

Also Published As

Publication number Publication date
TW201208688A (en) 2012-03-01
PT2578574E (pt) 2016-06-17
CA2801417C (en) 2017-07-11
WO2011152508A1 (ja) 2011-12-08
CN104529910B (zh) 2017-05-10
IL223377A0 (en) 2013-03-05
EP2578574B1 (en) 2016-04-27
KR20170078865A (ko) 2017-07-07
CN102933559A (zh) 2013-02-13
EP2578574A1 (en) 2013-04-10
TWI492749B (zh) 2015-07-21
KR20130111512A (ko) 2013-10-10
HK1179959A1 (zh) 2013-10-11
EP2578574A4 (en) 2013-12-04
BR112012030787A2 (pt) 2020-09-01
JPWO2011152508A1 (ja) 2013-08-01
JP5555320B2 (ja) 2014-07-23
ES2581557T3 (es) 2016-09-06
CA2801417A1 (en) 2011-12-08
MX338024B (es) 2016-03-31
CN102933559B (zh) 2016-01-27
ZA201209372B (en) 2014-02-26
US8906895B2 (en) 2014-12-09
CN104529910A (zh) 2015-04-22
EA024241B1 (ru) 2016-08-31
US20130225814A1 (en) 2013-08-29
AU2011259929B2 (en) 2014-07-31
MX2012014149A (es) 2013-02-27
IL223377A (en) 2016-12-29
AU2011259929A1 (en) 2013-01-17
IN2012CN10925A (ru) 2015-04-24

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