TN2016000460A1 - Aav vectors for retinal and cns gene therapy. - Google Patents
Aav vectors for retinal and cns gene therapy.Info
- Publication number
- TN2016000460A1 TN2016000460A1 TN2016000460A TN2016000460A TN2016000460A1 TN 2016000460 A1 TN2016000460 A1 TN 2016000460A1 TN 2016000460 A TN2016000460 A TN 2016000460A TN 2016000460 A TN2016000460 A TN 2016000460A TN 2016000460 A1 TN2016000460 A1 TN 2016000460A1
- Authority
- TN
- Tunisia
- Prior art keywords
- cns
- raav
- gene therapy
- improved
- disorders
- Prior art date
Links
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Provided herein are improved rAAV (e.g., rAAV2, rAAVrh8R, etc.) for enhanced gene therapy of ocular disorders or CNS disorders wherein the rAAV comprise one or more substitutions of amino acids that interact with heparan sulfate proteoglycan. The invention provides methods for improved transduction of retinal cells and methods for treating ocular diseases with improved compositions of rAAV particles. Further provided herein are improved recombinant adeno-associated virus (rAAV) (e.g., rAAV2, rAAVrh8R, etc.) for enhanced gene therapy of disorders of the CNS. The invention provides methods for delivering the rAAV to the CNS, methods for treating disorders of the CNS with improved compositions of rAAV particles, and kits for delivering the rAAV to the CNS and/or treating a CNS disorder.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461988131P | 2014-05-02 | 2014-05-02 | |
PCT/US2015/028966 WO2015168666A2 (en) | 2014-05-02 | 2015-05-02 | Aav vectors for retinal and cns gene therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
TN2016000460A1 true TN2016000460A1 (en) | 2018-04-04 |
Family
ID=58700040
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TN2016000460A TN2016000460A1 (en) | 2014-05-02 | 2015-05-02 | Aav vectors for retinal and cns gene therapy. |
Country Status (3)
Country | Link |
---|---|
AR (1) | AR100274A1 (en) |
MA (1) | MA39439B2 (en) |
TN (1) | TN2016000460A1 (en) |
-
2015
- 2015-05-02 MA MA39439A patent/MA39439B2/en unknown
- 2015-05-02 TN TN2016000460A patent/TN2016000460A1/en unknown
- 2015-05-04 AR ARP150101342A patent/AR100274A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
AR100274A1 (en) | 2016-09-21 |
MA39439B2 (en) | 2020-11-30 |
MA39439A1 (en) | 2018-06-29 |
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