ES2459195T3 - Compuestos de anillo espiro-tetracíclico como moduladores de beta-secretasa y métodos de uso - Google Patents

Compuestos de anillo espiro-tetracíclico como moduladores de beta-secretasa y métodos de uso Download PDF

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Publication number
ES2459195T3
ES2459195T3 ES09737222.1T ES09737222T ES2459195T3 ES 2459195 T3 ES2459195 T3 ES 2459195T3 ES 09737222 T ES09737222 T ES 09737222T ES 2459195 T3 ES2459195 T3 ES 2459195T3
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Spain
Prior art keywords
alkyl
independently
ring
oxazol
amine
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Application number
ES09737222.1T
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English (en)
Spanish (es)
Inventor
Ryan White
Albert Amegadzie
Marian C. Bryan
Jian J. Chen
Alan C. Cheng
Thomas Dineen
Oleg Epstein
Vijay Keshav Gore
Zihao Hua
Jason B. Human
Hongbing Huang
Charles Kreiman
Daniel La
Qingyian Liu
Vu Van Ma
Isaac Marx
Vinod F. Patel
Wenyuan Qian
Matthew Weiss
Chester C. Yuan
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Amgen Inc
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Amgen Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
ES09737222.1T 2008-09-11 2009-09-11 Compuestos de anillo espiro-tetracíclico como moduladores de beta-secretasa y métodos de uso Active ES2459195T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9608208P 2008-09-11 2008-09-11
US96082P 2008-09-11
PCT/US2009/056748 WO2010030954A1 (en) 2008-09-11 2009-09-11 Spiro-tetracyclic ring compounds as betasecretase modulators and methods of use

Publications (1)

Publication Number Publication Date
ES2459195T3 true ES2459195T3 (es) 2014-05-08

Family

ID=41319591

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09737222.1T Active ES2459195T3 (es) 2008-09-11 2009-09-11 Compuestos de anillo espiro-tetracíclico como moduladores de beta-secretasa y métodos de uso

Country Status (21)

Country Link
US (1) US8426447B2 (enExample)
EP (1) EP2328903B1 (enExample)
JP (1) JP5579720B2 (enExample)
KR (1) KR20110073511A (enExample)
CN (1) CN102209721A (enExample)
AU (1) AU2009291602B2 (enExample)
BR (1) BRPI0918449A2 (enExample)
CA (1) CA2736130C (enExample)
CL (1) CL2011000516A1 (enExample)
CO (1) CO6362014A2 (enExample)
CR (1) CR20110134A (enExample)
EA (1) EA201100461A1 (enExample)
ES (1) ES2459195T3 (enExample)
IL (1) IL211440A0 (enExample)
MA (1) MA32705B1 (enExample)
MX (1) MX2011002705A (enExample)
MY (1) MY148558A (enExample)
PE (1) PE20110805A1 (enExample)
TW (1) TWI385175B (enExample)
WO (1) WO2010030954A1 (enExample)
ZA (1) ZA201102674B (enExample)

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