MX2018003290A - Medios para el tratamiento del vih. - Google Patents
Medios para el tratamiento del vih.Info
- Publication number
- MX2018003290A MX2018003290A MX2018003290A MX2018003290A MX2018003290A MX 2018003290 A MX2018003290 A MX 2018003290A MX 2018003290 A MX2018003290 A MX 2018003290A MX 2018003290 A MX2018003290 A MX 2018003290A MX 2018003290 A MX2018003290 A MX 2018003290A
- Authority
- MX
- Mexico
- Prior art keywords
- treatment
- hiv
- coding sequence
- deoxyribonucleic acids
- sequence
- Prior art date
Links
- 108091026890 Coding region Proteins 0.000 abstract 2
- 108020004414 DNA Proteins 0.000 abstract 2
- 102000053602 DNA Human genes 0.000 abstract 2
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical group O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 abstract 2
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 abstract 2
- YKBGVTZYEHREMT-KVQBGUIXSA-N 2'-deoxyguanosine Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)O1 YKBGVTZYEHREMT-KVQBGUIXSA-N 0.000 abstract 1
- CKTSBUTUHBMZGZ-ULQXZJNLSA-N 4-amino-1-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-tritiopyrimidin-2-one Chemical compound O=C1N=C(N)C([3H])=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 CKTSBUTUHBMZGZ-ULQXZJNLSA-N 0.000 abstract 1
- 108010033040 Histones Proteins 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 238000011225 antiretroviral therapy Methods 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
- C12N15/1132—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses against retroviridae, e.g. HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/17—Immunomodulatory nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/31—Combination therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- AIDS & HIV (AREA)
- Mycology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La invención se refiere a una secuencia no codificante de ácidos desoxirribonucleicos que comprende al menos un motivo de secuencia N1N2CGN3N4, en donde N es un nucleótido que comprende A, C, T o G y C es desoxicitidina, G es desoxiguanosina, A es desoxiadenosina y T es desoxitimidina para el tratamiento de infecciones víricas. En particular, la secuencia no codificante de ácidos desoxirribonucleicos se usa en combinación con terapia antirretrovírica y/o inhibidores de la histona desacetilasa.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1516676.2A GB2542425A (en) | 2015-09-21 | 2015-09-21 | Means for the treatment of HIV |
PCT/EP2016/072385 WO2017050806A1 (en) | 2015-09-21 | 2016-09-21 | Means for the treatment of hiv |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018003290A true MX2018003290A (es) | 2018-06-20 |
Family
ID=54544545
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018003290A MX2018003290A (es) | 2015-09-21 | 2016-09-21 | Medios para el tratamiento del vih. |
Country Status (15)
Country | Link |
---|---|
US (2) | US11583581B2 (es) |
EP (1) | EP3353307A1 (es) |
JP (2) | JP7285074B2 (es) |
KR (1) | KR20180053664A (es) |
CN (1) | CN108138185B (es) |
AU (2) | AU2016328658B2 (es) |
BR (1) | BR112018005271A2 (es) |
CA (1) | CA2998265A1 (es) |
GB (1) | GB2542425A (es) |
HK (1) | HK1257272A1 (es) |
IL (1) | IL258137B2 (es) |
MX (1) | MX2018003290A (es) |
SG (1) | SG10201913196PA (es) |
WO (1) | WO2017050806A1 (es) |
ZA (1) | ZA201801495B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2968531A1 (en) | 2014-11-21 | 2016-05-26 | Northwestern University | The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates |
LU92821B1 (en) | 2015-09-09 | 2017-03-20 | Mologen Ag | Combination comprising immunostimulatory oligonucleotides |
GB2542425A (en) | 2015-09-21 | 2017-03-22 | Mologen Ag | Means for the treatment of HIV |
US11364304B2 (en) | 2016-08-25 | 2022-06-21 | Northwestern University | Crosslinked micellar spherical nucleic acids |
US11433131B2 (en) | 2017-05-11 | 2022-09-06 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (SNAs) |
Family Cites Families (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB191115253A (en) | 1911-06-30 | 1912-06-20 | Adolph Schneider | Improvements in Bottle-filling Machines. |
US2382696A (en) | 1939-04-01 | 1945-08-14 | Milleville Marie Joseph Mau De | Method and apparatus for filling containers |
GB684057A (en) | 1949-11-30 | 1952-12-10 | Stockholms Bryggerier Ab | Machine of the rotatory table type for the treatment of bottles and the like containers |
US2699718A (en) | 1952-04-10 | 1955-01-18 | Francis X Wright | Filling apparatus with beverage preparation mechanism |
FR1418965A (fr) | 1964-10-14 | 1965-11-26 | Chelle Ets | Tireuse de liquides à double utilisation |
AU554222B2 (en) | 1981-10-13 | 1986-08-14 | Toyo Garasu K.K. | Inspecting glass containers |
ES2099718T3 (es) | 1990-07-02 | 1997-06-01 | Hoechst Ag | Analogos de oligonucleotidos con uniones internucleotidicas de 3'-3' o 5'-5' terminales. |
DE69431669T2 (de) | 1993-09-02 | 2003-10-23 | Ribozyme Pharm Inc | Enzymatische nukleiksaüre die nicht-nukleotide enthaltet |
WO1995026204A1 (en) | 1994-03-25 | 1995-10-05 | Isis Pharmaceuticals, Inc. | Immune stimulation by phosphorothioate oligonucleotide analogs |
US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
US20030050263A1 (en) * | 1994-07-15 | 2003-03-13 | The University Of Iowa Research Foundation | Methods and products for treating HIV infection |
FR2732971B1 (fr) | 1995-04-13 | 1997-07-04 | Genset Sa | Oligonucleotide sens inhibiteur de virus herpes simplex (hsv) a structure en haltere |
US5856462A (en) | 1996-09-10 | 1999-01-05 | Hybridon Incorporated | Oligonucleotides having modified CpG dinucleosides |
HUP0001107A3 (en) | 1996-10-16 | 2003-01-28 | Icn Pharmaceuticals Inc Costa | Monocyclic l-nucleosides, analogs and pharmaceutical compositions thereof |
DE19648625A1 (de) | 1996-11-13 | 1998-05-14 | Soft Gene Gmbh | Mikroprojektil für das Einbringen von Substanzen in Zellen durch ballistischen Transfer |
EP0855184A1 (en) | 1997-01-23 | 1998-07-29 | Grayson B. Dr. Lipford | Pharmaceutical composition comprising a polynucleotide and an antigen especially for vaccination |
US6251666B1 (en) | 1997-03-31 | 2001-06-26 | Ribozyme Pharmaceuticals, Inc. | Nucleic acid catalysts comprising L-nucleotide analogs |
US6589940B1 (en) | 1997-06-06 | 2003-07-08 | Dynavax Technologies Corporation | Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof |
US6192481B1 (en) | 1998-08-18 | 2001-02-20 | International Business Machines Corporation | Structure and method for power sequencing of disk drives in a computer system |
CA2371994C (en) | 1999-02-26 | 2010-09-28 | Guido Grandi | Enhancement of bactericidal activity of neisseria antigens with oligonucleotides containing cg motifs |
US6977245B2 (en) | 1999-04-12 | 2005-12-20 | The United States Of America As Represented By The Department Of Health And Human Services | Oligodeoxynucleotide and its use to induce an immune response |
US6737066B1 (en) | 1999-05-06 | 2004-05-18 | The Immune Response Corporation | HIV immunogenic compositions and methods |
DE60023300T2 (de) * | 1999-06-29 | 2006-07-06 | Glaxosmithkline Biologicals S.A. | Verwendung von cpg als adjuvans für hivimpstoff |
DE19935756A1 (de) | 1999-07-27 | 2001-02-08 | Mologen Forschungs Entwicklung | Kovalent geschlossenes Nukleinsäuremolekül zur Immunstimulation |
AU1656601A (en) | 1999-11-12 | 2001-06-12 | Isis Pharmaceuticals, Inc. | Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages |
AU2001294750C1 (en) | 2000-09-26 | 2008-09-18 | Idera Pharmaceuticals, Inc. | Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes |
EP1355661A2 (de) | 2001-01-31 | 2003-10-29 | Mologen Forschungs-, Entwicklungs- und Vertriebs GmbH | Tumorvakzine |
CA2452458A1 (en) | 2001-07-03 | 2003-01-16 | Isis Pharmaceuticals, Inc. | Nuclease resistant chimeric oligonucleotides |
CN1310676C (zh) | 2001-10-02 | 2007-04-18 | 莫洛根股份公司 | 提高免疫应答的方法 |
AU2002349278A1 (en) | 2001-10-02 | 2003-04-22 | Mologen Ag | Dna-expression construct for treatment of infections with leishmaniasis |
WO2003035836A2 (en) | 2001-10-24 | 2003-05-01 | Hybridon Inc. | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends |
US7276489B2 (en) | 2002-10-24 | 2007-10-02 | Idera Pharmaceuticals, Inc. | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends |
JP2003204793A (ja) | 2002-01-15 | 2003-07-22 | Takeda Chem Ind Ltd | ウイルス性疾患の予防または治療剤 |
DE10211558A1 (de) | 2002-03-15 | 2003-10-09 | Noxxon Pharma Ag | Neue Formen RNAi |
AU2003287332A1 (en) | 2002-11-01 | 2004-06-07 | The Regents Of The University Of California | Methods of treating pulmonary fibrotic disorders |
US8158768B2 (en) | 2002-12-23 | 2012-04-17 | Dynavax Technologies Corporation | Immunostimulatory sequence oligonucleotides and methods of using the same |
US7501503B2 (en) | 2002-12-31 | 2009-03-10 | Mcgill University | Compositions and methods for inhibiting RNase H activity of retroid reverse transcriptase |
WO2004084940A1 (en) | 2003-03-26 | 2004-10-07 | Cytos Biotechnology Ag | Packaging of immunostimulatory oligonucleotides into virus-like particles: method of preparation and use |
PT1631672E (pt) | 2003-06-10 | 2007-01-31 | Mologen Ag | Vector de expressão circular destinado a aplicações na terapia genetica |
SG123799A1 (en) | 2003-10-30 | 2006-07-26 | Coley Pharm Gmbh | C-class oligonucleotide analogs with enchanced immunostimulatory potency |
EP1691817A2 (en) | 2003-12-02 | 2006-08-23 | Corgentech, Inc. | NF-kB OLIGONUCLEOTIDE DECOY MOLECULES |
RU2354694C2 (ru) | 2003-12-30 | 2009-05-10 | Мологен Аг | Аллогенное противоопухолевое терапевтическое средство |
CN1918293A (zh) * | 2004-02-20 | 2007-02-21 | 莫洛根股份公司 | 用于对人及高等动物进行治疗性和预防性免疫刺激的取代的非编码核酸分子 |
JP3976742B2 (ja) | 2004-02-27 | 2007-09-19 | 江守商事株式会社 | インターフェロンアルファを誘導する免疫刺激オリゴヌクレオチド |
US20090004703A1 (en) | 2004-05-28 | 2009-01-01 | Mologen Ag | Method for the Production of Suitable Dna Constructs for Specific Inhibition of Gene Expression by Rna Interference |
EP2901856B1 (en) | 2004-06-15 | 2017-08-09 | Idera Pharmaceuticals, Inc. | Immunostimulatory oligonucleotide multimers |
WO2006015560A1 (de) | 2004-08-09 | 2006-02-16 | Mologen Ag | Immunmodulierendes mittel in verbindung mit chemotherapeutischen massnahmen |
US7879992B2 (en) | 2005-01-31 | 2011-02-01 | Isis Pharmaceuticals, Inc. | Modification of MyD88 splicing using modified oligonucleotides |
WO2006091591A1 (en) | 2005-02-22 | 2006-08-31 | The Regents Of The University Of California | Methods of treating gastrointestinal inflammation |
WO2006116458A2 (en) | 2005-04-26 | 2006-11-02 | Coley Pharmaceutical Gmbh | Modified oligoribonucleotide analogs with enhances immunostimulatory activity |
US20090169472A1 (en) | 2005-10-12 | 2009-07-02 | Cancer Research Technology Ltd. | Methods and compositions for treating immune disorders |
US8357665B2 (en) | 2005-10-12 | 2013-01-22 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response |
BRPI0618473A2 (pt) | 2005-11-11 | 2011-08-30 | Pfizer | combinações e métodos de uso de um oligodeoxinucleotìdeo imunomodulador |
DK1951870T3 (da) | 2005-11-25 | 2013-07-29 | Mologen Ag | DNA-konstrukter til specifik inhibering af genekspression ved RNA-interferens |
CA2630738C (en) | 2005-11-25 | 2013-09-03 | Coley Pharmaceutical Gmbh | Immunostimulatory oligoribonucleotides |
RU2008135318A (ru) | 2006-02-01 | 2010-03-10 | Дзе Джонс Хопкинс Юниверсити (Us) | Конъюгат полипептид-нуклеиновая кислота для иммунопрофилактики или иммунотерапии неопластических или инфекционных заболеваний |
KR20090012265A (ko) | 2006-05-11 | 2009-02-02 | 몰로겐 아게 | 면역자극용 멀티머 |
EP2032144A4 (en) | 2006-06-13 | 2011-05-04 | Bayhill Therapeutics Inc | METHODS AND COMPOSITIONS BASED ON NUCLEIC ACID MODULATORS OF THE IMMUNE SYSTEM FOR THE PREVENTION AND TREATMENT OF DISEASE |
US20090181078A1 (en) | 2006-09-26 | 2009-07-16 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
LT2484375T (lt) | 2006-09-26 | 2018-07-10 | Infectious Disease Research Institute | Vakcinos kompozicija, turinti sintetinio adjuvanto |
US20080260820A1 (en) | 2007-04-19 | 2008-10-23 | Gilles Borrelly | Oral dosage formulations of protease-resistant polypeptides |
AU2008262478C1 (en) | 2007-05-29 | 2014-06-19 | Aldevron, L.L.C. | Vectors and methods for genetic immunization |
US8080634B2 (en) | 2007-07-27 | 2011-12-20 | Immatics Biotechnologies Gmbh | Immunogenic epitope for immunotherapy |
WO2009035554A2 (en) | 2007-09-07 | 2009-03-19 | University Of Florida Research Foundation, Inc. | Superior structure stability and selectivity of hairpin nucleic acid probes with an l-dna stem |
RU2010112771A (ru) | 2007-10-09 | 2011-11-20 | Коули Фармасьютикал ГмбХ (DE) | Иммуностимулирующие аналоги олигонуклеотидов, содержащие модифицированные сахарные группировки |
EP2058397A1 (de) * | 2007-11-07 | 2009-05-13 | Mologen AG | Multimeres Assemblat zur Immunstimulation |
WO2009069447A1 (ja) | 2007-11-28 | 2009-06-04 | Toray Industries, Inc. | インフルエンザワクチン用のアジュバント及びインフルエンザワクチン |
JP5359883B2 (ja) | 2007-11-28 | 2013-12-04 | 東レ株式会社 | 肝炎の治療剤又は予防剤 |
WO2010039137A1 (en) * | 2008-10-02 | 2010-04-08 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response |
EP2246433A1 (de) | 2009-04-30 | 2010-11-03 | Mologen AG | Concatemere zur Immunmodulation |
KR20130063493A (ko) * | 2010-03-26 | 2013-06-14 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | Hiv 백신 |
GB201021867D0 (en) | 2010-12-23 | 2011-02-02 | Mologen Ag | Non-coding immunomodulatory DNA construct |
GB201021873D0 (en) * | 2010-12-23 | 2011-02-02 | Mologen Ag | DNA expression construct |
JP5761707B2 (ja) | 2011-02-02 | 2015-08-12 | 国立研究開発法人産業技術総合研究所 | 高効率細胞融合法 |
GB2514591A (en) | 2013-05-30 | 2014-12-03 | Mologen Ag | Predictive biomarker for cancer therapy |
GB2523187A (en) | 2014-02-18 | 2015-08-19 | Mologen Ag | Covalently closed non-coding immunomodulatory DNA construct |
LU92821B1 (en) | 2015-09-09 | 2017-03-20 | Mologen Ag | Combination comprising immunostimulatory oligonucleotides |
GB2542425A (en) | 2015-09-21 | 2017-03-22 | Mologen Ag | Means for the treatment of HIV |
EP3392345A1 (en) | 2017-04-22 | 2018-10-24 | Mologen AG | Biomarker for small cell lung cancer therapy |
JP2020531555A (ja) | 2017-08-31 | 2020-11-05 | モロゲン・アーゲー | 腫瘍微小環境のモジュレーションのためのtlr−9アゴニスト |
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2015
- 2015-09-21 GB GB1516676.2A patent/GB2542425A/en not_active Withdrawn
-
2016
- 2016-09-21 US US15/760,424 patent/US11583581B2/en active Active
- 2016-09-21 CA CA2998265A patent/CA2998265A1/en active Pending
- 2016-09-21 AU AU2016328658A patent/AU2016328658B2/en active Active
- 2016-09-21 WO PCT/EP2016/072385 patent/WO2017050806A1/en active Application Filing
- 2016-09-21 IL IL258137A patent/IL258137B2/en unknown
- 2016-09-21 CN CN201680053311.1A patent/CN108138185B/zh active Active
- 2016-09-21 MX MX2018003290A patent/MX2018003290A/es unknown
- 2016-09-21 KR KR1020187007292A patent/KR20180053664A/ko not_active Application Discontinuation
- 2016-09-21 EP EP16767306.0A patent/EP3353307A1/en active Pending
- 2016-09-21 SG SG10201913196PA patent/SG10201913196PA/en unknown
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JP7285074B2 (ja) | 2023-06-01 |
RU2765589C2 (ru) | 2022-02-02 |
IL258137A (en) | 2018-05-31 |
AU2023200395A1 (en) | 2023-02-23 |
US20230310594A1 (en) | 2023-10-05 |
KR20180053664A (ko) | 2018-05-23 |
GB201516676D0 (en) | 2015-11-04 |
US11583581B2 (en) | 2023-02-21 |
AU2016328658A1 (en) | 2018-03-29 |
RU2018109402A (ru) | 2019-10-25 |
CN108138185A (zh) | 2018-06-08 |
RU2018109402A3 (es) | 2020-02-18 |
WO2017050806A9 (en) | 2018-03-08 |
BR112018005271A2 (pt) | 2018-10-09 |
CN108138185B (zh) | 2022-08-16 |
CA2998265A1 (en) | 2017-03-30 |
GB2542425A (en) | 2017-03-22 |
IL258137B1 (en) | 2023-09-01 |
AU2016328658B2 (en) | 2022-10-27 |
EP3353307A1 (en) | 2018-08-01 |
HK1257272A1 (zh) | 2019-10-18 |
US20200230234A1 (en) | 2020-07-23 |
SG10201913196PA (en) | 2020-02-27 |
ZA201801495B (en) | 2018-11-28 |
JP2018527002A (ja) | 2018-09-20 |
WO2017050806A1 (en) | 2017-03-30 |
IL258137B2 (en) | 2024-01-01 |
JP2022010100A (ja) | 2022-01-14 |
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