MX2022012490A - Vectores de aav para la terapia genica de la retina y el snc. - Google Patents

Vectores de aav para la terapia genica de la retina y el snc.

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Publication number
MX2022012490A
MX2022012490A MX2022012490A MX2022012490A MX2022012490A MX 2022012490 A MX2022012490 A MX 2022012490A MX 2022012490 A MX2022012490 A MX 2022012490A MX 2022012490 A MX2022012490 A MX 2022012490A MX 2022012490 A MX2022012490 A MX 2022012490A
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MX
Mexico
Prior art keywords
cns
raav
gene therapy
improved
disorders
Prior art date
Application number
MX2022012490A
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English (en)
Inventor
Abraham Scaria
Jennifer Sullivan
Lisa M Stanek
Original Assignee
Genzyme Corp
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53189202&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2022012490(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of MX2022012490A publication Critical patent/MX2022012490A/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
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    • A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
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    • A61P27/02—Ophthalmic agents
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    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
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Abstract

En la presente memoria se proporcionan rAAV mejorados (por ejemplo, rAAV2, rAAVrh8R, etc.) para la potenciación de la terapia génica de trastornos oculares o trastornos de SNC en donde el rAAV comprende una o más sustituciones de aminoácidos que interactúan con el proteoglicano heparán sulfato. La invención proporciona métodos para mejorar la transducción de células retinianas y métodos para tratar enfermedades oculares con composiciones mejoradas de partículas de rAAV. En la presente memoria se proporcionan adicionalmente virus adeno-asociados recombinantes (rAAV) (por ejemplo, rAAV2, rAAVrh8R, etc.) para potenciar la terapia génica de trastornos del SNC. La invención proporciona métodos para suministrar el rAAV al SNC, métodos para tratar trastornos del SNC con composiciones mejoradas de partículas de rAAV, y kits para suministrar la rAAV al SNC y/o tratar un trastorno del SNC.
MX2022012490A 2014-05-02 2016-10-28 Vectores de aav para la terapia genica de la retina y el snc. MX2022012490A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461988131P 2014-05-02 2014-05-02
US201562114575P 2015-02-10 2015-02-10

Publications (1)

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MX2022012490A true MX2022012490A (es) 2022-10-27

Family

ID=53189202

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016014220A MX2016014220A (es) 2014-05-02 2015-05-02 Vectores de aav para la terapia genica de la retina y el snc.
MX2022012490A MX2022012490A (es) 2014-05-02 2016-10-28 Vectores de aav para la terapia genica de la retina y el snc.

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MX2016014220A MX2016014220A (es) 2014-05-02 2015-05-02 Vectores de aav para la terapia genica de la retina y el snc.

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US (2) US10982228B2 (es)
EP (2) EP3137497B1 (es)
JP (3) JP6741591B2 (es)
KR (2) KR20160147974A (es)
CN (2) CN114231563A (es)
AU (3) AU2015252797C1 (es)
BR (1) BR112016025263A2 (es)
CA (1) CA2946593A1 (es)
CL (2) CL2016002713A1 (es)
CR (1) CR20160555A (es)
DK (1) DK3137497T3 (es)
DO (1) DOP2016000280A (es)
EA (1) EA034355B1 (es)
ES (1) ES2879636T3 (es)
GT (1) GT201600227A (es)
HR (1) HRP20211024T1 (es)
HU (1) HUE054768T2 (es)
IL (2) IL248102B (es)
LT (1) LT3137497T (es)
MX (2) MX2016014220A (es)
MY (1) MY188987A (es)
PE (1) PE20170260A1 (es)
PH (1) PH12016502046A1 (es)
PL (1) PL3137497T4 (es)
PT (1) PT3137497T (es)
RS (1) RS62078B1 (es)
SG (3) SG10201809739QA (es)
SI (1) SI3137497T1 (es)
TW (1) TWI686476B (es)
UY (1) UY36106A (es)
WO (1) WO2015168666A2 (es)
ZA (1) ZA201606763B (es)

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