MX2011002705A - Compuestos con anillos espiro-triciclicos como moduladores de beta-secretasas y metodos de uso. - Google Patents

Compuestos con anillos espiro-triciclicos como moduladores de beta-secretasas y metodos de uso.

Info

Publication number
MX2011002705A
MX2011002705A MX2011002705A MX2011002705A MX2011002705A MX 2011002705 A MX2011002705 A MX 2011002705A MX 2011002705 A MX2011002705 A MX 2011002705A MX 2011002705 A MX2011002705 A MX 2011002705A MX 2011002705 A MX2011002705 A MX 2011002705A
Authority
MX
Mexico
Prior art keywords
compounds
formula
beta
betasecretase
spiro
Prior art date
Application number
MX2011002705A
Other languages
English (en)
Spanish (es)
Inventor
Vinod F Patel
Qingyian Liu
Wenyuan Qian
Matthew Weiss
Daniel La
Vijay Keshav Gore
Ryan White
Charles Kreiman
Albert Amegadzie
Alan C Cheng
Thomas Dineen
Jason B Human
Jian J Chen
Vu Van Ma
Marian C Bryan
Oleg Epstein
Zihao Hua
Hongbing Huang
Isaac Marx
Chester C Yuan
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MX2011002705A publication Critical patent/MX2011002705A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
MX2011002705A 2008-09-11 2009-09-11 Compuestos con anillos espiro-triciclicos como moduladores de beta-secretasas y metodos de uso. MX2011002705A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9608208P 2008-09-11 2008-09-11
PCT/US2009/056748 WO2010030954A1 (en) 2008-09-11 2009-09-11 Spiro-tetracyclic ring compounds as betasecretase modulators and methods of use

Publications (1)

Publication Number Publication Date
MX2011002705A true MX2011002705A (es) 2011-09-09

Family

ID=41319591

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011002705A MX2011002705A (es) 2008-09-11 2009-09-11 Compuestos con anillos espiro-triciclicos como moduladores de beta-secretasas y metodos de uso.

Country Status (21)

Country Link
US (1) US8426447B2 (enExample)
EP (1) EP2328903B1 (enExample)
JP (1) JP5579720B2 (enExample)
KR (1) KR20110073511A (enExample)
CN (1) CN102209721A (enExample)
AU (1) AU2009291602B2 (enExample)
BR (1) BRPI0918449A2 (enExample)
CA (1) CA2736130C (enExample)
CL (1) CL2011000516A1 (enExample)
CO (1) CO6362014A2 (enExample)
CR (1) CR20110134A (enExample)
EA (1) EA201100461A1 (enExample)
ES (1) ES2459195T3 (enExample)
IL (1) IL211440A0 (enExample)
MA (1) MA32705B1 (enExample)
MX (1) MX2011002705A (enExample)
MY (1) MY148558A (enExample)
PE (1) PE20110805A1 (enExample)
TW (1) TWI385175B (enExample)
WO (1) WO2010030954A1 (enExample)
ZA (1) ZA201102674B (enExample)

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US9000182B2 (en) 2012-06-20 2015-04-07 Astrazeneca Ab 2H-imidazol-4-amine compounds and their use as BACE inhibitors
US9000185B2 (en) 2012-06-20 2015-04-07 Astrazeneca Ab Cycloalkyl ether compounds and their use as BACE inhibitors
US9000184B2 (en) 2012-06-20 2015-04-07 Astrazeneca Ab Cyclohexane-1,2′-naphthalene-1′,2″-imidazol compounds and their use as BACE inhibitors
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Also Published As

Publication number Publication date
JP2012502112A (ja) 2012-01-26
MY148558A (en) 2013-04-30
CO6362014A2 (es) 2012-01-20
JP5579720B2 (ja) 2014-08-27
CR20110134A (es) 2011-08-04
CN102209721A (zh) 2011-10-05
ZA201102674B (en) 2011-12-28
IL211440A0 (en) 2011-05-31
US20100087429A1 (en) 2010-04-08
EP2328903A1 (en) 2011-06-08
TWI385175B (zh) 2013-02-11
PE20110805A1 (es) 2011-11-09
ES2459195T3 (es) 2014-05-08
BRPI0918449A2 (pt) 2019-09-24
WO2010030954A1 (en) 2010-03-18
CA2736130C (en) 2014-01-14
CA2736130A1 (en) 2010-03-18
KR20110073511A (ko) 2011-06-29
TW201022280A (en) 2010-06-16
AU2009291602B2 (en) 2013-02-14
EA201100461A1 (ru) 2011-10-31
EP2328903B1 (en) 2014-03-05
MA32705B1 (fr) 2011-10-02
CL2011000516A1 (es) 2011-08-26
US8426447B2 (en) 2013-04-23
AU2009291602A1 (en) 2010-03-18

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