BR112018012340A2 - ?processo de produção de micropartículas e aparelhos? - Google Patents

?processo de produção de micropartículas e aparelhos?

Info

Publication number
BR112018012340A2
BR112018012340A2 BR112018012340A BR112018012340A BR112018012340A2 BR 112018012340 A2 BR112018012340 A2 BR 112018012340A2 BR 112018012340 A BR112018012340 A BR 112018012340A BR 112018012340 A BR112018012340 A BR 112018012340A BR 112018012340 A2 BR112018012340 A2 BR 112018012340A2
Authority
BR
Brazil
Prior art keywords
liquid
solvent
droplets
droplet generators
jet
Prior art date
Application number
BR112018012340A
Other languages
English (en)
Other versions
BR112018012340B1 (pt
Inventor
Jones Huw
Mcaleer Liam
Seaman Paul
Original Assignee
Midatech Pharma Wales Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Midatech Pharma Wales Ltd filed Critical Midatech Pharma Wales Ltd
Publication of BR112018012340A2 publication Critical patent/BR112018012340A2/pt
Publication of BR112018012340B1 publication Critical patent/BR112018012340B1/pt

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/06—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a liquid medium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/06—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a liquid medium
    • B01J2/08—Gelation of a colloidal solution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/18—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic using a vibrating apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
    • B29B9/00—Making granules
    • B29B9/10—Making granules by moulding the material, i.e. treating it in the molten state
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29B—PREPARATION OR PRETREATMENT OF THE MATERIAL TO BE SHAPED; MAKING GRANULES OR PREFORMS; RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIAL CONTAINING PLASTICS
    • B29B9/00—Making granules
    • B29B9/12—Making granules characterised by structure or composition
    • B29B2009/125—Micropellets, microgranules, microparticles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Communicable Diseases (AREA)
  • Mechanical Engineering (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurology (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Particle Formation And Scattering Control In Inkjet Printers (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Glanulating (AREA)

Abstract

é fornecido um aparelho para produzir micropartículas poliméricas sólidas, o aparelho compreendendo uma pluralidade de geradores de gotículas de líquido para formar gotículas de líquido de um primeiro líquido e um bocal para formar um jato de um segundo líquido, em que a pluralidade de geradores de gotículas de líquido e o bocal estão dispostos um em relação ao outro, de modo que, em uso, gotículas de líquido da pluralidade de geradores de gotículas de líquido passam através de um gás para o referido jato do segundo líquido. também é fornecido um processo para produzir micropartículas sólidas, o processo compreendendo: fornecer um primeiro líquido compreendendo um soluto e um solvente, o soluto compreendendo um polímero biocompatível, a concentração do polímero no primeiro líquido sendo ao menos 10% p/v, ?p? sendo o peso do polímero e ?v? sendo o volume do solvente, fornecer uma pluralidade de geradores de gotículas de líquidos, operável para gerar gotículas de líquido, fornecer um jato de um segundo líquido, fazer com que a pluralidade de geradores de gotículas de líquidos forme gotículas de líquido do primeiro líquido, passar as gotículas de líquido através de um gás para entrar em contato com o jato do segundo líquido de modo a fazer com que o solvente saia das gotículas, formando assim micropartículas sólidas, a solubilidade do solvente no segundo líquido sendo ao menos 5g de solvente por 100ml do segundo líquido, o solvente sendo substancialmente miscível com o segundo líquido.
BR112018012340-4A 2015-12-18 2016-12-16 processo de produção de micropartículas e aparelhos BR112018012340B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1522423.1A GB2551944B (en) 2015-12-18 2015-12-18 Microparticle production process and apparatus
GB1522423.1 2015-12-18
PCT/EP2016/081436 WO2017103113A2 (en) 2015-12-18 2016-12-16 Microparticle production process and apparatus

Publications (2)

Publication Number Publication Date
BR112018012340A2 true BR112018012340A2 (pt) 2018-12-04
BR112018012340B1 BR112018012340B1 (pt) 2021-03-09

Family

ID=55311254

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018012340-4A BR112018012340B1 (pt) 2015-12-18 2016-12-16 processo de produção de micropartículas e aparelhos

Country Status (12)

Country Link
US (2) US10981131B2 (pt)
EP (1) EP3389840B1 (pt)
JP (1) JP7112325B2 (pt)
CN (1) CN108602035B (pt)
AU (1) AU2016369412B2 (pt)
BR (1) BR112018012340B1 (pt)
CA (1) CA3008554A1 (pt)
ES (1) ES2749949T3 (pt)
GB (1) GB2551944B (pt)
MX (1) MX2018007466A (pt)
PL (1) PL3389840T3 (pt)
WO (1) WO2017103113A2 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201522441D0 (en) 2015-12-18 2016-02-03 Midatech Pharma Wales Ltd Sustained release cyclosporine-loaded microparticles
EP4000724A1 (en) * 2016-03-30 2022-05-25 IamFluidics Holding B.V. Process and device for in-air production of single droplets, compound droplets, and shape-controlled (compound) particles or fibers
EP4397343A2 (en) * 2018-10-01 2024-07-10 Pneuma Respiratory, Inc. Delivery of low surface tension compositions to the pulmonary system via electronic breath actuated droplet delivery device
JP2021028305A (ja) 2019-08-09 2021-02-25 株式会社リコー 粒子、医薬組成物、及び粒子の製造方法
GB202002727D0 (en) * 2020-02-26 2020-04-08 Midatech Pharma Wales Ltd Microparticle production platform, method of producing microparticles and a pharmaceutical composition
JP2021147330A (ja) 2020-03-16 2021-09-27 株式会社リコー 徐放性粒子及びその製造方法

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DE4338212C2 (de) * 1993-11-10 1996-01-18 Nukem Gmbh Verfahren und Vorrichtung zur Herstellung von aus Kunststoff bestehenden Partikeln
DE19750679B4 (de) * 1997-11-15 2004-10-21 Institut für Lebensmittelwissenschaft, Lehrstuhl für Lebensmittelverfahrenstechnik Verfahren zum Erzeugen von kaltgesprühten, verfestigten, lagerstabilen und rieselfähigen Mikrokapselsystemen sowie deren Verwendung
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Also Published As

Publication number Publication date
US20210268461A1 (en) 2021-09-02
AU2016369412B2 (en) 2021-04-01
PL3389840T3 (pl) 2020-01-31
BR112018012340B1 (pt) 2021-03-09
CA3008554A1 (en) 2017-06-22
AU2016369412A1 (en) 2018-06-14
JP2019507003A (ja) 2019-03-14
GB2551944A (en) 2018-01-10
GB2551944B (en) 2021-09-01
ES2749949T3 (es) 2020-03-24
WO2017103113A3 (en) 2017-08-24
CN108602035B (zh) 2021-10-15
KR20180111800A (ko) 2018-10-11
EP3389840A2 (en) 2018-10-24
CN108602035A (zh) 2018-09-28
US10981131B2 (en) 2021-04-20
WO2017103113A2 (en) 2017-06-22
JP7112325B2 (ja) 2022-08-03
US11794158B2 (en) 2023-10-24
MX2018007466A (es) 2018-11-14
US20190193037A1 (en) 2019-06-27
GB201522423D0 (en) 2016-02-03
EP3389840B1 (en) 2019-08-21

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Legal Events

Date Code Title Description
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 16/12/2016, OBSERVADAS AS CONDICOES LEGAIS.