MX2021003706A - Tratamiento del temblor esencial usando (r)-2-(4-isopropilfenil)-n -(1-(5-(2,2,2- trifluoroetoxi)piridin-2-il)etil)acetamida. - Google Patents
Tratamiento del temblor esencial usando (r)-2-(4-isopropilfenil)-n -(1-(5-(2,2,2- trifluoroetoxi)piridin-2-il)etil)acetamida.Info
- Publication number
- MX2021003706A MX2021003706A MX2021003706A MX2021003706A MX2021003706A MX 2021003706 A MX2021003706 A MX 2021003706A MX 2021003706 A MX2021003706 A MX 2021003706A MX 2021003706 A MX2021003706 A MX 2021003706A MX 2021003706 A MX2021003706 A MX 2021003706A
- Authority
- MX
- Mexico
- Prior art keywords
- essential tremor
- trifluoroethoxy
- isopropylphenyl
- pyridin
- acetamide
- Prior art date
Links
- 201000006517 essential tremor Diseases 0.000 title abstract 3
- IQIKXZMPPBEWAD-CQSZACIVSA-N 2-(4-propan-2-ylphenyl)-n-[(1r)-1-[5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethyl]acetamide Chemical compound C1=CC(C(C)C)=CC=C1CC(=O)N[C@H](C)C1=CC=C(OCC(F)(F)F)C=N1 IQIKXZMPPBEWAD-CQSZACIVSA-N 0.000 title abstract 2
- 241000124008 Mammalia Species 0.000 abstract 3
- 208000016285 Movement disease Diseases 0.000 abstract 2
- 208000018737 Parkinson disease Diseases 0.000 abstract 2
- 206010015037 epilepsy Diseases 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 229940127291 Calcium channel antagonist Drugs 0.000 abstract 1
- 101150110214 Cav3 gene Proteins 0.000 abstract 1
- 102000003691 T-Type Calcium Channels Human genes 0.000 abstract 1
- 108090000030 T-Type Calcium Channels Proteins 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862740755P | 2018-10-03 | 2018-10-03 | |
| US201862780049P | 2018-12-14 | 2018-12-14 | |
| PCT/US2019/054498 WO2020072773A1 (en) | 2018-10-03 | 2019-10-03 | Treating essential tremor using (r)-2-(4-isopropylphenyl)-n-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2021003706A true MX2021003706A (es) | 2021-11-04 |
Family
ID=70055875
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2021003706A MX2021003706A (es) | 2018-10-03 | 2019-10-03 | Tratamiento del temblor esencial usando (r)-2-(4-isopropilfenil)-n -(1-(5-(2,2,2- trifluoroetoxi)piridin-2-il)etil)acetamida. |
| MX2025002145A MX2025002145A (es) | 2018-10-03 | 2021-03-29 | Tratamiento del temblor esencial usando (r)-2-(4- isopropilfenil)-n-(1-(5-(2,2,2-trifluoroetoxi)piridin-2- il)etil)acetamida |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2025002145A MX2025002145A (es) | 2018-10-03 | 2021-03-29 | Tratamiento del temblor esencial usando (r)-2-(4- isopropilfenil)-n-(1-(5-(2,2,2-trifluoroetoxi)piridin-2- il)etil)acetamida |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US12383539B2 (enExample) |
| EP (1) | EP3860571A4 (enExample) |
| JP (2) | JP7480131B2 (enExample) |
| KR (1) | KR20210087459A (enExample) |
| CN (1) | CN113164393A (enExample) |
| AU (2) | AU2019355021B2 (enExample) |
| BR (1) | BR112021006398A2 (enExample) |
| CA (1) | CA3115235A1 (enExample) |
| IL (2) | IL282006B2 (enExample) |
| MX (2) | MX2021003706A (enExample) |
| TW (1) | TWI879741B (enExample) |
| WO (1) | WO2020072773A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3364993T3 (da) | 2015-10-22 | 2023-01-09 | Cavion Inc | Fremgangsmåder til behandling af angelman syndrom |
| MX2019012818A (es) | 2017-04-26 | 2020-07-14 | Cavion Inc | Metodos para mejorar la memoria y la cognicion y para el tratamiento de trastornos de la memoria y cognitivos. |
| WO2020072773A1 (en) | 2018-10-03 | 2020-04-09 | Cavion, Inc. | Treating essential tremor using (r)-2-(4-isopropylphenyl)-n-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetamide |
| JP2022540253A (ja) | 2019-07-11 | 2022-09-14 | プラクシス プレシジョン メディシンズ， インコーポレイテッド | Ｔ型カルシウムチャネル調節因子の製剤およびその使用方法 |
| TWI870475B (zh) * | 2019-10-02 | 2025-01-21 | 美商卡凡恩公司 | 用於治療神經毒性之方法及材料 |
| CN115776894A (zh) * | 2020-04-29 | 2023-03-10 | 普拉西斯精密医药公司 | T型钙通道调节剂的使用方法 |
| CA3219829A1 (en) * | 2021-05-24 | 2022-12-01 | Margaret S. Lee | Method of treating essential tremor |
| AU2024229800A1 (en) * | 2023-03-02 | 2025-09-11 | Praxis Precision Medicines, Inc. | Methods of treating essential tremor |
| KR20250165616A (ko) * | 2023-03-02 | 2025-11-26 | 프락시스 프리시젼 메디신즈, 인크. | 고함량 단일 투여 단위 제형 및 이의 사용 방법 |
Family Cites Families (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100389752C (zh) * | 1978-04-21 | 2008-05-28 | 莱博法姆公司 | 控释组合物 |
| DK171349B1 (da) | 1986-11-14 | 1996-09-16 | Hoffmann La Roche | Tetrahydronaphthalenderivater, fremgangsmåde til fremstilling deraf, lægemidler indeholdende forbindelserne samt anvendelse af forbindelserne til fremstilling af lægemidler |
| AU2436792A (en) | 1991-08-16 | 1993-03-16 | Merck & Co., Inc. | Quinazoline derivatives as inhibitors of hiv reverse transcriptase |
| CA2749312A1 (en) | 1996-02-14 | 1997-08-21 | Novartis Ag | Sugar-modified gapped oligonucleotides |
| WO2001062740A1 (en) | 2000-02-25 | 2001-08-30 | South Alabama Medical Science Foundation | Mibefradil analogues and their use |
| CA2443550A1 (en) | 2001-04-06 | 2002-10-24 | The Research Foundation Of The City University Of New York | Diagnosis and treatment of neural disease and injury using microvoltammetry |
| CA2469685C (en) | 2002-01-17 | 2013-03-12 | The University Of British Columbia | Bispecific antisense oligonucleotides that inhibit igfbp-2 and igfbp-5 and methods of using same |
| WO2004003500A1 (en) | 2002-07-01 | 2004-01-08 | University Of Manitoba | Measuring strain in a structure (bridge) with a (temperature compensated) electromagnetic resonator (microwave cavity) |
| US20060003985A1 (en) | 2002-10-17 | 2006-01-05 | Renger John J | Enhancement of sleep with t-type calcium channel antagonists |
| US8487002B2 (en) * | 2002-10-25 | 2013-07-16 | Paladin Labs Inc. | Controlled-release compositions |
| JP2006520799A (ja) * | 2003-03-21 | 2006-09-14 | ダイノジェン ファーマシューティカルズ， インコーポレイテッド | 平滑筋調節因子およびα２δサブユニットカルシウムチャネル調節因子を用いた、下部尿路障害を処置するための方法 |
| WO2005007124A2 (en) | 2003-07-23 | 2005-01-27 | Bristol-Myers Squibb Company | Substituted dihydropyrimidine inhibitors of calcium channel function |
| US7166603B2 (en) | 2003-07-23 | 2007-01-23 | Bristol-Myers Squibb Co. | Dihydropyrimidone inhibitors of calcium channel function |
| KR100610731B1 (ko) | 2004-02-24 | 2006-08-09 | 한국과학기술연구원 | Ｔ-형 칼슘 채널 차단제로서 유용한 ３,４-디히드로퀴나졸린유도체 및 그의 제조 방법 |
| US7504431B2 (en) | 2004-04-16 | 2009-03-17 | Bristol-Myers Squibb Company | Sulfonyl amide inhibitors of calcium channel function |
| WO2006023881A2 (en) | 2004-08-20 | 2006-03-02 | University Of Virginia Patent Foundation | T type calcium channel blockers and the treatment of diseases |
| ATE552233T1 (de) | 2004-08-20 | 2012-04-15 | Univ Virginia Patent Found | T-typ-calciumkanalinhibitoren |
| AU2006223469A1 (en) | 2005-03-09 | 2006-09-21 | Merck Sharp & Dohme Corp. | Quinazolinone T-type calcium channel antagonists |
| AU2006262101A1 (en) | 2005-06-23 | 2007-01-04 | Merck & Co., Inc. | 3-fluoro-piperidine T-type calcium channel antagonists |
| AU2006263564A1 (en) | 2005-06-29 | 2007-01-04 | Merck Sharp & Dohme Corp. | 4-fluoro-piperidine T-type calcium channel antagonists |
| WO2007007852A1 (ja) | 2005-07-14 | 2007-01-18 | Teijin Chemicals Ltd. | 発泡樹脂シートおよび液晶表示装置 |
| KR100654328B1 (ko) | 2005-08-26 | 2006-12-08 | 한국과학기술연구원 | 피페라지닐알킬피라졸계 ｔ-타입 칼슘 채널 억제 화합물 및이의 제조방법 |
| JP2009521471A (ja) | 2005-12-22 | 2009-06-04 | アイカジェン， インコーポレイテッド | カルシウムチャネルアンタゴニスト |
| PL2010493T3 (pl) | 2006-04-12 | 2016-08-31 | Merck Sharp & Dohme | Pirydyloamidy jako antagoniści kanałów wapniowych typu t |
| KR100743255B1 (ko) | 2006-05-04 | 2007-07-27 | 한국과학기술연구원 | Ｔ-형 칼슘 채널에 활성을 지닌 신규1,3-다이옥소아이소인돌 유도체 |
| KR100749843B1 (ko) | 2006-07-13 | 2007-08-21 | 한국과학기술연구원 | Ｔ-타입 칼슘 채널에 억제 활성을 지닌 신규2,4-디옥소-퀴나졸린 유도체 및 이의 제조방법 |
| KR100969686B1 (ko) | 2006-08-07 | 2010-07-14 | 한국과학기술연구원 | 신규한 티아졸계 화합물 및 이를 함유하는 ｔ-형 칼슘 채널저해제 |
| JP2010503676A (ja) | 2006-09-15 | 2010-02-04 | シェーリング コーポレイション | 疼痛、糖尿病および脂質代謝の障害の治療 |
| AR062789A1 (es) | 2006-09-15 | 2008-12-03 | Schering Corp | Derivados de azetidina y azetidona, composiciones farmaceuticas que los comprenden y su uso en el tratamiento del dolor y de trastornos del metabolismo de los lipidos. |
| US7884080B2 (en) | 2006-09-15 | 2011-02-08 | Schering Plough Corporation | Azetidinone derivatives and methods of use thereof |
| EP2061791A1 (en) | 2006-09-15 | 2009-05-27 | Schering Corporation | Spiro-condensed azetidine derivatives useful in treating pain, diabetes and disorders of lipid metabilism |
| WO2008033465A1 (en) | 2006-09-15 | 2008-03-20 | Schering Corporation | Azetidinone derivatives and methods of use thereof |
| WO2008050200A1 (en) | 2006-10-24 | 2008-05-02 | Pfizer Products Inc. | Oxadiazole compounds as calcium channel antagonists |
| US20080227823A1 (en) | 2007-03-12 | 2008-09-18 | Hassan Pajouhesh | Amide derivatives as calcium channel blockers |
| US8586619B2 (en) | 2007-03-12 | 2013-11-19 | Vm Therapeutics Llc | Agents of calcium ion channel modulators |
| WO2008117148A1 (en) | 2007-03-23 | 2008-10-02 | Pfizer Products Inc. | Substituted oxadiazole analogs as calcium channel antagonists |
| WO2008138126A1 (en) | 2007-05-09 | 2008-11-20 | Neuromed Pharmaceuticals Ltd. | Bicyclic pyrimidine derivatives as calcium channel blockers |
| KR100863239B1 (ko) | 2007-05-23 | 2008-10-15 | 한국과학기술연구원 | 신규한 2-이미노-1,3-티아졸린계 화합물 및 이를 함유하는ｔ-형 칼슘 채널 저해제 |
| CA2692783A1 (en) | 2007-07-10 | 2009-01-15 | Merck Sharp & Dohme Corp. | Quinazolinone t-type calcium channel antagonists |
| KR101079459B1 (ko) | 2007-09-14 | 2011-11-03 | 이화여자대학교 산학협력단 | 신규한 화합물, 이의 제조방법 및 이를 포함하는 통증억제용 조성물 |
| JP5524071B2 (ja) | 2007-10-24 | 2014-06-18 | メルク・シャープ・アンド・ドーム・コーポレーション | 複素環フェニルアミドｔ型カルシウムチャネルアンタゴニスト |
| JP2011500807A (ja) | 2007-10-24 | 2011-01-06 | メルク・シャープ・エンド・ドーム・コーポレイション | ピラジニルアミドｔ型カルシウムチャネルアンタゴニスト |
| AU2008317352A1 (en) | 2007-10-24 | 2009-04-30 | Merck Sharp & Dohme Corp. | Heterocycle amide T-type calcium channel antagonists |
| WO2009056934A1 (en) | 2007-10-31 | 2009-05-07 | Pfizer Products Inc. | 1,4-dihydronaphthyridine derivatives |
| KR100917037B1 (ko) | 2007-11-01 | 2009-09-10 | 한국과학기술연구원 | 피라졸릴카르복스아미도알킬피페라진 유도체 및 이의제조방법 |
| CA2722706A1 (en) | 2008-04-28 | 2009-11-05 | Zalicus Pharmaceuticals Ltd. | Di-t-butylphenyl piperazines as calcium channel blockers |
| ES2764480T3 (es) | 2008-04-29 | 2020-06-03 | Impact Coatings Ab | Composiciones de combinación para tratar la enfermedad de Alzheimer y trastornos relacionados con zonisamida y acamprosato |
| US20090298834A1 (en) | 2008-06-02 | 2009-12-03 | Hassan Pajouhesh | 4-(aminomethyl)cyclohexanamine derivatives as calcium channel blockers |
| US8377968B2 (en) | 2008-06-02 | 2013-02-19 | Zalicus Pharmaceuticals, Ltd. | N-piperidinyl acetamide derivatives as calcium channel blockers |
| KR101014887B1 (ko) | 2008-06-26 | 2011-02-15 | 한국과학기술연구원 | 칼슘이온 채널 조절제로서 유효한 이미다졸릴알킬카르보닐유도체 및 그의 제조방법 |
| KR20100005476A (ko) | 2008-07-07 | 2010-01-15 | 한국과학기술연구원 | Ｔ-형 칼슘 채널에 활성을 지닌 신규 아이소인돌리논유도체 및 이의 제조방법 |
| US20100137403A1 (en) | 2008-07-10 | 2010-06-03 | Scott Malstrom | Method for enhancing cognition or inhibiting cognitive decline |
| KR101052620B1 (ko) | 2008-08-28 | 2011-07-29 | 한국과학기술연구원 | 신규 페닐아세테이트 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 ｔ-형 칼슘 이온 채널의 활성에 의해 유발되는 질환의 예방 또는 치료용 조성물 |
| KR101052065B1 (ko) | 2008-10-15 | 2011-07-27 | 한국과학기술연구원 | 칼슘이온 채널 조절제로서 유효한 피라졸릴메틸아민-피페라진 유도체와 이의 제조방법 |
| TW201028421A (en) | 2009-01-15 | 2010-08-01 | Abbott Lab | Novel benzenesulfonamides as calcium channel blockers |
| CN106177963A (zh) | 2009-06-05 | 2016-12-07 | 陶制药有限责任公司 | 用于治疗癌症或癌前病症的交错方法 |
| BR112012003179A2 (pt) | 2009-08-12 | 2016-03-01 | Carlos Alberto Barcelo Rojas | sistema bio-eletrônico |
| US20130036482A1 (en) | 2010-01-29 | 2013-02-07 | National University Corporation Okayama University | Method for assessment of potential for development of dravet syndrome and use thereof |
| US8575361B2 (en) | 2010-03-02 | 2013-11-05 | Concert Pharmaceuticals Inc. | Tetrahydronaphthalene derivatives |
| WO2012032415A2 (en) * | 2010-09-08 | 2012-03-15 | Pronova Biopharma Norge As | Compositions comprising a fatty acid oil mixture comprising epa and dha in free acid form, a surfactant, and a statin |
| WO2012094615A2 (en) | 2011-01-07 | 2012-07-12 | Zenyaku Kogyo Kabushikikaisha | Use of cav3.1 selective t-type calcium channel antagonists |
| MX2014013599A (es) | 2012-05-08 | 2015-05-11 | Zafgen Inc | Tratamiento de la obesidad hipotalamica con inhibidores de metap2. |
| CN105189775A (zh) | 2013-01-10 | 2015-12-23 | 陶制药有限责任公司 | 用于治疗癌症的t-型钙通道抑制剂 |
| US10292989B2 (en) | 2014-03-28 | 2019-05-21 | University Of Virginia Patent Foundation | General anesthetics that are not neurotoxic |
| JP2018520112A (ja) | 2015-05-26 | 2018-07-26 | オディディ，イサ | 制御持続放出プレガバリン |
| KR101679262B1 (ko) | 2015-06-08 | 2016-11-24 | 한국과학기술연구원 | 4-이소프로필크로만-3-올 화합물 |
| GB2539472A (en) | 2015-06-17 | 2016-12-21 | Gw Res Ltd | Use of cannabinoids in the treatment of epilepsy |
| US9351968B1 (en) | 2015-09-09 | 2016-05-31 | Ovid Therapeutics Inc | Methods of treating developmental disorders using pipradrol |
| US9634019B1 (en) | 2015-10-01 | 2017-04-25 | Silicon Storage Technology, Inc. | Non-volatile split gate memory cells with integrated high K metal gate, and method of making same |
| DK3364993T3 (da) * | 2015-10-22 | 2023-01-09 | Cavion Inc | Fremgangsmåder til behandling af angelman syndrom |
| MX2018008021A (es) | 2015-12-30 | 2018-11-09 | Adamas Pharmaceuticals Inc | Metodos y composiciones para el tratamiento de trastornos relacionados con convulsiones. |
| SG11201909963YA (en) | 2017-04-26 | 2019-11-28 | Cavion Inc | Methods for treating dravet syndrome |
| MX2019012818A (es) | 2017-04-26 | 2020-07-14 | Cavion Inc | Metodos para mejorar la memoria y la cognicion y para el tratamiento de trastornos de la memoria y cognitivos. |
| GB2571978A (en) | 2018-03-15 | 2019-09-18 | Andre Fisahn | Uses, compositions and methods |
| WO2020072773A1 (en) | 2018-10-03 | 2020-04-09 | Cavion, Inc. | Treating essential tremor using (r)-2-(4-isopropylphenyl)-n-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetamide |
| JP2022540253A (ja) * | 2019-07-11 | 2022-09-14 | プラクシス プレシジョン メディシンズ， インコーポレイテッド | Ｔ型カルシウムチャネル調節因子の製剤およびその使用方法 |
| TWI870475B (zh) | 2019-10-02 | 2025-01-21 | 美商卡凡恩公司 | 用於治療神經毒性之方法及材料 |
-
2019
- 2019-10-03 WO PCT/US2019/054498 patent/WO2020072773A1/en not_active Ceased
- 2019-10-03 TW TW108135951A patent/TWI879741B/zh active
- 2019-10-03 AU AU2019355021A patent/AU2019355021B2/en active Active
- 2019-10-03 BR BR112021006398A patent/BR112021006398A2/pt not_active Application Discontinuation
- 2019-10-03 CN CN201980079029.4A patent/CN113164393A/zh active Pending
- 2019-10-03 CA CA3115235A patent/CA3115235A1/en active Pending
- 2019-10-03 IL IL282006A patent/IL282006B2/en unknown
- 2019-10-03 EP EP19868543.0A patent/EP3860571A4/en active Pending
- 2019-10-03 KR KR1020217013251A patent/KR20210087459A/ko active Pending
- 2019-10-03 IL IL300798A patent/IL300798B2/en unknown
- 2019-10-03 JP JP2021518473A patent/JP7480131B2/ja active Active
- 2019-10-03 US US17/282,730 patent/US12383539B2/en active Active
- 2019-10-03 MX MX2021003706A patent/MX2021003706A/es unknown
-
2021
- 2021-03-29 MX MX2025002145A patent/MX2025002145A/es unknown
- 2021-05-06 US US17/313,750 patent/US11311522B1/en active Active
-
2024
- 2024-04-24 JP JP2024070307A patent/JP2024102139A/ja active Pending
- 2024-12-06 AU AU2024278171A patent/AU2024278171A1/en active Pending
-
2025
- 2025-04-21 US US19/184,847 patent/US20250312323A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| BR112021006398A2 (pt) | 2021-07-06 |
| CA3115235A1 (en) | 2020-04-09 |
| IL282006B2 (en) | 2023-08-01 |
| IL300798B1 (en) | 2025-05-01 |
| US12383539B2 (en) | 2025-08-12 |
| KR20210087459A (ko) | 2021-07-12 |
| EP3860571A1 (en) | 2021-08-11 |
| TW202027728A (zh) | 2020-08-01 |
| WO2020072773A1 (en) | 2020-04-09 |
| CN113164393A (zh) | 2021-07-23 |
| US20250312323A1 (en) | 2025-10-09 |
| AU2019355021A1 (en) | 2021-05-06 |
| MX2025002145A (es) | 2025-04-02 |
| US11311522B1 (en) | 2022-04-26 |
| IL282006A (en) | 2021-05-31 |
| US20220016095A1 (en) | 2022-01-20 |
| EP3860571A4 (en) | 2022-06-29 |
| IL282006B1 (en) | 2023-04-01 |
| JP2024102139A (ja) | 2024-07-30 |
| AU2019355021B2 (en) | 2024-09-12 |
| TWI879741B (zh) | 2025-04-11 |
| JP2022504182A (ja) | 2022-01-13 |
| IL300798B2 (en) | 2025-09-01 |
| AU2024278171A1 (en) | 2025-01-02 |
| WO2020072773A9 (en) | 2020-07-16 |
| IL300798A (en) | 2023-04-01 |
| JP7480131B2 (ja) | 2024-05-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2021003706A (es) | Tratamiento del temblor esencial usando (r)-2-(4-isopropilfenil)-n -(1-(5-(2,2,2- trifluoroetoxi)piridin-2-il)etil)acetamida. | |
| SV2016005311A (es) | Compuestos y composiciones como agonistas del receptor tipo toll 7 | |
| MA44734A (fr) | Composés et compositions destinés au traitement d'états associés à une activité de nlrp | |
| MX2018010693A (es) | Compuestos biciclicos para diagnostico y terapia. | |
| MX2018003388A (es) | Agonistas del receptor farnesoide x y usos de los mismos. | |
| MX388562B (es) | Composiciones y métodos para el tratamiento de trastornos de almacenamiento lisosomal y trastornos caracterizados por disfunción lisosomal. | |
| AR086582A1 (es) | Anticuerpos anti-kir para el tratamiento de trastornos inflamatorios y autoinmunes | |
| CO2021010689A2 (es) | Formulaciones de 4-(7-hidroxi-2-isopropil-4-oxo-4h-quinazolin-3-il)-benzonitrilo | |
| CL2013001073A1 (es) | Compuestos derivados de 6-amino-nicotinamidas sustituidas, como moduladores de kcnq2/3; composicion farmaceutica que los comprende, util para el tratamiento y/o profilaxis de trastornos y/o enfermedades seleccionadas de dolor, epilepsia, ansiedad, enfermedades cognitivas, entre otras. | |
| AR101740A1 (es) | Terapia de combinación y composiciones | |
| MX2019001036A (es) | Tratamiento y prevencion de los trastornos del sueño. | |
| DOP2021000130A (es) | Moduladores de la expresion de hsd17b13 | |
| PH12019501074A1 (en) | Benzenesulfonamide compounds and their use as therapeutic agents | |
| TN2018000385A1 (en) | Benzenesulfonamide compounds and their use as therapeutic agents | |
| CO2021014008A2 (es) | Compuestos farmacéuticos para el tratamiento de trastornos mediados por complemento | |
| MX382175B (es) | Composiciones de profármaco de monometilfumarato | |
| MX2024013040A (es) | Pirfenidona enriquecida con deuterio y metodos para su uso | |
| CO2019014212A2 (es) | Métodos de tratamiento para la distonía cervical listado de secuencias | |
| EA202090180A1 (ru) | Композиции nk1-антагониста и способы лечения депрессии | |
| MX2021008941A (es) | Moduladores gpr35. | |
| PH12021550671A1 (en) | Prodrugs of cgrp antagonists | |
| BR112017021589A2 (pt) | métodos para o tratamento de transtornos cardiovasculares | |
| EA201991128A1 (ru) | ТРИЦИКЛИЧЕСКИЕ СУЛЬФОНЫ В КАЧЕСТВЕ МОДУЛЯТОРОВ RORγ | |
| MX2022013383A (es) | Composiciones y metodo para tratar la depresion. | |
| PH12020551620A1 (en) | Compositions for preventing or treating dry eye |