MX2015012615A - Inhibidores de hdac. - Google Patents
Inhibidores de hdac.Info
- Publication number
- MX2015012615A MX2015012615A MX2015012615A MX2015012615A MX2015012615A MX 2015012615 A MX2015012615 A MX 2015012615A MX 2015012615 A MX2015012615 A MX 2015012615A MX 2015012615 A MX2015012615 A MX 2015012615A MX 2015012615 A MX2015012615 A MX 2015012615A
- Authority
- MX
- Mexico
- Prior art keywords
- hdac inhibitors
- compounds
- formula
- hdac
- hdac3
- Prior art date
Links
- 239000003276 histone deacetylase inhibitor Substances 0.000 title 1
- 102000003964 Histone deacetylase Human genes 0.000 abstract 2
- 108090000353 Histone deacetylase Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102100039996 Histone deacetylase 1 Human genes 0.000 abstract 1
- 102100039999 Histone deacetylase 2 Human genes 0.000 abstract 1
- 102100021455 Histone deacetylase 3 Human genes 0.000 abstract 1
- 101001035024 Homo sapiens Histone deacetylase 1 Proteins 0.000 abstract 1
- 101001035011 Homo sapiens Histone deacetylase 2 Proteins 0.000 abstract 1
- 101000899282 Homo sapiens Histone deacetylase 3 Proteins 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Communicable Diseases (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Se describen en la presente compuestos de fórmula (I), y método para inhibir enzimas de histona deacetilasa ("HDAC") (por ejemplo, HDACI, HDAC2 y HDAC3) usando compuestos de fórmula (I).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361800170P | 2013-03-15 | 2013-03-15 | |
US201361863235P | 2013-08-07 | 2013-08-07 | |
PCT/US2014/027633 WO2014143666A1 (en) | 2013-03-15 | 2014-03-14 | Hdac inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015012615A true MX2015012615A (es) | 2016-05-31 |
MX370142B MX370142B (es) | 2019-12-03 |
Family
ID=50680153
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015012615A MX370142B (es) | 2013-03-15 | 2014-03-14 | Inhibidores de hdac. |
Country Status (18)
Country | Link |
---|---|
US (3) | US10029988B2 (es) |
EP (1) | EP2970139B1 (es) |
JP (1) | JP6503338B2 (es) |
KR (1) | KR20150132345A (es) |
CN (1) | CN105121415B (es) |
AU (1) | AU2014228344C1 (es) |
BR (1) | BR112015023399A8 (es) |
CA (1) | CA2903490C (es) |
DK (1) | DK2970139T3 (es) |
ES (1) | ES2680224T3 (es) |
HK (1) | HK1217702A1 (es) |
IL (1) | IL240937B (es) |
MX (1) | MX370142B (es) |
NZ (1) | NZ711585A (es) |
PT (1) | PT2970139T (es) |
RU (1) | RU2665554C2 (es) |
WO (1) | WO2014143666A1 (es) |
ZA (1) | ZA201506516B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
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CN104876872B (zh) * | 2015-04-24 | 2017-07-07 | 昆明理工大学 | 一种制备1‑叔丁氧基羰基‑3‑羟甲基吲唑的方法及应用 |
US20170240535A1 (en) * | 2016-02-01 | 2017-08-24 | Regenacy Pharmaceuticals, Llc | Hdac1/2 inhibitors for the treatment of neurodegenerative and/or cognitive disorders |
UY38765A (es) * | 2019-06-27 | 2021-01-29 | Biogen Ma Inc | Derivados de 2h-indazol y su uso en el tratamiento de enfermedades |
KR102507397B1 (ko) | 2020-09-10 | 2023-03-07 | 계명대학교 산학협력단 | 히스톤 탈아세틸화효소 억제 활성을 갖는 신규 화합물 및 이의 용도 |
US11866405B2 (en) | 2020-12-10 | 2024-01-09 | Astrazeneca Ab | Substituted indazoles as IRAK4 inhibitors |
WO2023034440A1 (en) | 2021-09-01 | 2023-03-09 | Case Western Reserve University | Treatment of neurodegenerative diseases with hdac inhibitors |
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EP2970139A1 (en) | 2016-01-20 |
PT2970139T (pt) | 2018-08-01 |
RU2015143841A3 (es) | 2018-03-01 |
CA2903490A1 (en) | 2014-09-18 |
KR20150132345A (ko) | 2015-11-25 |
CA2903490C (en) | 2021-04-13 |
CN105121415B (zh) | 2018-10-12 |
AU2014228344C1 (en) | 2019-02-07 |
HK1217702A1 (zh) | 2017-01-20 |
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EP2970139B1 (en) | 2018-05-30 |
JP2016516716A (ja) | 2016-06-09 |
US20180362472A1 (en) | 2018-12-20 |
IL240937A0 (en) | 2015-11-30 |
NZ711585A (en) | 2020-05-29 |
US10428028B2 (en) | 2019-10-01 |
RU2665554C2 (ru) | 2018-08-31 |
US20160031823A1 (en) | 2016-02-04 |
RU2015143841A (ru) | 2017-05-05 |
BR112015023399A8 (pt) | 2019-12-03 |
MX370142B (es) | 2019-12-03 |
DK2970139T3 (en) | 2018-08-13 |
BR112015023399A2 (pt) | 2017-07-18 |
CN105121415A (zh) | 2015-12-02 |
US10029988B2 (en) | 2018-07-24 |
WO2014143666A1 (en) | 2014-09-18 |
ES2680224T3 (es) | 2018-09-05 |
ZA201506516B (en) | 2016-06-29 |
AU2014228344A1 (en) | 2015-09-17 |
US20190382351A1 (en) | 2019-12-19 |
JP6503338B2 (ja) | 2019-04-17 |
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