MX2018000305A - Anticuerpo anti-receptor de transferrina humana que penetra la barrera hematoencefalica. - Google Patents
Anticuerpo anti-receptor de transferrina humana que penetra la barrera hematoencefalica.Info
- Publication number
- MX2018000305A MX2018000305A MX2018000305A MX2018000305A MX2018000305A MX 2018000305 A MX2018000305 A MX 2018000305A MX 2018000305 A MX2018000305 A MX 2018000305A MX 2018000305 A MX2018000305 A MX 2018000305A MX 2018000305 A MX2018000305 A MX 2018000305A
- Authority
- MX
- Mexico
- Prior art keywords
- brain barrier
- receptor antibody
- transferrin receptor
- human transferrin
- permeating
- Prior art date
Links
- 102000007238 Transferrin Receptors Human genes 0.000 title abstract 3
- 108010033576 Transferrin Receptors Proteins 0.000 title abstract 3
- 230000008499 blood brain barrier function Effects 0.000 title abstract 3
- 210000001218 blood-brain barrier Anatomy 0.000 title abstract 3
- 239000000126 substance Substances 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 150000003384 small molecules Chemical class 0.000 abstract 1
Classifications
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- C07K16/2881—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD71
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Abstract
Se da a conocer un medio para convertir compuestos, los cuales tienen actividad fisiológica o farmacológica y son incapaces de pasar a través de la barrera hematoencefálica, a una forma que les permite pasar a través de la barrera hematoencefálica, así como compuestos convertidos de ese modo. El medio es un anticuerpo anti-receptor de transferrina humana, y los compuestos convertidos son conjugados moleculares entre una proteína fisiológicamente activa o un compuesto de bajo peso molecular farmacológicamente activo y un anticuerpo anti-receptor de transferrina humana.
Applications Claiming Priority (2)
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JP2015144379 | 2015-06-24 | ||
PCT/JP2016/068738 WO2016208695A1 (ja) | 2015-06-24 | 2016-06-24 | 血液脳関門を通過する抗ヒトトランスフェリン受容体抗体 |
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MX2018000305A MX2018000305A (es) | 2015-06-24 | 2016-06-24 | Anticuerpo anti-receptor de transferrina humana que penetra la barrera hematoencefalica. |
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JP (5) | JP6328851B2 (es) |
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