JP7285074B2 - Hivの治療のための手段 - Google Patents
Hivの治療のための手段 Download PDFInfo
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- JP7285074B2 JP7285074B2 JP2018513772A JP2018513772A JP7285074B2 JP 7285074 B2 JP7285074 B2 JP 7285074B2 JP 2018513772 A JP2018513772 A JP 2018513772A JP 2018513772 A JP2018513772 A JP 2018513772A JP 7285074 B2 JP7285074 B2 JP 7285074B2
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- hiv
- deoxyribonucleic acid
- cells
- medicament according
- coding sequence
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Description
a.GTTCCTGGAG ACGTTCTTAG GAACGTTCTC CTTGACGTTG GAGAGAAC(配列番号1)または
b.ACCTTCCTTG TACTAACGTT GCCTCAAGGA AGGTTGATCT TCATAACGTT GCCTAGATCA(配列番号2)、または
c.AACGTTCTTCGGGG CGTT(配列番号3)、または
d.AGGTGGTAAC CCCTAGGGGT TACCACCTTC ATCGTCGTTT TGTCGTTTTG TCGTTCTT(配列番号4)
の配列のうちの少なくとも1つが含まれていてもよいことが意図される。
Claims (12)
- 少なくとも1つの配列モチーフN1N2CGN3N4[式中、Nは、A、C、T、またはGを含むヌクレオチドであり、Cはデオキシシチジンであり、Gはデオキシグアノシンであり、Aはデオキシアデノシンであり、Tはデオキシチミジンである]を含む非コード配列のデオキシリボ核酸を有効成分として含有するウイルス感染の治療のための医薬品であって、前記非コード配列のデオキシリボ核酸は、
CCTAGGGGTT ACCACCTTCA TTGGAAAACG TTCTTCGGGG CGTTCTTAGG TGGTAACC CCTAGGGGTT ACCACCTTCA TTGGAAAACG TTCTTCGGGG CGTTCTTAGG TGGTAACC(配列番号5)の配列を含む非コード配列のデオキシリボ核酸
である、ウイルス感染の治療のための医薬品。 - 組合せ抗レトロウイルス療法および/またはヒストン脱アセチル化酵素阻害剤を更に備える、請求項1に記載の医薬品。
- ウイルス感染が潜伏性である、請求項1または2に記載の医薬品。
- ウイルス感染がHIV-1感染である、請求項1から3のいずれか一項に記載の医薬品。
- ウイルス感染が潜伏性HIV-1感染である、請求項1から4のいずれか一項に記載の医薬品。
- 前記非コード配列のデオキシリボ核酸において、直鎖状開鎖非コード配列のデオキシリボ核酸のDNA一本鎖の5’端および/または3’端に位置する5つの末端ヌクレオチドのうちの1つが、L-立体配座にある、請求項1から5のいずれか一項に記載の医薬品。
- 前記非コード配列のデオキシリボ核酸が、116から200ヌクレオチドの長さを有する、請求項1から6のいずれか一項に記載の医薬品。
- 前記非コード配列のデオキシリボ核酸において、前記配列モチーフN1N2CGN3N
4が、一本鎖領域の部分である、請求項1から7のいずれか一項に記載の医薬品。 - 前記非コード配列のデオキシリボ核酸が、組合せ抗レトロウイルス療法および/またはヒストン脱アセチル化酵素阻害剤と同時に、交互にまたは連続して提供される、請求項1から8のいずれか一項に記載の医薬品。
- 前記非コード配列のデオキシリボ核酸が、組合せ抗レトロウイルス療法および/またはヒストン脱アセチル化酵素阻害剤の前に提供される、請求項9に記載の医薬品。
- ワクチン用の、請求項1から10のいずれか一項に記載の医薬品。
- HIV-1感染の治療用または予防用のワクチン接種におけるアジュバント用の、請求項1から11のいずれか一項に記載の医薬品。
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GB1516676.2A GB2542425A (en) | 2015-09-21 | 2015-09-21 | Means for the treatment of HIV |
GB1516676.2 | 2015-09-21 | ||
PCT/EP2016/072385 WO2017050806A1 (en) | 2015-09-21 | 2016-09-21 | Means for the treatment of hiv |
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JP2018527002A JP2018527002A (ja) | 2018-09-20 |
JP2018527002A5 JP2018527002A5 (ja) | 2019-10-31 |
JP7285074B2 true JP7285074B2 (ja) | 2023-06-01 |
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EP (1) | EP3353307A1 (ja) |
JP (2) | JP7285074B2 (ja) |
KR (1) | KR20180053664A (ja) |
CN (1) | CN108138185B (ja) |
AU (2) | AU2016328658B2 (ja) |
BR (1) | BR112018005271A2 (ja) |
CA (1) | CA2998265A1 (ja) |
GB (1) | GB2542425A (ja) |
HK (1) | HK1257272A1 (ja) |
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CA2968531A1 (en) | 2014-11-21 | 2016-05-26 | Northwestern University | The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates |
LU92821B1 (en) | 2015-09-09 | 2017-03-20 | Mologen Ag | Combination comprising immunostimulatory oligonucleotides |
GB2542425A (en) | 2015-09-21 | 2017-03-22 | Mologen Ag | Means for the treatment of HIV |
US11364304B2 (en) | 2016-08-25 | 2022-06-21 | Northwestern University | Crosslinked micellar spherical nucleic acids |
US11433131B2 (en) | 2017-05-11 | 2022-09-06 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (SNAs) |
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RU2765589C2 (ru) | 2022-02-02 |
IL258137A (en) | 2018-05-31 |
AU2023200395A1 (en) | 2023-02-23 |
US20230310594A1 (en) | 2023-10-05 |
KR20180053664A (ko) | 2018-05-23 |
GB201516676D0 (en) | 2015-11-04 |
US11583581B2 (en) | 2023-02-21 |
AU2016328658A1 (en) | 2018-03-29 |
RU2018109402A (ru) | 2019-10-25 |
CN108138185A (zh) | 2018-06-08 |
RU2018109402A3 (ja) | 2020-02-18 |
WO2017050806A9 (en) | 2018-03-08 |
BR112018005271A2 (pt) | 2018-10-09 |
CN108138185B (zh) | 2022-08-16 |
CA2998265A1 (en) | 2017-03-30 |
GB2542425A (en) | 2017-03-22 |
IL258137B1 (en) | 2023-09-01 |
AU2016328658B2 (en) | 2022-10-27 |
MX2018003290A (es) | 2018-06-20 |
EP3353307A1 (en) | 2018-08-01 |
HK1257272A1 (zh) | 2019-10-18 |
US20200230234A1 (en) | 2020-07-23 |
SG10201913196PA (en) | 2020-02-27 |
ZA201801495B (en) | 2018-11-28 |
JP2018527002A (ja) | 2018-09-20 |
WO2017050806A1 (en) | 2017-03-30 |
IL258137B2 (en) | 2024-01-01 |
JP2022010100A (ja) | 2022-01-14 |
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