MX2018006632A - Inhibidores biciclicos de peptidilarginina deiminasa 4 (pad4). - Google Patents

Inhibidores biciclicos de peptidilarginina deiminasa 4 (pad4).

Info

Publication number
MX2018006632A
MX2018006632A MX2018006632A MX2018006632A MX2018006632A MX 2018006632 A MX2018006632 A MX 2018006632A MX 2018006632 A MX2018006632 A MX 2018006632A MX 2018006632 A MX2018006632 A MX 2018006632A MX 2018006632 A MX2018006632 A MX 2018006632A
Authority
MX
Mexico
Prior art keywords
pad4
inhibitors
bicyclic inhibitors
bicyclic
compositions
Prior art date
Application number
MX2018006632A
Other languages
English (en)
Spanish (es)
Inventor
Tye Heather
Gadouleau Elise
Kumaravel Gnanasambandam
Devraj Rajesh
F Parker Michael
Beaumont Edward
Bowles Lee
Brombridge Steve
Cooper Sophie
Gleave Laura
Kerry Philip
Kotey Adrian
Krulle Thomas
Lecci Cristina
Loke Pui
Meniconi Mirco
Monck Nat
North Carl
Palfrey Jordan
Parrott Shelley
Ridgill Mark
Original Assignee
Padlock Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Padlock Therapeutics Inc filed Critical Padlock Therapeutics Inc
Publication of MX2018006632A publication Critical patent/MX2018006632A/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3199601A1 (en) * 2015-05-21 2016-11-24 Glaxosmithkline Intellectual Property Development Limited Benzoimidazole derivatives as pad4 inhibitors
EP3419969B1 (en) * 2016-02-23 2019-12-18 Padlock Therapeutics, Inc. Heteroaryl inhibitors of pad4
WO2018022897A1 (en) 2016-07-27 2018-02-01 Padlock Therapeutics, Inc. Covalent inhibitors of pad4
CN110248934B (zh) 2016-09-12 2022-05-24 帕德罗科治疗公司 杂芳基pad4抑制剂
JP2021515043A (ja) * 2018-02-26 2021-06-17 南京薬捷安康生物科技有限公司Ｎａｎｊｉｎｇ Ｔｒａｎｓｔｈｅｒａ Ｂｉｏｓｃｉｅｎｃｅｓ Ｃｏ．， Ｌｔｄ． ペプチジルアルギニンデイミナーゼ阻害剤及びその使用
KR20210042933A (ko) 2018-08-08 2021-04-20 브리스톨-마이어스 스큅 컴퍼니 Pad 효소의 벤즈이미다졸 억제제
CN112566916B (zh) * 2018-08-08 2023-10-20 百时美施贵宝公司 作为pad4抑制剂的经取代的噻吩并吡咯
MX2021001471A (es) * 2018-08-08 2021-04-28 Bristol Myers Squibb Co Benzimidazoles sustituidos como inhibidores de peptidil arginina deiminasa 4 (pad4).
EP3833440A1 (en) 2018-08-08 2021-06-16 Bristol-Myers Squibb Company Indole and azaindole inhibitors of pad enzymes
CA3132508A1 (en) 2019-03-28 2020-10-01 Lupin Limited Macrocyclic compounds as sting agonists
TW202115083A (zh) * 2019-09-27 2021-04-16 大陸商南京藥捷安康生物科技有限公司 肽醯精胺酸脫亞胺酶抑制劑及其用途
WO2021158840A1 (en) * 2020-02-06 2021-08-12 Bristol-Myers Squibb Company Macrocyclic pad4 inhibitors useful as immunosuppressant
TW202140477A (zh) 2020-02-12 2021-11-01 美商必治妥美雅史谷比公司 雜環ｐａｄ４抑制劑
PE20230488A1 (es) * 2020-04-30 2023-03-21 Gilead Sciences Inc Inhibidores macrociclicos de las peptidilarginina deiminasas
TW202227409A (zh) 2020-08-19 2022-07-16 美商必治妥美雅史谷比公司 作為tlr9抑制劑之經取代苯并咪唑
CN112618546B (zh) * 2020-12-22 2022-03-01 陈昊 Pad4抑制剂在制备放射治疗增敏药物方面的应用
EP4267562A1 (en) 2020-12-22 2023-11-01 Gilead Sciences, Inc. Inhibitors of peptidylarginine deiminases
US12240862B2 (en) 2020-12-22 2025-03-04 Gilead Sciences, Inc. Inhibitors of peptidylarginine deiminases
AU2023387505A1 (en) * 2022-11-24 2025-07-10 Helios Huaming Biopharma Co., Ltd. Selenium containing heterocycle compounds and use thereof
WO2025024265A1 (en) 2023-07-21 2025-01-30 Bristol-Myers Squibb Company Methods of assessing citrullination and activity of pad4 modulators
WO2025181830A2 (en) * 2024-03-01 2025-09-04 Jubilant Epipad LLC Polyheterocyclic compounds as peptidyl arginine deiminase 4 (pad4) inhibitors

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20012060A1 (it) * 2001-10-05 2003-04-05 Recordati Chem Pharm Nuovi eterocilcli n-acilati
US6897208B2 (en) 2001-10-26 2005-05-24 Aventis Pharmaceuticals Inc. Benzimidazoles
JP2006513159A (ja) 2002-11-01 2006-04-20 メルク　エンド　カムパニー　インコーポレーテッド アンドロゲン受容体モジュレーターとしてのカルボニルアミノ−ベンズイミダゾール誘導体
EP2234487A4 (en) 2007-12-19 2011-09-07 Scripps Research Inst ANILIDES AND ANALOGUES AS INHIBITORS OF RHO KINASE
CN103189063B (zh) * 2010-11-01 2016-10-19 宾夕法尼亚州研究基金会 治疗组合物和方法
JP5721484B2 (ja) 2011-03-17 2015-05-20 富士フイルム株式会社 重合性液晶組成物、それを用いた高分子材料および光学異方性フィルム、並びに重合性液晶化合物
WO2013052263A2 (en) 2011-09-16 2013-04-11 Microbiotix, Inc. Antifungal compounds
WO2013157021A1 (en) 2012-04-20 2013-10-24 Advinus Therapeutics Limited Bicyclic compounds, compositions and medicinal applications thereof
CN104428293B (zh) 2012-06-11 2018-06-08 Ucb生物制药私人有限公司 调节TNFα的苯并咪唑类
EP3255049A1 (en) 2012-06-29 2017-12-13 Pfizer Inc Novel 4-(substituted-amino)-7h-pyrrolo[2,3-d]pyrimidines as lrrk2 inhibitors
WO2014015905A1 (en) * 2012-07-26 2014-01-30 Glaxo Group Limited 2 - (azaindol- 2 -yl) benz imidazoles as pad4 inhibitors
CA3199601A1 (en) 2015-05-21 2016-11-24 Glaxosmithkline Intellectual Property Development Limited Benzoimidazole derivatives as pad4 inhibitors

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