MX2018007466A - Proceso y aparato para la produccion de microparticulas. - Google Patents

Proceso y aparato para la produccion de microparticulas.

Info

Publication number
MX2018007466A
MX2018007466A MX2018007466A MX2018007466A MX2018007466A MX 2018007466 A MX2018007466 A MX 2018007466A MX 2018007466 A MX2018007466 A MX 2018007466A MX 2018007466 A MX2018007466 A MX 2018007466A MX 2018007466 A MX2018007466 A MX 2018007466A
Authority
MX
Mexico
Prior art keywords
liquid
solvent
droplets
droplet generators
jet
Prior art date
Application number
MX2018007466A
Other languages
English (en)
Inventor
Jones Huw
Seaman Paul
Mcaleer Liam
Original Assignee
Midatech Pharma Wales Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Midatech Pharma Wales Ltd filed Critical Midatech Pharma Wales Ltd
Publication of MX2018007466A publication Critical patent/MX2018007466A/es

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/06—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a liquid medium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/06—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a liquid medium
    • B01J2/08—Gelation of a colloidal solution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/18—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic using a vibrating apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
    • B29B9/00—Making granules
    • B29B9/10—Making granules by moulding the material, i.e. treating it in the molten state
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
    • B29B9/00—Making granules
    • B29B9/12—Making granules characterised by structure or composition
    • B29B2009/125—Micropellets, microgranules, microparticles

Abstract

Se proporciona un aparato para producir microparticulas polimericas solidas, el aparato comprende multiples generadores de gotas liquidas para formar gotas liquidas de un primer liquido y una boquilla para formar un chorro de un segundo liquido, donde los multiples generadores de gotas liquidas y la boquilla estan dispuestos en relacion uno con otro de manera que, cuando se usan, las gotas liquidas de los multiples generadores de gotas liquidas pasan a traves de un gas a dicho chorro del segundo liquido. Tambien se proporciona un proceso para producir microparticulas solidas, el proceso comprende: proporcionar un primer liquido que comprende un soluto y un solvente, el soluto comprende un polimero biocompatible, la concentracion de polímero en el primer liquido es de al menos 10 % p/v, donde "p" es el peso del polimero y "v" es el volumen del solvente, proporcionando multiples generadores de gotas liquidas que se pueden operar para generar gotas liquidas, proporcionando un chorro de un segundo liquido, haciendo que los multiples generadores de gotas liquidas formen gotas liquidas del primer liquido, pasando las gotas liquidas a traves de un gas para poner en contacto el chorro del segundo liquido para hacer que el solvente salga de las gotas, formando de esa manera microparticulas solidas, la solubilidad del solvente en el segundo liquido es de al menos 5 g de solvente cada 100 ml del segundo liquido, el solvente es sustancialmente mezclable con el segundo liquido.
MX2018007466A 2015-12-18 2016-12-16 Proceso y aparato para la produccion de microparticulas. MX2018007466A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1522423.1A GB2551944B (en) 2015-12-18 2015-12-18 Microparticle production process and apparatus
PCT/EP2016/081436 WO2017103113A2 (en) 2015-12-18 2016-12-16 Microparticle production process and apparatus

Publications (1)

Publication Number Publication Date
MX2018007466A true MX2018007466A (es) 2018-11-14

Family

ID=55311254

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018007466A MX2018007466A (es) 2015-12-18 2016-12-16 Proceso y aparato para la produccion de microparticulas.

Country Status (13)

Country Link
US (2) US10981131B2 (es)
EP (1) EP3389840B1 (es)
JP (1) JP7112325B2 (es)
KR (1) KR20180111800A (es)
CN (1) CN108602035B (es)
AU (1) AU2016369412B2 (es)
BR (1) BR112018012340B1 (es)
CA (1) CA3008554A1 (es)
ES (1) ES2749949T3 (es)
GB (1) GB2551944B (es)
MX (1) MX2018007466A (es)
PL (1) PL3389840T3 (es)
WO (1) WO2017103113A2 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201522441D0 (en) 2015-12-18 2016-02-03 Midatech Pharma Wales Ltd Sustained release cyclosporine-loaded microparticles
EP3436188B8 (en) * 2016-03-30 2020-12-30 IamFluidics Holding B.V. Process and device for in flight production of single droplets, compound droplets, and shape-controlled (compound) particles or fibers
EP3860768A4 (en) * 2018-10-01 2022-06-29 Pneuma Respiratory, Inc. Delivery of low surface tension compositions to the pulmonary system via electronic breath actuated droplet delivery device
KR102230329B1 (ko) * 2019-05-15 2021-03-22 경희대학교 산학협력단 마이크로 입자의 대량 생산 방법 및 이를 통해 제조된 마이크로 입자
JP2021028305A (ja) 2019-08-09 2021-02-25 株式会社リコー 粒子、医薬組成物、及び粒子の製造方法
GB202002727D0 (en) * 2020-02-26 2020-04-08 Midatech Pharma Wales Ltd Microparticle production platform, method of producing microparticles and a pharmaceutical composition
JP2021147330A (ja) 2020-03-16 2021-09-27 株式会社リコー 徐放性粒子及びその製造方法

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Also Published As

Publication number Publication date
PL3389840T3 (pl) 2020-01-31
CN108602035A (zh) 2018-09-28
GB2551944A (en) 2018-01-10
KR20180111800A (ko) 2018-10-11
EP3389840A2 (en) 2018-10-24
US20190193037A1 (en) 2019-06-27
ES2749949T3 (es) 2020-03-24
JP7112325B2 (ja) 2022-08-03
AU2016369412B2 (en) 2021-04-01
BR112018012340B1 (pt) 2021-03-09
CN108602035B (zh) 2021-10-15
WO2017103113A2 (en) 2017-06-22
US20210268461A1 (en) 2021-09-02
GB2551944B (en) 2021-09-01
BR112018012340A2 (pt) 2018-12-04
GB201522423D0 (en) 2016-02-03
WO2017103113A3 (en) 2017-08-24
JP2019507003A (ja) 2019-03-14
US10981131B2 (en) 2021-04-20
EP3389840B1 (en) 2019-08-21
AU2016369412A1 (en) 2018-06-14
CA3008554A1 (en) 2017-06-22
US11794158B2 (en) 2023-10-24

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