MX2020003526A - Una plataforma universal para la preparación de un receptor antigénico quimérico inhibidor (icar). - Google Patents

Una plataforma universal para la preparación de un receptor antigénico quimérico inhibidor (icar).

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Publication number
MX2020003526A
MX2020003526A MX2020003526A MX2020003526A MX2020003526A MX 2020003526 A MX2020003526 A MX 2020003526A MX 2020003526 A MX2020003526 A MX 2020003526A MX 2020003526 A MX2020003526 A MX 2020003526A MX 2020003526 A MX2020003526 A MX 2020003526A
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MX
Mexico
Prior art keywords
icar
antigen receptor
chimeric antigen
preparing
inhibitory chimeric
Prior art date
Application number
MX2020003526A
Other languages
English (en)
Inventor
Gideon Gross
Merav Beiman
Dvir Dahary
Will Gibson
Original Assignee
Immpact Bio Ltd
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Publication date
Application filed by Immpact Bio Ltd filed Critical Immpact Bio Ltd
Publication of MX2020003526A publication Critical patent/MX2020003526A/es

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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
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    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/46—Cellular immunotherapy
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/27—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by targeting or presenting multiple antigens
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K2317/00—Immunoglobulins specific features
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    • C12Q2531/00—Reactions of nucleic acids characterised by
    • C12Q2531/10—Reactions of nucleic acids characterised by the purpose being amplify/increase the copy number of target nucleic acid
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Abstract

La presente invención proporciona un método para identificar una diana para la preparación de un receptor antigénico quimérico inhibidor (iCAR) o un receptor antigénico quimérico protector (pCAR) capaz de prevenir o atenuar la activación no deseada de una célula inmunitaria efectora. También se proporciona una lista de dianas de iCAR, así como vectores y células inmunitarias efectoras transducidas que comprenden la molécula de ácido nucleico y también se proporcionan métodos para el tratamiento del cáncer que comprenden administrar las células inmunitarias efectoras transducidas.
MX2020003526A 2017-09-28 2018-09-28 Una plataforma universal para la preparación de un receptor antigénico quimérico inhibidor (icar). MX2020003526A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762564454P 2017-09-28 2017-09-28
US201862649429P 2018-03-28 2018-03-28
PCT/US2018/053583 WO2019068007A1 (en) 2017-09-28 2018-09-28 UNIVERSAL PLATFORM FOR PREPARING AN INHIBITORY CHIMERIC ANTIGEN RECEPTOR (ICAR)

Publications (1)

Publication Number Publication Date
MX2020003526A true MX2020003526A (es) 2020-09-14

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MX2020003526A MX2020003526A (es) 2017-09-28 2018-09-28 Una plataforma universal para la preparación de un receptor antigénico quimérico inhibidor (icar).

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US (2) US11660315B2 (es)
EP (1) EP3688155B1 (es)
JP (2) JP2020535814A (es)
KR (1) KR20200071740A (es)
CN (1) CN111465693A (es)
AU (1) AU2018338975A1 (es)
BR (1) BR112020006106A2 (es)
CA (1) CA3077174A1 (es)
DK (1) DK3688155T3 (es)
ES (1) ES2941966T3 (es)
FI (1) FI3688155T3 (es)
HU (1) HUE061502T2 (es)
IL (1) IL273598A (es)
MX (1) MX2020003526A (es)
PL (1) PL3688155T3 (es)
PT (1) PT3688155T (es)
WO (1) WO2019068007A1 (es)

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