EA201890130A1 - Антитело к рецептору трансферрина человека, проникающее через гематоэнцефалический барьер - Google Patents

Антитело к рецептору трансферрина человека, проникающее через гематоэнцефалический барьер

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Publication number
EA201890130A1
EA201890130A1 EA201890130A EA201890130A EA201890130A1 EA 201890130 A1 EA201890130 A1 EA 201890130A1 EA 201890130 A EA201890130 A EA 201890130A EA 201890130 A EA201890130 A EA 201890130A EA 201890130 A1 EA201890130 A1 EA 201890130A1
Authority
EA
Eurasian Patent Office
Prior art keywords
antibody
transferrin receptor
human transferrin
compounds
penetrating
Prior art date
Application number
EA201890130A
Other languages
English (en)
Other versions
EA039366B1 (ru
Inventor
Хироюки Сонода
Кенити Такахаси
Original Assignee
Джей Си Ар ФАРМАСЬЮТИКАЛЗ КО., ЛТД.
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57585554&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201890130(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Джей Си Ар ФАРМАСЬЮТИКАЛЗ КО., ЛТД. filed Critical Джей Си Ар ФАРМАСЬЮТИКАЛЗ КО., ЛТД.
Publication of EA201890130A1 publication Critical patent/EA201890130A1/ru
Publication of EA039366B1 publication Critical patent/EA039366B1/ru

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    • C07K16/2881—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD71
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    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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Abstract

Раскрыты средства для того, чтобы превращать соединения, обладающие физиологической или фармакологической активностью и неспособные проходить через гематоэнцефалический барьер, в форму, которая позволяет им проходить через гематоэнцефалический барьер, и соединения, превращенные таким образом. Средством является антитело к рецептору трансферрина человека, и превращенными соединениями являются молекулярные конъюгаты между физиологически активным белком или фармакологически активными низкомолекулярными соединениями и антителом к рецептору трансферрина человека.
EA201890130A 2015-06-24 2016-06-24 Антитело к рецептору трансферрина человека, проникающее через гематоэнцефалический барьер EA039366B1 (ru)

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Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114409783A (zh) 2015-06-24 2022-04-29 Jcr制药股份有限公司 通过血脑屏障的抗人转铁蛋白受体抗体
US11130815B2 (en) 2015-06-24 2021-09-28 Jcr Pharmaceuticals Co., Ltd. Fusion proteins containing a BDNF and an anti-human transferrin receptor antibody
BR112017024610A2 (pt) 2015-06-24 2018-07-31 F. Hoffmann-La Roche Ag anticorpos para receptor antitransferrina com afinidade especificada
AR106189A1 (es) 2015-10-02 2017-12-20 Hoffmann La Roche ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO
CN114031689A (zh) 2015-10-02 2022-02-11 豪夫迈·罗氏有限公司 双特异性抗人cd20/人转铁蛋白受体抗体及使用方法
SG11201804375WA (en) * 2015-12-08 2018-06-28 Regeneron Pharma Compositions and methods for internalizing enzymes
US10759864B2 (en) * 2016-12-26 2020-09-01 Jcr Pharmaceuticals Co., Ltd. Anti-human transferrin receptor antibody capable of penetrating blood-brain barrier
KR102471458B1 (ko) 2016-12-28 2022-11-25 제이씨알 파마 가부시키가이샤 동결건조 제제
US10457717B2 (en) 2017-02-17 2019-10-29 Denali Therapeutics Inc. Engineered polypeptides
HRP20221505T1 (hr) * 2017-02-17 2023-02-17 Denali Therapeutics Inc. Proizvedeni polipeptidi za vezanje receptora transferina
US10143187B2 (en) * 2017-02-17 2018-12-04 Denali Therapeutics Inc. Transferrin receptor transgenic models
SG10201913676QA (en) 2017-04-01 2020-03-30 Beijing hanmi pharm co ltd Anti-pd-l1/anti-pd-1 natural antibody structure-like heterodimeric bispecific antibody and preparation thereof
EP3434692A1 (en) 2017-07-24 2019-01-30 Encefa Compounds which specifically binds to cd38 for use in the treatment of neurodegenerative diseases
WO2019024979A1 (en) * 2017-07-31 2019-02-07 Institute For Research In Biomedicine FUNCTIONAL DOMAIN ANTIBODIES IN THE ELBOW REGION
WO2019049967A1 (ja) * 2017-09-07 2019-03-14 Ｊｃｒファーマ株式会社 水性医薬組成物
BR112020005271A2 (pt) 2017-10-02 2020-09-15 Denali Therapeutics Inc. proteína, polipeptídeo, polinucleotídeo, vetor, célula hospedeira, método para produção de um polipeptídeo, métodos de tratamento de um distúrbio, de diminuição do acúmulo, de monitoramento, de transporte de um agente e de tratamento de um lsd e composição farmacêutica
CA3088157A1 (en) * 2018-01-10 2019-07-18 Denali Therapeutics Inc. Transferrin receptor-binding polypeptides and uses thereof
IL276327B2 (en) * 2018-02-05 2024-05-01 Japan Chem Res A method of administering a drug to a muscle
US11753455B2 (en) 2018-06-21 2023-09-12 Novo Nordisk A/S Compounds for treatment of obesity
CN112512584A (zh) 2018-07-27 2021-03-16 国立大学法人大阪大学 用于抑制衰老、预防、改善或治疗衰老相关疾病或症状、或者延长寿命的组合物
WO2020037150A2 (en) 2018-08-16 2020-02-20 Denali Therapeutics Inc. Engineered bispecific proteins
WO2020068058A1 (en) * 2018-09-25 2020-04-02 Academia Sinica Anti-siglec antibody, pharmaceutical composition comprising the same, and uses thereof
TW202029980A (zh) * 2018-10-26 2020-08-16 美商免疫遺傳股份有限公司 Ｅ ｐ Ｃ Ａ Ｍ 抗體、可活化抗體及免疫偶聯物以及其用途
KR20200047937A (ko) * 2018-10-26 2020-05-08 재단법인 목암생명과학연구소 Ids를 포함하는 융합 단백질 및 이의 용도
SG11202105163UA (en) * 2018-11-20 2021-06-29 Perseus Proteomics Inc Agent for inhibiting iron uptake into cells
CN109486793B (zh) * 2018-11-27 2020-08-04 江南大学 一种蔗糖水解酶突变体及其制备方法与应用
US20210403584A1 (en) * 2019-01-08 2021-12-30 Armagen, Inc. Methods and compositions for increasing galactosidase beta-1 activity in the cns
CN113474369A (zh) 2019-01-09 2021-10-01 维克塔-霍洛斯公司 转铁蛋白受体结合分子、其偶联物和它们的用途
BR112021014574A2 (pt) 2019-01-23 2021-10-05 Encefa Competidores cd31 e usos dos mesmos
PE20230036A1 (es) 2019-12-23 2023-01-10 Denali Therapeutics Inc Variantes de progranulina
AU2021224412A1 (en) 2020-02-22 2022-09-15 Jcr Pharmaceuticals Co., Ltd. Human transferrin receptor binding peptide
CA3197506A1 (en) 2020-10-14 2022-04-21 Denali Therapeutics Inc. Fusion proteins comprising sulfoglucosamine sulfohydrolase enzymes and methods thereof
US20240066149A1 (en) 2021-01-12 2024-02-29 Jcr Pharmaceuticals Co., Ltd. Nucleic Acid Molecule Containing Incorporated Gene Encoding Fused Protein of Ligand and Protein Having Physiological Activity
EP4298132A1 (en) * 2021-02-23 2024-01-03 Ichilov Tech Ltd. Fusion proteins for treating cns diseases
WO2022239817A1 (ja) * 2021-05-12 2022-11-17 Ｊｃｒファーマ株式会社 ムコ多糖症ｉ型の治療用医薬組成物
WO2023287238A1 (ko) * 2021-07-15 2023-01-19 한양대학교 산학협력단 뇌혈관장벽 통과 효율이 향상된 항 인간 트랜스페린 수용체 항체, 및 이를 이용한 다중특이적 항체 및 약학 조성물
EP4373511A1 (en) 2021-07-23 2024-05-29 Denali Therapeutics Inc. Methods for the treatment of hunter syndrome
IL310898A (en) 2021-08-19 2024-04-01 Peptidream Inc Human transfer receptor-peptide connector
WO2023026994A1 (ja) * 2021-08-21 2023-03-02 武田薬品工業株式会社 ヒトトランスフェリンレセプター結合ペプチド－薬物コンジュゲート
IL311025A (en) 2021-08-24 2024-04-01 Peptidream Inc Human receptor binding antibody-peptides
US11827702B2 (en) 2021-09-01 2023-11-28 Biogen Ma Inc. Anti-transferrin receptor antibodies and uses thereof
WO2023090409A1 (ja) * 2021-11-19 2023-05-25 Ｊｃｒファーマ株式会社 ヒトトランスフェリン受容体親和性ペプチド
AR128003A1 (es) * 2021-12-17 2024-03-20 Denali Therapeutics Inc PROTEÍNAS DE FUSIÓN QUE COMPRENDEN ENZIMAS DE a-L-IDURONIDASA Y MÉTODOS PARA LAS MISMAS
WO2023204202A1 (ja) * 2022-04-19 2023-10-26 Ｊｃｒファーマ株式会社 マンノース－６－リン酸の数を減少させた糖蛋白質
WO2023207574A1 (zh) * 2022-04-28 2023-11-02 领诺(上海)医药科技有限公司 一种穿越血脑屏障的重组hARSA
WO2024010067A1 (ja) * 2022-07-08 2024-01-11 Ｊｃｒファーマ株式会社 中枢神経系疾患の治療のための、核酸分子、ベクター、組換え細胞及び薬剤

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5977307A (en) 1989-09-07 1999-11-02 Alkermes, Inc. Transferrin receptor specific ligand-neuropharmaceutical agent fusion proteins
US5672683A (en) 1989-09-07 1997-09-30 Alkermes, Inc. Transferrin neuropharmaceutical agent fusion protein
US5527527A (en) * 1989-09-07 1996-06-18 Alkermes, Inc. Transferrin receptor specific antibody-neuropharmaceutical agent conjugates
US5154924A (en) * 1989-09-07 1992-10-13 Alkermes, Inc. Transferrin receptor specific antibody-neuropharmaceutical agent conjugates
CA2123307A1 (en) 1991-11-26 1993-06-10 Phillip M. Friden Process for the preparation of transferrin receptor specific antibody-neuro-pharmaceutical or diagnostic agent conjugates
JPH06228199A (ja) 1992-11-27 1994-08-16 Takeda Chem Ind Ltd 血液脳関門通過可能なペプチド結合体
EP0599303A3 (en) 1992-11-27 1998-07-29 Takeda Chemical Industries, Ltd. Peptide conjugate
US6472147B1 (en) 1999-05-25 2002-10-29 The Scripps Research Institute Methods for display of heterodimeric proteins on filamentous phage using pVII and pIX, compositions, vectors and combinatorial libraries
EP1197755A1 (en) * 2000-10-11 2002-04-17 Pepscan Systems B.V. Identification of protein binding sites
EP2277894A1 (en) * 2000-10-27 2011-01-26 Novartis Vaccines and Diagnostics S.r.l. Nucleic acids and proteins from streptococcus groups A & B
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
US7388079B2 (en) 2002-11-27 2008-06-17 The Regents Of The University Of California Delivery of pharmaceutical agents via the human insulin receptor
US20050026823A1 (en) 2003-06-20 2005-02-03 Biomarin Pharmaceutical Inc. Use of the chaperone receptor-associated protein (RAP) for the delivery of therapeutic compounds to the brain and other tissues
US7442372B2 (en) 2003-08-29 2008-10-28 Biomarin Pharmaceutical Inc. Delivery of therapeutic compounds to the brain and other tissues
US8053569B2 (en) 2005-10-07 2011-11-08 Armagen Technologies, Inc. Nucleic acids encoding and methods of producing fusion proteins
AR059089A1 (es) 2006-01-20 2008-03-12 Genzyme Corp Administracion intraventricular de una enzima para enfermedades de almacenamiento lisosomal
GB0624500D0 (en) * 2006-12-07 2007-01-17 Istituto Superiore Di Sanito A novel passive vaccine for candida infections
CN101245107B (zh) * 2007-02-14 2010-10-13 中国人民解放军军事医学科学院生物工程研究所 抗人转铁蛋白受体人源抗体及其应用
CA2607771A1 (en) * 2007-11-01 2009-05-01 Her Majesty The Queen In Right Of Canada As Represented By The Minister Of National Defence Humanized anti-venezuelan equine encephalitis virus recombinant antibody
US20100077498A1 (en) 2008-09-11 2010-03-25 Pardridge William M Compositions and methods for blood-brain barrier delivery in the mouse
EP2337795A2 (en) 2008-10-01 2011-06-29 Dako Denmark A/S Mhc multimers in cancer vaccines and immune monitoring
CN102439040B (zh) * 2009-04-16 2017-05-03 艾伯维生物医疗股份有限公司 抗TNF‑α抗体和其用途
PT2485761T (pt) * 2009-10-09 2019-05-30 Armagen Inc Métodos e composições para aumentar a atividade da iduronato 2-sulfatase no snc
JP5500944B2 (ja) 2009-10-29 2014-05-21 三菱電機株式会社 加熱調理器
JP2012062312A (ja) 2010-08-19 2012-03-29 Yoshikatsu Eto ハンター症候群の治療剤
ES2631356T3 (es) 2010-11-30 2017-08-30 F. Hoffmann-La Roche Ag Anticuerpos anti-receptor de transferrina de baja afinidad y su uso para transferir scFv terapéuticos a través de la barrera hematoencefálica
WO2012122396A1 (en) * 2011-03-08 2012-09-13 Baylor Research Institute Novel vaccine adjuvants based on targeting adjuvants to antibodies directly to antigen-presenting cells
CA2828662A1 (en) 2011-04-20 2012-10-26 Roche Glycart Ag Method and constructs for the ph dependent passage of the blood-brain-barrier
EP2708560A4 (en) 2011-05-09 2015-01-14 Perseus Proteomics Inc ANTIBODIES FOR THE SPECIFIC DETECTION OF TRANSFERRIN RECEPTORS
TWI450727B (zh) 2011-12-29 2014-09-01 Ind Tech Res Inst 抗人類輸鐵蛋白受體的單域抗體與其應用
EP3594239A1 (en) * 2012-05-21 2020-01-15 F. Hoffmann-La Roche AG Methods for improving safety of blood-brain barrier transport
RU2018129572A (ru) * 2012-12-24 2018-10-12 Эббви Инк. Белки, связывающие рецептор пролактина, и их применение
US9708406B2 (en) 2013-05-20 2017-07-18 Genentech, Inc. Anti-transferrin receptor antibodies and methods of use
EP3003368A4 (en) * 2013-05-24 2017-05-03 Biogen MA Inc. Anti-gpiib/iiia antibodies or uses thereof
TW201536811A (zh) * 2013-05-31 2015-10-01 Biogen Idec Inc 嵌合ｆｖｉｉ－ｘｔｅｎ分子及其用途
US10906981B2 (en) 2013-07-19 2021-02-02 The Regents Of The University Of California Compositions and methods related to structures that cross the blood brain barrier
PE20160720A1 (es) 2013-08-02 2016-07-28 Hoffmann La Roche Proteina de fusion terapeutica
WO2015098989A1 (ja) 2013-12-25 2015-07-02 Ｊｃｒファーマ株式会社 血液脳関門を通過する新規抗トランスフェリン受容体抗体
MX2016008190A (es) 2014-01-06 2016-10-21 Hoffmann La Roche Modulos de lanzadera de barrera cerebral sanguinea monovalente.
CA2874083C (en) * 2014-12-05 2024-01-02 Universite Laval Tdp-43-binding polypeptides useful for the treatment of neurodegenerative diseases
CN114409783A (zh) 2015-06-24 2022-04-29 Jcr制药股份有限公司 通过血脑屏障的抗人转铁蛋白受体抗体
US11130815B2 (en) 2015-06-24 2021-09-28 Jcr Pharmaceuticals Co., Ltd. Fusion proteins containing a BDNF and an anti-human transferrin receptor antibody
MX2018000621A (es) 2015-07-13 2018-05-11 Cytomx Therapeutics Inc Anticuerpos anti-pd-1, anticuerpos anti-pd-1 activables, y metodos de uso de los mismos.
US10548986B2 (en) 2016-03-02 2020-02-04 Eisai R&D Management Co., Ltd. Eribulin-based antibody-drug conjugates and methods of use
KR102318480B1 (ko) 2016-08-25 2021-10-28 제이씨알 파마 가부시키가이샤 항체 융합 단백질의 제조 방법
US10759864B2 (en) 2016-12-26 2020-09-01 Jcr Pharmaceuticals Co., Ltd. Anti-human transferrin receptor antibody capable of penetrating blood-brain barrier
KR102471458B1 (ko) 2016-12-28 2022-11-25 제이씨알 파마 가부시키가이샤 동결건조 제제
WO2019049967A1 (ja) 2017-09-07 2019-03-14 Ｊｃｒファーマ株式会社 水性医薬組成物

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