PL3688155T3 - Uniwersalna platforma do wytwarzania hamującego chimerycznego receptora antygenowego (icar) - Google Patents

Uniwersalna platforma do wytwarzania hamującego chimerycznego receptora antygenowego (icar)

Info

Publication number
PL3688155T3
PL3688155T3 PL18803487.0T PL18803487T PL3688155T3 PL 3688155 T3 PL3688155 T3 PL 3688155T3 PL 18803487 T PL18803487 T PL 18803487T PL 3688155 T3 PL3688155 T3 PL 3688155T3
Authority
PL
Poland
Prior art keywords
icar
manufacturing
antigen receptor
chimeric antigen
universal platform
Prior art date
Application number
PL18803487.0T
Other languages
English (en)
Inventor
Gideon Gross
Will Gibson
Dvir Dahary
Merav Beiman
Original Assignee
Immpact-Bio Ltd.
Gavish-Galilee Bio Applications Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immpact-Bio Ltd., Gavish-Galilee Bio Applications Ltd filed Critical Immpact-Bio Ltd.
Publication of PL3688155T3 publication Critical patent/PL3688155T3/pl

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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
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    • A61K40/41—Vertebrate antigens
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C—CHEMISTRY; METALLURGY
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1055—Protein x Protein interaction, e.g. two hybrid selection
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
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    • A—HUMAN NECESSITIES
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/75—Agonist effect on antigen
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
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    • C12Q2531/00—Reactions of nucleic acids characterised by
    • C12Q2531/10—Reactions of nucleic acids characterised by the purpose being amplify/increase the copy number of target nucleic acid
    • C12Q2531/113—PCR
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    • C12Q2535/131—Allele specific probes
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  • General Health & Medical Sciences (AREA)
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  • Immunology (AREA)
  • Zoology (AREA)
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  • Biochemistry (AREA)
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  • Medicinal Chemistry (AREA)
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  • Veterinary Medicine (AREA)
  • Public Health (AREA)
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  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Analytical Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL18803487.0T 2017-09-28 2018-09-28 Uniwersalna platforma do wytwarzania hamującego chimerycznego receptora antygenowego (icar) PL3688155T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762564454P 2017-09-28 2017-09-28
US201862649429P 2018-03-28 2018-03-28
PCT/US2018/053583 WO2019068007A1 (en) 2017-09-28 2018-09-28 UNIVERSAL PLATFORM FOR PREPARING AN INHIBITORY CHIMERIC ANTIGEN RECEPTOR (ICAR)

Publications (1)

Publication Number Publication Date
PL3688155T3 true PL3688155T3 (pl) 2023-09-11

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PL18803487.0T PL3688155T3 (pl) 2017-09-28 2018-09-28 Uniwersalna platforma do wytwarzania hamującego chimerycznego receptora antygenowego (icar)

Country Status (17)

Country Link
US (3) US11660315B2 (pl)
EP (1) EP3688155B1 (pl)
JP (2) JP2020535814A (pl)
KR (1) KR20200071740A (pl)
CN (1) CN111465693A (pl)
AU (1) AU2018338975A1 (pl)
BR (1) BR112020006106A2 (pl)
CA (1) CA3077174A1 (pl)
DK (1) DK3688155T5 (pl)
ES (1) ES2941966T3 (pl)
FI (1) FI3688155T3 (pl)
HU (1) HUE061502T2 (pl)
IL (1) IL273598A (pl)
MX (1) MX2020003526A (pl)
PL (1) PL3688155T3 (pl)
PT (1) PT3688155T (pl)
WO (1) WO2019068007A1 (pl)

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CA3077174A1 (en) 2017-09-28 2019-04-04 Immpact-Bio Ltd. A universal platform for preparing an inhibitory chimeric antigen receptor (icar)
MX2021003711A (es) * 2018-09-28 2021-08-11 Immpact Bio Ltd Métodos para identificar pares de receptor de antígeno activador (acar)/receptor de antígeno quimérico inhibidor (icar) para su uso en terapias contra el cáncer.
GB201820157D0 (en) * 2018-12-11 2019-01-23 Imperial Innovations Ltd Method of treatment
AU2020265679A1 (en) * 2019-04-30 2021-12-23 Senti Biosciences, Inc. Chimeric receptors and methods of use thereof
BR112022002465A2 (pt) * 2019-08-09 2022-05-03 A2 Biotherapeutics Inc Receptores de superfície celular responsivos à perda de heterozigosidade
MX2022001812A (es) 2019-08-12 2022-03-11 Regeneron Pharma Variantes del receptor estimulante de macrofagos 1 (mst1r) y sus usos.
WO2021096868A1 (en) 2019-11-12 2021-05-20 A2 Biotherapeutics, Inc. Engineered t cell receptors and uses thereof
IL293716A (en) 2019-12-11 2022-08-01 A2 Biotherapeutics Inc Lilrb1-based chimeric antigen receptor
WO2021168298A1 (en) * 2020-02-20 2021-08-26 Senti Biosciences, Inc. Inhibitory chimeric receptor architectures
CN115397845A (zh) * 2020-02-20 2022-11-25 森迪生物科学公司 抑制性嵌合受体架构
EP4110354A4 (en) * 2020-02-24 2024-11-13 The Regents of The University of California Use of brain-specific antigens to home, block and deliver cell-based treatments to the brain
WO2021252635A1 (en) * 2020-06-11 2021-12-16 A2 Biotherapeutics, Inc. Compositions and methods for treating cancers
CN114058589B (zh) * 2020-07-30 2023-05-12 华东师范大学 具有嵌合抗原受体修饰的免疫细胞、制备方法和药物
IL300500A (en) 2020-08-20 2023-04-01 A2 Biotherapeutics Inc Preparations and methods for the treatment of mesothelin positive cancer
MX2023002017A (es) * 2020-08-20 2023-04-28 A2 Biotherapeutics Inc Composiciones y métodos para tratar cánceres positivos para ceacam.
JP7621461B2 (ja) 2020-08-20 2025-01-24 エー２ バイオセラピューティクス， インコーポレイテッド Ｅｇｆｒ陽性がんを治療するための組成物及び方法
CN112194726B (zh) * 2020-09-02 2023-06-23 沣潮医药科技（上海）有限公司 用于病理性蛋白聚集物清除的嵌合抗原受体及其应用
JP2023540339A (ja) * 2020-09-04 2023-09-22 インパクト バイオ ユーエスエー インコーポレイテッド 癌治療に使用するためのバイシストロン性阻害性キメラ抗原受容体（ｉＣＡＲ）／活性化キメラ抗原受容体（ａＣＡＲ）構築物
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